Details of the Target

General Information of Target

Target ID LDTP08359
Target Name Condensin-2 complex subunit G2 (NCAPG2)
Gene Name NCAPG2
Gene ID 54892
Synonyms
LUZP5; Condensin-2 complex subunit G2; Chromosome-associated protein G2; CAP-G2; hCAP-G2; Leucine zipper protein 5; Non-SMC condensin II complex subunit G2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKRETFVQAVSKELVGEFLQFVQLDKEASDPFSLNELLDELSRKQKEELWQRLKNLLTD
VLLESPVDGWQVVEAQGEDNMETEHGSKMRKSIEIIYAITSVILASVSVINESENYEALL
ECVIILNGILYALPESERKLQSSIQDLCVTWWEKGLPAKEDTGKTAFVMLLRRSLETKTG
ADVCRLWRIHQALYCFDYDLEESGEIKDMLLECFININYIKKEEGRRFLSCLFNWNINFI
KMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFHGIHLPRRS
PVHSKVREVLSYFHHQKKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPI
RDPNLHAIEMDSEIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILIDLL
KKVTGELAFDTSSADVRCSVFKCLPMILDNKLSHPLLEQLLPALRYSLHDNSEKVRVAFV
DMLLKIKAVRAAKFWKICPMEHILVRLETDSRPVSRRLVSLIFNSFLPVNQPEEVWCERC
VTLVQMNHAAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGRE
KENVTVLDKTLSVNDVACMAGLLEIIVILWKSIDRSMENNKEAKLYTINKFASVLPEYLK
VFKDDRCKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKSYCTLLDCLCSWGQVG
HILELVDNWLPTEHAQAKSNTASKGRVQIHDTRPVKPELALVYIEYLLTHPKNRECLLSA
PRKKLNHLLKALETSKADLESLLQTPGGKPRGFSEAAAPRAFGLHCRLSIHLQHKFCSEG
KVYLSMLEDTGFWLESKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCKDVVMVGLGDHQ
FQMQLLQRSLGIMQTVKGFFYVSLLLDILKEITGSSLIQKTDSDEEVAMLLDTVQKVFQK
MLECIARSFRKQPEEGLRLLYSVQRPLHEFITAVQSRHTDTPVHRGVLSTLIAGPVVEIS
HQLRKVSDVEELTPPEHLSDLPPFSRCLIGIIIKSSNVVRSFLDELKACVASNDIEGIVC
LTAAVHIILVINAGKHKSSKVREVAATVHRKLKTFMEITLEEDSIERFLYESSSRTLGEL
LNS
Target Bioclass
Other
Subcellular location
Nucleus
Function Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
Uniprot ID
Q86XI2
Ensemble ID
ENST00000356309.8
HGNC ID
HGNC:21904

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.P685L .
DU145 SNV: p.G245W DBIA    Probe Info 
HCT15 SNV: p.A351V .
KURAMOCHI SNV: p.V480L .
MOLT4 SNV: p.M846I IA-alkyne    Probe Info 
OCUM1 SNV: p.R4H DBIA    Probe Info 
RKO SNV: p.R985M; p.C1069Y DBIA    Probe Info 
SKMEL2 SNV: p.L20M DBIA    Probe Info 
SNU1 SNV: p.P528S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.39  LDD0402  [1]
TH211
 Probe Info  		Y331(20.00); Y466(8.51)  LDD0257  [2]
STPyne
 Probe Info  		K332(10.00); K744(1.10); K796(7.14)  LDD0277  [3]
ONAyne
 Probe Info  		K178(10.00)  LDD0275  [3]
Probe 1
 Probe Info  		Y1130(20.16)  LDD3495  [4]
BTD
 Probe Info  		C776(1.45)  LDD2091  [5]
Curcusone 37
 Probe Info  		2.40  LDD0188  [6]
AHL-Pu-1
 Probe Info  		C498(2.38); C964(2.49); C184(2.62)  LDD0168  [7]
Alkyne-RA190
 Probe Info  		2.02  LDD0299  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
DBIA
 Probe Info  		C826(71.36); C184(4.91); C964(18.95); C964(19.34)  LDD0209  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C443(0.00); C540(0.00); C285(0.00); C184(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C540(0.00); C776(0.00); C564(0.00); C498(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C776(0.00); C231(0.00); C564(0.00); C498(0.00)  LDD0037  [11]
TFBX
 Probe Info  		C964(0.00); C776(0.00); C401(0.00)  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
Compound 10
 Probe Info  		C401(0.00); C776(0.00)  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Methacrolein
 Probe Info  		C776(0.00); C564(0.00)  LDD0218  [16]
AOyne
 Probe Info  		10.80  LDD0443  [17]
NAIA_5
 Probe Info  		C443(0.00); C148(0.00); C618(0.00)  LDD2223  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C776(0.66)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C776(1.10)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C401(1.25)  LDD2117  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C776(1.00)  LDD2103  [5]
 LDCM0025  4SU-RNA HEK-293T C498(2.38); C964(2.49); C184(2.62)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C184(2.28)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C184(0.92); C964(0.92); C564(1.01); C776(0.99)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C184(1.05); C964(0.97); C564(0.99); C776(0.98)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C964(0.94); C564(1.04); C776(1.01); C401(0.93)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C184(0.95); C964(0.91); C564(1.01); C776(1.01)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C184(1.14); C964(0.90); C564(1.01); C776(1.06)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C184(1.03); C964(1.01); C564(1.01); C776(1.02)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C184(0.98); C964(0.96); C564(1.04); C776(1.03)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C184(1.01); C964(0.97); C564(1.01); C776(0.95)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C964(0.97); C564(1.22); C776(1.12); C401(1.03)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C184(1.04); C964(0.91); C564(0.99); C776(0.95)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C184(0.93); C964(0.94); C564(1.06); C776(0.96)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C184(1.04); C964(0.94); C564(1.01); C776(1.00)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C184(1.03); C964(0.95); C564(0.98); C776(1.01)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C184(0.91); C964(1.00); C564(