Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name 8d  Probe Info 
Criteria Other data
Quantitative Method
LFQ
Competitor Name 15d  Competitor Info 
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Acute monocytic leukemia [ICD-11:2A60]
Model Name Human acute monocytic leukemia cell lysate (THP-1)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name
 LDTP10649  28S rRNA (cytosine-C(5))-methyltransferase (NSUN5)
 LDTP09605  E3 ubiquitin-protein ligase RNF138 (RNF138)
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
 LDTP12128  Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1)
 LDTP12627  Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (DECR2)
 LDTP13673  Probable dimethyladenosine transferase (DIMT1)
 LDTP09464  Serine/threonine-protein kinase Nek7 (NEK7)
 LDTP10399  Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5)
 LDTP11571  Uridine-cytidine kinase 2 (UCK2)
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name
 LDTP03810  ATP synthase subunit gamma, mitochondrial (ATP5F1C)

References

1 Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. J Med Chem. 2021 Jan 14;64(1):768-781. doi: 10.1021/acs.jmedchem.0c01743. Epub 2020 Dec 1.