Details of the Target

General Information of Target

Target ID LDTP03810
Target Name ATP synthase subunit gamma, mitochondrial (ATP5F1C)
Gene Name ATP5F1C
Gene ID 509
Synonyms
ATP5C; ATP5C1; ATP5CL1; ATP synthase subunit gamma, mitochondrial; ATP synthase F1 subunit gamma; F-ATPase gamma subunit
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAE
RELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVAT
LTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEF
DEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYY
SLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
Target Bioclass
Transporter and channel
Family
ATPase gamma chain family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Uniprot ID
P36542
Ensemble ID
ENST00000335698.4
HGNC ID
HGNC:833
ChEMBL ID
CHEMBL4295752

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NALM6 SNV: p.R277H; p.R279H DBIA    Probe Info 
SNU869 SNV: p.Y77F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.43  LDD0402  [1]
CHEMBL5175495
 Probe Info  		7.79  LDD0196  [2]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y196(13.37)  LDD0257  [4]
TH216
 Probe Info  		Y196(20.00); Y69(20.00); Y77(6.94)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
Probe 1
 Probe Info  		Y77(14.06); Y196(90.68)  LDD3495  [7]
DBIA
 Probe Info  		C103(4.71)  LDD3310  [8]
BTD
 Probe Info  		C103(2.43)  LDD1700  [9]
Alkyne-RA190
 Probe Info  		2.27  LDD0299  [10]
W1
 Probe Info  		N47(0.86)  LDD0238  [11]
ATP probe
 Probe Info  		K112(0.00); K115(0.00); K154(0.00); K90(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
ATP probe
 Probe Info  		K115(0.00); K270(0.00); K79(0.00)  LDD0035  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
Compound 10
 Probe Info  		N.A.  LDD2216  [18]
Compound 11
 Probe Info  		N.A.  LDD2213  [18]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
SF
 Probe Info  		Y77(0.00); K154(0.00)  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		K270(0.00); K262(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C103(0.00); H145(0.00); H91(0.00); H107(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		C103(0.00); H145(0.00); H91(0.00); H107(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		N.A.  LDD0218  [22]
8d
 Probe Info  		N.A.  LDD0305  [23]
AOyne
 Probe Info  		15.00  LDD0443  [24]
MPP-AC
 Probe Info  		N.A.  LDD0428  [25]
NAIA_5
 Probe Info  		N.A.  LDD2223  [16]
TER-AC
 Probe Info  		N.A.  LDD0426  [25]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.26  LDD1740  [26]
C092
 Probe Info  		36.50  LDD1783  [26]
C218
 Probe Info  		14.22  LDD1892  [26]
C265
 Probe Info  		20.11  LDD1936  [26]
C355
 Probe Info  		22.16  LDD2016  [26]
C367
 Probe Info  		5.13  LDD2028  [26]
FFF probe11
 Probe Info  		7.02  LDD0471  [27]
FFF probe13
 Probe Info  		20.00  LDD0475  [27]
FFF probe14
 Probe Info  		12.03  LDD0477  [27]
FFF probe15
 Probe Info  		5.80  LDD0478  [27]
FFF probe2
 Probe Info  		11.47  LDD0463  [27]
FFF probe3
 Probe Info  		12.12  LDD0464  [27]
FFF probe6
 Probe Info  		5.25  LDD0467  [27]
JN0003
 Probe Info  		20.00  LDD0469  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
STS-2
 Probe Info  		7.00  LDD0138  [28]
DA-2
 Probe Info  		N.A.  LDD0072  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C103(0.53)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C103(0.86)  LDD2112  [9]
 LDCM0132  15d THP-1 N.A.  LDD0305  [23]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C103(1.19)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C103(1.38)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C103(0.39)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C103(0.69)  LDD2131  [9]
 LDCM0214  AC1 HEK-293T C103(1.11)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C103(0.95)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C103(1.03)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C103(1.00)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C103(1.00)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C103(1.08)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C103(1.10)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C103(1.02)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C103(1.15)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C103(0.96)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C103(1.02)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C103(1.02)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C103(1.07)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C103(1.06)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C103(0.95)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C103(1.08)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C103(0.98)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C103(1.03)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C103(1.00)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C103(0.96)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C103(1.05)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C103(1.05)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C103(1.07)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C103(1.06)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C103(1.04)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C103(0.93)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C103(1.03)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C103(1.00)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C103(0.89)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C103(1.04)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C103(1.01)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C103(0.99)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C103(1.01)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C103(1.01)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C103(0.95)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C103(0.99)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C103(0.98)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C103(0.95)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C103(1.05)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C103(1.04)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C103(0.93)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C103(1.02)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C103(1.00)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C103(0.94)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C103(0.97)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C103(0.98)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C103(0.93)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C103(0.99)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C103(0.99)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C103(0.99)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C103(0.99)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C103(0.92)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C103(0.90)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C103(1.01)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C103(0.96)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C103(0.91)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C103(0.96)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C103(0.97)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C103(0.92)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C103(1.01)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C103(1.04)  LDD1569  [30]
 LDCM0545  Acetamide MDA-MB-231 C103(0.47)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C103(0.88)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C103(0.88)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C103(1.02)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C103(0.98)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 12.03  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C103(1.02)  LDD2171  [31]
 LDCM0498  BS-3668 MDA-MB-231 C103(0.60)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa H145(0.00); C103(0.00); H91(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C103(0.73)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C103(0.95)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C103(1.56)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C103(1.06)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C103(0.95)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C103(1.17)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C103(0.94)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C103(1.02)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C103(1.01)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C103(1.05)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C103(1.07)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C103(1.08)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C103(1.06)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C103(1.28)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C103(1.29)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C103(1.08)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C103(1.06)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C103(0.93)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C103(1.22)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C103(0.93)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C103(1.03)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C103(0.92)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C103(0.92)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C103(0.95)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C103(1.08)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C103(1.00)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C103(0.97)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C103(0.98)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C103(1.17)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C103(1.05)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C103(0.77)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C103(0.90)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C103(0.86)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C103(0.94)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C103(0.92)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C103(0.98)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C103(1.13)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C103(1.01)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C103(1.37)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C103(0.99)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C103(0.99)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C103(0.92)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