1.00); C776(0.96)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C184(0.96); C964(1.03); C564(0.99); C776(1.03)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C184(0.94); C964(0.93); C564(1.07); C776(1.02)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C184(1.03); C964(0.96); C564(0.97); C776(0.95)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C964(1.01); C564(1.05); C776(1.01); C401(0.91)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C184(1.00); C964(1.04); C564(1.02); C776(0.97)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C184(1.02); C964(1.02); C564(0.99); C776(0.99)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C964(1.03); C564(1.02); C776(1.01); C401(0.94)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C184(1.05); C964(0.91); C564(1.00); C776(1.03)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C184(1.11); C964(0.99); C564(1.00); C776(0.92)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C184(1.13); C964(0.95); C564(0.99); C776(0.97)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C184(0.99); C964(0.94); C564(1.09); C776(1.00)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C184(1.10); C964(0.98); C564(1.02); C776(0.95)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C964(0.95); C564(1.06); C776(0.99); C401(0.91)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C184(1.01); C964(0.89); C564(0.99); C776(0.97)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C184(1.10); C964(0.95); C564(0.98); C776(0.99)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C184(1.13); C964(0.88); C564(1.01); C776(1.02)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C184(1.02); C964(0.98); C564(0.95); C776(0.97)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C184(0.95); C964(0.94); C564(1.01); C776(0.91)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C184(1.01); C964(1.03); C564(1.03); C776(1.10)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C184(1.02); C964(0.91); C564(1.09); C776(1.02)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C184(1.04); C964(1.00); C564(0.97); C776(1.01)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C964(0.96); C564(1.05); C776(1.02); C401(0.90)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C184(0.97); C964(0.88); C564(0.95); C776(1.01)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C184(1.12); C964(0.95); C564(0.96); C776(1.05)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C184(1.10); C964(0.98); C564(0.99); C776(1.02)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C184(1.11); C964(0.94); C564(0.96); C776(0.94)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C184(1.15); C964(0.96); C564(0.97); C776(1.02)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C184(1.00); C964(0.94); C564(1.06); C776(1.01)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C184(0.96); C964(0.92); C564(0.99); C776(0.95)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C184(1.07); C964(0.98); C564(0.99); C776(0.93)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C964(1.04); C564(1.03); C776(1.02); C401(0.91)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C184(1.01); C964(0.90); C564(1.01); C776(0.99)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C184(1.03); C964(0.95); C564(1.02); C776(0.96)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C184(1.14); C964(0.94); C564(1.01); C776(1.03)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C184(1.05); C964(1.00); C564(0.98); C776(0.96)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C184(1.02); C964(1.01); C564(1.02); C776(0.98)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C184(0.90); C964(1.00); C564(1.10); C776(0.99)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C184(1.03); C964(0.99); C564(0.98); C776(0.93)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C964(0.96); C564(0.99); C776(0.98); C401(0.96)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C184(1.02); C964(1.02); C564(1.02); C776(1.04)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C184(0.93); C964(0.91); C564(1.01); C776(0.99)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C184(0.95); C964(1.01); C564(1.02); C776(0.98)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C184(1.00); C964(0.91); C564(1.02); C776(1.02)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C184(0.97); C964(0.96); C564(0.98); C776(1.01)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C184(1.06); C964(0.99); C564(1.00); C776(0.96)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C184(0.96); C964(0.98); C564(0.99); C776(0.97)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C184(1.02); C964(0.95); C564(0.95); C776(0.95)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C184(1.07); C964(0.94); C564(1.01); C776(1.01)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C184(1.01); C964(0.91); C564(1.03); C776(1.04)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C184(1.17); C964(0.98); C564(1.04); C776(1.05)  LDD1514  [19]
