Details of the Target

General Information of Target

Target ID LDTP10062
Target Name Synapse-associated protein 1 (SYAP1)
Gene Name SYAP1
Gene ID 94056
Synonyms
Synapse-associated protein 1; BSD domain-containing signal transducer and Akt interactor protein; BSTA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQKLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPED
RSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATA
RAPLHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVV
LDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDL
CRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation.
Uniprot ID
Q96A49
Ensemble ID
ENST00000380155.4
HGNC ID
HGNC:16273

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y60(7.54)  LDD0257  [2]
TH214
 Probe Info  		Y60(16.93)  LDD0258  [2]
TH216
 Probe Info  		Y60(20.00)  LDD0259  [2]
DA-P3
 Probe Info  		37.47  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C283(2.64)  LDD0168  [4]
HHS-475
 Probe Info  		Y60(0.67)  LDD0264  [5]
HHS-465
 Probe Info  		Y60(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C283(1.28)  LDD0080  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD2156  [11]
NHS
 Probe Info  		K84(0.00); K71(0.00); K194(0.00); K98(0.00)  LDD0010  [12]
STPyne
 Probe Info  		K98(0.00); K71(0.00); K84(0.00); K210(0.00)  LDD0009  [12]
1c-yne
 Probe Info  		K210(0.00); K147(0.00)  LDD0228  [13]
1d-yne
 Probe Info  		N.A.  LDD0357  [13]
AOyne
 Probe Info  		13.70  LDD0443  [14]
TPP-AC
 Probe Info  		N.A.  LDD0427  [15]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1 PP
 Probe Info  		2.07  LDD0417  [16]
C040
 Probe Info  		6.63  LDD1740  [17]
FFF probe11
 Probe Info  		6.02  LDD0472  [18]
FFF probe12
 Probe Info  		16.77  LDD0473  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe3
 Probe Info  		6.88  LDD0465  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C283(2.64)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C283(3.28)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C283(1.35)  LDD1507  [20]
 LDCM0215  AC10 HCT 116 C283(1.11)  LDD0532  [7]
 LDCM0226  AC11 HCT 116 C283(1.35)  LDD0543  [7]
 LDCM0237  AC12 HCT 116 C283(0.68)  LDD0554  [7]
 LDCM0246  AC128 HCT 116 C283(1.72)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C283(1.20)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C283(1.46)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C283(0.99)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C283(1.29)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C283(1.53)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C283(1.94)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C283(1.64)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C283(1.05)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C283(1.02)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C283(1.55)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C283(1.55)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C283(0.80)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C283(1.60)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C283(1.48)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C283(1.24)  LDD0579  [7]
 LDCM0270  AC15 HCT 116 C283(0.83)  LDD0587  [7]
 LDCM0276  AC17 HEK-293T C283(1.16)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C283(0.98)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C283(0.97)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C283(0.94)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C283(1.16)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C283(1.05)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C283(0.98)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C283(1.16)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C283(1.25)  LDD1523  [20]
 LDCM0285  AC25 HCT 116 C283(1.31)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C283(1.47)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C283(1.45)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C283(1.35)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C283(1.55)  LDD0606  [7]
 LDCM0290  AC3 HEK-293T C283(1.00)  LDD1529  [20]
 LDCM0291  AC30 HCT 116 C283(1.40)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C283(1.38)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C283(1.82)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C283(1.72)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C283(1.65)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C283(0.73)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C283(1.10)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C283(1.09)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C283(1.02)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C283(1.22)  LDD0617  [7]
 LDCM0301  AC4 HEK-293T C283(1.16)  LDD1540  [20]
 LDCM0302  AC40 HCT 116 C283(1.30)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C283(1.18)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C283(1.22)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C283(1.40)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C283(1.42)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C283(1.17)  LDD0624  [7]
 LDCM0308  AC46 PaTu 8988t C283(0.99)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C283(1.11)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C283(1.43)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C283(1.40)  LDD1190  [7]
 LDCM0312  AC5 HEK-293T C283(1.01)  LDD1551  [20]
 LDCM0313  AC50 PaTu 8988t C283(0.97)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C283(0.94)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C283(1.13)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C283(1.65)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C283(1.68)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C283(1.46)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C283(1.08)  LDD1198  [7]
