Probe Name	EA-probe					Probe Info
Probe concentration	40 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Experiment Method	RD-ABPP
Competitor Name	Ethacrynic acid					Competitor Info
Competitor Concentration	200 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Cervix uteri
	Disease Model		Endocervical adenocarcinoma [ICD-11:2C77]
	Model Name		Human endocervical adenocarcinoma cell lysate (HeLa)

Target ID	Target Name
LDTP02356	2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)
LDTP07447	2',5'-phosphodiesterase 12 (PDE12)
LDTP00294	26S proteasome non-ATPase regulatory subunit 14 (PSMD14)
LDTP00714	26S proteasome non-ATPase regulatory subunit 3 (PSMD3)
LDTP06325	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)
LDTP14535	6-phosphogluconolactonase (PGLS)
LDTP13131	7-dehydrocholesterol reductase (DHCR7)
LDTP06905	Acylglycerol kinase, mitochondrial (AGK)
LDTP02942	ADP-ribosylation factor 4 (ARF4)
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)
LDTP15097	All-trans-retinol 13,14-reductase (RETSAT)
LDTP05480	Amidophosphoribosyltransferase (PPAT)
LDTP05289	AMP deaminase 2 (AMPD2)
LDTP13409	Anaphase-promoting complex subunit 7 (ANAPC7)
LDTP01382	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)
LDTP10346	Aurora kinase B (AURKB)
LDTP06558	Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
LDTP12163	Calcyclin-binding protein (CACYBP)
LDTP11152	Cancer-related nucleoside-triphosphatase (NTPCR)
LDTP03985	Caspase-2 (CASP2)
LDTP02223	Cathepsin B (CTSB)
LDTP02198	Cathepsin D (CTSD)
LDTP00416	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT)
LDTP01773	Cytochrome c oxidase subunit 2 (MT-CO2)
LDTP11199	DCN1-like protein 5 (DCUN1D5)
LDTP06375	Delta(24)-sterol reductase (DHCR24)
LDTP03643	Deoxycytidylate deaminase (DCTD)
LDTP11960	Dimethyladenosine transferase 2, mitochondrial (TFB2M)
LDTP03481	DNA-3-methyladenine glycosylase (MPG)
LDTP01047	Dolichol-phosphate mannosyltransferase subunit 1 (DPM1)
LDTP13087	Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
LDTP14214	Dolichyl-phosphate beta-glucosyltransferase (ALG5)
LDTP00273	Dynamin-1-like protein (DNM1L)
LDTP12757	E3 ubiquitin-protein ligase MARCHF5 (MARCHF5)
LDTP07216	E3 ubiquitin-protein ligase RNF220 (RNF220)
LDTP05071	Elongation factor 1-alpha 1 (EEF1A1)
LDTP10386	ERO1-like protein alpha (ERO1A)
LDTP12346	Exosome complex component RRP41 (EXOSC4)
LDTP10049	FAST kinase domain-containing protein 4 (TBRG4)
LDTP09628	Fatty acyl-CoA reductase 1 (FAR1)
LDTP09939	Glutaryl-CoA dehydrogenase, mitochondrial (GCDH)
LDTP16040	Glyoxalase domain-containing protein 4 (GLOD4)
LDTP01275	GTPase Era, mitochondrial (ERAL1)
LDTP11297	Guanine nucleotide-binding protein-like 3 (GNL3)
LDTP08352	Histone-arginine methyltransferase CARM1 (CARM1)
LDTP06295	Histone-lysine N-methyltransferase SETDB1 (SETDB1)
LDTP06787	Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1)
LDTP10104	Interferon-stimulated gene 20 kDa protein (ISG20)
LDTP06303	Kinesin-like protein KIF14 (KIF14)
LDTP08082	L-xylulose reductase (DCXR)
LDTP13337	Leucine carboxyl methyltransferase 1 (LCMT1)
LDTP07967	Lysophosphatidylcholine acyltransferase 2 (LPCAT2)
LDTP12227	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)
LDTP09396	Minor histocompatibility antigen H13 (HM13)
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)
LDTP05795	Nucleoside diphosphate kinase 3 (NME3)
LDTP06432	Pachytene checkpoint protein 2 homolog (TRIP13)
LDTP05573	Peptidyl-prolyl cis-trans isomerase D (PPID)
LDTP06104	Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)
LDTP05503	Peroxiredoxin-1 (PRDX1)
LDTP03626	Peroxiredoxin-2 (PRDX2)
LDTP05773	Peroxiredoxin-4 (PRDX4)
