Details of the Target

General Information of Target

Target ID LDTP05476
Target Name 3-ketodihydrosphingosine reductase (KDSR)
Gene Name KDSR
Gene ID 2531
Synonyms
FVT1; SDR35C1; 3-ketodihydrosphingosine reductase; KDS reductase; EC 1.1.1.102; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1; Short chain dehydrogenase/reductase family 35C member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFIT
LVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVN
CAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGL
FGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISE
TTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLF
RTIALFYLGSFDSIVRRCMMQREKSENADKTA
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Endoplasmic reticulum membrane
Function Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Uniprot ID
Q06136
Ensemble ID
ENST00000326575.9
HGNC ID
HGNC:4021

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCLP1 SNV: p.A57V DBIA    Probe Info 
DU145 SNV: p.M273T DBIA    Probe Info 
IGROV1 SNV: p.N103S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.46  LDD0402  [1]
FBPP2
 Probe Info  		6.97  LDD0324  [2]
N1
 Probe Info  		100.00  LDD0242  [3]
D5yne
 Probe Info  		2.69  LDD0055  [4]
Jackson_14
 Probe Info  		2.94  LDD0123  [5]
ART-yne
 Probe Info  		2.10  LDD0234  [6]
DBIA
 Probe Info  		C121(20.00)  LDD0080  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
BTD
 Probe Info  		N.A.  LDD0004  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
IPM
 Probe Info  		C121(0.00); C245(0.00)  LDD0005  [10]
PPMS
 Probe Info  		N.A.  LDD0008  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 122 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1 PP
 Probe Info  		5.94  LDD0417  [15]
C001
 Probe Info  		5.74  LDD1711  [16]
C004
 Probe Info  		5.70  LDD1714  [16]
C007
 Probe Info  		5.10  LDD1716  [16]
C022
 Probe Info  		15.24  LDD1728  [16]
C040
 Probe Info  		11.88  LDD1740  [16]
C041
 Probe Info  		9.25  LDD1741  [16]
C055
 Probe Info  		17.15  LDD1752  [16]
C056
 Probe Info  		24.25  LDD1753  [16]
C063
 Probe Info  		14.72  LDD1760  [16]
C070
 Probe Info  		13.74  LDD1766  [16]
C071
 Probe Info  		8.06  LDD1767  [16]
C072
 Probe Info  		19.84  LDD1768  [16]
C082
 Probe Info  		7.11  LDD1774  [16]
C085
 Probe Info  		5.98  LDD1777  [16]
C091
 Probe Info  		13.00  LDD1782  [16]
C092
 Probe Info  		30.06  LDD1783  [16]
C094
 Probe Info  		29.45  LDD1785  [16]
C100
 Probe Info  		5.06  LDD1789  [16]
C106
 Probe Info  		22.16  LDD1793  [16]
C107
 Probe Info  		7.41  LDD1794  [16]
C108
 Probe Info  		13.09  LDD1795  [16]
C112
 Probe Info  		48.50  LDD1799  [16]
C122
 Probe Info  		5.17  LDD1808  [16]
C130
 Probe Info  		11.24  LDD1812  [16]
C134
 Probe Info  		48.17  LDD1816  [16]
C135
 Probe Info  		34.78  LDD1817  [16]
C138
 Probe Info  		5.21  LDD1820  [16]
C139
 Probe Info  		31.78  LDD1821  [16]
C140
 Probe Info  		27.10  LDD1822  [16]
C141
 Probe Info  		9.78  LDD1823  [16]
C143
 Probe Info  		13.74  LDD1825  [16]
C153
 Probe Info  		17.63  LDD1834  [16]
C159
 Probe Info  		11.63  LDD1839  [16]
C160
 Probe Info  		12.82  LDD1840  [16]
C161
 Probe Info  		32.90  LDD1841  [16]
C163
 Probe Info  		10.63  LDD1843  [16]
C166
 Probe Info  		12.04  LDD1846  [16]
C169
 Probe Info  		25.99  LDD1849  [16]
C174
 Probe Info  		9.19  LDD1854  [16]
C178
 Probe Info  		16.22  LDD1857  [16]
C183
 Probe Info  		7.94  LDD1861  [16]
C185
 Probe Info  		6.59  LDD1863  [16]
C186
 Probe Info  		28.05  LDD1864  [16]
C191
 Probe Info  		12.64  LDD1868  [16]
C194
 Probe Info  		17.03  LDD1870  [16]
C197
 Probe Info  		6.82  LDD1873  [16]
C198
 Probe Info  		13.09  LDD1874  [16]
C199
 Probe Info  		5.03  LDD1875  [16]
C201
 Probe Info  		46.85  LDD1877  [16]
C206
 Probe Info  		31.34  LDD1881  [16]
C210
 Probe Info  		72.00  LDD1884  [16]
C211
 Probe Info  		25.63  LDD1885  [16]
C213
 Probe Info  		26.35  LDD1887  [16]
C215
 Probe Info  		7.16  LDD1889  [16]
C218
 Probe Info  		12.47  LDD1892  [16]
C220
 Probe Info  		13.36  LDD1894  [16]
C225
 Probe Info  		5.82  LDD1898  [16]
C226
 Probe Info  		5.58  LDD1899  [16]
C228
 Probe Info  		25.46  LDD1901  [16]
C229
 Probe Info  		13.64  LDD1902  [16]
C231
 Probe Info  		32.45  LDD1904  [16]
C232
 Probe Info  		48.50  LDD1905  [16]
C233
 Probe Info  		18.77  LDD1906  [16]
C234
 Probe Info  		9.38  LDD1907  [16]
C235
 Probe Info  		36.76  LDD1908  [16]
C238
 Probe Info  		18.51  LDD1911  [16]
C240
 Probe Info  		10.41  LDD1913  [16]
C243
 Probe Info  		18.13  LDD1916  [16]
C244
 Probe Info  		27.10  LDD1917  [16]
C246
 Probe Info  		23.75  LDD1919  [16]
C258
 Probe Info  		5.62  LDD1931  [16]
C265
 Probe Info  		13.00  LDD1936  [16]
C270
 Probe Info  		16.68  LDD1940  [16]
C273
 Probe Info  		8.88  LDD1943  [16]
C277
 Probe Info  		18.64  LDD1947  [16]
C280
 Probe Info  		16.22  LDD1950  [16]
C282
 Probe Info  		25.46  LDD1952  [16]
C284
 Probe Info  		26.54  LDD1954  [16]
C286
 Probe Info  		5.17  LDD1956  [16]
C289
 Probe Info  		25.63  LDD1959  [16]
C292
 Probe Info  		5.21  LDD1962  [16]
C293
 Probe Info  		19.56  LDD1963  [16]
C307
 Probe Info  		5.62  LDD1975  [16]
C311
 Probe Info  		8.11  LDD1978  [16]
C317
 Probe Info  		6.23  LDD1983  [16]
C338
 Probe Info  		10.13  LDD2001  [16]
C339
 Probe Info  		19.97  LDD2002  [16]
C340
 Probe Info  		8.94  LDD2003  [16]
C346
 Probe Info  		13.64  LDD2007  [16]
C356
 Probe Info  		8.88  LDD2017  [16]
C357
 Probe Info  		7.78  LDD2018  [16]
