Details of the Target

General Information of Target

Target ID LDTP13367
Target Name Glutathione hydrolase 7 (GGT7)
Gene Name GGT7
Gene ID 2686
Synonyms
GGTL3; GGTL5; Glutathione hydrolase 7; EC 3.4.19.13; Gamma-glutamyltransferase 7; GGT 7; EC 2.3.2.2; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPED
RRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRN
PGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMV
EREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVT
AVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSP
LTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHS
LGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVI
TMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFR
RAQFLIKTKSQLSVSQDSDILFGSASSDTRDNN
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Gamma-glutamyltransferase family
Subcellular location
Membrane
Function Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.
TTD ID
T25122
Uniprot ID
Q9UJ14
DrugMap ID
TT62BC7
Ensemble ID
ENST00000336431.10
HGNC ID
HGNC:4259

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.W222Ter .
FTC133 SNV: p.G469R .
HS936T SNV: p.S532L .
HT115 SNV: p.V408M .
HT29 Deletion: p.L492Ter .
KPNYN SNV: p.D468E .
MEWO SNV: p.R652Q .
MONOMAC6 SNV: p.L331F .
NCIH1048 SNV: p.Q601L .
REH SNV: p.S440N .
SKMEL28 Substitution: p.A445V .
TCCSUP SNV: p.R297P .
TOV21G SNV: p.R89C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.79  LDD0403  [1]
P12
 Probe Info  		15.35  LDD0202  [2]
Alkyne-RA190
 Probe Info  		3.04  LDD0302  [3]
DBIA
 Probe Info  		C100(1.26); C102(1.26)  LDD0078  [4]
IPM
 Probe Info  		C555(0.00); C100(0.00)  LDD2156  [5]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		8.17  LDD1733  [6]
C082
 Probe Info  		5.17  LDD1774  [6]
C106
 Probe Info  		27.47  LDD1793  [6]
C107
 Probe Info  		8.00  LDD1794  [6]
C108
 Probe Info  		10.41  LDD1795  [6]
C153
 Probe Info  		17.03  LDD1834  [6]
C169
 Probe Info  		25.63  LDD1849  [6]
C170
 Probe Info  		8.17  LDD1850  [6]
C201
 Probe Info  		37.27  LDD1877  [6]
C206
 Probe Info  		18.25  LDD1881  [6]
C293
 Probe Info  		20.53  LDD1963  [6]
C296
 Probe Info  		12.91  LDD1966  [6]
C328
 Probe Info  		30.48  LDD1992  [6]
C343
 Probe Info  		15.45  LDD2005  [6]
C362
 Probe Info  		37.01  LDD2023  [6]
C363
 Probe Info  		16.80  LDD2024  [6]
C366
 Probe Info  		5.31  LDD2027  [6]
C388
 Probe Info  		54.95  LDD2047  [6]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C102(1.25); C100(1.04)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C102(1.24); C100(1.25)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C100(0.80); C102(0.80)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C100(1.03); C102(1.03)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C100(1.04); C102(1.04)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C100(1.08); C102(1.08)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C100(1.05); C102(1.05)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C100(1.31); C102(1.31)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C100(1.24); C102(1.24)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C100(1.16); C102(1.16)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C100(1.07); C102(1.07)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C100(0.97); C102(0.97)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C102(1.22); C100(1.22)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C100(1.01); C102(1.01)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C100(1.23); C102(1.23)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C100(1.12); C102(1.12)  LDD0546  [4]
 LDCM0230  AC113 HEK-293T C102(0.85); C100(0.74)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C102(0.90); C100(0.64)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C102(0.83); C100(0.61)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C102(1.06); C100(0.76)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C102(0.93); C100(0.74)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C102(0.89); C100(0.73)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C102(1.09); C100(0.83)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C102(1.23); C100(1.16)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C102(0.99); C100(0.79)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C102(0.89); C100(0.73)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C102(0.93); C100(0.71)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C102(1.02); C100(0.83)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C102(1.04); C100(0.89)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C102(1.03); C100(0.79)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C102(1.13); C100(0.92)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C102(0.99); C100(0.71)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C102(1.27); C100(1.24)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C102(1.26); C100(1.17)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C102(1.27); C100(1.12)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C102(1.44); C100(1.44)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C102(1.42); C100(1.35)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C102(1.48); C100(1.05)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C102(1.37); C100(1.15)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C102(1.60); C100(1.22)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C102(1.24); C100(0.99)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C102(1.31); C100(0.97)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C102(1.43); C100(1.06)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C102(1.78); C100(1.29)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C102(1.40); C100(1.29)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C102(1.51); C100(1.14)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C102(1.26); C100(1.05)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C102(1.66); C100(1.22)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C100(0.91); C102(0.91)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C100(1.01); C102(1.01)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C100(0.83); C102(0.83)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C100(1.03); C102(1.03)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C100(0.99); C102(0.99)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C100(1.04); C102(1.04)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C100(1.26); C102(1.26)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C102(1.34); C100(1.15)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C100(1.11); C102(1.11)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C100(1.21); C102(1.21)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C100(0.99); C102(0.99)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C100(1.00); C102(1.00)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C100(1.02); C102(1.02)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C100(1.11); C102(1.11)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C100(0.87); C102(0.87)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C100(0.78); C102(0.78)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C102(1.37); C100(0.86)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C102(1.36); C100(1.09)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C102(1.36); C100(1.04)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C102(1.12); C100(0.95)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C102(1.45); C100(1.08)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C102(1.30); C100(1.00)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C102(1.38); C100(0.97)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C102(2.24); C100(1.51)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C102(1.32); C100(1.20)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C102(0.92); C100(1.03)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C102(0.98); C100(0.92)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C102(0.92); C100(0.95)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C102(0.96); C100(0.92)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C102(0.96); C100(