 LDCM0320  AC57 PaTu 8988t C283(1.38)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C283(1.24)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C283(1.71)  LDD1201  [7]
 LDCM0323  AC6 HCT 116 C283(0.98)  LDD0640  [7]
 LDCM0324  AC60 PaTu 8988t C283(1.96)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C283(1.32)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C283(1.65)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C283(1.65)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C283(1.24)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C283(2.02)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C283(1.57)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C283(1.35)  LDD1210  [7]
 LDCM0332  AC68 PaTu 8988t C283(1.09)  LDD1211  [7]
 LDCM0333  AC69 PaTu 8988t C283(1.24)  LDD1212  [7]
 LDCM0334  AC7 HCT 116 C283(0.79)  LDD0651  [7]
 LDCM0335  AC70 PaTu 8988t C283(0.95)  LDD1214  [7]
 LDCM0336  AC71 PaTu 8988t C283(0.96)  LDD1215  [7]
 LDCM0337  AC72 PaTu 8988t C283(0.83)  LDD1216  [7]
 LDCM0338  AC73 PaTu 8988t C283(0.82)  LDD1217  [7]
 LDCM0339  AC74 PaTu 8988t C283(0.85)  LDD1218  [7]
 LDCM0340  AC75 PaTu 8988t C283(1.22)  LDD1219  [7]
 LDCM0341  AC76 PaTu 8988t C283(0.98)  LDD1220  [7]
 LDCM0342  AC77 PaTu 8988t C283(0.97)  LDD1221  [7]
 LDCM0343  AC78 PaTu 8988t C283(0.75)  LDD1222  [7]
 LDCM0344  AC79 PaTu 8988t C283(0.96)  LDD1223  [7]
 LDCM0345  AC8 HCT 116 C283(1.12)  LDD0662  [7]
 LDCM0346  AC80 PaTu 8988t C283(0.91)  LDD1225  [7]
 LDCM0347  AC81 PaTu 8988t C283(0.88)  LDD1226  [7]
 LDCM0348  AC82 PaTu 8988t C283(0.83)  LDD1227  [7]
 LDCM0349  AC83 HCT 116 C283(1.24)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C283(1.71)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C283(1.35)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C283(1.23)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C283(0.95)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C283(1.40)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C283(1.26)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C283(0.96)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C283(1.18)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C283(1.07)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C283(0.81)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C283(1.04)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C283(0.86)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C283(1.52)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C283(1.66)  LDD0681  [7]
 LDCM0248  AKOS034007472 HCT 116 C283(1.02)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C283(0.92)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C283(0.99)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C283(0.89)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C283(1.12)  LDD0685  [7]
 LDCM0369  CL100 HEK-293T C283(1.17)  LDD1573  [20]
 LDCM0370  CL101 HCT 116 C283(1.23)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C283(1.18)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C283(0.99)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C283(0.85)  LDD0690  [7]
 LDCM0374  CL105 HEK-293T C283(1.21)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C283(0.96)  LDD1579  [20]
 LDCM0377  CL108 HEK-293T C283(1.04)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C283(1.11)  LDD1582  [20]
 LDCM0379  CL11 HCT 116 C283(0.94)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C283(0.88)  LDD1584  [20]
 LDCM0382  CL112 HCT 116 C283(1.08)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C283(1.14)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C283(1.22)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C283(1.62)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C283(1.46)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C283(1.88)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C283(1.22)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C283(1.15)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C283(1.18)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C283(1.01)  LDD0708  [7]
 LDCM0392  CL121 PaTu 8988t C283(1.13)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C283(1.42)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C283(1.45)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C283(1.18)  LDD1274  [7]
 LDCM0396  CL125 PaTu 8988t C283(1.50)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C283(1.89)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C283(1.38)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C283(1.49)  LDD1278  [7]
 LDCM0400  CL13 HCT 116 C283(1.31)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C283(1.01)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C283(1.35)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C283(1.02)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C283(1.13)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C283(1.14)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C283(1.13)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C283(1.19)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C283(1.14)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C283(1.49)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C283(1.44)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C283(0.99)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C283(0.98)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C283(1.41)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C283(0.88)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C283(1.11)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C283(1.16)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C283(0.89)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C283(0.77)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C283(0.73)  LDD0736  [7]
