Details of the Target

General Information of Target

Target ID LDTP15898
Target Name HIG1 domain family member 2A, mitochondrial (HIGD2A)
Gene Name HIGD2A
Gene ID 192286
Synonyms
HIG1 domain family member 2A, mitochondrial; RCF1 homolog B; RCF1b
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFS
KVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGG
AVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK
Target Bioclass
Transporter and channel
Subcellular location
Mitochondrion membrane
Function
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes.
Uniprot ID
Q9BW72
Ensemble ID
ENST00000274787.3
HGNC ID
HGNC:28311

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K36(2.41); K38(2.90)  LDD0277  [1]
Alkyne-RA190
 Probe Info  		79.14  LDD0299  [2]
EA-probe
 Probe Info  		C53(1.99)  LDD2210  [3]
DBIA
 Probe Info  		C53(0.94)  LDD1492  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0147  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C293
 Probe Info  		16.11  LDD1963  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C53(1.02)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C53(0.98)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C53(0.90)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C53(1.02)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C53(1.28)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C53(1.07)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C53(0.99)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C53(1.06)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C53(0.84)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C53(1.01)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C53(1.05)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C53(0.95)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C53(1.17)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C53(1.03)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C53(1.01)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C53(1.10)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C53(0.87)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C53(1.08)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C53(0.91)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C53(0.92)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C53(1.03)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C53(1.09)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C53(1.19)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C53(0.95)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C53(1.12)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C53(1.15)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C53(0.99)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C53(0.96)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C53(1.09)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C53(1.02)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C53(1.15)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C53(1.01)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C53(0.91)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C53(0.95)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C53(0.96)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C53(1.01)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C53(1.01)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C53(1.19)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C53(0.93)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C53(1.05)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C53(0.92)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C53(0.99)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C53(0.95)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C53(1.04)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C53(1.01)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C53(1.10)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C53(0.96)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C53(0.95)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C53(0.94)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C53(0.95)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C53(0.90)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C53(1.02)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C53(1.03)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C53(1.00)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C53(0.90)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C53(1.08)  LDD1570  [4]
 LDCM0367  CL1 HEK-293T C53(0.91)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C53(1.57)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C53(0.81)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C53(1.03)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C53(1.15)  LDD1576  [4]
 LDCM0374  CL105 HEK-293T C53(0.92)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C53(0.88)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C53(1.01)  LDD1580  [4]
 LDCM0378  CL109 HEK-293T C53(0.87)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C53(1.46)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C53(1.00)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C53(1.08)  LDD1585  [4]
 LDCM0383  CL113 HEK-293T C53(0.88)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C53(1.20)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C53(1.12)  LDD1589  [4]
 LDCM0387  CL117 HEK-293T C53(0.90)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C53(0.90)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C53(1.03)  LDD1593  [4]
 LDCM0392  CL121 HEK-293T C53(0.88)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C53(0.91)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C53(1.04)  LDD1598  [4]
 LDCM0396  CL125 HEK-293T C53(0.68)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C53(0.92)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C53(0.93)  LDD1602  [4]
 LDCM0400  CL13 HEK-293T C53(0.91)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C53(1.10)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C53(1.20)  LDD1606  [4]
 LDCM0404  CL17 HEK-293T C53(1.17)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C53(0.89)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C53(1.00)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C53(0.82)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C53(1.37)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C53(1.01)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C53(1.33)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C53(1.41)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C53(0.90)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C53(1.01)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C53(1.24)  LDD1619  [4]
 LDCM0417  CL29 HEK-293T C53(0.82)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C53(1.16)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C53(1.04)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C53(0.94)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C53(1.30)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C53(1.05)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C53(1.26)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C53(1.13)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C53(0.88)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C53(1.07)  LDD1632  [4]
 LDCM0431  CL41 HEK-293T C53(1.19)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C53(0.97)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C53(1.15)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C53(1.35)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C53(1.08)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C53(1.15)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C53(1.13)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C53(0.90)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C53(1.06)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C53(1.11)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C53(1.14)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C53(1.15)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C53(1.08)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C53(1.27)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C53(1.11)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C53(1.30)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C53(1.18)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C53(0.94)  LDD1654  [4]
 LDCM0453  CL61 HEK-293T C53(0.95)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C53(1.21)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C53(1.11)  LDD1658  [4]
 LDCM0457  CL65 HEK-293T C53(1.07)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C53(1.27)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C53(1.04)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C53(1.06)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C53(1.08)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C53(0.86)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C53(1.33)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C53(1.25)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C53(0.81)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C53(1.01)  LDD1670  [4]
 LDCM0470  CL77 HEK-293T C53(1.10)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C53(1.05)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C53(1.02)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C53(1.46)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C53(1.13)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C53(1.08)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C53(1.34)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C53(1.24)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C53(1.05)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C53(0.95)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C53(0.97)  LDD1684  [4]
 LDCM0483  CL89 HEK-293T C53(0.87)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C53(1.10)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C53(0.99)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C53(0.89)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C53(1.12)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C53(0.82)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C53(1.02)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C53(1.18)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C53(0.77)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C53(0.97)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C53(1.01)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C53(1.23)  LDD1698  [4]
 LDCM0175  Ethacrynic acid HeLa C53(1.99)  LDD2210  [3]
 LDCM0625  F8 Ramos C53(1.10)  LDD2187  [11]
 LDCM0573  Fragment11 Ramos C53(1.00)  LDD2190  [11]
 LDCM0586  Fragment28 Ramos C53(0.80)  LDD2198  [11]
 LDCM0468  Fragment33 HEK-293T C53(1.07)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C53(1.00)  LDD1631  [4]
 LDCM0569  Fragment7 Ramos C53(0.48)  LDD2186  [11]
 LDCM0022  KB02 HEK-293T C53(0.94)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C53(0.85)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C53(0.96)  LDD1502  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C53(1.00)  LDD2206  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C53(1.92)  LDD2207  [12]
 LDCM0131  RA190 MM1.R 79.14  LDD0299  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.