Details of the Target

General Information of Target

Target ID LDTP09502
Target Name Nuclear pore membrane glycoprotein 210 (NUP210)
Gene Name NUP210
Gene ID 23225
Synonyms
KIAA0906; Nuclear pore membrane glycoprotein 210; Nuclear pore protein gp210; Nuclear envelope pore membrane protein POM 210; POM210; Nucleoporin Nup210; Pore membrane protein of 210 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWLSTR
PEVASIEPLGLDEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHDIQ
IVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRIL
TFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLIL
ENILLNPAYDVYLMVGTSIHYKVQKIRQGKITELSMPSDQYELQLQNSIPGPEGDPARPV
AVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASRLPNSTIYVVEPGYLGFTVHPGDRWVL
ETGRLYEITIEVFDKFSNKVYVSDNIRIETVLPAEFFEVLSSSQNGSYHRIRALKRGQTA
IDAALTSVVDQDGGVHILQVPVWNQQEVEIHIPITLYPSILTFPWQPKTGAYQYTIRAHG
GSGNFSWSSSSHLVATVTVKGVMTTGSDIGFSVIQAHDVQNPLHFGEMKVYVIEPHSMEF
APCQVEARVGQALELPLRISGLMPGGASEVVTLSDCSHFDLAVEVENQGVFQPLPGRLPP
GSEHCSGIRVKAEAQGSTTLLVSYRHGHVHLSAKITIAAYLPLKAVDPSSVALVTLGSSK
EMLFEGGPRPWILEPSKFFQNVTAEDTDSIGLALFAPHSSRNYQQHWILVTCQALGEQVI
ALSVGNKPSLTNPFPAVEPAVVKFVCAPPSRLTLAPVYTSPQLDMSCPLLQQNKQVVPVS
SHRNPRLDLAAYDQEGRRFDNFSSLSIQWESTRPVLASIEPELPMQLVSQDDESGQKKLH
GLQAILVHEASGTTAITATATGYQESHLSSARTKQPHDPLVPLSASIELILVEDVRVSPE
EVTIYNHPGIQAELRIREGSGYFFLNTSTADVVKVAYQEARGVAMVHPLLPGSSTIMIHD
LCLVFPAPAKAVVYVSDIQELYIRVVDKVEIGKTVKAYVRVLDLHKKPFLAKYFPFMDLK
LRAASPIITLVALDEALDNYTITFLIRGVAIGQTSLTASVTNKAGQRINSAPQQIEVFPP
FRLMPRKVTLLIGATMQVTSEGGPQPQSNILFSISNESVALVSAAGLVQGLAIGNGTVSG
LVQAVDAETGKVVIISQDLVQVEVLLLRAVRIRAPIMRMRTGTQMPIYVTGITNHQNPFS
FGNAVPGLTFHWSVTKRDVLDLRGRHHEASIRLPSQYNFAMNVLGRVKGRTGLRVVVKAV
DPTSGQLYGLARELSDEIQVQVFEKLQLLNPEIEAEQILMSPNSYIKLQTNRDGAASLSY
RVLDGPEKVPVVHVDEKGFLASGSMIGTSTIEVIAQEPFGANQTIIVAVKVSPVSYLRVS
MSPVLHTQNKEALVAVPLGMTVTFTVHFHDNSGDVFHAHSSVLNFATNRDDFVQIGKGPT
NNTCVVRTVSVGLTLLRVWDAEHPGLSDFMPLPVLQAISPELSGAMVVGDVLCLATVLTS
LEGLSGTWSSSANSILHIDPKTGVAVARAVGSVTVYYEVAGHLRTYKEVVVSVPQRIMAR
HLHPIQTSFQEATASKVIVAVGDRSSNLRGECTPTQREVIQALHPETLISCQSQFKPAVF
DFPSQDVFTVEPQFDTALGQYFCSITMHRLTDKQRKHLSMKKTALVVSASLSSSHFSTEQ
VGAEVPFSPGLFADQAEILLSNHYTSSEIRVFGAPEVLENLEVKSGSPAVLAFAKEKSFG
WPSFITYTVGVLDPAAGSQGPLSTTLTFSSPVTNQAIAIPVTVAFVVDRRGPGPYGASLF
QHFLDSYQVMFFTLFALLAGTAVMIIAYHTVCTPRDLAVPAALTPRASPGHSPHYFAASS
PTSPNALPPARKASPPSGLWSPAYASH
Target Bioclass
Transporter and channel
Family
NUP210 family
Subcellular location
Nucleus, nuclear pore complex
Function Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
Uniprot ID
Q8TEM1
Ensemble ID
ENST00000254508.7
HGNC ID
HGNC:30052

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A1132T DBIA    Probe Info 
CAL148 SNV: p.G433E DBIA    Probe Info 
CAMA1 SNV: p.S1213Y DBIA    Probe Info 
COLO800 SNV: p.A582T DBIA    Probe Info 
DANG SNV: p.E534Ter DBIA    Probe Info 
DU145 SNV: p.I452T DBIA    Probe Info 
FTC133 SNV: p.T1405A DBIA    Probe Info 
HCT15 SNV: p.E127K; p.L673I; p.F1201S; p.P1761H DBIA    Probe Info 
HEC1 SNV: p.I421T DBIA    Probe Info 
JEKO1 SNV: p.I1187V DBIA    Probe Info 
JURKAT SNV: p.E1035D .