0.87)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C102(0.87); C100(0.86)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C102(1.07); C100(0.99)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C102(0.96); C100(1.14)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C102(1.05); C100(0.96)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C102(1.10); C100(1.04)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C102(1.37); C100(1.38)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C102(0.90); C100(0.98)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C102(1.11); C100(0.98)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C102(0.96); C100(0.80)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C102(1.11); C100(1.18)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C102(1.12); C100(1.19)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C102(1.00); C100(1.05)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C102(1.24); C100(1.18)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C102(1.26); C100(1.11)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C102(1.38); C100(1.20)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C102(1.25); C100(1.09)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C102(1.26); C100(1.13)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C102(1.35); C100(1.18)  LDD0905  [4]
 LDCM0308  AC46 HCT 116 C100(0.72); C102(0.72)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C100(0.74); C102(0.74)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C100(0.84); C102(0.84)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C100(0.74); C102(0.74)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C102(1.17); C100(1.15)  LDD0910  [4]
 LDCM0313  AC50 HCT 116 C100(0.89); C102(0.89)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C100(0.82); C102(0.82)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C100(0.84); C102(0.84)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C100(0.80); C102(0.80)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C100(0.66); C102(0.66)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C100(1.03); C102(1.03)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C100(0.71); C102(0.71)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C100(1.03); C102(1.03)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C100(0.88); C102(0.88)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C100(1.15); C102(1.15)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C102(1.29); C100(1.55)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C100(1.29); C102(1.29)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C100(1.02); C102(1.02)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C100(1.04); C102(1.04)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C100(1.09); C102(1.09)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C100(1.06); C102(1.06)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C100(1.06); C102(1.06)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C100(1.05); C102(1.05)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C100(1.28); C102(1.28)  LDD0648  [4]
 LDCM0332  AC68 HEK-293T C102(0.96); C100(0.93)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C102(1.00); C100(0.91)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C102(1.23); C100(1.24)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C102(1.03); C100(0.80)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C102(1.04); C100(0.75)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C102(1.16); C100(0.92)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C102(1.16); C100(0.85)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C102(1.13); C100(0.78)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C102(1.23); C100(1.14)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C102(0.98); C100(0.84)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C102(1.14); C100(0.85)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C102(1.13); C100(0.95)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C102(1.13); C100(0.95)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C102(1.46); C100(1.23)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C102(1.12); C100(0.86)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C102(1.17); C100(1.20)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C102(1.31); C100(0.81)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C102(0.93); C100(0.83)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C102(1.04); C100(0.76)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C102(1.07); C100(0.90)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C102(1.15); C100(0.91)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C102(1.02); C100(0.85)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C102(1.11); C100(0.81)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C102(1.12); C100(0.80)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C102(1.23); C100(0.93)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C102(1.00); C100(0.74)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C102(1.09); C100(0.86)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C102(1.11); C100(0.80)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C102(1.07); C100(0.70)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C102(1.04); C100(0.74)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C102(0.97); C100(0.70)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C102(1.23); C100(0.67)  LDD0962  [4]
 LDCM0365  AC98 HCT 116 C100(1.15); C102(1.15)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C100(0.91); C102(0.91)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C102(1.27); C100(1.17)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C102(1.34); C100(1.13)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C102(1.54); C100(1.38)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 12.79  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C100(1.26); C102(1.26)  LDD0078  [4]
 LDCM0088  C45 HEK-293T 15.35  LDD0202  [2]
 LDCM0367  CL1 HEK-293T C102(2.42); C100(3.29)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C102(2.54); C100(3.78)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C102(1.28); C100(1.08)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C102(1.50); C100(1.24)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C102(4.73); C100(4.50)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C102(1.48); C100(1.23)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C102(1.54); C100(1.32)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C102(1.26); C100(0.99)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C102(1.73); C100(1.59)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C102(1.30); C100(1.17)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C102(1.27); C100(1.01)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C102(3.15); C100(3.03)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C102(1.27); C100(1.37)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C102(3.34); C100(2.93)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C102(2.08); C100(1.77)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C102(1.21); C100(1.00)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C102(1.19); C100(1.13)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C102(4.72); C100(2.70)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C102(1.30); C100(1.11)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C102(1.16); C100(0.98)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C102(1.21); C100(1.15)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C102(1.04); C100(0.94)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C102(1.41); C100(1.52)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C102(1.34); C100(1.60)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C102(1.29); C100(1.50)  LDD0989  [4]
