Details of the Target

General Information of Target

Target ID LDTP13800
Target Name Proteasome maturation protein (POMP)
Gene Name POMP
Gene ID 51371
Synonyms
C13orf12; UMP1; Proteasome maturation protein; Proteassemblin; Protein UMP1 homolog; hUMP1; Voltage-gated K channel beta subunit 4.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
Target Bioclass
Other
Family
POMP/UMP1 family
Subcellular location
Cytoplasm, cytosol
Function
Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.
Uniprot ID
Q9Y244
Ensemble ID
ENST00000380842.5
HGNC ID
HGNC:20330

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K61(10.00)  LDD0277  [2]
Alkyne-RA190
 Probe Info  		35.38  LDD0299  [3]
HHS-475
 Probe Info  		Y136(1.38)  LDD0264  [4]
IA-alkyne
 Probe Info  		C37(2.07)  LDD2182  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C231
 Probe Info  		14.22  LDD1904  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C37(1.27)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C37(2.37)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C37(0.47)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C37(1.22)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C37(1.07)  LDD2192  [5]
 LDCM0576  Fragment14 Ramos C37(0.79)  LDD2193  [5]
 LDCM0579  Fragment20 Ramos C37(2.17)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C37(0.89)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C37(1.09)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C37(1.06)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C37(0.93)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C37(2.10)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C37(1.19)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C37(2.42)  LDD2201  [5]
 LDCM0468  Fragment33 Ramos C37(1.52)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C37(1.07)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C37(0.84)  LDD2184  [5]
 LDCM0610  Fragment52 Ramos C37(1.16)  LDD2204  [5]
 LDCM0614  Fragment56 Ramos C37(1.07)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C37(1.62)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C37(1.44)  LDD2188  [5]
 LDCM0116  HHS-0101 DM93 Y136(1.38)  LDD0264  [4]
 LDCM0119  HHS-0401 DM93 Y136(4.74)  LDD0267  [4]
 LDCM0022  KB02 Ramos C37(2.07)  LDD2182  [5]
 LDCM0023  KB03 Ramos C37(0.70)  LDD2183  [5]
 LDCM0024  KB05 Ramos C37(1.16)  LDD2185  [5]
 LDCM0131  RA190 MM1.R 35.38  LDD0299  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Proteasome subunit beta type-3 (PSMB3) Peptidase T1B family P49720
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Proteasome subunit beta type-7 (PSMB7) Peptidase T1B family Q99436
Proteasome subunit beta type-9 (PSMB9) Peptidase T1B family P28065
Metallophosphoesterase MPPED2 (MPPED2) UPF0046 family Q15777

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587