LDTP12608	Phosphatidylinositol-3-phosphatase SAC1 (SACM1L)
LDTP13814	Phospholipase A-2-activating protein (PLAA)
LDTP03333	Proteasome subunit alpha type-4 (PSMA4)
LDTP00449	Proteasome subunit alpha type-7 (PSMA7)
LDTP00877	Protein SCO2 homolog, mitochondrial (SCO2)
LDTP01039	Protein-S-isoprenylcysteine O-methyltransferase (ICMT)
LDTP03607	RAC-alpha serine/threonine-protein kinase (AKT1)
LDTP13799	RAC-gamma serine/threonine-protein kinase (AKT3)
LDTP02002	RAF proto-oncogene serine/threonine-protein kinase (RAF1)
LDTP12166	Ras-related GTP-binding protein C (RRAGC)
LDTP04401	Ras-related protein Rab-13 (RAB13)
LDTP04901	Ras-related protein Rab-14 (RAB14)
LDTP16032	Retinoid-inducible serine carboxypeptidase (SCPEP1)
LDTP03259	Ribonucleoside-diphosphate reductase large subunit (RRM1)
LDTP04471	Ribosomal protein S6 kinase alpha-3 (RPS6KA3)
LDTP00597	Serine palmitoyltransferase 1 (SPTLC1)
LDTP02493	Serine/threonine-protein kinase A-Raf (ARAF)
LDTP01751	Serine/threonine-protein kinase PAK 4 (PAK4)
LDTP05841	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)
LDTP12473	Sialic acid synthase (NANS)
LDTP00502	TATA-binding protein-associated factor 172 (BTAF1)
LDTP03258	Thymidylate kinase (DTYMK)
LDTP05240	Transcription initiation factor IIB (GTF2B)
LDTP13200	tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1)
LDTP06190	Ubiquitin carboxyl-terminal hydrolase 10 (USP10)
LDTP09060	Ubiquitin-associated domain-containing protein 2 (UBAC2)
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)
LDTP06111	UDP-glucose 4-epimerase (GALE)
LDTP12116	Uridine-cytidine kinase 1 (UCK1)
LDTP11571	Uridine-cytidine kinase 2 (UCK2)
LDTP12745	Uridine-cytidine kinase-like 1 (UCKL1)
LDTP03859	V-type proton ATPase catalytic subunit A (ATP6V1A)
LDTP12954	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3)

Target ID	Target Name
LDTP07152	Acyl-CoA-binding domain-containing protein 5 (ACBD5)
LDTP02608	ADP/ATP translocase 1 (SLC25A4)
LDTP02087	ADP/ATP translocase 2 (SLC25A5)
LDTP02609	ADP/ATP translocase 3 (SLC25A6)
LDTP02199	Annexin A2 (ANXA2)
LDTP10036	BOS complex subunit NCLN (NCLN)
LDTP03405	Calnexin (CANX)
LDTP02823	CD44 antigen (CD44)
LDTP02057	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1)
LDTP01301	Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12)
LDTP13393	Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)
LDTP00501	Exportin-1 (XPO1)
LDTP04662	Exportin-2 (CSE1L)
LDTP12142	Exportin-5 (XPO5)
LDTP13335	Exportin-7 (XPO7)
LDTP00810	Exportin-T (XPOT)
LDTP02028	HLA class II histocompatibility antigen gamma chain (CD74)
LDTP05305	Large neutral amino acids transporter small subunit 1 (SLC7A5)
LDTP00477	Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)
LDTP12210	Mitochondrial thiamine pyrophosphate carrier (SLC25A19)
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)
LDTP04932	Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1)
LDTP04866	Protein transport protein Sec61 subunit beta (SEC61B)
LDTP11626	Protein YIPF3 (YIPF3)
LDTP05238	Solute carrier family 25 member 3 (SLC25A3)
LDTP11813	Solute carrier family 25 member 32 (SLC25A32)
LDTP10533	Sorting nexin-27 (SNX27)
LDTP14173	Sorting nexin-8 (SNX8)
LDTP03380	Stomatin (STOM)
LDTP18448	Transmembrane 9 superfamily member 3 (TM9SF3)
LDTP15948	Transmembrane protein 126A (TMEM126A)
LDTP07477	Transmembrane protein 214 (TMEM214)
LDTP04787	Transmembrane protein 33 (TMEM33)
LDTP11229	Transmembrane protein 70, mitochondrial (TMEM70)
LDTP09949	Transportin-1 (TNPO1)
LDTP14133	Transportin-3 (TNPO3)
LDTP04553	Tricarboxylate transport protein, mitochondrial (SLC25A1)
LDTP13319	V-type proton ATPase subunit H (ATP6V1H)
LDTP04071	Voltage-dependent anion-selective channel protein 2 (VDAC2)
