Details of the Target

General Information of Target

Target ID LDTP04038
Target Name Melanoma-associated antigen 1 (MAGEA1)
Gene Name MAGEA1
Gene ID 4100
Synonyms
MAGE1; MAGE1A; Melanoma-associated antigen 1; Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQG
ASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAR
EPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYD
GLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLT
QDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREA
ALREEEEGV
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
TTD ID
T42854
Uniprot ID
P43355
DrugMap ID
TT63M7Q
Ensemble ID
ENST00000356661.7
HGNC ID
HGNC:6796

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C92(5.06)  LDD0304  [1]
DBIA
 Probe Info  		C139(1.75)  LDD3364  [2]
Alkyne-RA190
 Probe Info  		10.69  LDD0299  [1]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
m-APA
 Probe Info  		N.A.  LDD0404  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [4]
 LDCM0022  KB02 AGS C139(1.77)  LDD2263  [2]
 LDCM0023  KB03 G-361 C139(5.17)  LDD2746  [2]
 LDCM0024  KB05 NCI-N87 C139(1.75)  LDD3364  [2]
 LDCM0131  RA190 MM1.R 10.69  LDD0299  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Ras-related protein Rab-17 (RAB17) Rab family Q9H0T7
E3 ubiquitin-protein ligase TRIM31 (TRIM31) TRIM/RBCC family Q9BZY9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Endophilin-B2 (SH3GLB2) Endophilin family Q9NR46
EP300-interacting inhibitor of differentiation 3 (EID3) NSE4 family Q8N140
Protein S100-A9 (S100A9) S-100 family P06702
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) SHFL family Q9NUL5
Mitochondrial dynamics protein MIEF1 (MIEF1) SMCR7 family Q9NQG6
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Huntingtin-interacting protein K (HYPK) . Q9NX55

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Car-t Cells Targeting Mage-a1 CAR T Cell Therapy D0NA4J
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Melanoma Vaccine (Alvac) Vaccine D0C1EO

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.