Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FBPP2  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 52 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02198  Cathepsin D (CTSD) 154.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 67.3
 LDTP02651  Gamma-interferon-inducible lysosomal thiol reductase (IFI30) 56.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 55.3
 LDTP01776  Superoxide dismutase [Cu-Zn] (SOD1) 33.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 23.8
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 18.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 18.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 17.5
 LDTP13294  Dipeptidyl peptidase 2 (DPP7) 17.1
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 16.3
 LDTP00316  Ribonuclease T2 (RNASET2) 15.7
 LDTP02217  Procathepsin L (CTSL) 15.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 15.3
 LDTP02505  Lysosomal protective protein (CTSA) 15.0
 LDTP13147  Cathepsin Z (CTSZ) 14.1
 LDTP02223  Cathepsin B (CTSB) 10.0
 LDTP02141  Alpha-galactosidase A (GLA) 9.7
 LDTP02883  Alpha-N-acetylgalactosaminidase (NAGA) 9.3
 LDTP03858  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) 8.7
 LDTP10888  Legumain (LGMN) 8.3
 LDTP01372  Carboxypeptidase D (CPD) 8.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.0
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 7.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.5
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 6.3
 LDTP02837  Beta-galactosidase (GLB1) 6.2
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 6.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 5.4
 LDTP04341  Histamine N-methyltransferase (HNMT) 5.1
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 4.9
 LDTP00888  EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) 4.7
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 4.4
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 3.9
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 3.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 3.4
 LDTP10884  Sialidase-1 (NEU1) 3.2
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 3.2
 LDTP02776  Arylsulfatase A (ARSA) 3.0
 LDTP04248  Deoxyhypusine synthase (DHPS) 2.9
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 2.7
 LDTP02384  Furin (FURIN) 2.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 2.6
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 2.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 2.6
 LDTP03816  Oxidized purine nucleoside triphosphate hydrolase (NUDT1) 2.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 2.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 2.3
 LDTP05891  V-type proton ATPase 116 kDa subunit a 3 (TCIRG1) 2.3
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 2.2
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 2.2
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 2.0
Transporter and channel
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02215  Prosaposin (PSAP) 91.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 64.5
 LDTP05631  Bone marrow stromal antigen 2 (BST2) 38.7
 LDTP11116  45 kDa calcium-binding protein (SDF4) 35.8
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 25.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.2
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 12.8
 LDTP00321  Podocalyxin (PODXL) 12.3
 LDTP02071  Amyloid-beta precursor protein (APP) 11.4
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 10.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 9.6
 LDTP10885  Sortilin (SORT1) 7.9
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 7.6
 LDTP09838  Sortilin-related receptor (SORL1) 7.4
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 6.9
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 6.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 6.9
 LDTP08327  Osteopetrosis-associated transmembrane protein 1 (OSTM1) 6.0
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.8
 LDTP14274  Proton-coupled zinc antiporter SLC30A1 (SLC30A1) 5.6
 LDTP02295  Integrin alpha-5 (ITGA5) 5.5
 LDTP02166  Integrin alpha-V (ITGAV) 5.4
 LDTP04612  Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) 5.0
 LDTP12635  Transmembrane protein 106B (TMEM106B) 4.8
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 4.6
 LDTP02823  CD44 antigen (CD44) 4.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 4.1
 LDTP03211  Integrin alpha-6 (ITGA6) 4.1
 LDTP11265  Vesicle-associated membrane protein 8 (VAMP8) 3.9
 LDTP05528  Apoptosis regulator BAX (BAX) 3.7
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 3.5
 LDTP02122  Integrin beta-1 (ITGB1) 3.3
 LDTP15481  Transmembrane protein 87A (TMEM87A) 3.2
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 2.5
 LDTP13497  Integrin alpha-11 (ITGA11) 2.4
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 2.2
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 2.1
 LDTP04624  Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3) 2.1
 LDTP00310  Syntenin-1 (SDCBP) 2.0
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 2.0
 LDTP02068  Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) 2.0
 LDTP05538  Prolow-density lipoprotein receptor-related protein 1 (LRP1) 2.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 2.0
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02317  Alpha-2A adrenergic receptor (ADRA2A) 4.4
Immunoglobulin
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 5.1
 LDTP04020  Cell surface glycoprotein MUC18 (MCAM) 5.1
 LDTP07280  CD276 antigen (CD276) 4.6
 LDTP03624  Neural cell adhesion molecule L1 (L1CAM) 3.1
 LDTP01108  Immunoglobulin superfamily member 3 (IGSF3) 2.1
Other
Click to Show/Hide to Show 38 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02443  Calmodulin-3 (CALM3) 24.5
 LDTP13114  C-type mannose receptor 2 (MRC2) 18.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 16.6
 LDTP06097  Reticulocalbin-2 (RCN2) 9.7
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 8.2
 LDTP05375  Nucleobindin-1 (NUCB1) 7.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 7.0
 LDTP02977  Cadherin-2 (CDH2) 6.5
 LDTP02941  Integrin beta-5 (ITGB5) 6.5
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 6.0
 LDTP02526  Clusterin (CLU) 5.8
 LDTP09920  Golgi apparatus protein 1 (GLG1) 4.9
 LDTP02927  Ganglioside GM2 activator (GM2A) 4.5
 LDTP11894  DnaJ homolog subfamily C member 5 (DNAJC5) 4.4
 LDTP02895  Atrial natriuretic peptide receptor 3 (NPR3) 4.1
 LDTP00887  Calumenin (CALU) 4.0
 LDTP03342  Integrin alpha-3 (ITGA3) 3.9
 LDTP04698  Cadherin-13 (CDH13) 3.7
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 3.7
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 3.6
 LDTP10908  Protein S100-A13 (S100A13) 3.5
 LDTP07698  Plexin domain-containing protein 2 (PLXDC2) 3.4
 LDTP02893  Integrin alpha-2 (ITGA2) 3.1
 LDTP05277  Protein SET (SET) 3.1
 LDTP09787  Nicastrin (NCSTN) 3.0
 LDTP05215  Very low-density lipoprotein receptor (VLDLR) 2.9
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 2.8
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 2.6
 LDTP06042  Desmoglein-2 (DSG2) 2.4
 LDTP06557  Synaptophysin-like protein 1 (SYPL1) 2.4
 LDTP07760  CD109 antigen (CD109) 2.4
 LDTP06036  Low-density lipoprotein receptor-related protein 8 (LRP8) 2.3
 LDTP10969  Gamma-soluble NSF attachment protein (NAPG) 2.3
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 2.1
 LDTP00759  Tumor protein D54 (TPD52L2) 2.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 2.1
 LDTP13309  Prefoldin subunit 2 (PFDN2) 2.0
 LDTP12412  Reticulon-4 (RTN4) 2.0

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580