C361
 Probe Info  		17.51  LDD2022  [16]
C362
 Probe Info  		35.26  LDD2023  [16]
C364
 Probe Info  		18.25  LDD2025  [16]
C366
 Probe Info  		6.82  LDD2027  [16]
C367
 Probe Info  		6.68  LDD2028  [16]
C373
 Probe Info  		17.15  LDD2033  [16]
C374
 Probe Info  		11.63  LDD2034  [16]
C375
 Probe Info  		9.06  LDD2035  [16]
C376
 Probe Info  		12.64  LDD2036  [16]
C380
 Probe Info  		5.62  LDD2039  [16]
C382
 Probe Info  		11.39  LDD2041  [16]
C387
 Probe Info  		5.66  LDD2046  [16]
C390
 Probe Info  		20.53  LDD2049  [16]
C399
 Probe Info  		11.47  LDD2058  [16]
C403
 Probe Info  		26.54  LDD2061  [16]
C407
 Probe Info  		15.03  LDD2064  [16]
C423
 Probe Info  		14.72  LDD2078  [16]
C424
 Probe Info  		7.36  LDD2079  [16]
C426
 Probe Info  		74.54  LDD2081  [16]
C429
 Probe Info  		15.35  LDD2084  [16]
C430
 Probe Info  		5.70  LDD2085  [16]
C431
 Probe Info  		14.72  LDD2086  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe3
 Probe Info  		20.00  LDD0464  [17]
FFF probe9
 Probe Info  		20.00  LDD0485  [17]
JN0003
 Probe Info  		20.00  LDD0484  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]
A-DA
 Probe Info  		12.90  LDD0145  [19]
OEA-DA
 Probe Info  		20.00  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C245(0.84)  LDD2142  [21]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C245(0.90); C318(0.94)  LDD2112  [21]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C245(0.67)  LDD2095  [21]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C245(0.97)  LDD2130  [21]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C245(1.03)  LDD2117  [21]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C245(1.34); C318(1.67)  LDD2152  [21]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C245(0.86)  LDD2103  [21]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C245(0.61)  LDD2132  [21]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C245(0.65)  LDD2131  [21]
 LDCM0214  AC1 HCT 116 C121(1.67); C245(1.01)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C245(1.02)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C121(0.89)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C121(0.97)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C121(0.99)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C121(1.26)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C121(1.15)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C121(1.02)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C121(1.12)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C121(1.47)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C121(0.87)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C121(0.90)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C245(1.07)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C121(1.02)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C121(1.01)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C121(1.37)  LDD0546  [7]
 LDCM0230  AC113 PaTu 8988t C245(1.00); C121(0.89)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C245(0.89); C121(0.95)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C245(1.28); C121(0.98)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C245(1.49); C121(0.93)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C245(1.18); C121(0.94)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C245(1.31); C121(1.05)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C245(1.06); C121(1.04)  LDD1115  [7]
 LDCM0237  AC12 HCT 116 C245(1.07)  LDD0554  [7]
 LDCM0238  AC120 PaTu 8988t C245(1.00); C121(0.96)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C245(0.84); C121(1.02)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C245(1.03); C121(0.93)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C245(1.32); C121(0.96)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C245(1.42); C121(1.05)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C245(1.42); C121(1.06)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C245(1.05); C121(0.89)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C245(1.10); C121(1.07)  LDD1124  [7]
 LDCM0246  AC128 HCT 116 C121(1.73)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C121(0.94)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C121(1.04)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C121(0.97)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C121(0.95)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C121(1.26)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C121(1.31)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C121(1.08)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C121(1.16)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C121(1.05)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C121(1.25)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C121(1.06)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C245(0.93)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C121(1.12)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C121(1.27)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C121(0.91)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C121(1.03)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C121(1.46)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C121(1.25)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C121(1.48)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C121(1.56)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