Probe Name	Alkyne-RA190					Probe Info
Probe concentration	30 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	LFQ
Competitor Name	RA190					Competitor Info
Competitor Concentration	5 uM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Peripheral blood
	Disease Model		Plasma cell myeloma [ICD-11:2A83]
	Model Name		Human plasma cell myeloma cells (MM1.R)

Target ID	Target Name					Binding Ratio
LDTP07362	Atlastin-3 (ATL3)					9.9
LDTP02812	Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)					9.0
LDTP00294	26S proteasome non-ATPase regulatory subunit 14 (PSMD14)					8.0
LDTP15154	Dehydrogenase/reductase SDR family member 13 (DHRS13)					7.7
LDTP04358	Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)					5.3
LDTP11127	ADP-dependent glucokinase (ADPGK)					5.0
LDTP12105	L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH)					5.0
LDTP07967	Lysophosphatidylcholine acyltransferase 2 (LPCAT2)					4.8
LDTP19892	DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68)					4.7
LDTP10432	ATP synthase membrane subunit K, mitochondrial (ATP5MK)					4.4
LDTP07290	Lysophospholipid acyltransferase LPCAT4 (LPCAT4)					4.4
LDTP01462	Endonuclease domain-containing 1 protein (ENDOD1)					4.1
LDTP03458	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)					4.1
LDTP10201	Atypical kinase COQ8B, mitochondrial (COQ8B)					3.9
LDTP04889	Signal peptidase complex subunit 3 (SPCS3)					3.6
LDTP13282	Prenylcysteine oxidase 1 (PCYOX1)					3.4
LDTP10888	Legumain (LGMN)					3.2
LDTP04310	E3 SUMO-protein ligase RanBP2 (RANBP2)					3.2
LDTP14074	Ribosomal biogenesis protein LAS1L (LAS1L)					3.1
LDTP03985	Caspase-2 (CASP2)					2.9
LDTP10038	Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1)					2.9
LDTP03540	Heme oxygenase 2 (HMOX2)					2.9
LDTP07227	Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1)					2.9
LDTP08799	Lysophosphatidylserine lipase ABHD12 (ABHD12)					2.8
LDTP01514	NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4)					2.6
LDTP04690	Double-stranded RNA-specific adenosine deaminase (ADAR)					2.6
LDTP07511	Long-chain fatty acid transport protein 4 (SLC27A4)					2.6
LDTP00597	Serine palmitoyltransferase 1 (SPTLC1)					2.4
LDTP10399	Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5)					2.4
LDTP04519	Kinesin-like protein KIF11 (KIF11)					2.4
LDTP06104	Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)					2.3
LDTP10077	Patatin-like phospholipase domain-containing protein 2 (PNPLA2)					2.3
LDTP08156	Schlafen family member 11 (SLFN11)					2.2
LDTP10471	Protein disulfide-isomerase TMX3 (TMX3)					2.2
LDTP02055	Thymidylate synthase (TYMS)					2.2
LDTP13675	COP9 signalosome complex subunit 3 (COPS3)					2.1
LDTP13533	Long-chain-fatty-acid--CoA ligase 5 (ACSL5)					2.1

Target ID	Target Name					Binding Ratio
LDTP15898	HIG1 domain family member 2A, mitochondrial (HIGD2A)					79.1
LDTP04407	Amiloride-sensitive sodium channel subunit beta (SCNN1B)					17.0
LDTP01060	PRA1 family protein 2 (PRAF2)					12.9
LDTP06945	Sigma intracellular receptor 2 (TMEM97)					9.9
LDTP15948	Transmembrane protein 126A (TMEM126A)					9.2
LDTP14952	Mpv17-like protein 2 (MPV17L2)					6.8
LDTP12210	Mitochondrial thiamine pyrophosphate carrier (SLC25A19)					3.7
LDTP09502	Nuclear pore membrane glycoprotein 210 (NUP210)					3.4
LDTP18053	Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40)					3.4
LDTP07477	Transmembrane protein 214 (TMEM214)					2.9
LDTP02058	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2)					2.8
LDTP05528	Apoptosis regulator BAX (BAX)					2.8
LDTP02658	Cytochrome b-245 light chain (CYBA)					2.8
LDTP05631	Bone marrow stromal antigen 2 (BST2)					2.8
LDTP09579	Nuclear pore complex protein Nup133 (NUP133)					2.7
LDTP10897	Nuclear pore complex protein Nup88 (NUP88)					2.6
LDTP03061	Cation-dependent mannose-6-phosphate receptor (M6PR)					2.4
LDTP01969	Transferrin receptor protein 1 (TFRC)					2.3
LDTP03810	ATP synthase subunit gamma, mitochondrial (ATP5F1C)					2.3
LDTP11213	Nucleoporin NDC1 (NDC1)					2.2
LDTP06462	Neutral amino acid transporter B(0) (SLC1A5)					2.1
LDTP13824	Voltage-dependent anion-selective channel protein 3 (VDAC3)					2.1
LDTP05780	Syntaxin-5 (STX5)					2.0

