Details of the Target

General Information of Target

Target ID LDTP04211
Target Name Isocitrate dehydrogenase [NADP], mitochondrial (IDH2)
Gene Name IDH2
Gene ID 3418
Synonyms
Isocitrate dehydrogenase [NADP], mitochondrial; IDH; EC 1.1.1.42; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
Target Bioclass
Enzyme
Family
Isocitrate and isopropylmalate dehydrogenases family
Subcellular location
Mitochondrion
Function Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Uniprot ID
P48735
Ensemble ID
ENST00000330062.8
HGNC ID
HGNC:5383
ChEMBL ID
CHEMBL3991501

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 SNV: p.V335A DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Q95R DBIA    Probe Info 
PF382 SNV: p.N136I DBIA    Probe Info 
RKO SNV: p.G190D DBIA    Probe Info 
RL952 SNV: p.D446H DBIA    Probe Info 
SNU1 SNV: p.T341A DBIA    Probe Info 
SNU5 SNV: p.V403L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y179(20.00)  LDD0257  [1]
TH214
 Probe Info  		Y274(20.00)  LDD0258  [1]
TH216
 Probe Info  		Y179(20.00); Y285(14.96)  LDD0259  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
YN-4
 Probe Info  		100.00  LDD0445  [2]
OPA-S-S-alkyne
 Probe Info  		K384(3.48)  LDD3494  [3]
Probe 1
 Probe Info  		Y81(95.92); Y107(55.01); Y179(36.94)  LDD3495  [4]
BTD
 Probe Info  		C418(0.52)  LDD2106  [5]
AHL-Pu-1
 Probe Info  		C402(3.00)  LDD0172  [6]
DBIA
 Probe Info  		C418(0.89); C308(0.86)  LDD0078  [7]
5E-2FA
 Probe Info  		H74(0.00); H430(0.00); H348(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		K166(0.00); K180(0.00); K272(0.00); K275(0.00)  LDD0199  [9]
m-APA
 Probe Info  		H430(0.00); H74(0.00)  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C113(0.00); C418(0.00); C235(0.00); C154(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C402(0.00); C418(0.00); C308(0.00); C154(0.00)  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		C402(0.00); C113(0.00); C418(0.00); C308(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C113(0.00); C235(0.00); C418(0.00); C154(0.00)  LDD0037  [10]
ATP probe
 Probe Info  		K272(0.00); K263(0.00); K45(0.00)  LDD0035  [13]
TFBX
 Probe Info  		C113(0.00); C402(0.00)  LDD0027  [14]
Compound 10
 Probe Info  		C113(0.00); C154(0.00); C308(0.00); C418(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
Phosphinate-6
 Probe Info  		C154(0.00); C418(0.00)  LDD0018  [17]
Ox-W18
 Probe Info  		N.A.  LDD2175  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [19]
Acrolein
 Probe Info  		C418(0.00); C308(0.00); C402(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		H348(0.00); C418(0.00); C308(0.00); H287(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		C418(0.00); C402(0.00); H348(0.00)  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		13.50  LDD0443  [22]
NAIA_5
 Probe Info  		C113(0.00); C418(0.00); C154(0.00); C308(0.00)  LDD2223  [23]
HHS-465
 Probe Info  		N.A.  LDD2240  [24]
HHS-482
 Probe Info  		Y179(0.48)  LDD2239  [25]
PAL-AfBPP Probe
Click To Hide/Show 67 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		21.11  LDD1714  [26]
C017
 Probe Info  		7.67  LDD1725  [26]
C027
 Probe Info  		10.78  LDD1733  [26]
C039
 Probe Info  		5.03  LDD1739  [26]
C062
 Probe Info  		9.85  LDD1759  [26]
C073
 Probe Info  		5.50  LDD1769  [26]
C085
 Probe Info  		5.21  LDD1777  [26]
C087
 Probe Info  		8.34  LDD1779  [26]
C089
 Probe Info  		5.13  LDD1781  [26]
C102
 Probe Info  		4.92  LDD1790  [26]
C113
 Probe Info  		5.24  LDD1800  [26]
C116
 Probe Info  		14.22  LDD1803  [26]
C131
 Probe Info  		5.46  LDD1813  [26]
C132
 Probe Info  		12.64  LDD1814  [26]
C137
 Probe Info  		5.98  LDD1819  [26]
C140
 Probe Info  		8.22  LDD1822  [26]
C145
 Probe Info  		15.78  LDD1827  [26]
C146
 Probe Info  		11.47  LDD1828  [26]
C165
 Probe Info  		19.16  LDD1845  [26]
C170
 Probe Info  		8.57  LDD1850  [26]
C174
 Probe Info  		15.89  LDD1854  [26]
C179
 Probe Info  		14.52  LDD1858  [26]
C186
 Probe Info  		15.03  LDD1864  [26]
C191
 Probe Info  		17.15  LDD1868  [26]
C197
 Probe Info  		6.32  LDD1873  [26]
C208
 Probe Info  		5.74  LDD1883  [26]
C211
 Probe Info  		17.63  LDD1885  [26]
C227
 Probe Info  		8.00  LDD1900  [26]
C235
 Probe Info  		24.25  LDD1908  [26]
C237
 Probe Info  		5.70  LDD1910  [26]
C239
 Probe Info  		5.90  LDD1912  [26]
C242
 Probe Info  		13.74  LDD1915  [26]
C258
 Probe Info  		11.79  LDD1931  [26]
C268
 Probe Info  		5.78  LDD1938  [26]
C270
 Probe Info  		17.51  LDD1940  [26]
C279
 Probe Info  		19.97  LDD1949  [26]
C280
 Probe Info  		11.63  LDD1950  [26]
C286
 Probe Info  		11.24  LDD1956  [26]
C295
 Probe Info  		7.73  LDD1965  [26]
C302
 Probe Info  		13.64  LDD1971  [26]
C303
 Probe Info  		10.48  LDD1972  [26]
C314
 Probe Info  		14.93  LDD1981  [26]
C319
 Probe Info  		6.54  LDD1985  [26]
C331
 Probe Info  		7.06  LDD1994  [26]
C342
 Probe Info  		9.51  LDD2004  [26]
C346
 Probe Info  		16.00  LDD2007  [26]
C348
 Probe Info  		10.41  LDD2009  [26]
C365
 Probe Info  		6.59  LDD2026  [26]
C374
 Probe Info  		8.94  LDD2034  [26]
C381
 Probe Info  		4.92  LDD2040  [26]
C384
 Probe Info  		5.28  LDD2043  [26]
C385
 Probe Info  		5.17  LDD2044  [26]
C397
 Probe Info  		9.45  LDD2056  [26]
C424
 Probe Info  		8.00  LDD2079  [26]
C428
 Probe Info  		5.21  LDD2083  [26]
C430
 Probe Info  		5.82  LDD2085  [26]
FFF probe11
 Probe Info  		20.00  LDD0471  [27]
FFF probe12
 Probe Info  		18.93  LDD0487  [27]
FFF probe13
 Probe Info  		13.51  LDD0475  [27]
FFF probe14
 Probe Info  		12.29  LDD0477  [27]
FFF probe2
 Probe Info  		10.72  LDD0463  [27]
FFF probe3
 Probe Info  		18.83  LDD0464  [27]
FFF probe6
 Probe Info  		5.79  LDD0467  [27]
FFF probe9
 Probe Info  		6.39  LDD0470  [27]
JN0003
 Probe Info  		14.65  LDD0469  [27]
STS-2
 Probe Info  		N.A.  LDD0139  [28]
OEA-DA
 Probe Info  		5.08  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C418(0.69)  LDD2117  [5]
 LDCM0025  4SU-RNA HEK-293T C402(3.00)  LDD0172  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C402(2.13)  LDD0173  [6]