C121(2.31)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C121(1.82)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C245(0.95)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C121(1.21)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C121(1.21)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C121(1.76)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C121(2.29)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C121(1.41)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C121(1.42)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C121(1.14)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C121(1.03)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C121(1.10)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C121(1.62)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C121(1.04)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C245(1.06); C121(1.51)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C121(1.03)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C121(1.05)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C121(0.95)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C121(0.95)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C121(0.96)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C245(0.86); C121(1.14)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C245(0.93); C121(1.08)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C121(1.01); C245(1.06)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C245(0.90); C121(0.97)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C121(0.86); C245(0.99)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C245(1.20); C121(1.46)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C121(0.94); C245(1.01)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C245(0.93); C121(1.09)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C245(1.00); C121(1.03)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C245(0.93); C121(1.07)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C245(1.04); C121(1.07)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C121(0.96)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C121(0.87)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C121(0.87)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C121(0.89)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C121(1.05)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C245(1.17); C121(1.66)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C121(1.17)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C121(0.98)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C121(1.10)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C121(1.02)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C121(1.07)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C121(1.16)  LDD0624  [7]
 LDCM0308  AC46 PaTu 8988t C245(0.92); C121(1.14)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C245(1.04); C121(1.25)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C245(0.98); C121(1.38)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C245(0.91); C121(1.61)  LDD1190  [7]
 LDCM0312  AC5 HCT 116 C245(1.16); C121(1.72)  LDD0629  [7]
 LDCM0313  AC50 PaTu 8988t C245(1.06); C121(1.78)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C245(0.62); C121(1.45)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C245(0.96); C121(1.49)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C245(0.90); C121(1.94)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C245(0.95); C121(1.95)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C245(0.87); C121(1.47)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C245(1.00); C121(1.76)  LDD1198  [7]
 LDCM0320  AC57 HEK-293T C245(0.87); C121(1.07); C47(0.89)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C245(0.98); C121(1.01); C47(0.96)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C245(1.04); C121(0.98); C47(0.97)  LDD1561  [22]
 LDCM0323  AC6 HCT 116 C245(1.07)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C245(0.90); C121(0.95); C47(1.03)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C245(0.90); C121(1.08); C47(0.91)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C245(0.94); C121(0.99); C47(0.91)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C245(0.86); C121(0.84); C47(0.99)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C245(1.02); C121(0.95); C47(0.86)  LDD1567  [22]
 LDCM0332  AC68 PaTu 8988t C121(0.79)  LDD1211  [7]
 LDCM0333  AC69 PaTu 8988t C121(1.12)  LDD1212  [7]
 LDCM0334  AC7 HCT 116 C245(0.86)  LDD0651  [7]
 LDCM0335  AC70 PaTu 8988t C121(0.88)  LDD1214  [7]
 LDCM0336  AC71 PaTu 8988t C121(0.84)  LDD1215  [7]
 LDCM0337  AC72 PaTu 8988t C121(0.81)  LDD1216  [7]
 LDCM0338  AC73 PaTu 8988t C121(0.76)  LDD1217  [7]
 LDCM0339  AC74 PaTu 8988t C121(0.87)  LDD1218  [7]
 LDCM0340  AC75 PaTu 8988t C121(1.03)  LDD1219  [7]
 LDCM0341  AC76 PaTu 8988t C121(0.81)  LDD1220  [7]
 LDCM0342  AC77 PaTu 8988t C121(0.91)  LDD1221  [7]
 LDCM0343  AC78 PaTu 8988t C121(0.88)  LDD1222  [7]
 LDCM0344  AC79 PaTu 8988t C121(0.89)  LDD1223  [7]
 LDCM0345  AC8 HCT 116 C245(0.98)  LDD0662  [7]
 LDCM0346  AC80 PaTu 8988t C121(0.87)  LDD1225  [7]
 LDCM0347  AC81 PaTu 8988t C121(0.83)  LDD1226  [7]
 LDCM0348  AC82 PaTu 8988t C121(0.78)  LDD1227  [7]
