Details of the Target

General Information of Target

Target ID LDTP03659
Target Name CD70 antigen (CD70)
Gene Name CD70
Gene ID 970
Synonyms
CD27L; CD27LG; TNFSF7; CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAEL
QLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTA
SRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRN
TDETFFGVQWVRP
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Family
Tumor necrosis factor family
Subcellular location
Membrane
Function
Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
TTD ID
T67805
Uniprot ID
P32970
DrugMap ID
TTNCIE0
Ensemble ID
ENST00000245903.4
HGNC ID
HGNC:11937
ChEMBL ID
CHEMBL3712913

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.A154T .
HEC1B SNV: p.A154T .
LS180 Deletion: p.G78AfsTer33 .
NALM6 SNV: p.W75Ter .
NCIH2172 SNV: p.S141R .
P31FUJ SNV: p.R157P .
RL SNV: p.Y104C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K93(3.66)  LDD3494  [1]
DBIA
 Probe Info  		C17(2.36)  LDD3370  [2]
Alkyne-RA190
 Probe Info  		2.43  LDD0299  [3]
IA-alkyne
 Probe Info  		C8(4.51)  LDD2182  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		H148(0.00); H87(0.00)  LDD2231  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C8(1.08)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C8(2.55)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C8(3.04)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C8(2.83)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C8(1.34)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C8(3.67)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C8(3.04)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C8(1.57)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C8(0.77)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C8(1.17)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C8(1.56)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C8(1.36)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C8(0.76)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C8(2.65)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C8(1.48)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C8(2.49)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C8(2.44)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C8(2.49)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C8(1.26)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C8(2.27)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C8(3.48)  LDD2188  [4]
 LDCM0022  KB02 Ramos C8(4.51)  LDD2182  [4]
 LDCM0023  KB03 Ramos C8(5.93)  LDD2183  [4]
 LDCM0024  KB05 OCI-AML-2 C17(2.36)  LDD3370  [2]
 LDCM0131  RA190 MM1.R 2.43  LDD0299  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Jnj-74494550 Antibody D6Q5MG
4scar19 And 4scar70 CAR T Cell Therapy (Dual specific) D02YRD
Phase 1
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mdx-1203 Antibody D03KLF
Mdx-1411 Antibody D03KVW
Sea-cd70 Antibody D6H9TE
Sgn-70 Antibody D09PQP
Sgn-cd70a Antibody D0E2ZX
Anti-hcd70 Car Transduced Pbl CAR T Cell Therapy D0JO9M
Ctx130 CAR T Cell Therapy DVIY25
Amg 172 . D0NC1Q
Bms-936561 . D06FHQ
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Trimixdc Vaccine D04PFD
Cusatuzumab . DB15100
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vorsetuzumab Mafodotin Antibody D08WTE

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255