C103(0.95)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C103(1.30)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C103(1.11)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C103(1.21)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C103(1.11)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C103(1.10)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C103(1.03)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C103(1.02)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C103(0.98)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C103(1.09)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C103(0.96)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C103(0.96)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C103(1.12)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C103(1.04)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C103(1.27)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C103(1.10)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C103(1.28)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C103(1.19)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C103(0.93)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C103(1.07)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C103(0.98)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C103(1.02)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C103(1.13)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C103(1.01)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C103(1.07)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C103(1.07)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C103(1.08)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C103(1.08)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C103(1.22)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C103(1.16)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C103(0.86)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C103(1.00)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C103(1.09)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C103(0.97)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C103(1.26)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C103(1.17)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C103(1.07)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C103(1.02)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C103(0.95)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C103(1.11)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C103(1.18)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C103(1.06)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C103(1.09)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C103(0.78)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C103(0.96)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C103(0.96)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C103(1.12)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C103(1.08)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C103(1.03)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C103(1.08)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C103(0.99)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C103(0.92)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C103(0.99)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C103(1.09)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C103(1.08)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C103(1.04)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C103(0.95)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C103(0.93)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C103(1.04)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C103(1.27)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C103(0.97)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C103(1.04)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C103(1.52)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C103(0.98)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C103(1.03)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C103(1.10)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C103(1.20)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C103(1.15)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C103(0.72)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C103(0.71)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C103(0.79)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C103(0.88)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C103(0.92)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C103(1.04)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C103(1.54)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C103(0.98)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C103(0.98)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C103(1.05)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C103(1.04)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C103(1.68)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C103(0.94)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C103(1.08)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C103(1.02)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C103(1.03)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C103(0.93)  LDD1698  [30]
 LDCM0625  F8 Ramos C103(0.77)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C103(0.64)  LDD2189  [32]
 LDCM0574  Fragment12 Ramos C103(0.74)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C103(0.84)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C103(1.07)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C103(0.50)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C103(0.78)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C103(0.89)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C103(0.68)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C103(0.96)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C103(0.96)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C103(1.27)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C103(0.65)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C103(0.95)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C103(0.92)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C103(0.83)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C103(1.02)  LDD1631  [30]
 LDCM0610  Fragment52 Ramos C103(0.94)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C103(0.88)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C103(0.66)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C103(0.60)  LDD2188  [32]
 LDCM0015  HNE MDA-MB-231 C103(1.28)  LDD0346  [32]
 LDCM0107  IAA HeLa H145(0.00); H91(0.00); C103(0.00); H107(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C103(0.90)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C103(0.98)  LDD1497  [30]
 LDCM0024  KB05 COLO792 C103(4.71)  LDD3310  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C103(1.17)  LDD2102  [9]
 LDCM0109  NEM HeLa H145(0.00); C103(0.00); H91(0.00); H107(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C103(0.63)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C103(0.94)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C103(0.87)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C103(1.54)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C103(1.27)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C103(0.25)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C103(0.95)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C103(1.00)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C103(1.43)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C103(0.45)  LDD2100  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C103(0.55)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C103(1.72)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C103(0.52)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C103(1.02)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C103(0.64)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C103(0.86)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C103(1.12)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C103(0.44)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C103(0.46)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C103(0.54)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C103(0.55)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C103(1.93)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C103(0.86)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C103(0.36)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C103(1.40)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C103(0.64)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C103(1.02)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C103(0.38)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C103(1.13)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C103(0.62)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C103(1.44)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C103(0.73)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C103(0.42)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C103(1.63)  LDD2135  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C103(0.99)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C103(2.43)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C103(1.06)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C103(0.61)  LDD2143  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C103(0.32)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C103(1.16)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C103(1.41)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C103(0.49)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C103(0.47)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C103(0.46)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C103(0.37)  LDD2151  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C103(0.73); C103(0.72)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C103(0.79); C103(0.70)  LDD2207  [33]
 LDCM0131  RA190 MM1.R 2.27  LDD0299  [10]
 LDCM0021  THZ1 HCT 116 C103(1.02)  LDD2173  [31]
 LDCM0111  W14 Hep-G2 N47(0.86)  LDD0238  [11]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Piceatannol Small molecular drug DB08399
Quercetin Small molecular drug DB04216
1-acetyl-2-carboxypiperidine . DB07384
Aurovertin B . DB07394
N1-(2-amino-4-methylpentyl)Octahydro-pyrrolo[12-a] Pyrimidine . DB08629

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. J Med Chem. 2021 Jan 14;64(1):768-781. doi: 10.1021/acs.jmedchem.0c01743. Epub 2020 Dec 1.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.