General Information of Experiment

Probe Name Alkyne-RA190  Probe Info 
Probe concentration 30 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name RA190  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Skin
Disease Model Cutaneous melanoma [ICD-11:2B00]
Model Name Human cutaneous melanoma cells (SK-MEL-5)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13367  Glutathione hydrolase 7 (GGT7) 3.0
 LDTP10038  Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) 2.4
 LDTP09620  Soluble calcium-activated nucleotidase 1 (CANT1) 2.2
 LDTP03599  Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4) 2.2
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09502  Nuclear pore membrane glycoprotein 210 (NUP210) 3.3
 LDTP06490  Vesicle-associated membrane protein 3 (VAMP3) 2.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 2.1
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 10.0
 LDTP13664  Syntaxin-8 (STX8) 3.3

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.