Probe Name	JN0003					Probe Info
Probe concentration	20 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	SILAC
Competitor Name	Compound 33					Competitor Info
Competitor Concentration	160 uM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Peripheral blood
	Disease Model		Normal
	Model Name		Human normal cells (HEK-293T)

Target ID	Target Name					Binding Ratio
LDTP04211	Isocitrate dehydrogenase [NADP], mitochondrial (IDH2)					12.1
LDTP04008	Endothelin-converting enzyme 1 (ECE1)					11.3
LDTP03257	Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)					11.0
LDTP06618	ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)					10.9
LDTP16032	Retinoid-inducible serine carboxypeptidase (SCPEP1)					10.6
LDTP03189	Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2)					10.5
LDTP02198	Cathepsin D (CTSD)					10.2
LDTP13751	Exonuclease 1 (EXO1)					10.2
LDTP04471	Ribosomal protein S6 kinase alpha-3 (RPS6KA3)					9.7
LDTP05476	3-ketodihydrosphingosine reductase (KDSR)					9.6
LDTP02837	Beta-galactosidase (GLB1)					8.3
LDTP16007	Lipid droplet-associated hydrolase (LDAH)					7.9
LDTP02602	Histidine--tRNA ligase, cytoplasmic (HARS1)					7.8
LDTP03540	Heme oxygenase 2 (HMOX2)					7.8
LDTP06648	Lanosterol 14-alpha demethylase (CYP51A1)					7.6
LDTP15988	Probable serine carboxypeptidase CPVL (CPVL)					7.6
LDTP10887	Synaptic vesicle membrane protein VAT-1 homolog (VAT1)					7.1
LDTP02385	Leukotriene A-4 hydrolase (LTA4H)					7.1
LDTP12610	Obg-like ATPase 1 (OLA1)					7.0
LDTP08979	Prostaglandin reductase 2 (PTGR2)					7.0
LDTP02651	Gamma-interferon-inducible lysosomal thiol reductase (IFI30)					6.8
LDTP06375	Delta(24)-sterol reductase (DHCR24)					6.7
LDTP03139	Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)					6.6
LDTP04004	Lysosomal Pro-X carboxypeptidase (PRCP)					6.3
LDTP15422	Prostaglandin reductase 3 (PTGR3)					6.2
LDTP05724	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)					6.1
LDTP05192	ADP-ribosylation factor 1 (ARF1)					5.9
LDTP03912	Trifunctional enzyme subunit alpha, mitochondrial (HADHA)					5.2
LDTP12628	Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10)					5.0
LDTP01773	Cytochrome c oxidase subunit 2 (MT-CO2)					4.7
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)					4.7
LDTP04051	Nicotinamide phosphoribosyltransferase (NAMPT)					4.5
LDTP12013	dCTP pyrophosphatase 1 (DCTPP1)					4.5
LDTP06901	Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12)					4.2
LDTP04285	Proteasome subunit beta type-2 (PSMB2)					3.7
LDTP03689	Serine hydroxymethyltransferase, mitochondrial (SHMT2)					3.7

Target ID	Target Name					Binding Ratio
LDTP14952	Mpv17-like protein 2 (MPV17L2)					16.4
LDTP11213	Nucleoporin NDC1 (NDC1)					13.7
LDTP01745	Putative lipid scramblase CLPTM1 (CLPTM1)					10.5
LDTP04071	Voltage-dependent anion-selective channel protein 2 (VDAC2)					10.4
LDTP13824	Voltage-dependent anion-selective channel protein 3 (VDAC3)					9.8
LDTP01059	Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B)					9.3
LDTP06034	Lysosome membrane protein 2 (SCARB2)					8.7
LDTP02215	Prosaposin (PSAP)					8.1
LDTP03132	Voltage-dependent anion-selective channel protein 1 (VDAC1)					7.9
LDTP00310	Syntenin-1 (SDCBP)					5.1

Target ID	Target Name					Binding Ratio
LDTP14486	Clustered mitochondria protein homolog (CLUH)					5.6

1	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.