 LDCM0498  BS-3668 MDA-MB-231 C776(1.45)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C184(1.07); C964(1.03); C564(1.36); C776(1.91)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C184(1.14); C964(2.22); C564(3.07); C776(6.19)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C184(1.20); C964(1.09); C564(1.26); C776(1.26)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C184(1.09); C964(1.02); C564(0.93); C776(1.21)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C184(1.21); C964(1.50); C564(1.50); C776(1.91)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C184(1.05); C964(0.96); C564(1.03); C776(1.04)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C184(1.08); C964(1.08); C564(1.09); C776(1.05)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C184(1.09); C964(1.13); C564(1.15); C776(1.39)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C184(1.09); C964(1.14); C564(1.21); C776(1.42)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C184(1.00); C964(0.99); C564(1.03); C776(0.96)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C184(1.08); C964(0.99); C564(1.03); C776(0.94)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C184(1.14); C964(1.16); C564(1.21); C776(1.70)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C184(1.09); C964(1.17); C564(1.45); C776(2.15)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C184(1.28); C964(2.06); C564(1.81); C776(2.28)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C184(1.21); C964(1.30); C564(1.22); C776(1.55)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C184(1.24); C964(1.06); C564(1.02); C776(1.11)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C184(0.97); C964(0.97); C564(0.96); C776(1.00)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C184(1.26); C964(1.60); C564(1.58); C776(2.43)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C184(0.96); C964(0.97); C564(1.01); C776(0.97)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C184(1.05); C964(0.99); C564(1.01); C776(0.94)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C184(1.03); C964(0.93); C564(0.94); C776(1.00)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C184(1.04); C964(0.91); C564(0.97); C776(1.07)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C184(1.02); C964(0.94); C564(0.97); C776(1.00)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C184(1.32); C964(1.10); C564(1.36); C776(1.61)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C184(1.05); C964(1.00); C564(1.11); C776(0.92)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C184(0.97); C964(1.06); C564(1.01); C776(1.16)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C184(1.12); C964(1.11); C564(1.30); C776(1.37)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C184(1.34); C964(1.49); C564(1.76); C776(2.91)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C184(1.24); C964(1.42); C564(1.28); C776(1.18)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C184(1.04); C964(1.05); C564(1.03); C776(0.96)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C184(1.06); C964(1.01); C564(1.13); C776(1.32)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C184(0.99); C964(1.03); C564(1.04); C776(1.00)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C184(0.93); C964(1.04); C564(1.15); C776(0.92)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C184(1.02); C964(0.93); C564(1.05); C776(1.16)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C184(1.06); C964(0.90); C564(1.01); C776(1.10)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C184(1.34); C964(2.47); C564(1.77); C776(2.93)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C184(1.05); C964(0.90); C564(1.06); C776(1.13)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C184(0.95); C964(1.94); C564(1.71); C776(3.53)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C184(1.09); C964(0.97); C564(0.94); C776(1.04)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C964(1.03); C564(1.10); C776(1.07); C401(1.06)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C184(1.04); C964(0.91); C564(1.05); C776(1.05)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C184(0.99); C964(0.99); C564(1.10); C776(1.18)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C184(1.09); C964(1.71); C564(1.74); C776(3.89)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C184(1.22); C964(1.06); C564(1.23); C776(1.46)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C184(1.12); C964(1.00); C564(1.17); C776(1.33)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C184(1.16); C964(1.03); C564(1.19); C776(1.26)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C184(1.25); C964(1.42); C564(1.84); C776(1.84)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C184(1.01); C964(0.95); C564(1.10); C776(1.11)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C184(1.02); C964(0.98); C564(1.00); C776(1.03)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C184(1.15); C964(1.08); C564(1.26); C776(1.20)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C184(1.12); C964(0.99); C564(1.03); C776(1.03)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C184(1.13); C964(1.05); C564(1.27); C776(1.37)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C184(1.16); C964(0.89); C564(0.97); C776(0.96)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C964(1.09); C564(1.13); C776(1.47); C401(1.08)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C184(1.07); C964(0.94); C564(1.25); C776