Details of the Target

General Information of Target

Target ID LDTP02823
Target Name CD44 antigen (CD44)
Gene Name CD44
Gene ID 960
Synonyms
LHR; MDU2; MDU3; MIC4; CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD antigen CD44
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTL
PTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFN
ASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSS
GSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQE
TWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDD
EDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWN
PEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDS
HSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSIT
LQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDV
TGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNR
SLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLAL
ALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSET
PDQFMTADETRNLQNVDMKIGV
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Subcellular location
Cell membrane
Function
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
TTD ID
T78319
Uniprot ID
P16070
DrugMap ID
TTWFBT7
Ensemble ID
ENST00000263398.11
HGNC ID
HGNC:1681
ChEMBL ID
CHEMBL3232692

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.S434N .
HEC1 SNV: p.A69D DBIA    Probe Info 
NCIH1299 Insertion: p.G613WfsTer10 .
WM1552C SNV: p.H459Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.93  LDD0402  [1]
AZ-9
 Probe Info  		2.66  LDD0393  [2]
FBPP2
 Probe Info  		4.36  LDD0324  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
SAA-alkyne
 Probe Info  		1.12  LDD0252  [5]
ONAyne
 Probe Info  		K158(4.09)  LDD0274  [6]
STPyne
 Probe Info  		K158(6.02); K54(0.95); K681(4.32); K695(4.80)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K158(4.38); K38(5.01)  LDD3494  [7]
Probe 1
 Probe Info  		Y169(17.98)  LDD3495  [8]
BTD
 Probe Info  		C77(2.86); C53(2.61)  LDD1700  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
HHS-475
 Probe Info  		Y79(0.73)  LDD0264  [11]
DBIA
 Probe Info  		C77(1.04)  LDD0078  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
IPM
 Probe Info  		C53(0.00); C77(0.00)  LDD0147  [16]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Acrolein
 Probe Info  		C77(0.00); C53(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
NAIA_5
 Probe Info  		C77(0.00); C53(0.00)  LDD2223  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C53(0.79)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C53(0.75)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C53(0.53)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C53(0.65)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C53(1.11); C77(1.03)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C53(1.21); C77(1.35)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C53(0.82)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C53(0.55)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C53(0.77)  LDD2131  [9]
 LDCM0214  AC1 HCT 116 C77(1.21)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C77(1.40)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C77(1.00)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C77(0.93)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C77(0.98)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C77(1.09)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C77(0.99)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C77(1.02)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C77(1.03)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C77(1.01)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C77(0.92)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C77(0.80)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C77(1.26)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C77(0.89)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C77(0.81)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C77(0.94)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C77(1.04)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C77(1.18)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C77(1.17)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C77(1.20)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C77(1.06)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C77(1.14)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C77(1.05)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C77(1.14)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C77(1.13)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C77(1.05)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C77(1.10)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C77(0.98)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C77(1.15)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C77(1.09)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C77(1.22)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C77(1.16)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C77(1.07)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C77(0.99)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C77(1.19)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C77(0.98)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C77(1.14)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C77(1.03)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C77(0.95)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C77(1.13)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C77(1.17)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C77(0.99)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C77(1.18)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C77(1.21)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C77(1.08)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C77(1.18)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C77(1.05)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C77(1.14)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C77(1.13)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C77(1.17)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C77(1.10)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C77(1.18)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C77(1.12)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C77(1.33)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C77(1.17)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C77(1.10)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C77(1.04)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C77(1.21)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C77(1.15)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C77(1.25)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C77(1.26)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C77(1.41)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C77(1.17)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C77(1.15)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C77(1.11)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C77(1.16)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C77(1.08)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C77(1.28)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C77(1.01)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C77(1.06)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C77(1.08)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C77(0.95)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C77(1.05)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C77(0.97)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C77(1.01)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C77(1.14)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C77(1.09)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C77(1.11)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C77(1.60)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C77(1.12)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C77(1.09)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C77(1.22)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C77(1.22)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C77(1.18)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C77(0.83)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C77(0.89)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C77(0.90)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C77(0.89)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C77(1.01)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C77(1.56)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C77(0.95)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C77(0.96)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C77(1.03)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C77(1.01)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C77(1.10)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C77(1.03)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C77(0.92)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C77(1.09)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C77(0.97)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C77(1.14)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C77(1.57)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C77(1.09)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C77(0.87)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C77(1.01)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C77(1.01)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C77(1.17)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C77(1.12)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C77(1.12)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C77(1.11)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C77(1.01)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C77(1.35)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C77(1.21)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C77(1.30)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C77(1.22)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C77(1.17)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C77(1.23)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C77(1.28)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C77(1.18)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C77(1.16)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C77(1.11)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C77(1.11)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C77(1.04)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C77(1.17)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C77(1.03)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C77(1.00)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C77(1.05)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C77(1.10)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C77(1.16)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C77(1.12)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C77(1.08)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C77(1.02)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C77(1.03)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C77(1.05)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C77(1.20)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C77(1.03)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C77(0.93)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C77(0.89)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C77(1.32)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C77(1.31)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C77(1.30)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C77(1.10)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C77(1.00)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C77(1.04)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C77(1.17)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C77(0.98)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C77(1.32)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C77(1.35)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C77(1.09)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C77(1.18)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C77(1.04)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C77(1.18)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C77(1.24)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C77(0.89)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C77(0.89)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C53(0.62)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