Details of the Target

General Information of Target

Target ID LDTP04612
Target Name Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)
Gene Name CACNA2D1
Gene ID 781
Synonyms
CACNL2A; CCHL2A; MHS3; Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLL
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Calcium channel subunit alpha-2/delta family
Subcellular location
Membrane
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
TTD ID
T84316
Uniprot ID
P54289
DrugMap ID
TTFK1JQ
Ensemble ID
ENST00000356860.8
HGNC ID
HGNC:1399
ChEMBL ID
CHEMBL1919

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		4.50  LDD0318  [1]
OPA-S-S-alkyne
 Probe Info  		K88(1.78); K586(2.90); K634(3.07); K690(3.51)  LDD3494  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C1026(0.76)  LDD0812  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
Crotonaldehyde
 Probe Info  		C697(0.00); C904(0.00)  LDD0219  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C425
 Probe Info  		9.00  LDD2080  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1026(0.76)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C1026(1.08)  LDD0813  [4]
 LDCM0226  AC11 HEK-293T C1026(1.11)  LDD0824  [4]
 LDCM0237  AC12 HEK-293T C1026(1.05)  LDD0835  [4]
 LDCM0259  AC14 HEK-293T C1026(1.45)  LDD0857  [4]
 LDCM0263  AC143 HEK-293T C1026(1.35)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C1026(1.55)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C1026(1.60)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C1026(1.46)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C1026(2.20)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C1026(1.74)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C1026(1.20)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C1026(1.18)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C1026(1.48)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C1026(1.44)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C1026(1.55)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C1026(1.35)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C1026(1.27)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C1026(1.36)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C1026(1.86)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C1026(2.50)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C1026(0.80)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C1026(0.78)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C1026(0.89)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C1026(1.03)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C1026(1.45)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C1026(0.73)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C1026(0.82)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C1026(0.97)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C1026(0.92)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C1026(1.16)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C1026(1.41)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C1026(1.27)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C1026(0.88)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C1026(1.11)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C1026(0.94)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C1026(1.17)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C1026(1.05)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C1026(1.14)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C1026(1.11)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C1026(1.09)  LDD0893  [4]
 LDCM0301  AC4 HEK-293T C1026(0.76)  LDD0899  [4]
 LDCM0308  AC46 HEK-293T C1026(1.20)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C1026(1.18)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C1026(1.32)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C1026(1.14)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C1026(0.82)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C1026(1.15)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C1026(1.39)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C1026(1.35)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C1026(0.99)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C1026(1.35)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C1026(1.12)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C1026(1.28)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C1026(0.97)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C1026(0.98)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C1026(0.94)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C1026(0.92)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C1026(0.83)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C1026(1.30)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C1026(1.07)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C1026(1.16)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C1026(0.98)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C1026(1.16)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C1026(1.05)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C1026(1.06)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C1026(0.85)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C1026(0.96)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C1026(1.79)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C1026(1.23)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C1026(0.83)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C1026(0.81)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C1026(1.15)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C1026(0.74)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C1026(0.88)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C1026(0.88)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C1026(1.52)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C1026(1.04)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C1026(0.99)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C1026(1.49)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C1026(1.22)