LDTP13824	Voltage-dependent anion-selective channel protein 3 (VDAC3)

Target ID	Target Name
LDTP03790	Aryl hydrocarbon receptor (AHR)
LDTP14241	eIF5-mimic protein 1 (BZW2)
LDTP05201	Forkhead box protein K1 (FOXK1)
LDTP06215	Myocyte-specific enhancer factor 2D (MEF2D)
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)
LDTP05883	Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2)
LDTP14199	Nuclear receptor corepressor 2 (NCOR2)
LDTP02892	Transcription factor JunB (JUNB)
LDTP03781	Transcription factor SOX-5 (SOX5)
LDTP09710	Transcriptional repressor p66-beta (GATAD2B)

Target ID	Target Name
LDTP06163	Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Target ID	Target Name
LDTP11597	182 kDa tankyrase-1-binding protein (TNKS1BP1)
LDTP00880	A-kinase anchor protein 8 (AKAP8)
LDTP13591	A-kinase anchor protein 8-like (AKAP8L)
LDTP04903	Actin-related protein 2 (ACTR2)
LDTP13414	ADP-ribosylation factor-binding protein GGA2 (GGA2)
LDTP00202	AH receptor-interacting protein (AIP)
LDTP01814	Alpha-2-macroglobulin (A2M)
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)
LDTP07385	Anamorsin (CIAPIN1)
LDTP08793	Armadillo repeat-containing protein 10 (ARMC10)
LDTP15101	Armadillo repeat-containing protein 6 (ARMC6)
LDTP13091	Ataxin-10 (ATXN10)
LDTP05864	Beta-2-syntrophin (SNTB2)
LDTP01316	Breast cancer anti-estrogen resistance protein 3 (BCAR3)
LDTP14238	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1)
LDTP10864	Calponin-2 (CNN2)
LDTP06383	Calponin-3 (CNN3)
LDTP05106	Cancer/testis antigen 1 (CTAG1A; CTAG1B)
LDTP00720	Centromere/kinetochore protein zw10 homolog (ZW10)
LDTP13579	Cip1-interacting zinc finger protein (CIZ1)
LDTP08062	CLIP-associating protein 1 (CLASP1)
LDTP01129	CLIP-associating protein 2 (CLASP2)
LDTP06515	Coiled-coil domain-containing protein 6 (CCDC6)
LDTP08359	Condensin-2 complex subunit G2 (NCAPG2)
LDTP05185	Conserved oligomeric Golgi complex subunit 7 (COG7)
LDTP13580	Coronin-1C (CORO1C)
LDTP13269	Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)
LDTP11139	DNA replication complex GINS protein PSF3 (GINS3)
LDTP12214	Echinoderm microtubule-associated protein-like 4 (EML4)
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)
LDTP06450	ELAV-like protein 1 (ELAVL1)
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)
LDTP07521	Enhancer of mRNA-decapping protein 4 (EDC4)
LDTP09938	Far upstream element-binding protein 2 (KHSRP)
LDTP05558	Galectin-3-binding protein (LGALS3BP)
LDTP11159	Gamma-tubulin complex component 2 (TUBGCP2)
LDTP09783	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1)
LDTP08069	HAUS augmin-like complex subunit 6 (HAUS6)
LDTP02053	Heat shock protein beta-1 (HSPB1)
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)
LDTP04500	Heterogeneous nuclear ribonucleoprotein M (HNRNPM)
LDTP06562	Histone-binding protein RBBP7 (RBBP7)
LDTP14059	Insulin receptor substrate 2 (IRS2)
LDTP05689	Interleukin enhancer-binding factor 3 (ILF3)
LDTP12591	Kinesin light chain 4 (KLC4)
LDTP10433	Kinetochore-associated protein NSL1 homolog (NSL1)
LDTP07605	La-related protein 1 (LARP1)
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)
LDTP03968	Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO)
LDTP02535	Laminin subunit gamma-1 (LAMC1)
LDTP05196	Large ribosomal subunit protein eL19 (RPL19)
LDTP04107	Large ribosomal subunit protein eL21 (RPL21)
LDTP04108	Large ribosomal subunit protein eL28 (RPL28)
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)
LDTP15108	Large ribosomal subunit protein uL14m (MRPL14)
LDTP02961	Large ribosomal subunit protein uL22 (RPL17)
LDTP12554	Latent-transforming growth factor beta-binding protein 3 (LTBP3)