 LDCM0214  AC1 HCT 116 C308(0.72)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C308(0.92)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C308(1.02)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C308(1.09)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C308(0.99)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C308(1.07)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C308(1.01)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C308(1.05)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C308(1.14)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C308(1.04)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C308(1.08)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C308(0.97)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C308(1.20)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C308(1.16)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C308(1.15)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C308(1.14)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C308(1.05); C418(0.95)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C308(1.10); C418(0.76)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C308(1.13); C418(0.50)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C308(1.01); C418(0.54)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C308(0.99); C418(0.86)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C308(0.99); C418(0.99)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C308(1.13); C418(0.80)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C308(0.92)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C308(1.20); C418(0.86)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C308(0.91); C418(1.12)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C308(1.06); C418(1.04)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C308(0.95); C418(1.08)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C308(0.99); C418(1.21)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C308(1.07); C418(0.89)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C308(1.03); C418(0.58)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C308(1.04); C418(0.66)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C308(1.09); C418(1.01)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C308(0.99); C418(1.03)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C308(0.98); C418(0.97)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C308(1.16); C418(0.93)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C308(1.22); C418(1.10)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C308(1.12); C418(0.95)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C308(1.06); C418(0.91)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C308(1.08); C418(0.92)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C308(1.03); C418(0.99)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C308(1.02); C418(1.03)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C308(0.91); C418(1.07)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C308(1.15); C418(0.96)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C308(0.88)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C308(0.96); C418(1.00)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C308(0.91); C418(1.14)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C308(1.22); C418(1.81)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C308(1.02)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C308(0.79)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C308(0.73)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C308(0.86)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C308(0.84)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C308(0.94)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C308(0.90)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C308(0.73)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C308(1.00)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C308(1.07)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C308(0.94)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C308(0.79)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C308(0.85)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C308(0.84)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C308(0.90)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C308(0.85)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C308(0.97)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C308(0.98)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C308(1.11)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C308(0.74)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C308(1.08)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C308(0.86)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C308(1.03)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C308(0.74)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C308(1.06)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C308(0.90)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C308(1.17)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C308(1.24)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C308(0.97)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C308(1.22)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C308(0.73)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C308(1.38)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C308(1.22)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C308(1.18)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C308(0.95)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C308(0.99)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C308(1.11); C418(1.23)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C418(1.14); C308(1.15)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C308(1.10); C418(1.22)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C308(1.05); C418(1.24)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C418(0.90); C308(1.06)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C308(0.67)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C418(0.83); C308(1.10)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C418(0.97); C308(1.10)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C418(0.86); C308(1.02