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C1026(1.12)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C1026(0.92)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C1026(0.91)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1026(1.21)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1026(0.92)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1026(0.88)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1026(1.00)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1026(1.11)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1026(1.07)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1026(1.01)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1026(0.95)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1026(1.13)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1026(1.06)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1026(1.21)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1026(1.03)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1026(1.08)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1026(1.89)  LDD0962  [4]
 LDCM0248  AKOS034007472 HEK-293T C1026(1.16)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C1026(1.46)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C1026(1.23)  LDD0873  [4]
 LDCM0367  CL1 HEK-293T C1026(1.14)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C1026(2.46)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C1026(1.04)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C1026(1.07)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C1026(1.02)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C1026(1.58)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C1026(1.23)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C1026(0.88)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C1026(0.78)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C1026(0.89)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C1026(1.01)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C1026(0.77)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C1026(2.18)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C1026(0.87)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C1026(0.86)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C1026(1.20)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C1026(1.05)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C1026(1.36)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C1026(1.07)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C1026(1.18)  LDD0984  [4]
 LDCM0390  CL12 HEK-293T C1026(1.41)  LDD0988  [4]
 LDCM0392  CL121 HEK-293T C1026(1.13)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C1026(1.28)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C1026(1.07)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C1026(1.00)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C1026(0.96)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C1026(1.12)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C1026(1.01)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C1026(0.92)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C1026(1.57)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C1026(1.22)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C1026(1.45)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C1026(0.91)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C1026(1.05)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C1026(1.15)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C1026(1.16)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C1026(1.14)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C1026(1.07)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C1026(1.20)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C1026(1.21)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C1026(1.20)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C1026(1.19)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C1026(1.14)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C1026(1.05)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C1026(1.14)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C1026(1.11)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C1026(1.25)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C1026(1.12)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C1026(1.61)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C1026(1.02)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C1026(0.98)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C1026(1.10)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C1026(1.11)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C1026(1.11)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C1026(1.10)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C1026(1.21)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C1026(1.84)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C1026(1.41)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C1026(1.17)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C1026(1.48)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C1026(1.61)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C1026(1.72)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C1026(1.17)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C1026(1.42)  LDD1033  [4]
 LDCM0440  CL5 HEK-293T C1026(1.29)  LDD1038  [4]
 LDCM0451  CL6 HEK-293T C1026(1.19)  LDD1049  [4]
 LDCM0462  CL7 HEK-293T C1026(1.48)  LDD1060  [4]