(1.29)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C184(1.12); C964(2.37); C564(3.12); C776(7.84)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C184(1.20); C964(1.11); C564(1.49); C776(2.30)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C184(1.12); C964(1.11); C564(1.16); C776(1.41)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C184(1.29); C964(1.13); C564(1.29); C776(1.68)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C184(1.06); C964(1.16); C564(1.18); C776(1.17)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C184(1.14); C964(0.98); C564(1.13); C776(1.52)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C184(1.06); C964(1.06); C564(1.55); C776(1.50)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C184(1.11); C964(1.06); C564(0.97); C776(0.99)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C184(1.13); C964(1.31); C564(1.17); C776(1.51)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C184(1.13); C964(0.97); C564(0.95); C776(0.99)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C964(1.00); C564(1.08); C776(1.33); C401(0.99)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C184(1.07); C964(0.99); C564(1.16); C776(1.23)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C184(1.15); C964(1.14); C564(1.51); C776(2.49)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C184(1.16); C964(1.07); C564(1.27); C776(1.71)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C184(1.27); C964(1.03); C564(1.17); C776(1.53)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C184(0.99); C964(1.08); C564(1.31); C776(1.37)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C184(1.01); C964(0.91); C564(1.09); C776(1.16)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C184(0.94); C964(0.95); C564(1.05); C776(1.00)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C184(1.16); C964(1.16); C564(1.25); C776(1.60)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C184(1.14); C964(1.02); C564(1.05); C776(1.03)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C184(1.08); C964(1.70); C564(1.47); C776(2.49)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C184(1.08); C964(1.46); C564(2.04); C776(4.86)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C964(1.03); C564(1.11); C776(1.18); C401(1.00)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C184(1.09); C964(0.93); C564(1.10); C776(1.32)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C184(1.29); C964(1.15); C564(1.54); C776(3.06)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C184(1.30); C964(1.02); C564(1.31); C776(3.10)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C184(1.19); C964(1.04); C564(1.15); C776(1.48)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C184(1.00); C964(1.54); C564(1.66); C776(2.25)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C184(1.31); C964(1.03); C564(1.31); C776(1.68)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C184(1.02); C964(0.91); C564(0.98); C776(0.95)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C184(0.99); C964(0.90); C564(0.98); C776(1.00)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C184(0.93); C964(0.90); C564(0.94); C776(0.96)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C184(1.25); C964(1.58); C564(1.67); C776(1.72)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C184(1.02); C964(0.93); C564(1.07); C776(1.00)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C184(1.07); C964(0.99); C564(0.99); C776(1.19)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C964(0.99); C564(1.02); C776(1.07); C401(1.02)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C184(1.03); C964(0.98); C564(1.22); C776(1.83)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C184(1.14); C964(1.10); C564(1.34); C776(2.19)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C964(1.06); C564(1.15); C776(1.18); C401(1.00)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C184(1.17); C964(1.04); C564(1.15); C776(1.36)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C184(1.09); C964(1.15); C564(1.11); C776(1.34)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C184(1.41); C964(1.06); C564(1.01); C776(1.34)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C184(1.15); C964(1.32); C564(1.39); C776(1.50)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C184(0.98); C964(0.88); C564(1.02); C776(0.98)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C184(1.02); C964(1.02); C564(1.02); C776(0.94)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C184(1.04); C964(1.71); C564(1.50); C776(2.47)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C184(1.18); C964(0.89); C564(0.95); C776(0.97)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C964(1.07); C564(1.04); C776(1.16); C401(0.93)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C184(0.55); C964(9.10); C564(3.43); C776(6.29)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C184(1.17); C964(0.97); C564(1.03); C776(1.01)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C184(1.22); C964(1.00); C564(1.10); C776(1.24)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C184(1.19); C964(1.00); C564(1.12); C776(1.23)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C184(0.95); C964(1.09); C564(1.35); C776(1.66)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C184(1.38); C964(1.51); C564(1.54); C776(2.22)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C184(1.05); C964(0.93); C564(1.06); C776(0.98)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C184(1.09); C964(0.97); C564(1.05); C776(1.11)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C184(1.13); C964(1.03); C564(1.12); C776(1.11)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C184(0.99); C964(1.01); C564(1.13); C776(0.93)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C184(0.98); C964(0.90); C564(1.01); C776(1.09)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C184(1.03); C964(1.07); C564(1.34); C776(1.68)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C184(0.83); C964(3.23); C564(4.44); C776(6.82)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C964(1.02); C564(1.05); C776(1.06); C401(0.97)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C184(0.95); C964(1.05); C564(1.45); C776(2.44)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C184(1.11); C964(1.00); C564(1.57); C776(2.42)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C184(1.13); C964(0.94); C564(1.16); C776(1.42)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C184(0.80); C964(3.27); C564(1.78); C776(5.13)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C184(2.03); C964(1.66); C564(1.58); C776(2.29)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C184(1.24); C964(1.34); C564(1.39); C776(2.12)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C184(1.08); C964(1.08); C564(1.16); C776(1.46)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C184(1.05); C964(0.97); C564(1.10); C776(1.16)  LDD1697  [19]
 LDCM0033  Curcusone1d MCF-7 2.40  LDD0188  [6]
 LDCM0495  E2913 HEK-293T C184(0.99); C964(0.92); C564(1.00); C776(1.38)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C964(9.65); C776(4.13); C498(0.98)  LDD1702  [5]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0625  F8 Ramos C498(0.98)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C498(2.44)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C498(20.00)  LDD2190  [20]
 LDCM0580  Fragment21 Ramos C498(1.51)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C498(0.67)  LDD2196  [20]
 LDCM0586  Fragment28 Ramos C498(0.88)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C498(1.68)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C498(1.45)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C498(4.02)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C184(1.07); C964(0.96); C564(1.07); C776(1.19)  LDD1671  [19]
 LDCM0596  Fragment38 Ramos C498(1.70)  LDD2203  [20]
 LDCM0427  Fragment51 HEK-293T C184(0.96); C964(0.89); C564(0.96); C776(1.04)  LDD1631  [19]
 LDCM0614  Fragment56 Ramos C498(0.92)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C498(1.86)  LDD2186  [20]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C184(0.88); C581(0.93); C564(0.84); C540(0.91)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C826(71.36); C184(4.91); C964(18.95); C964(19.34)  LDD0209  [10]
 LDCM0024  KB05 COLO792 C540(1.52); C498(2.13); C964(3.44)  LDD3310  [21]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C776(1.01)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C776(0.98)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C776(1.01)  LDD2094  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C776(0.99)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C776(0.85); C401(1.37)  LDD2099  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C776(0.48)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C776(1.18)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C776(0.48)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C776(0.78)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C776(0.64)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C776(0.85)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C776(0.91); C964(0.81)  LDD2111  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C776(0.36); C577(0.46)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C776(0.64)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C776(1.20)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C184(2.92)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C776(0.85); C964(1.17); C401(0.78)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C776(0.84)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C776(1.27)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C184(1.52)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C184(3.55)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C776(0.66)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C776(0.42)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C184(3.98)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C776(0.44)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C776(0.79); C826(0.95)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C184(0.58)  LDD2150  [5]
 LDCM0131  RA190 MM1.R 2.02  LDD0299  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Condensin-2 complex subunit H2 (NCAPH2) CND2 H2 (condensin-2 subunit 2) family Q6IBW4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840