Details of the Target

General Information of Target

Target ID LDTP05891
Target Name V-type proton ATPase 116 kDa subunit a 3 (TCIRG1)
Gene Name TCIRG1
Gene ID 10312
Synonyms
ATP6N1C; ATP6V0A3; V-type proton ATPase 116 kDa subunit a 3; V-ATPase 116 kDa subunit a 3; Osteoclastic proton pump 116 kDa subunit; OC-116 kDa; OC116; T-cell immune regulator 1; T-cell immune response cDNA7 protein; TIRC7; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEE
LEKTFTFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRA
QLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAP
ALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCFH
CHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMK
AVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAHRIPCRDMPPT
LIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAM
VLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAA
MANQSGWSDAFLAQHTMLTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSVI
LGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAARA
ASAPSILIHFINMFLFSHSPSNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHR
RRLRRRPADRQEENKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHT
IEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAAVVLVPIFAAF
AVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAATDD
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
V-ATPase 116 kDa subunit family
Subcellular location
Membrane
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Seems to be directly involved in T-cell activation.
TTD ID
T80912
Uniprot ID
Q13488
DrugMap ID
TTVRN05
Ensemble ID
ENST00000265686.8
HGNC ID
HGNC:11647

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DETROIT562 SNV: p.V10M .
HEL SNV: p.P390S .
HEL9217 SNV: p.P390S .
JURKAT SNV: p.L653Q .
LNCaP clone FGC SNV: p.V637A; p.L820P .
TGBC1TKB Insertion: p.P82AfsTer56 .
TOV21G SNV: p.A634D; p.T635K .
VMRCRCW SNV: p.Q126H .
WM1552C SNV: p.G767S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.26  LDD0324  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
BTD
 Probe Info  		C58(0.63)  LDD2096  [3]
Acrolein
 Probe Info  		H162(0.00); H128(0.00)  LDD0227  [4]
DBIA
 Probe Info  		C238(0.94); C241(0.94)  LDD0531  [5]
NAIA_5
 Probe Info  		C464(0.00); C309(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C238(0.94); C241(0.94)  LDD0531  [5]
 LDCM0216  AC100 HCT 116 C238(0.86); C241(0.86)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C238(0.87); C241(0.87)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C238(1.00); C241(1.00)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C238(0.89); C241(0.89)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C238(0.98); C241(0.98)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C238(0.76); C241(0.76)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C238(0.86); C241(0.86)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C238(0.76); C241(0.76)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C238(0.90); C241(0.90)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C238(0.99); C241(0.99)  LDD0542  [5]
 LDCM0227  AC110 HCT 116 C238(0.87); C241(0.87)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C238(0.90); C241(0.90)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C238(0.83); C241(0.83)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C238(0.85); C241(0.85)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C238(0.84); C241(0.84)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C238(0.78); C241(0.78)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C238(0.89); C241(0.89)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C238(1.00); C241(1.00)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C238(0.97); C241(0.97)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C238(0.94); C241(0.94)  LDD0553  [5]
 LDCM0238  AC120 HCT 116 C238(1.08); C241(1.08)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C238(1.12); C241(1.12)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C238(0.90); C241(0.90)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C238(1.15); C241(1.15)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C238(1.22); C241(1.22)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C238(1.01); C241(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C238(1.10); C241(1.10)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C238(0.99); C241(0.99)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C317(0.84); C324(0.84)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C317(0.78); C324(0.78)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C317(0.89); C324(0.89)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C317(0.86); C324(0.86)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C317(0.67); C324(0.67)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C317(0.77); C324(0.77)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C317(0.80); C324(0.80)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C317(0.73); C324(0.73)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C317(0.91); C324(0.91)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C317(0.90); C324(0.90)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C317(0.88); C324(0.88)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C317(1.13); C324(1.13)  LDD1137  [5]
 LDCM0260  AC140 PaTu 8988t C317(0.65); C324(0.65)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C317(0.86); C324(0.86)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C317(0.81); C324(0.81)  LDD1141  [5]
 LDCM0279  AC2 HCT 116 C238(0.89); C241(0.89)  LDD0596  [5]