KURAMOCHI SNV: p.G862S DBIA    Probe Info 
LS180 SNV: p.H117N DBIA    Probe Info 
MCC13 Substitution: p.R797C DBIA    Probe Info 
MEWO Substitution: p.R558K DBIA    Probe Info 
MFE319 SNV: p.T151A; p.S288N DBIA    Probe Info 
MOLT4 Deletion: p.P1715RfsTer9 IA-alkyne    Probe Info 
NCIH446 SNV: p.P1689T DBIA    Probe Info 
NCIH716 Substitution: p.K874T .
SHP77 SNV: p.V1098L DBIA    Probe Info 
SKN Insertion: p.S1763FfsTer178 DBIA    Probe Info 
SKOV3 SNV: p.M538T DBIA    Probe Info 
SW403 SNV: p.T257I .
TE10 SNV: p.D432G DBIA    Probe Info 
U2OS SNV: p.L1752F DBIA    Probe Info 
UMUC3 SNV: p.Q615K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y1855(5.75)  LDD0260  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
BTD
 Probe Info  		C1592(0.78)  LDD2127  [3]
HPAP
 Probe Info  		3.57  LDD0062  [4]
Alkyne-RA190
 Probe Info  		3.44  LDD0299  [5]
DBIA
 Probe Info  		C1592(1.91)  LDD0531  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C109(0.00); C746(0.00); C1592(0.00); C767(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C1592(0.00); C76(0.00)  LDD0032  [9]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C109(0.00); C746(0.00); C767(0.00); C76(0.00)  LDD0037  [8]
IPM
 Probe Info  		C543(0.00); C767(0.00)  LDD2156  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
VSF
 Probe Info  		C767(0.00); C1592(0.00)  LDD0007  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		C76(0.00); H1561(0.00); H1386(0.00); H1563(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		H174(0.00); C746(0.00); C1592(0.00); C76(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C76(0.00); C1592(0.00)  LDD0218  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
NAIA_5
 Probe Info  		C109(0.00); C767(0.00); C1592(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		12.25  LDD0472  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
STS-1
 Probe Info  		7.33  LDD0136  [19]
STS-2
 Probe Info  		6.00  LDD0138  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]
DA-2
 Probe Info  		N.A.  LDD0072  [21]
OEA-DA
 Probe Info  		4.09  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1592(1.91)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C1592(0.68)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1592(2.02)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1592(0.65)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1592(0.83)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1592(0.78)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1592(0.59)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1592(0.51)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1592(0.82)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1592(0.89)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1592(0.87)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1592(0.82)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C1592(1.10)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1592(0.48)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1592(0.57)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1592(0.67)  LDD0546  [6]
 LDCM0230  AC113 PaTu 8988t C767(0.71)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C767(0.83)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C767(0.68)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C767(0.77)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C767(0.67)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C767(1.04)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C767(0.69)  LDD1115  [6]
 LDCM0237  AC12 HCT 116 C1592(0.77)  LDD0554  [6]
 LDCM0238  AC120 PaTu 8988t C767(0.64)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C767(0.74)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C767(0.80)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C767(0.63)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C767(0.64)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C767(0.66)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C767(0.72)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C767(0.72)  LDD1124  [6]
 LDCM0246  AC128 HCT 116 C1592(0.95)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C1592(1.15)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C1592(0.76)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C1592(0.74)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C1592(1.13)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C1592(1.01)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C1592(0.89)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C1592(0.68)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C1592(1.03)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C1592(1.07)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C1592(1.09)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C1592(0.79)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C1592(0.84)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C1592(0.88)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C1592(1.20)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C1592(1.81)  LDD0579  [6]
 LDCM0263  AC143 HEK-293T C767(0.89)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C767(0.91)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C767(0.90)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C767(0.95)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C767(0.98)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C767(1.35)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C767(1.34)  LDD0867  [6]
 LDCM0270  AC15 HCT 116 C1592(0.55)  LDD0587  [6]
 LDCM0271  AC150 HEK-293T C767(1.03)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C767(0.83)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C767(0.87)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C767(0.81)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C767(0.99)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C767(0.93)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C767(1.13)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C767(1.09)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C1592(1.27)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C1592(1.19)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C1592(1.57)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C1592(1.27)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C1592(1.23)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C1592(2.37)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C1592(1.81)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C1592(0.83)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C1592(0.95)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1592(0.25)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C1592(0.42)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C1592(0.26)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C1592(0.38)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C1592(0.44)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C1592(1.38)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C1592(0.40)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C1592(0.50)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C1592(0.40)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1592(0.48)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1592(0.37)  LDD0612  [6]