 LDCM0392  CL121 HCT 116 C100(1.09); C102(1.09)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C100(0.99); C102(0.99)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C100(1.31); C102(1.31)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C100(0.84); C102(0.84)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C100(0.92); C102(0.92)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C100(1.14); C102(1.14)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C100(1.04); C102(1.04)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C100(0.91); C102(0.91)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C102(1.09); C100(1.16)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C102(1.57); C100(1.96)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C102(2.98); C100(4.85)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C102(1.20); C100(1.43)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C102(3.66); C100(3.42)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C102(1.12); C100(0.94)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C102(1.07); C100(1.05)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C102(1.11); C100(1.29)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C102(1.15); C100(1.27)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C102(1.08); C100(0.60)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C102(1.39); C100(1.18)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C102(0.89); C100(0.92)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C102(1.20); C100(1.37)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C102(3.49); C100(3.48)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C102(1.24); C100(1.21)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C102(1.29); C100(1.40)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C102(1.27); C100(1.31)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C102(1.26); C100(1.58)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C102(1.61); C100(1.94)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C102(1.24); C100(1.03)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C102(1.12); C100(1.40)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C102(1.11); C100(1.35)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C102(20.00); C100(0.93)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C102(1.19); C100(1.08)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C102(0.96); C100(1.01)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C102(1.15); C100(1.11)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C102(1.67); C100(1.32)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C102(1.81); C100(1.14)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C102(1.71); C100(2.25)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C102(1.15); C100(1.06)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C102(3.50); C100(2.01)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C102(1.14); C100(0.83)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C102(1.21); C100(0.84)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C102(1.09); C100(1.15)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C102(1.97); C100(1.26)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C102(1.36); C100(1.24)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C102(1.10); C100(1.15)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C102(1.32); C100(1.50)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C102(1.39); C100(1.32)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C102(1.32); C100(1.43)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C102(1.72); C100(1.37)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C102(3.45); C100(3.23)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C102(1.18); C100(1.37)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C102(4.04); C100(4.31)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C102(3.81); C100(3.82)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C102(1.30); C100(1.17)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C102(1.10); C100(1.38)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C102(1.83); C100(1.77)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C102(1.09); C100(1.09)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C102(1.22); C100(1.02)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C102(3.30); C100(5.62)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C102(1.38); C100(1.06)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C102(0.94); C100(1.09)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C102(0.99); C100(1.17)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C102(1.00); C100(1.01)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C102(0.92); C100(1.06)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C102(1.15); C100(1.14)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C102(1.38); C100(1.29)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C102(1.21); C100(1.11)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C102(1.53); C100(1.21)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C102(1.68); C100(1.52)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C102(1.42); C100(1.60)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C102(1.18); C100(1.12)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C102(1.30); C100(1.27)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C102(1.25); C100(1.43)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C102(2.64); C100(2.35)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C102(1.41); C100(0.94)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C102(1.14); C100(1.09)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C102(3.24); C100(2.93)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C102(2.00); C100(1.78)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C102(1.46); C100(1.31)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C102(0.99); C100(1.53)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C102(1.22); C100(1.01)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C102(1.22); C100(1.01)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C102(0.98); C100(0.88)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C102(1.61); C100(1.40)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C102(2.55); C100(2.30)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C102(1.77); C100(1.46)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C102(2.03); C100(1.65)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C102(1.82); C100(1.28)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C102(1.80); C100(1.51)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C102(1.57); C100(1.24)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C102(0.85); C100(1.06)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C102(2.17); C100(1.02)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C102(1.19); C100(1.41)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C102(2.44); C100(1.66)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C102(2.32); C100(1.70)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C102(1.32); C100(1.11)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C102(7.17); C100(3.84)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C102(1.73); C100(1.46)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C102(2.84); C100(2.13)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C102(1.72); C100(1.33)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C102(1.10); C100(1.01)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C363(0.97); C555(1.12)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C102(1.52); C100(1.13)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C102(1.21); C100(1.07)  LDD1025  [4]
 LDCM0022  KB02 HEK-293T C363(0.96)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C363(1.08)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C363(0.89)  LDD1502  [8]
 LDCM0131  RA190 SK-MEL-5 3.04  LDD0302  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Probable UDP-sugar transporter protein SLC35A4 (SLC35A4) Nucleotide-sugar transporter family Q96G79
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 25 (GPR25) G-protein coupled receptor 1 family O00155
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) Chemokine-like factor family Q96FZ5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MAL-like protein (MALL) MAL family Q13021

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402