 LDCM0285  AC25 HCT 116 C238(1.73); C241(1.73)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C238(1.65); C241(1.65)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C238(1.52); C241(1.52)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C238(1.38); C241(1.38)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C238(1.20); C241(1.20)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C238(0.97); C241(0.97)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C238(1.26); C241(1.26)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C238(1.31); C241(1.31)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C238(1.14); C241(1.14)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C238(1.42); C241(1.42)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C238(1.23); C241(1.23)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C238(0.94); C241(0.94)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C238(1.15); C241(1.15)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C238(1.16); C241(1.16)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C238(1.17); C241(1.17)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C238(1.02); C241(1.02)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C238(1.12); C241(1.12)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C238(1.06); C241(1.06)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C238(1.30); C241(1.30)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C238(1.10); C241(1.10)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C238(1.04); C241(1.04)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C238(1.30); C241(1.30)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C238(1.15); C241(1.15)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C238(0.82); C241(0.82)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C238(0.82); C241(0.82)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C238(0.79); C241(0.79)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C238(0.77); C241(0.77)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C238(1.10); C241(1.10)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C238(0.77); C241(0.77)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C238(0.78); C241(0.78)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C238(0.84); C241(0.84)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C238(0.71); C241(0.71)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C238(0.78); C241(0.78)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C238(0.66); C241(0.66)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C238(0.66); C241(0.66)  LDD0636  [5]
 LDCM0332  AC68 HCT 116 C238(0.87); C241(0.87)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C238(0.76); C241(0.76)  LDD0650  [5]
 LDCM0335  AC70 HCT 116 C238(0.78); C241(0.78)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C238(0.88); C241(0.88)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C238(0.80); C241(0.80)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C238(0.82); C241(0.82)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C238(0.80); C241(0.80)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C238(0.73); C241(0.73)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C238(0.89); C241(0.89)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C238(0.89); C241(0.89)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C238(0.80); C241(0.80)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C238(1.03); C241(1.03)  LDD0661  [5]
 LDCM0346  AC80 HCT 116 C238(0.87); C241(0.87)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C238(0.73); C241(0.73)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C238(0.64); C241(0.64)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C238(1.23); C241(1.23)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C238(0.86); C241(0.86)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C238(0.74); C241(0.74)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C238(0.84); C241(0.84)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C238(0.98); C241(0.98)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C238(1.45); C241(1.45)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C238(0.79); C241(0.79)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C238(1.01); C241(1.01)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C238(1.04); C241(1.04)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C238(0.55); C241(0.55)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C238(0.99); C241(0.99)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C238(0.81); C241(0.81)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C238(0.98); C241(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C238(0.97); C241(0.97)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C238(0.87); C241(0.87)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C238(0.81); C241(0.81)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C238(0.93); C241(0.93)  LDD0683  [5]
 LDCM0367  CL1 PaTu 8988t C317(0.62); C324(0.62)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C317(0.64); C324(0.64)  LDD1247  [5]
 LDCM0369  CL100 HCT 116 C238(0.97); C241(0.97)  LDD0686  [5]
 LDCM0379  CL11 PaTu 8988t C317(0.76); C324(0.76)  LDD1258  [5]
 LDCM0382  CL112 HCT 116 C238(1.28); C241(1.28)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C238(1.25); C241(1.25)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C238(1.26); C241(1.26)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C238(1.53); C241(1.53)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C238(1.51); C241(1.51)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C238(1.11); C241(1.11)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C238(1.01); C241(1.01)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C238(1.03); C241(1.03)  LDD0706  [5]
 LDCM0390  CL12 PaTu 8988t C317(0.54); C324(0.54)  LDD1269  [5]
 LDCM0391  CL120 HCT 116 C238(1.07); C241(1.07)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C238(0.70); C241(0.70)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C238(0.63); C241(0.63)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C238(0.89); C241(0.89)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C238(0.73); C241(0.73)  LDD0712  [5]
