Details of the Target

General Information of Target

Target ID LDTP06915
Target Name Borealin (CDCA8)
Gene Name CDCA8
Gene ID 55143
Synonyms
PESCRG3; Borealin; Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRKGSSRVAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILR
LPKALREMNWLDYFALGGNKQALEEAATADLDITEINKLTAEAIQTPLKSAKTRKVIQVD
EMIVEEEEEEENERKNLQTARVKRCPPSKKRTQSIQGKGKGKRSSRANTVTPAVGRLEVS
MVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGNGSPLADSKEIFLTVPVGGGESLR
LLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSSIRTHK
Target Type
Literature-reported
Target Bioclass
Other
Family
Borealin family
Subcellular location
Nucleus, nucleolus
Function
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
TTD ID
T46541
Uniprot ID
Q53HL2
DrugMap ID
TT04YCM
Ensemble ID
ENST00000327331.2
HGNC ID
HGNC:14629

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
BTD
 Probe Info  		C273(0.23)  LDD2117  [3]
Alkyne-RA190
 Probe Info  		2.56  LDD0299  [4]
DBIA
 Probe Info  		C273(5.79)  LDD0209  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0147  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C343
 Probe Info  		13.74  LDD2005  [11]
C346
 Probe Info  		13.36  LDD2007  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C273(0.23)  LDD2117  [3]
 LDCM0214  AC1 HCT 116 C273(0.94)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C273(1.27)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C273(0.96)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C273(0.92)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C273(1.00)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C273(1.21)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C273(1.04)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C273(1.10)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C273(1.35)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C273(0.96)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C273(1.04)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C273(0.76)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C273(1.07)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C273(0.92)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C273(0.94)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C273(0.98)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C273(0.97)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C273(0.97)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C273(0.91)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C273(1.08)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C273(1.40)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C273(1.16)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C273(1.15)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C273(1.10)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C273(1.00)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C273(1.23)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C273(0.99)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C273(1.24)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C273(1.23)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C273(0.90)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C273(1.01)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C273(1.09)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C273(0.78)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C273(0.70)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C273(0.76)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C273(0.77)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C273(0.85)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C273(0.87)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C273(0.77)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C273(0.83)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C273(0.78)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C273(0.73)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C273(0.76)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C273(0.94)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C273(1.11)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C273(0.76)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C273(0.69)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C273(0.88)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C273(1.03)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C273(1.29)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C273(1.29)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C273(1.29)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C273(1.28)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C273(1.76)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C273(1.43)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C273(1.12)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C273(1.06)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C273(1.36)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C273(1.34)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C273(1.71)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C273(1.27)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C273(1.43)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C273(1.18)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C273(1.19)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C273(1.14)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C273(1.05)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C273(1.10)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C273(0.83)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C273(1.01)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C273(1.38)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C273(1.21)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C273(1.11)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C273(1.18)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C273(1.00)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C273(1.04)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C273(1.30)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C273(1.19)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C273(1.04)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C273(0.89)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C273(0.99)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C273(1.12)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C273(1.01)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C273(0.95)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C273(1.10)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C273(1.09)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C273(0.97)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C273(0.88)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C273(1.26)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C273(1.23)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C273(0.95)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C273(0.91)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C273(0.97)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C273(0.99)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C273(1.03)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C273(1.13)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C273(1.09)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C273(1.01)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C273(0.89)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C273(0.93)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C273(1.03)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C273(0.85)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C273(1.14)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C273(1.00)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C273(1.02)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C273(1.00)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C273(0.97)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C273(1.09)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C273(1.52)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C273(0.97)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C273(1.08)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C273(1.00)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C273(1.15)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C273(1.11)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C273(1.10)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C273(1.06)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C273(1.10)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C273(1.05)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C273(0.83)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C273(0.84)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C273(0.89)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C273(1.04)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C273(1.02)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C273(1.03)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C273(1.12)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C273(1.13)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C273(1.19)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C273(1.27)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C273(1.28)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C273(1.44)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C273(1.19)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C273(1.06)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C273(1.08)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C273(1.21)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C273(1.22)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C273(1.02)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C273(1.18)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C273(1.48)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C273(1.28)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C273(1.27)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C273(1.24)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C273(1.12)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C273(1.08)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C273(1.24)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C273(1.19)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C273(0.95)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C273(1.19)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C273(1.36)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C273(1.13)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C273(1.00)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C273(1.27)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C273(1.13)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C273(1.26)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C273(1.34)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C273(0.94)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C273(1.17)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C273(1.11)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C273(1.42)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 