LDTP08273	Leucine zipper protein 1 (LUZP1)
LDTP06362	Leucine-rich repeat-containing protein 41 (LRRC41)
LDTP14217	Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1)
LDTP14683	Melanoma-associated antigen 10 (MAGEA10)
LDTP04041	Melanoma-associated antigen 4 (MAGEA4)
LDTP13657	Melanoma-associated antigen D2 (MAGED2)
LDTP03773	Metalloproteinase inhibitor 3 (TIMP3)
LDTP03404	Microtubule-associated protein 4 (MAP4)
LDTP11304	Mitochondrial import inner membrane translocase subunit Tim21 (TIMM21)
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)
LDTP11079	Myb-binding protein 1A (MYBBP1A)
LDTP05597	Neuroblast differentiation-associated protein AHNAK (AHNAK)
LDTP14268	NF-kappa-B essential modulator (IKBKG)
LDTP06456	NGFI-A-binding protein 2 (NAB2)
LDTP14011	Nucleolar complex protein 2 homolog (NOC2L)
LDTP02164	Nucleophosmin (NPM1)
LDTP14139	Origin recognition complex subunit 6 (ORC6)
LDTP11930	Oxysterol-binding protein-related protein 3 (OSBPL3)
LDTP13167	Peflin (PEF1)
LDTP10889	Perilipin-2 (PLIN2)
LDTP08172	Pleckstrin homology-like domain family B member 2 (PHLDB2)
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)
LDTP06367	Poly(rC)-binding protein 2 (PCBP2)
LDTP04793	Poly(rC)-binding protein 3 (PCBP3)
LDTP13906	Polymerase delta-interacting protein 2 (POLDIP2)
LDTP13309	Prefoldin subunit 2 (PFDN2)
LDTP04935	Prefoldin subunit 3 (VBP1)
LDTP04917	Proteasome activator complex subunit 3 (PSME3)
LDTP09779	Proteasome inhibitor PI31 subunit (PSMF1)
LDTP18309	Protein HGH1 homolog (HGH1)
LDTP03426	Protein ITPRID2 (ITPRID2)
LDTP17214	Protein odr-4 homolog (ODR4)
LDTP00812	Protein sprouty homolog 2 (SPRY2)
LDTP00512	Protein transport protein Sec16A (SEC16A)
LDTP11890	Protein unc-45 homolog A (UNC45A)
LDTP06174	Pumilio homolog 1 (PUM1)
LDTP10802	Ran-binding protein 9 (RANBP9)
LDTP09509	Rap guanine nucleotide exchange factor 6 (RAPGEF6)
LDTP08288	Ras GTPase-activating-like protein IQGAP3 (IQGAP3)
LDTP05257	Receptor expression-enhancing protein 5 (REEP5)
LDTP07213	Regulation of nuclear pre-mRNA domain-containing protein 2 (RPRD2)
LDTP07909	Ribosomal protein eS27-like (RPS27L)
LDTP03479	SHC-transforming protein 1 (SHC1)
LDTP11331	Sideroflexin-3 (SFXN3)
LDTP02263	Signal recognition particle receptor subunit alpha (SRPRA)
LDTP16323	Signal recognition particle receptor subunit beta (SRPRB)
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)
LDTP12605	Sister chromatid cohesion protein PDS5 homolog B (PDS5B)
LDTP14791	Small ribosomal subunit protein bS21m (MRPS21)
LDTP05002	Small ribosomal subunit protein eS6 (RPS6)
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)
LDTP04590	Smoothelin (SMTN)
LDTP08735	Spartin (SPART)
LDTP06376	Splicing factor 3B subunit 3 (SF3B3)
LDTP06094	Src substrate cortactin (CTTN)
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)
LDTP09878	Symplekin (SYMPK)
LDTP14072	Telomere length regulation protein TEL2 homolog (TELO2)
LDTP14259	Testis-expressed protein 264 (TEX264)
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)
LDTP09215	Torsin-1A-interacting protein 2 (TOR1AIP2)
LDTP04321	Transcription initiation factor TFIID subunit 6 (TAF6)
LDTP01210	Transforming acidic coiled-coil-containing protein 1 (TACC1)
LDTP16826	Translation initiation factor eIF2 assembly protein (CDC123)
LDTP02205	Tubulin beta chain (TUBB)
LDTP12025	UPF0488 protein C8orf33 (C8orf33)
LDTP11866	UPF0696 protein C11orf68 (C11orf68)
LDTP04372	Vasodilator-stimulated phosphoprotein (VASP)
LDTP12023	WD repeat-containing protein 26 (WDR26)
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)
LDTP09872	Zinc finger protein ubi-d4 (DPF2)

1	Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.