 LDCM0400  CL13 PaTu 8988t C317(0.63); C324(0.63)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C317(0.73); C324(0.73)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C317(0.62); C324(0.62)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C238(0.99); C241(0.99)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C238(1.16); C241(1.16)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C238(1.15); C241(1.15)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C238(1.00); C241(1.00)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C317(0.61); C324(0.61)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C238(1.07); C241(1.07)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C238(1.19); C241(1.19)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C238(1.25); C241(1.25)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C238(1.16); C241(1.16)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C238(0.99); C241(0.99)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C238(0.88); C241(0.88)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C238(1.01); C241(1.01)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C238(0.87); C241(0.87)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C238(1.08); C241(1.08)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C238(1.25); C241(1.25)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C317(0.44); C324(0.44)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C238(0.96); C241(0.96)  LDD1298  [5]
 LDCM0420  CL31 PaTu 8988t C238(1.03); C241(1.03)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C238(0.74); C241(0.74)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C238(0.92); C241(0.92)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C238(0.61); C241(0.61)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C238(0.63); C241(0.63)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C238(0.56); C241(0.56)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C238(0.51); C241(0.51)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C238(0.57); C241(0.57)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C317(0.42); C324(0.42)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C238(0.98); C241(0.98)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C238(0.58); C241(0.58)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C238(0.71); C241(0.71)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C238(0.56); C241(0.56)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C238(0.71); C241(0.71)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C238(0.62); C241(0.62)  LDD1314  [5]
 LDCM0436  CL46 PaTu 8988t C238(0.73); C241(0.73)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C238(0.70); C241(0.70)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C238(0.61); C241(0.61)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C238(0.60); C241(0.60)  LDD1318  [5]
 LDCM0440  CL5 PaTu 8988t C317(1.04); C324(1.04)  LDD1319  [5]
 LDCM0441  CL50 PaTu 8988t C238(0.56); C241(0.56)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C238(0.75); C241(0.75)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C238(0.76); C241(0.76)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C238(0.52); C241(0.52)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C238(0.50); C241(0.50)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C238(0.49); C241(0.49)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C238(0.18); C241(0.18)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C238(0.43); C241(0.43)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C238(0.53); C241(0.53)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C238(0.46); C241(0.46)  LDD1329  [5]
 LDCM0451  CL6 PaTu 8988t C317(0.58); C324(0.58)  LDD1330  [5]
 LDCM0452  CL60 PaTu 8988t C238(0.40); C241(0.40)  LDD1331  [5]
 LDCM0462  CL7 PaTu 8988t C317(0.65); C324(0.65)  LDD1341  [5]
 LDCM0469  CL76 HCT 116 C238(1.14); C241(1.14)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C238(1.13); C241(1.13)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C238(1.13); C241(1.13)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C238(1.10); C241(1.10)  LDD0789  [5]
 LDCM0473  CL8 PaTu 8988t C317(0.53); C324(0.53)  LDD1352  [5]
 LDCM0474  CL80 HCT 116 C238(0.98); C241(0.98)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C238(1.03); C241(1.03)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C238(0.99); C241(0.99)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C238(1.09); C241(1.09)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C238(1.19); C241(1.19)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C238(1.04); C241(1.04)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C238(0.98); C241(0.98)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C238(1.07); C241(1.07)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C238(1.15); C241(1.15)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C238(1.12); C241(1.12)  LDD0800  [5]
 LDCM0484  CL9 PaTu 8988t C317(0.55); C324(0.55)  LDD1363  [5]
 LDCM0485  CL90 HCT 116 C238(1.16); C241(1.16)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C238(1.04); C241(1.04)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C238(1.28); C241(1.28)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C238(0.91); C241(0.91)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C238(1.11); C241(1.11)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C238(1.04); C241(1.04)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C238(1.19); C241(1.19)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C238(1.08); C241(1.08)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C238(1.18); C241(1.18)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C238(1.21); C241(1.21)  LDD0811  [5]
 LDCM0427  Fragment51 PaTu 8988t C238(0.50); C241(0.50)  LDD1306  [5]
 LDCM0022  KB02 A2058 C25(1.33)  LDD2253  [7]
 LDCM0023  KB03 A2058 C25(1.90)  LDD2670  [7]
 LDCM0024  KB05 HMCB C25(2.58)  LDD3312  [7]
 LDCM0109  NEM HeLa H162(0.00); H128(0.00)  LDD0227  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C58(0.63)  LDD2096  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C58(1.51)  LDD2100  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C58(0.90)  LDD2108  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C58(0.75)  LDD2118  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C58(0.48)  LDD2124  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C58(0.77)  LDD2151  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
T-cell leukemia homeobox protein 3 (TLX3) . O43711

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tiludronic Acid Small molecular drug DB01133

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840