)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C308(0.98); C418(1.08)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C418(0.86); C308(1.12)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C418(0.86); C308(1.12)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C418(1.27); C308(1.29)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C418(1.01); C308(1.08)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C308(1.46); C418(2.04)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C418(0.99); C308(1.11)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C308(0.70)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C418(0.82); C308(1.03)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C308(1.50); C418(1.98)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C418(0.89); C308(1.06)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C418(0.83); C308(0.85)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C418(0.85); C308(1.02)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C418(0.89); C308(0.97)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C308(1.05); C418(1.09)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C418(0.71); C308(0.86)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C418(0.61); C308(0.89)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C418(0.58); C308(0.80)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C308(0.95)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C308(0.86); C418(0.86)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C308(1.06); C418(1.40)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C418(0.59); C308(0.79)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C418(0.69); C308(0.85)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C308(0.62); C418(0.65)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C418(0.76); C308(0.83)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C418(0.80); C308(0.91)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C418(0.72); C308(0.90)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C418(0.73); C308(0.75)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C418(0.79); C308(0.83)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C308(0.94)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C418(0.65); C308(0.89)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C308(0.78); C418(1.10)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C418(0.71); C308(0.77)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C308(0.88); C418(0.95)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C308(0.82); C418(0.94)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C308(0.89); C418(0.89)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C418(0.65); C308(0.85)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C418(0.70); C308(0.90)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C308(0.85); C418(1.18)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C418(0.84); C308(1.01)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C308(0.98)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C418(0.66); C308(1.03)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C308(1.06); C418(1.56)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C308(0.88); C418(1.06)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C308(1.00)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C308(0.94)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C308(1.26)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C308(1.00)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C308(1.10)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C308(1.28)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C308(1.00)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C308(1.26)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C308(1.04)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C308(0.96)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C308(1.03)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C308(1.61)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C308(1.49)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C308(1.10)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C308(0.98)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C308(1.13)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C308(1.01)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C308(0.93)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C308(1.01)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C308(0.82)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C418(0.89); C308(0.86)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C418(0.00); H348(0.00); C308(0.00); C113(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C308(1.61); C113(1.44); C154(0.87); C418(0.84)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C418(1.04); C308(1.06)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C418(0.80); C308(0.98)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C308(0.73)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C308(1.03)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C308(0.64)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C308(1.00)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C308(0.97)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C308(0.81)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C308(0.74)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C308(0.80)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C308(0.78)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C308(0.98)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C418(0.76); C308(0.81)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C308(0.71)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C308(0.88)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C308(0.78)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C308(1.00)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C308(0.90)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C308(1.06)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C308(1.06)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C308(1.00); C418(1.07)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C418(0.87); C308(1.01)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C418(0.76); C308(1.00)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C418(0.69); C308(0.93)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C418(0.94); C308(1.06)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C308(0.90); C418(0.93)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C308(1.04); C418(1.27)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C418(0.72); C308(0.89)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C418(0.85); C308(1.06)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C308(0.87); C418(1.00)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C418(1.08); C308(1.11)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C418(1.14); C308(1.22)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C418(0.63); C308(0.84)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C418(0.88); C308(0.93)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C418(0.81); C308(0.99)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C308(1.29); C418(1.87)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C418(0.76); C308(1.09)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C418(1.03); C308(1.06)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C418(1.16); C308(1.28)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C418(0.98); C308(1.09)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C418(0.88); C308(1.22)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C418(0.54); C308(0.82)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C418(0.60); C308(0.67)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C418(0.83); C308(0.96)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C418(0.65); C308(0.83)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C418(0.58); C308(0.85)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C308(0.77); C418(0.49)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C308(0.83); C418(0.64)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C308(0.79); C418(0.70)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C308(0.87); C418(0.63)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C308(0.88); C418(0.61)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C308(1.12); C418(0.92)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C308(1.05); C418(0.89)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C308(0.89); C418(0.76)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C308(0.98); C418(0.97)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C308(0.85); C418(0.81)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C308(1.06); C418(0.47)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C308(1.01); C418(0.41)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C308(0.89); C418(0.46)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C308(0.84); C418(0.44)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C308(1.06); C418(0.43)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C308(0.92); C418(1.04)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C308(0.80); C418(0.48)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C308(0.98); C418(0.43)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C308(0.88); C418(0.67)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C308(1.04); C418(0.52)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C308(0.93); C418(0.59)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C308(0.85); C418(0.55)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C308(0.91)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C308(0.93)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C308(0.86)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C308(0.97)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C308(1.01); C418(0.74)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C308(0.77)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C308(0.86)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C308(1.09)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C308(1.02)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C308(0.83)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C308(0.78)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C308(0.78)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C308(0.84)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C308(0.84)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C308(0.75)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C308(1.23); C418(1.24)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C308(0.81)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C308(0.95)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C308(0.88)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C308(0.78)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C308(0.81)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C308(0.90)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C308(0.71)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C308(0.79)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C308(0.90)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C308(1.13)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C308(0.86); C418(0.77)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C308(1.09)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C308(0.82)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C308(1.17)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C308(0.87)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C308(0.79)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C308(0.93); C418(0.86)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C308(0.82); C418(0.63)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C308(0.77); C418(0.50)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C308(0.90); C418(0.32)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C308(0.77); C418(0.83)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C308(0.71); C418(0.85)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C308(0.80); C418(0.48)