13.45  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C273(0.95)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C273(1.25)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C273(0.93)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C273(1.09)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C273(1.10)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C273(1.24)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C273(1.26)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C273(0.98)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C273(1.16)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C273(1.07)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C273(0.99)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C273(1.16)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C273(1.12)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C273(1.14)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C273(1.01)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C273(0.85)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C273(0.95)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C273(0.86)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C273(1.10)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C273(0.95)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C273(1.54)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C273(0.91)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C273(1.01)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C273(1.28)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C273(0.93)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C273(1.26)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C273(0.80)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C273(0.89)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C273(1.10)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C273(0.97)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C273(0.95)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C273(0.93)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C273(0.98)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C273(1.30)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C273(1.18)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C273(1.27)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C273(1.20)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C273(0.89)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C273(1.23)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C273(1.11)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C273(1.06)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C273(1.14)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C273(1.24)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C273(1.33)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C273(1.32)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C273(1.29)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C273(1.18)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C273(1.23)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C273(1.09)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C273(1.10)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C273(1.18)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C273(1.01)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C273(1.23)  LDD0736  [12]
 LDCM0420  CL31 HEK-293T C273(0.92)  LDD1018  [12]
 LDCM0421  CL32 HCT 116 C273(1.13)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C273(1.05)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C273(0.94)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C273(1.07)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C273(0.76)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C273(0.99)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C273(1.11)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C273(1.02)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C273(1.06)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C273(1.00)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C273(1.06)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C273(1.03)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C273(0.88)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C273(0.94)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C273(1.14)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C273(1.11)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C273(1.48)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C273(1.35)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C273(1.29)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C273(1.11)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C273(1.25)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C273(1.28)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C273(1.27)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C273(1.32)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C273(1.31)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C273(1.11)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C273(1.12)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C273(1.29)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C273(1.37)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C273(1.31)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C273(1.02)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C273(0.98)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C273(0.86)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C273(0.95)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C273(1.05)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C273(1.04)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C273(1.04)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C273(1.08)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C273(1.11)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C273(1.03)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C273(1.43)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C273(0.98)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C273(0.99)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C273(1.16)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C273(0.97)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C273(0.98)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C273(1.03)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C273(0.85)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C273(0.94)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C273(0.97)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C273(1.22)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C273(1.03)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C273(0.94)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C273(1.09)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C273(1.00)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C273(1.13)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C273(0.95)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C273(0.88)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C273(0.78)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C273(0.99)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C273(1.25)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C273(1.15)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C273(0.90)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C273(0.94)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C273(0.89)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C273(0.90)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C273(0.93)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C273(0.97)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C273(0.97)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C273(0.86)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C273(0.84)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C273(0.85)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C273(1.00)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C273(4.11)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C273(1.02)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C273(0.80)  LDD0744  [12]
 LDCM0022  KB02 HEK-293T C273(0.93)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C273(5.79)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C273(4.49)  LDD3310  [14]
 LDCM0109  NEM HeLa N.A.  LDD0233  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C273(0.37)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C273(0.26)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C273(0.18)  LDD2144  [3]
 LDCM0131  RA190 MM1.R 2.56  LDD0299  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen [starch] synthase, muscle (GYS1) Glycosyltransferase 3 family P13807
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
F-box only protein 17 (FBXO17) . Q96EF6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GAS2-like protein 3 (GAS2L3) GAS2 family Q86XJ1
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
Inner centromere protein (INCENP) INCENP family Q9NQS7
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Shugoshin 1 (SGO1) Shugoshin family Q5FBB7
Shugoshin 2 (SGO2) Shugoshin family Q562F6
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840