Target ID	Target Name					Binding Ratio
LDTP06354	Interferon regulatory factor 4 (IRF4)					2.8

Target ID	Target Name					Binding Ratio
LDTP12387	SLAM family member 7 (SLAMF7)					3.0

Target ID	Target Name					Binding Ratio
LDTP03659	CD70 antigen (CD70)					2.4

Target ID	Target Name					Binding Ratio
LDTP13800	Proteasome maturation protein (POMP)					35.4
LDTP14139	Origin recognition complex subunit 6 (ORC6)					25.7
LDTP04038	Melanoma-associated antigen 1 (MAGEA1)					10.7
LDTP03527	G1/S-specific cyclin-D2 (CCND2)					8.3
LDTP18373	Thioredoxin-related transmembrane protein 4 (TMX4)					6.3
LDTP19831	Protein THEM6 (THEM6)					5.9
LDTP10584	Junctional sarcoplasmic reticulum protein 1 (JSRP1)					5.7
LDTP01379	Ribosomal L1 domain-containing protein 1 (RSL1D1)					5.3
LDTP12755	OCIA domain-containing protein 1 (OCIAD1)					5.3
LDTP15395	Cell cycle exit and neuronal differentiation protein 1 (CEND1)					5.0
LDTP11324	RNA-binding protein 4 (RBM4)					4.9
LDTP07205	Telomere-associated protein RIF1 (RIF1)					4.5
LDTP12506	DNA polymerase epsilon subunit 3 (POLE3)					4.2
LDTP16080	Protein FAM114A2 (FAM114A2)					4.2
LDTP13338	Vacuolar protein sorting-associated protein 51 homolog (VPS51)					3.9
LDTP07521	Enhancer of mRNA-decapping protein 4 (EDC4)					3.6
LDTP09587	Protein BRICK1 (BRK1)					3.6
LDTP10353	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1)					3.5
LDTP09787	Nicastrin (NCSTN)					3.4
LDTP00691	TELO2-interacting protein 1 homolog (TTI1)					3.3
LDTP10091	Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1)					3.2
LDTP05922	Dynactin subunit 2 (DCTN2)					3.2
LDTP06412	Telomeric repeat-binding factor 2 (TERF2)					3.1
LDTP01021	Perilipin-3 (PLIN3)					3.1
LDTP13094	Tuftelin-interacting protein 11 (TFIP11)					3.0
LDTP13657	Melanoma-associated antigen D2 (MAGED2)					3.0
LDTP11766	Activating signal cointegrator 1 complex subunit 2 (ASCC2)					2.8
LDTP01522	Reticulon-3 (RTN3)					2.8
LDTP06915	Borealin (CDCA8)					2.6
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)					2.5
LDTP15253	HEAT repeat-containing protein 3 (HEATR3)					2.5
LDTP00517	U2 snRNP-associated SURP motif-containing protein (U2SURP)					2.5
LDTP13701	Serine/threonine-protein phosphatase 6 regulatory subunit 1 (PPP6R1)					2.5
LDTP02302	Small ribosomal subunit protein eS17 (RPS17)					2.4
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)					2.4
LDTP10914	Translin-associated protein X (TSNAX)					2.4
LDTP06954	Nucleolar MIF4G domain-containing protein 1 (NOM1)					2.3
LDTP12680	Fanconi anemia group I protein (FANCI)					2.3
LDTP07401	Ragulator complex protein LAMTOR1 (LAMTOR1)					2.2
LDTP06109	Guanine nucleotide-binding protein subunit alpha-13 (GNA13)					2.2
LDTP04729	Ribosomal RNA processing protein 1 homolog A (RRP1)					2.2
LDTP06809	Tubulin beta-8 chain (TUBB8)					2.1
LDTP05867	Treacle protein (TCOF1)					2.1
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)					2.1
LDTP13913	Inner nuclear membrane protein Man1 (LEMD3)					2.1
LDTP05257	Receptor expression-enhancing protein 5 (REEP5)					2.1
LDTP05898	Sequestosome-1 (SQSTM1)					2.1
LDTP14980	RRP12-like protein (RRP12)					2.1
LDTP08359	Condensin-2 complex subunit G2 (NCAPG2)					2.0
LDTP03841	Hippocalcin-like protein 1 (HPCAL1)					2.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)					2.0

1	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.