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C308(0.67); C418(0.39)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C308(0.76); C418(0.36)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C308(0.70); C418(0.38)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C308(0.72); C418(0.51)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C308(0.70); C418(0.86)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C308(0.68); C418(0.39)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C308(0.69); C418(0.34)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C308(0.70); C418(0.50)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C308(0.96); C418(0.70)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C308(0.58); C418(0.84)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C308(0.80)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C308(0.80)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C308(0.73)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C308(0.71)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C308(0.66)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C308(0.75)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C308(0.87)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C308(0.74)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C308(0.74)  LDD0811  [7]
 LDCM0189  Compound 16 HEK-293T 14.71  LDD0492  [27]
 LDCM0185  Compound 17 HEK-293T 11.19  LDD0504  [27]
 LDCM0182  Compound 18 HEK-293T 5.78  LDD0501  [27]
 LDCM0184  Compound 20 HEK-293T 13.47  LDD0503  [27]
 LDCM0191  Compound 21 HEK-293T 11.83  LDD0493  [27]
 LDCM0186  Compound 31 HEK-293T 8.74  LDD0506  [27]
 LDCM0187  Compound 32 HEK-293T 16.28  LDD0507  [27]
 LDCM0188  Compound 33 HEK-293T 12.10  LDD0505  [27]
 LDCM0190  Compound 34 HEK-293T 13.61  LDD0497  [27]
 LDCM0192  Compound 35 HEK-293T 10.87  LDD0491  [27]
 LDCM0193  Compound 36 HEK-293T 11.17  LDD0494  [27]
 LDCM0194  Compound 37 HEK-293T 14.49  LDD0498  [27]
 LDCM0195  Compound 38 HEK-293T 16.26  LDD0499  [27]
 LDCM0196  Compound 39 HEK-293T 10.93  LDD0496  [27]
 LDCM0197  Compound 40 HEK-293T 14.93  LDD0495  [27]
 LDCM0181  Compound 41 HEK-293T 6.10  LDD0502  [27]
 LDCM0634  CY-0357 Hep-G2 C308(0.68); C418(0.58)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C418(1.01); C402(0.91); C308(0.94); C154(0.97)  LDD1698  [30]
 LDCM0625  F8 Ramos C113(0.98); C402(0.56); C154(0.82); C418(1.16)  LDD2187  [31]
 LDCM0572  Fragment10 MDA-MB-231 C308(1.14)  LDD1389  [32]
 LDCM0573  Fragment11 MDA-MB-231 C308(1.13)  LDD1391  [32]
 LDCM0574  Fragment12 MDA-MB-231 C308(1.70)  LDD1393  [32]
 LDCM0575  Fragment13 MDA-MB-231 C308(1.09)  LDD1395  [32]
 LDCM0576  Fragment14 MDA-MB-231 C308(4.70)  LDD1397  [32]
 LDCM0579  Fragment20 MDA-MB-231 C308(0.46)  LDD1402  [32]
 LDCM0580  Fragment21 MDA-MB-231 C308(0.64)  LDD1404  [32]
 LDCM0582  Fragment23 Ramos C113(0.39); C402(3.54); C154(0.31)  LDD2196  [31]
 LDCM0584  Fragment25 MDA-MB-231 C308(14.53)  LDD1411  [32]
 LDCM0578  Fragment27 MDA-MB-231 C308(1.87)  LDD1401  [32]
 LDCM0586  Fragment28 MDA-MB-231 C308(0.89)  LDD1415  [32]
 LDCM0587  Fragment29 MDA-MB-231 C308(0.99)  LDD1417  [32]
 LDCM0588  Fragment30 MDA-MB-231 C308(0.70)  LDD1419  [32]
 LDCM0589  Fragment31 MDA-MB-231 C308(1.29)  LDD1421  [32]
 LDCM0590  Fragment32 Ramos C113(0.49); C402(0.91); C154(0.42)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C308(0.83)  LDD0785  [7]
 LDCM0594  Fragment36 MDA-MB-231 C308(1.32)  LDD1431  [32]
 LDCM0596  Fragment38 MDA-MB-231 C308(1.21)  LDD1433  [32]
 LDCM0566  Fragment4 MDA-MB-231 C308(0.69)  LDD1378  [32]
 LDCM0601  Fragment43 MDA-MB-231 C308(0.78)  LDD1441  [32]
 LDCM0603  Fragment45 MDA-MB-231 C308(0.97)  LDD1444  [32]
 LDCM0604  Fragment46 MDA-MB-231 C308(0.23)  LDD1445  [32]
 LDCM0605  Fragment47 MDA-MB-231 C308(1.24)  LDD1446  [32]
 LDCM0606  Fragment48 MDA-MB-231 C308(1.05)  LDD1447  [32]
 LDCM0608  Fragment50 MDA-MB-231 C308(2.21)  LDD1449  [32]
 LDCM0427  Fragment51 HCT 116 C308(0.71); C418(0.50)  LDD0744  [7]
 LDCM0610  Fragment52 MDA-MB-231 C308(1.11)  LDD1452  [32]
 LDCM0611  Fragment53 MDA-MB-231 C308(0.45)  LDD1454  [32]
 LDCM0614  Fragment56 MDA-MB-231 C308(1.03)  LDD1458  [32]
 LDCM0569  Fragment7 MDA-MB-231 C308(0.90)  LDD1383  [32]
 LDCM0570  Fragment8 MDA-MB-231 C308(1.29)  LDD1385  [32]
 LDCM0571  Fragment9 MDA-MB-231 C308(1.41)  LDD1387  [32]
 LDCM0107  IAA HeLa H348(0.00); H74(0.00)  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C308(2.26); C418(1.43)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C308(15.79); C418(8.47)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C308(2.27); C418(1.66)  LDD0082  [7]
 LDCM0109  NEM HeLa H430(0.00); H348(0.00); H287(0.00); H74(0.00)  LDD0223  [20]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C418(0.52)  LDD2106  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C418(0.68)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C418(0.77)  LDD2110  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C418(0.39)  LDD2118  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C418(0.96)  LDD2123  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C418(0.76)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C418(0.94)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C418(1.50)  LDD2135  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C418(1.02)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C418(0.85); C402(0.57)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C418(1.05)  LDD2146  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C402(1.03); C154(0.93); C113(0.92); C418(0.32)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C308(0.69); C154(0.62)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C402(1.48); C308(1.33); C154(1.21); C418(1.16)  LDD0304  [34]
 LDCM0021  THZ1 HCT 116 C308(0.80)  LDD2173  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Enasidenib . DB13874
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isocitric Acid Small molecular drug DB01727

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD038010
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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