C53(0.60); C77(0.95)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C77(1.18)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C77(1.23)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C77(1.48)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C77(1.04)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C53(0.94)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C77(0.00); H711(0.00); C53(0.00); H85(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C77(0.97)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C77(1.14)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C77(1.13)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C77(1.25)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C77(1.17)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C77(1.07)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C77(1.06)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C77(1.15)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C77(1.25)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C77(1.36)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C77(1.37)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C77(1.18)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C77(1.17)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C77(1.23)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C77(1.15)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C77(0.95)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C77(1.07)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C77(1.03)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C77(1.15)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C77(1.19)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C77(1.17)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C77(1.02)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C77(0.98)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C77(1.24)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C77(1.00)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C77(1.15)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C77(1.08)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C77(1.07)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C77(1.14)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C77(1.01)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C77(0.99)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C77(1.01)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C77(1.12)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C77(0.98)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C77(0.96)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C77(1.08)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C77(1.14)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C77(1.08)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C77(1.28)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C77(1.12)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C77(1.10)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C77(1.16)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C77(1.18)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C77(1.23)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C77(1.16)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C77(1.19)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C77(1.19)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C77(1.17)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C77(1.13)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C77(1.16)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C77(1.19)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C77(1.08)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C77(1.17)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C77(1.01)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C77(1.23)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C77(0.96)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C77(1.26)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C77(1.18)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C77(1.13)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C77(1.21)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C77(1.13)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C77(1.00)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C77(1.13)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C77(1.16)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C77(1.27)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C77(1.24)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C77(1.15)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C77(1.40)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C77(0.87)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C77(0.88)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C77(0.88)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C77(0.96)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C77(0.97)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C77(0.87)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C77(0.85)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C77(0.88)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C77(0.91)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C77(0.89)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C77(0.96)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C77(1.05)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C77(0.90)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C77(0.90)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C77(0.97)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C77(1.13)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C77(1.03)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C77(1.18)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C77(1.04)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C77(1.10)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C77(1.39)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C77(1.02)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C77(1.45)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C77(1.19)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C77(1.16)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C77(1.14)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C77(1.25)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C77(1.10)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C77(1.12)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C77(0.93)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C77(1.00)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C77(1.08)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C77(0.92)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C77(0.89)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C77(1.00)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C77(1.21)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C77(1.15)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C77(0.97)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C77(1.14)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C77(1.26)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C77(1.30)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C77(1.41)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C77(1.02)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C77(1.00)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C77(1.07)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C77(1.13)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C77(1.37)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C77(1.12)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C77(0.75)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C77(1.14)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C77(0.96)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C77(1.02)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C77(1.07)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C77(1.24)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C77(1.47)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C77(1.44)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C77(1.21)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C77(1.25)  LDD0811  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C77(0.81)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0468  Fragment33 HCT 116 C77(1.17)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C77(1.39)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y79(0.73)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y79(0.48)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y79(0.53)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y79(0.54)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y79(0.26)  LDD0268  [11]
 LDCM0107  IAA HeLa C77(0.00); H85(0.00); H711(0.00)  LDD0221  [18]
 LDCM0022  KB02 42-MG-BA C53(0.88)  LDD2244  [19]
 LDCM0023  KB03 MDA-MB-231 C77(0.77)  LDD1701  [9]
 LDCM0024  KB05 G361 C77(1.31)  LDD3311  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C53(1.23)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C53(0.98)  LDD2121  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C53(0.99)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C53(2.35)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C53(0.99)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C53(0.68); C77(1.15)  LDD2093  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C53(0.65); C77(0.68)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C53(0.83)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C53(1.46); C77(1.16)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C53(0.39)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C53(0.60); C77(1.60)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C53(0.42)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C53(1.40)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C53(0.38)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C77(1.08)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C53(0.72)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C53(1.00); C77(0.92)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C53(0.60)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C53(1.24); C77(1.24)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C53(0.32)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C53(0.38)  LDD2115  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C53(1.92); C77(1.60)  LDD2119  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C53(0.83); C77(0.86)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C53(0.75); C77(0.99)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C53(0.92); C77(1.32)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C53(1.24); C77(1.27)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C53(0.41); C77(0.65)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C53(0.31); C77(0.35)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C53(1.05); C77(1.93)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C53(1.02); C77(1.16)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C53(0.92); C77(0.99)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C77(2.86); C53(2.61)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C53(0.71); C77(0.95)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C53(0.88)  LDD2141  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C53(2.10); C77(1.53)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C53(0.55)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C53(0.96); C77(0.95)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C53(0.43); C77(0.43)  LDD2148  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C53(0.68)  LDD2150  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C53(1.13)  LDD2153  [9]
 LDCM0021  THZ1 HCT 116 C77(1.06)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cystine/glutamate transporter (SLC7A11) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UPY5
HLA class II histocompatibility antigen gamma chain (CD74) . P04233
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Moesin (MSN) . P26038

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hyaluronic Acid Small molecular drug DB08818
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Spl-108 Peptide D2C0DY
A-6 . D0CT7M
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biwa 4 Antibody D05OXZ
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bivatuzumab . DB06550
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bivatuzumab Mertansine Antibody D0R6EQ

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840