Details of the Target

General Information of Target

Target ID LDTP02977
Target Name Cadherin-2 (CDH2)
Gene Name CDH2
Gene ID 1000
Synonyms
CDHN; NCAD; Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD antigen CD325
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKF
SNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVK
LSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQEL
VRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAV
DINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNAL
NGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTY
GLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVY
RISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQS
TATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDP
ANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDIND
NAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGD
FAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGL
GTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGE
EDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGL
KAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADM
YGGGDD
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
TTD ID
T16868
Uniprot ID
P19022
DrugMap ID
TT1WS0T
Ensemble ID
ENST00000269141.8
HGNC ID
HGNC:1759
ChEMBL ID
CHEMBL1697669

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.R812S .
CAL148 SNV: p.D786N .
CALU6 SNV: p.A118V .
COLO678 SNV: p.A432P .
DU145 SNV: p.D262N .
HEPG2 SNV: p.R748G .
HSC4 SNV: p.R697S .
HT115 SNV: p.L738R .
IPC298 SNV: p.R808Q .
K562 SNV: p.Y345C; p.S691L .
MDAMB453 SNV: p.E781K .
MELJUSO SNV: p.S694F .
NALM6 SNV: p.E776Ter .
NCIH1944 SNV: p.A610S .
NCIH2291 Deletion: p.P427LfsTer17
SNV: p.D426V		 .
NCIH661 SNV: p.D262E; p.P358H .
OCILY3 SNV: p.N243Y .
SKMEL5 SNV: p.D84N .
SW1271 SNV: p.G361V .
TE4 Substitution: p.Y345I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		5.85  LDD0318  [1]
FBP2
 Probe Info  		2.59  LDD0317  [1]
OPA-S-S-alkyne
 Probe Info  		K223(2.63); K448(3.81); K189(4.45); K699(10.57)  LDD3494  [2]
DBIA
 Probe Info  		C703(3.88); C701(3.99); C709(3.99)  LDD0080  [3]
m-APA
 Probe Info  		H815(0.00); H511(0.00); H828(0.00)  LDD2231  [4]
IPM
 Probe Info  		C703(0.00); C701(0.00)  LDD2156  [5]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		9.85  LDD1838  [7]
C384
 Probe Info  		5.66  LDD2043  [7]
FFF probe11
 Probe Info  		13.17  LDD0471  [8]
FFF probe3
 Probe Info  		13.62  LDD0464  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C703(1.00)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C709(1.23)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C703(1.26)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C703(0.98)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C703(1.07)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C703(1.24)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C703(1.08)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C703(0.81)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C703(0.81)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C703(0.96)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C703(1.06)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C703(0.90)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C709(1.34)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C703(1.34)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C703(1.80)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C703(1.87)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C709(0.95)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C709(1.07)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C709(1.20)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C709(0.93)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C709(0.78)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C709(0.66)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C709(0.53)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C709(1.79)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C709(0.65)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C709(0.55)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C709(0.42)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C709(0.42)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C709(0.54)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C709(0.46)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C709(0.34)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C709(0.38)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C709(0.92)  LDD0857  [3]
 LDCM0263  AC143 HEK-293T C703(1.15); C709(0.92)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C703(1.53); C709(0.45)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C703(1.38); C709(0.38)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C703(1.66); C709(0.49)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C703(1.86); C709(0.39)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C703(1.40); C709(0.50)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C703(1.12); C709(0.91)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C709(0.97)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C703(1.35); C709(0.69)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C703(1.35); C709(0.61)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C703(1.44); C709(0.68)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C703(1.28); C709(0.54)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C703(1.19); C709(0.89)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C703(2.14); C709(0.71)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C703(1.52); C709(0.43)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C703(2.03); C709(0.38)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C709(1.08)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C709(1.12)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C709(1.23)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C703(1.23)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C709(1.12)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C709(0.82)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C709(1.04)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C709(2.22)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C709(1.65)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C709(0.78)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C709(0.80)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C709(0.85)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C709(0.60)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C709(0.69)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C703(0.96)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C709(0.71)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C709(0.76)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C709(0.81)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C709(0.86)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C709(0.88)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C703(0.88)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C703(1.08)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C703(1.05)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C703(1.03)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C703(1.22)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C703(1.06)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C703(1.13)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C703(1.23)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C703(1.40)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C703(1.12)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C703(1.38)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C703(1.28)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C703(1.00)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C703(1.19)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C703(1.24)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C703(1.24)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C703(0.98)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C703(0.89)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C703(1.60)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C703(1.10)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C703(1.23)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C703(1.37)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C703(1.13)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C703(1.11)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C63(1.13)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C63(1.13); C701(1.24)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C63(1.00); C703(0.90)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C709(0.75)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C63(1.12); C703(1.19)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C63(1.12)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C63(1.12)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C63(0.91); C701(1.19)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C63(1.09)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C709(1.11)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C709(1.09)  LDD0943  [3]