 LDCM0420  CL31 PaTu 8988t C283(1.12)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C283(1.58)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C283(1.17)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C283(1.58)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C283(1.54)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C283(1.16)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C283(1.79)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C283(1.50)  LDD1307  [7]
 LDCM0429  CL4 HCT 116 C283(1.03)  LDD0746  [7]
 LDCM0430  CL40 PaTu 8988t C283(1.60)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C283(1.41)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C283(1.73)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C283(2.76)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C283(2.04)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C283(1.46)  LDD1314  [7]
 LDCM0436  CL46 HCT 116 C283(1.08)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C283(0.78)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C283(0.74)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C283(1.26)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C283(1.18)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C283(0.94)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C283(1.08)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C283(1.00)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C283(0.92)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C283(1.01)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C283(1.05)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C283(1.01)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C283(1.08)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C283(0.86)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C283(0.94)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C283(1.25)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C283(0.76)  LDD0769  [7]
 LDCM0453  CL61 PaTu 8988t C283(1.24)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C283(1.74)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C283(1.16)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C283(2.05)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C283(1.42)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C283(1.59)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C283(1.53)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C283(1.57)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C283(1.49)  LDD1340  [7]
 LDCM0462  CL7 HCT 116 C283(1.05)  LDD0779  [7]
 LDCM0463  CL70 PaTu 8988t C283(2.00)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C283(1.42)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C283(1.22)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C283(1.82)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C283(1.55)  LDD1346  [7]
 LDCM0469  CL76 PaTu 8988t C283(1.01)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C283(1.08)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C283(1.43)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C283(1.07)  LDD1351  [7]
 LDCM0473  CL8 HCT 116 C283(1.03)  LDD0790  [7]
 LDCM0474  CL80 PaTu 8988t C283(1.21)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C283(1.32)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C283(1.56)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C283(1.59)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C283(1.06)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C283(1.23)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C283(1.17)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C283(1.55)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C283(1.26)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C283(1.13)  LDD1362  [7]
 LDCM0484  CL9 HCT 116 C283(1.53)  LDD0801  [7]
 LDCM0485  CL90 PaTu 8988t C283(1.05)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C283(1.03)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C283(1.18)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C283(0.97)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C283(0.73)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C283(0.72)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C283(1.11)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C283(1.16)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C283(1.07)  LDD1696  [20]
 LDCM0027  Dopamine HEK-293T 37.47  LDD0179  [3]
 LDCM0031  Epigallocatechin gallate HEK-293T 9.30  LDD0183  [3]
 LDCM0468  Fragment33 PaTu 8988t C283(1.48)  LDD1347  [7]
 LDCM0427  Fragment51 PaTu 8988t C283(2.03)  LDD1306  [7]
 LDCM0116  HHS-0101 DM93 Y60(0.67)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y60(1.12)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y60(0.70)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y60(1.56)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y60(1.09)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C283(1.28)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C283(1.23)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C283(1.01)  LDD0082  [7]
 LDCM0030  Luteolin HEK-293T 6.01  LDD0182  [3]
 LDCM0029  Quercetin HEK-293T 8.49  LDD0181  [3]
 LDCM0131  RA190 MM1.R C283(1.11)  LDD0304  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Adiponectin (ADIPOQ) . Q15848
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thyroid hormone receptor alpha (THRA) Nuclear hormone receptor family P10827
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) . O14798
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Necdin (NDN) . Q99608

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
16 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.