 LDCM0349  AC83 PaTu 8988t C121(0.80)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C121(0.83)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C121(0.77)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C121(0.79)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C121(0.78)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C121(0.85)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C121(0.94)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C121(1.01)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C121(0.77)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C121(0.74)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C121(0.82)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C121(0.86)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C121(0.78)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C121(0.88)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C121(0.80)  LDD1243  [7]
 LDCM0365  AC98 HCT 116 C121(1.14)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C121(0.86)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C245(0.39)  LDD2138  [21]
 LDCM0520  AKOS000195272 MDA-MB-231 C245(0.66)  LDD2113  [21]
 LDCM0248  AKOS034007472 HCT 116 C245(0.97)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C245(1.34)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C245(1.17)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.41  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C121(0.91)  LDD2171  [7]
 LDCM0091  Astemisinin MCF-7 2.10  LDD0234  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C121(0.99)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C121(1.26)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C245(1.06); C121(1.49)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C245(0.94)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C245(1.07)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C245(1.00)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C245(1.07)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C121(1.17)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C121(1.64)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C121(1.63)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C121(1.85)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C121(1.12)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C121(1.32)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C121(1.24)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C121(1.12)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C121(0.78); C245(0.90)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C121(0.86); C245(0.93)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C245(0.84); C121(1.16)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C245(1.01); C121(1.21)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C121(1.10); C245(1.14)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C121(1.55)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C121(1.07)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C121(1.07)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C121(1.51)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C121(0.92)  LDD0708  [7]
 LDCM0392  CL121 PaTu 8988t C245(0.93); C121(1.19)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C245(0.94); C121(1.35)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C245(1.04); C121(1.39)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C245(0.90); C121(1.81)  LDD1274  [7]
 LDCM0396  CL125 HEK-293T C245(0.95); C121(1.28); C47(0.93)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C245(0.89); C121(1.17); C47(0.91)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C245(0.92); C121(1.01); C279(0.81); C47(0.91)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C245(0.84); C121(0.95); C47(0.93)  LDD1603  [22]
 LDCM0400  CL13 HCT 116 C121(1.31)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C121(1.09)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C121(1.20)  LDD0719  [7]
 LDCM0403  CL16 PaTu 8988t C121(1.18)  LDD1282  [7]
 LDCM0404  CL17 PaTu 8988t C121(1.63)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C121(1.47)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C121(1.14)  LDD1285  [7]
 LDCM0407  CL2 HCT 116 C121(0.94)  LDD0724  [7]
 LDCM0408  CL20 PaTu 8988t C121(1.23)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C121(2.33)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C121(1.73)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C121(1.42)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C121(1.37)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C121(1.31)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C121(1.29)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C121(1.50)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C121(1.85)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C121(1.25)  LDD1296  [7]
 LDCM0418  CL3 HCT 116 C121(0.89)  LDD0735  [7]
 LDCM0419  CL30 PaTu 8988t C121(1.48)  LDD1298  [7]