 LDCM0469  CL76 HEK-293T C1026(1.46)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C1026(0.98)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C1026(0.69)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C1026(1.30)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C1026(0.96)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C1026(0.94)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C1026(0.82)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C1026(1.23)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C1026(2.47)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C1026(1.23)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C1026(0.76)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C1026(1.08)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C1026(1.50)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C1026(0.96)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C1026(1.21)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C1026(0.66)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C1026(1.64)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C1026(0.72)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C1026(0.77)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C1026(0.84)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C1026(0.85)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C1026(0.98)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C1026(0.83)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C1026(0.77)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C1026(0.89)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C1026(0.93)  LDD1092  [4]
 LDCM0427  Fragment51 HEK-293T C1026(1.17)  LDD1025  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 20 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amlodipine Small molecular drug D08JIV
Cyclandelate Small molecular drug DB04838
Diltiazem Small molecular drug D0OB1J
Enflurane Small molecular drug DB00228
Ergocalciferol Small molecular drug DB00153
Felodipine Small molecular drug DB01023
Gabapentin Small molecular drug DB00996
Gabapentin Enacarbil Small molecular drug DB08872
Ibutilide Small molecular drug DB00308
Isradipine Small molecular drug DB00270
Lercanidipine Small molecular drug D0P6ZH
Nicardipine Small molecular drug DB00622
Nilvadipine Small molecular drug DB06712
Nisoldipine Small molecular drug DB00401
Nitrendipine Small molecular drug D0A1DH
Pregabalin Small molecular drug D00WUF
Spironolactone Small molecular drug DB00421
Verapamil Small molecular drug DB00661
Bioallethrin . DB13746
Butamben . DB11148
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Imagabalin Small molecular drug D05DBY
Clinical trial
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mirogabalin Small molecular drug D07VFD
Investigative
Click To Hide/Show 55 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(R)-3-(Aminomethyl)-4-(Furan-2-yl)Butanoic Acid Small molecular drug D0R1QW
(S)-2-amino-2-cyclohexylacetic Acid Small molecular drug D0GB8J
(S)-2-amino-2-o-tolylacetic Acid Small molecular drug D0CU9Y
(S)-2-amino-2-p-tolylacetic Acid Small molecular drug D0RC5X
(S)-2-amino-2-phenylpropanoic Acid Small molecular drug D0Z0VF
(S)-2-amino-3-(Benzylthio)Propanoic Acid Small molecular drug D07BMX
(S)-2-amino-3-cyclohexylpropanoic Acid Small molecular drug D00XUE
(S)-2-amino-4-(Benzylthio)Butanoic Acid Small molecular drug D0W2EX
(S)-3-(Aminomethyl)-4-(Furan-2-yl)Butanoic Acid Small molecular drug D0X1BT
(S)-phenylglycine Small molecular drug D03KKH
1-benzhydryl-4-(3,3-diphenylpropyl)Piperazine Small molecular drug D06NUU
1-benzhydryl-4-(4,4-diphenylbutyl)Piperazine Small molecular drug D07QDU
2-(1-(Aminomethyl)-3-butylcyclopentyl)Acetic Acid Small molecular drug D0V2ZB
2-(1-(Aminomethyl)-3-ethylcyclopentyl)Acetic Acid Small molecular drug D0RS3R
2-amino-2-(2,3-difluorophenyl)Acetic Acid Small molecular drug D0Q3KV
2-amino-2-(2,4-difluorophenyl)Acetic Acid Small molecular drug D07QGX
2-amino-2-(2-fluorophenyl)Acetic Acid Small molecular drug D0V6SS
2-amino-2-(3-bromophenyl)Acetic Acid Small molecular drug D05WDV
2-amino-2-(3-chloro-4-fluorophenyl)Acetic Acid Small molecular drug D05JAZ
2-amino-2-(3-chlorophenyl)Acetic Acid Small molecular drug D08ZGW
2-amino-2-(Thiophen-2-yl)Acetic Acid Small molecular drug D0RA0P
2-amino-4-(2-methyl-benzylsulfanyl)-butyric Acid Small molecular drug D04YNS
3-(Aminomethyl)-4-(Furan-2-yl)Butanoic Acid Small molecular drug D0KZ7A
3-(Aminomethyl)-4-(Furan-3-yl)Butanoic Acid Small molecular drug D0T2VK
3-(Aminomethyl)-4-(Thiophen-2-yl)Butanoic Acid Small molecular drug D08BOL
3-(Aminomethyl)-4-(Thiophen-3-yl)Butanoic Acid Small molecular drug D0J3NS
3-aminomethyl-5-methyl-hexanoic Acid Small molecular drug D0T6DR
4-(2,3-dichlorobenzylthio)-2-aminobutanoic Acid Small molecular drug D0S0WU
4-(2,5-dichlorobenzylthio)-2-aminobutanoic Acid Small molecular drug D0VA2O
4-(2-bromobenzylthio)-2-aminobutanoic Acid Small molecular drug D09QVD
4-(2-cyanobenzylthio)-2-aminobutanoic Acid Small molecular drug D02IRC
4-(2-methoxybenzylthio)-2-aminobutanoic Acid Small molecular drug D0OI6B
4-(2-nitrobenzylthio)-2-aminobutanoic Acid Small molecular drug D01PWO
4-(3,4-dichlorobenzylthio)-2-aminobutanoic Acid Small molecular drug D06VUC
4-(3,4-dimethylbenzylthio)-2-aminobutanoic Acid Small molecular drug D09CKV
4-(3,5-dichlorobenzylthio)-2-aminobutanoic Acid Small molecular drug D0L2VI
4-(3,5-dimethylbenzylthio)-2-aminobutanoic Acid Small molecular drug D09EQN
4-(3-bromobenzylthio)-2-aminobutanoic Acid Small molecular drug D0N6QW
4-(3-chlorobenzylthio)-2-aminobutanoic Acid Small molecular drug D0T6YJ
4-(3-cyanobenzylthio)-2-aminobutanoic Acid Small molecular drug D0GU5E
4-(3-fluorobenzylthio)-2-aminobutanoic Acid Small molecular drug D02ANL
4-(3-methoxybenzylthio)-2-aminobutanoic Acid Small molecular drug D06RSF
4-(3-nitrobenzylthio)-2-aminobutanoic Acid Small molecular drug D0C6FW
4-(4-bromobenzylthio)-2-aminobutanoic Acid Small molecular drug D0O6HW
4-(4-chlorobenzylthio)-2-aminobutanoic Acid Small molecular drug D0I0SK
4-(4-tert-butylbenzylthio)-2-aminobutanoic Acid Small molecular drug D09VTR
Ethionine Small molecular drug D0LN2D
Gababutin Small molecular drug D0L7AO
N'-acridin-9-yl-n,N-diethyl-butane-1,4-diamine Small molecular drug D0VQ4G
N,4-dibenzhydrylpiperazine-1-carboxamide Small molecular drug D0H2VW
Pd-144550 Small molecular drug D0D1EU
Rac-2-amino-4-phenylbutanoic Acid Small molecular drug D0D7FX
Rac-2-amino-5-cyclohexylpentanoic Acid Small molecular drug D06EUM
Trans-dimethyl Gababutin Small molecular drug D09UXA
Efonidipine . DB09235
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Np-118809 Small molecular drug D06FSC

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587