Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C384  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 10.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 5.5
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.5
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 5.4
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 5.3
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 5.1
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00433  Neuropilin-1 (NRP1) 5.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 5.0
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15623  Neuferricin (CYB5D2) 5.7
 LDTP02977  Cadherin-2 (CDH2) 5.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587