 LDCM0420  CL31 HCT 116 C121(1.28); C245(1.04)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C121(1.47); C245(0.96)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C121(1.21); C245(0.90)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C121(1.79); C245(1.20)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C121(1.49); C245(0.85)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C121(1.45); C245(1.28)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C121(1.71); C245(1.01)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C121(1.74); C245(0.97)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C121(1.05)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C121(1.40); C245(1.08)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C121(1.44); C245(0.94)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C121(1.85); C245(1.60)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C121(1.75); C245(1.07)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C121(1.61); C245(1.15)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C121(1.67); C245(1.30)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C245(0.85)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C245(0.90)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C245(0.80)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C245(1.01)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C121(1.08)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C245(0.92)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C245(0.89)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C245(0.90)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C245(0.98)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C245(0.85)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C245(0.89)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C245(0.90)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C245(1.08)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C245(0.88)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C245(0.90)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C121(1.13)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C245(1.01)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C121(1.12)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C121(1.03)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C121(1.13)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C121(1.36)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C121(1.23)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C121(1.73)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C121(1.46)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C121(1.36)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C121(1.26)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C121(1.21)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C121(1.42)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C121(1.33)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C121(1.19)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C121(1.26)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C121(1.31)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C121(1.14)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C121(1.06)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C121(1.02)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C121(1.53)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C121(1.37)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C121(1.30)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C121(1.30)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C121(1.74)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C121(1.83)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C121(2.05)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C121(1.21)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C121(1.13)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C121(1.41)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C121(1.50)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C121(2.37)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C121(1.25)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C121(1.03)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C121(1.33); C245(1.07)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C121(1.15); C245(0.83)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C121(1.20); C245(0.82)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C121(1.29); C245(1.05)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C121(1.28); C245(0.94)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C121(1.13); C245(1.04)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C121(1.32); C245(1.15)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C121(1.85); C245(1.03)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C121(1.48); C245(1.10)  LDD0811  [7]
 LDCM0189  Compound 16 HEK-293T 11.63  LDD0492  [17]
 LDCM0184  Compound 20 HEK-293T 18.35  LDD0503  [17]
 LDCM0191  Compound 21 HEK-293T 8.97  LDD0493  [17]
 LDCM0186  Compound 31 HEK-293T 5.33  LDD0506  [17]
 LDCM0188  Compound 33 HEK-293T 9.62  LDD0505  [17]
 LDCM0190  Compound 34 HEK-293T 18.52  LDD0497  [17]
 LDCM0192  Compound 35 HEK-293T 8.89  LDD0491  [17]
 LDCM0193  Compound 36 HEK-293T 8.26  LDD0494  [17]
 LDCM0194  Compound 37 HEK-293T 14.81  LDD0498  [17]
 LDCM0195  Compound 38 HEK-293T 12.50  LDD0499  [17]
 LDCM0196  Compound 39 HEK-293T 10.05  LDD0496  [17]
 LDCM0197  Compound 40 HEK-293T 13.61  LDD0495  [17]
 LDCM0095  DC-LC3IN-D5 HeLa 2.69  LDD0055  [4]
 LDCM0495  E2913 HEK-293T C245(0.90); C121(0.97); C279(1.09); C47(0.99)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C245(1.42); C121(1.22); C47(0.98)  LDD1702  [21]
