Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | ILS-1 PP | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | 3 uM | |||||
| Criteria | Quantification: Probe vs DMSO | |||||
| Quantitative Method |
SILAC
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Lung | ||||
| Disease Model | Lung adenocarcinoma [ICD-11:2C25] | |||||
| Model Name | Human lung adenocarcinoma cells (A-549) | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 14.7 | ||||
| LDTP16007 | Lipid droplet-associated hydrolase (LDAH) | 9.0 | ||||
| LDTP02198 | Cathepsin D (CTSD) | 8.4 | ||||
| LDTP05476 | 3-ketodihydrosphingosine reductase (KDSR) | 5.9 | ||||
| LDTP06334 | Serum paraoxonase/lactonase 3 (PON3) | 5.6 | ||||
| LDTP03787 | Choline kinase alpha (CHKA) | 3.8 | ||||
| LDTP06501 | Ras-related protein Rab-11B (RAB11B) | 2.9 | ||||
| LDTP03560 | Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) | 2.8 | ||||
| LDTP02359 | Heme oxygenase 1 (HMOX1) | 2.5 | ||||
| LDTP17410 | Cytochrome P450 20A1 (CYP20A1) | 2.4 | ||||
| LDTP13282 | Prenylcysteine oxidase 1 (PCYOX1) | 2.3 | ||||
| LDTP02718 | Glucosidase 2 subunit beta (PRKCSH) | 2.2 | ||||
| LDTP03418 | Proteasome subunit beta type-6 (PSMB6) | 2.1 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 5.0 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 4.6 | ||||
| LDTP00541 | NPC intracellular cholesterol transporter 1 (NPC1) | 4.2 | ||||
| LDTP06034 | Lysosome membrane protein 2 (SCARB2) | 3.0 | ||||
| LDTP00562 | Membrane-associated progesterone receptor component 2 (PGRMC2) | 2.4 | ||||
| LDTP14178 | Heme transporter FLVCR1 (FLVCR1) | 2.3 | ||||
| LDTP02122 | Integrin beta-1 (ITGB1) | 2.1 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 6.4 | ||||
| LDTP07495 | Caveolae-associated protein 1 (CAVIN1) | 4.0 | ||||
| LDTP04958 | Small ribosomal subunit protein eS7 (RPS7) | 3.0 | ||||
| LDTP10924 | Prohibitin-2 (PHB2) | 2.7 | ||||
| LDTP04241 | Nuclear autoantigenic sperm protein (NASP) | 2.6 | ||||
| LDTP02124 | Keratin, type I cytoskeletal 18 (KRT18) | 2.3 | ||||
| LDTP00887 | Calumenin (CALU) | 2.2 | ||||
| LDTP10062 | Synapse-associated protein 1 (SYAP1) | 2.1 | ||||