 LDCM0296  AC35 PaTu 8988t C109(1.17); C767(0.87)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C109(1.27); C767(0.71)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C109(1.33); C767(0.69)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C109(1.48); C767(0.75)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C109(1.13); C767(0.71)  LDD1179  [6]
 LDCM0301  AC4 HCT 116 C1592(1.16)  LDD0618  [6]
 LDCM0302  AC40 PaTu 8988t C109(1.20); C767(0.81)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C109(0.82); C767(0.66)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C109(1.09); C767(0.81)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C109(1.19); C767(0.66)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C109(1.05); C767(0.65)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C109(1.24); C767(0.78)  LDD1186  [6]
 LDCM0308  AC46 HCT 116 C1592(0.95)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C1592(0.67)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C1592(0.69)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C1592(0.88)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C1592(1.73)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C1592(0.89)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C1592(0.60)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C1592(0.89)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C1592(0.72)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C1592(1.21)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C1592(0.85)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C1592(0.78)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C767(1.26)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C767(1.21)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C767(1.21)  LDD0920  [6]
 LDCM0323  AC6 HCT 116 C1592(0.53)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C767(1.05)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C767(0.96)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C767(1.12)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C767(1.03)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C767(1.06)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C767(0.92)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C767(1.33)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C767(1.02)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C1592(1.19)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C1592(1.29)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C1592(1.49)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C1592(0.93)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C1592(2.02)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C1592(0.74)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C1592(0.72)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C1592(0.93)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C1592(0.74)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C1592(1.34)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C1592(0.92)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C1592(1.29)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C1592(0.97)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C1592(1.44)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C1592(0.88)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C1592(1.57)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C1592(0.54)  LDD0665  [6]
 LDCM0365  AC98 HCT 116 C1592(0.32)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C1592(0.90)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C1592(1.25)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C1592(0.91)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C1592(0.53)  LDD0592  [6]
 LDCM0108  Chloroacetamide HeLa C76(0.00); H1561(0.00); C1592(0.00); C746(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C767(20.00)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C1592(1.57)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C1592(0.93)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C1592(1.51)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C1592(0.90)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C1592(0.96)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C1592(0.61)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C1592(0.60)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C1592(1.75)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C1592(1.73)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C1592(1.79)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C1592(1.98)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C1592(2.53)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C1592(0.93)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C1592(1.38)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C1592(1.38)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C1592(0.34)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1592(0.50)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C1592(0.42)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C1592(0.35)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C1592(0.35)  LDD0703  [6]
 LDCM0387  CL117 PaTu 8988t C109(1.09); C767(0.82)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C109(1.09); C767(1.85)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C109(0.93); C767(0.76)  LDD1268  [6]
 LDCM0390  CL12 HCT 116 C1592(1.05)  LDD0707  [6]
 LDCM0391  CL120 PaTu 8988t C109(0.82); C767(0.68)  LDD1270  [6]
 LDCM0392  CL121 HCT 116 C1592(1.07)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C1592(0.82)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C1592(0.72)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C1592(1.38)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C767(1.11)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C767(1.23)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C767(1.22)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C767(1.22)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C1592(1.17)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C1592(1.35)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C1592(0.79)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C767(1.10)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C767(1.08)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C767(1.00)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C767(0.99)  LDD1004  [6]