 LDCM0625  F8 Ramos C245(0.83)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C245(1.46)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C245(2.02)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C245(0.85)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C245(0.85)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C245(0.58)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C245(1.05)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C245(0.76)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C245(1.02)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C245(0.74)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C245(0.90)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C245(1.20)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C245(0.69)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C245(1.65)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C121(1.39)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C245(0.65)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C245(1.18)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C121(2.26); C245(1.50)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C245(1.04)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C245(0.77)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C245(1.53)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C245(0.76)  LDD2188  [23]
 LDCM0022  KB02 HCT 116 C121(20.00)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C121(1.24)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C121(1.08)  LDD0082  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C245(1.09)  LDD2102  [21]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C245(0.74)  LDD2121  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C245(0.61); C318(0.79)  LDD2089  [21]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C245(1.03)  LDD2090  [21]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C245(0.80); C318(1.01)  LDD2092  [21]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C245(0.89)  LDD2093  [21]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C245(1.05); C318(1.88)  LDD2094  [21]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C245(0.47)  LDD2096  [21]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C245(0.70); C318(1.43)  LDD2098  [21]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C245(1.02)  LDD2099  [21]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C245(0.80)  LDD2100  [21]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C245(0.62)  LDD2104  [21]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C245(1.11)  LDD2105  [21]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C245(0.65)  LDD2106  [21]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C245(0.83)  LDD2107  [21]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C245(0.75)  LDD2108  [21]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C245(0.78)  LDD2109  [21]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C245(1.56)  LDD2110  [21]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C245(0.64); C318(1.29)  LDD2114  [21]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C245(0.56)  LDD2118  [21]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C318(1.73)  LDD2119  [21]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C245(0.86)  LDD2120  [21]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C245(0.35)  LDD2122  [21]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C245(0.74)  LDD2123  [21]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C245(0.56)  LDD2124  [21]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C245(0.83)  LDD2125  [21]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C245(0.91)  LDD2127  [21]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C245(1.25)  LDD2128  [21]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C245(0.87); C318(0.88)  LDD2129  [21]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C245(0.99); C318(1.21)  LDD2135  [21]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C245(0.96)  LDD2137  [21]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C245(1.62)  LDD1700  [21]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C245(0.70)  LDD2140  [21]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C245(0.67)  LDD2141  [21]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C245(1.10)  LDD2143  [21]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C245(3.69); C318(1.28)  LDD2144  [21]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C245(0.73); C318(0.90)  LDD2146  [21]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C245(3.41)  LDD2147  [21]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C245(0.67)  LDD2149  [21]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C245(0.40)  LDD2150  [21]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C245(0.38)  LDD2151  [21]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C245(1.63)  LDD2153  [21]
 LDCM0627  NUDT7-COV-1 HEK-293T C245(1.02)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C245(0.34)  LDD2207  [24]
 LDCM0131  RA190 MM1.R C121(1.33)  LDD0304  [25]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.94  LDD0123  [5]
 LDCM0084  Ro 48-8071 A-549 12.90  LDD0145  [19]
 LDCM0021  THZ1 HCT 116 C121(0.91)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transthyretin (TTR) Transthyretin family P02766
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

References

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2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6. Cell Chem Biol. 2022 Mar 17;29(3):530-537.e7. doi: 10.1016/j.chembiol.2021.07.012. Epub 2021 Aug 5.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.