 LDCM0365  AC98 HEK-293T C703(0.99)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C703(0.81)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C709(0.63)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C709(1.70)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C709(0.72)  LDD0873  [3]
 LDCM0367  CL1 HEK-293T C703(1.02)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C703(2.08)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C703(1.27)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C709(1.05)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C709(0.95)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C709(1.07)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C709(1.62)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C709(1.13)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C709(0.99)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C709(0.99)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C709(0.98)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C709(1.35)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C703(2.07)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C709(1.21)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C709(0.88)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C709(0.69)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C709(0.90)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C709(0.46)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C709(0.79)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C709(0.76)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C703(0.96)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C703(1.07)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C703(1.20)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C703(1.04)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C703(1.54)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C703(1.16)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C703(1.13)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C703(1.06)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C703(1.34)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C63(1.31)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C701(0.95)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C701(0.91)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C701(1.32)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C703(1.05)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C703(1.20)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C703(1.77)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C701(1.16)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C63(1.05)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C63(0.93); C701(1.46)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C63(0.86); C703(0.91)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C703(1.09)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C63(1.00); C703(0.91)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C63(1.03)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C63(0.90)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C63(0.91); C701(1.39)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C63(0.86)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C63(1.09)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C701(0.81)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C701(0.79)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C701(1.71)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C63(0.97)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C703(1.01)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C63(0.96); C701(1.16)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C703(1.23)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C703(1.27)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C703(1.50)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C703(1.16)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C703(1.27)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C703(1.31)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C703(1.31)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C703(2.32)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C703(1.05)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C703(1.29)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C703(2.09)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C703(1.95)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C703(1.99)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C703(1.29)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C703(2.12)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C63(0.99)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C63(0.96); C701(1.73)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C63(0.97)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C63(1.17)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C703(1.01)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C701(1.45)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C701(1.44)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C63(1.04)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C63(1.02); C701(1.12)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C63(0.87); C703(1.04)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C63(1.11); C703(0.82)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C63(1.14)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C63(1.11)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C63(0.90); C701(1.58)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C703(1.42)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C63(0.97)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C703(1.44)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C703(2.02)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C703(1.23)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C703(1.16)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C703(1.29)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C703(1.39)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C703(1.48)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C703(1.51)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C703(1.09)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C703(1.38)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C703(1.19)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C703(1.46)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C703(1.24)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C703(1.69)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C703(2.16)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C703(1.25)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C703(1.20)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C703(1.57)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C703(1.61)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C63(1.15); C703(1.06)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C703(1.52)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C703(1.43)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C703(1.22)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C703(1.44)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C703(2.12)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C703(2.38)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C703(2.13)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C703(1.53)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C703(1.41)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C703(1.48)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C63(0.87)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C703(1.57)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C703(1.01)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C703(1.06)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C703(1.05)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C703(1.17)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C703(1.30)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C703(0.96)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C703(1.02)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C703(1.04)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C703(0.94)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C701(1.15)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C703(2.12)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C703(1.45)  LDD1025  [3]
 LDCM0022  KB02 HCT 116 C703(3.88); C701(3.99); C709(3.99)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C703(3.35); C701(2.77); C709(2.77)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C703(5.58); C701(3.99); C709(3.99)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Junction plakoglobin (JUP) Beta-catenin family P14923

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Exherin Small molecular drug D0KK9E

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402