 LDCM0407  CL2 HCT 116 C1592(1.88)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C767(1.13)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C767(1.19)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C767(0.94)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C767(1.19)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C767(1.04)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C767(0.98)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C767(0.91)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C767(1.01)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C767(1.19)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C767(1.13)  LDD1015  [6]
 LDCM0418  CL3 HCT 116 C1592(1.46)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C767(0.99)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C767(0.84)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C767(0.87)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C767(0.75)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C767(0.90)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C767(0.76)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C767(0.95)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C767(0.78)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C767(0.66)  LDD1026  [6]
 LDCM0429  CL4 HCT 116 C1592(1.19)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C767(0.70)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C767(0.72)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C767(0.67)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C767(0.70)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C767(0.82)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C767(0.69)  LDD1033  [6]
 LDCM0436  CL46 PaTu 8988t C767(0.83)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C767(0.83)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C767(0.80)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C767(0.89)  LDD1318  [6]
 LDCM0440  CL5 HCT 116 C1592(1.13)  LDD0757  [6]
 LDCM0441  CL50 PaTu 8988t C767(0.82)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C767(0.91)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C767(1.11)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C767(0.96)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C767(0.88)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C767(1.04)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C767(1.07)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C767(0.91)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C767(0.98)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C767(0.91)  LDD1329  [6]
 LDCM0451  CL6 HCT 116 C1592(1.48)  LDD0768  [6]
 LDCM0452  CL60 PaTu 8988t C767(1.01)  LDD1331  [6]
 LDCM0453  CL61 HEK-293T C767(1.02)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C767(0.99)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C767(0.88)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C767(1.13)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C767(0.91)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C767(0.97)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C767(1.13)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C767(0.94)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C767(1.08)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C1592(1.12)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C767(1.19)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C767(0.97)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C767(1.02)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C767(0.99)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C767(0.83)  LDD1065  [6]
 LDCM0469  CL76 PaTu 8988t C1592(2.53); C767(1.00)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C1592(1.02); C767(0.81)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C1592(0.75); C767(0.97)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C1592(0.81); C767(0.97)  LDD1351  [6]
 LDCM0473  CL8 HCT 116 C1592(0.97)  LDD0790  [6]
 LDCM0474  CL80 PaTu 8988t C1592(1.36); C767(0.79)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C1592(0.74); C767(1.03)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C1592(0.93); C767(0.91)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C1592(1.22); C767(1.22)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C1592(0.76); C767(0.91)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C1592(0.92); C767(1.02)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C1592(1.06); C767(1.00)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C1592(0.63); C767(1.04)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C1592(0.74); C767(0.88)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C1592(0.85); C767(0.85)  LDD1362  [6]
 LDCM0484  CL9 HCT 116 C1592(1.06)  LDD0801  [6]
 LDCM0485  CL90 PaTu 8988t C1592(0.73); C767(0.86)  LDD1364  [6]
 LDCM0486  CL91 HCT 116 C1592(1.61)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1592(0.84)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1592(0.99)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1592(1.42)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1592(0.89)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1592(0.95)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1592(1.24)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1592(1.06)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1592(1.35)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C1592(0.87); C1611(0.97); C767(1.40)  LDD1698  [23]
 LDCM0468  Fragment33 HEK-293T C767(0.72)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C767(0.74)  LDD1025  [6]
 LDCM0107  IAA HeLa H1561(0.00); H626(0.00); H174(0.00); H1563(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C1592(0.99); C1611(0.97); C76(1.08); C767(0.86)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C1592(1.02); C1611(1.03); C76(1.01); C767(0.95)  LDD1497  [23]
 LDCM0024  KB05 COLO792 C746(3.19); C76(1.31)  LDD3310  [24]
 LDCM0109  NEM HeLa H1851(0.00); H1561(0.00); H174(0.00); H907(0.00)  LDD0223  [15]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1592(0.78)  LDD2127  [3]
 LDCM0014  Panhematin HEK-293T 3.57  LDD0062  [4]
 LDCM0131  RA190 MM1.R 3.44  LDD0299  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840