Details of the Target

General Information of Target

Target ID LDTP02122
Target Name Integrin beta-1 (ITGB1)
Gene Name ITGB1
Gene ID 3688
Synonyms
FNRB; MDF2; MSK12; Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD antigen CD29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPT
SARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLV
LRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDF
RIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQR
ISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQ
CHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTL
SANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISI
GDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEG
NGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRK
RDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCE
ASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDT
CTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVEN
PECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGEN
PIYKSAVTTVVNPKYEGK
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Integrin beta chain family
Subcellular location
Cell membrane, sarcolemma; Cell membrane
Function
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. Plays an important role in myoblast differentiation and fusion during skeletal myogenesis. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion. Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction.; [Isoform 2]: Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro).; [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles.; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.; (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.; (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.; (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.; (Microbial infection) Acts as a receptor for Mammalian reovirus.; (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.; (Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi. Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.; (Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis.
TTD ID
T01851
Uniprot ID
P05556
DrugMap ID
TTBVIQC
Ensemble ID
ENST00000302278.8
HGNC ID
HGNC:6153
ChEMBL ID
CHEMBL1905

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.E693V DBIA    Probe Info 
A172 SNV: p.V231I DBIA    Probe Info 
CCK81 SNV: p.Y219C DBIA    Probe Info 
HCT116 SNV: p.C615R .
KASUMI2 SNV: p.G572V .
MFE319 SNV: p.D695V DBIA    Probe Info 
NCIH1048 SNV: p.D697E DBIA    Probe Info 
NCIH1793 SNV: p.D78Y .
NCIH446 SNV: p.P194L DBIA    Probe Info 
PC9 SNV: p.I334F .
TCCSUP SNV: p.Q535H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		5.33  LDD0318  [1]
DA-P2
 Probe Info  		10.92  LDD0348  [2]
HRP
 Probe Info  		5.74  LDD0347  [2]
TG42
 Probe Info  		4.42  LDD0326  [3]
W1
 Probe Info  		34.68  LDD0235  [4]
FBP2
 Probe Info  		2.51  LDD0317  [1]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K105(10.00); K107(10.00); K134(4.87); K202(7.36)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K238(1.34); K107(1.41); K91(1.54); K136(1.75)  LDD3494  [7]
Dasatinib-CA-4PAP
 Probe Info  		7.40  LDD0270  [8]
DBIA
 Probe Info  		C691(1.69); C75(1.44)  LDD3310  [9]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [10]
BTD
 Probe Info  		C691(2.35)  LDD1700  [11]
HPAP
 Probe Info  		3.19  LDD0064  [12]
5E-2FA
 Probe Info  		H690(0.00); H283(0.00)  LDD2235  [13]
m-APA
 Probe Info  		H690(0.00); H302(0.00); H283(0.00)  LDD2231  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C64(0.00); C691(0.00); C75(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C64(0.00); C691(0.00); C301(0.00)  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		C64(0.00); C691(0.00); C75(0.00); C301(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		K190(0.00); K107(0.00)  LDD0035  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
IPM
 Probe Info  		N.A.  LDD0147  [17]
NHS
 Probe Info  		N.A.  LDD0010  [18]
1c-yne
 Probe Info  		K228(0.00); K190(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
Methacrolein
 Probe Info  		C555(0.00); C560(0.00); C691(0.00); C649(0.00)  LDD0218  [20]
AOyne
 Probe Info  		6.10  LDD0443  [21]
NAIA_5
 Probe Info  		C64(0.00); C27(0.00); C691(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		4.02  LDD0398  [22]
ILS-1 PP
 Probe Info  		2.13  LDD0417  [23]
C158
 Probe Info  		16.22  LDD1838  [24]
C362
 Probe Info  		27.47  LDD2023  [24]
STS-1
 Probe Info  		N.A.  LDD0136  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C691(0.58)  LDD2142  [11]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C691(0.82)  LDD2112  [11]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C691(0.62)  LDD2095  [11]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C691(1.03)  LDD2130  [11]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C691(0.91); C649(0.88)  LDD2117  [11]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C691(1.32); C649(0.96)  LDD2152  [11]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C691(0.46)  LDD2132  [11]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C691(0.83)  LDD2131  [11]
 LDCM0214  AC1 HEK-293T C301(1.04); C477(1.14); C553(1.01); C633(1.10)  LDD1507  [26]
 LDCM0215  AC10 HEK-293T C301(1.13); C261(0.99); C691(1.47); C477(1.40)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C301(0.86); C261(1.02); C477(1.10); C553(1.15)  LDD1509  [26]
 LDCM0237  AC12 HEK-293T C301(0.94); C64(0.89); C477(1.14); C500(0.90)  LDD1510  [26]
 LDCM0259  AC14 HEK-293T C301(0.98); C477(1.29); C618(1.40); C553(1.15)  LDD1512  [26]
 LDCM0270  AC15 HEK-293T C301(0.95); C261(1.39); C500(1.86); C618(0.82)  LDD1513  [26]
 LDCM0276  AC17 HEK-293T C301(0.95); C477(1.10); C553(1.02); C633(0.97)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C301(0.90); C261(1.01); C691(1.31); C477(1.02)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C301(1.24); C261(0.91); C477(1.66); C553(2.23)  LDD1517  [26]
 LDCM0279  AC2 HEK-293T C301(1.05); C261(0.98); C691(1.46); C477(0.98)  LDD1518  [26]
 LDCM0280  AC20 HEK-293T C301(1.05); C64(0.87); C477(1.10); C500(0.88)  LDD1519  [26]
 LDCM0281  AC21 HEK-293T C301(0.97); C261(1.03); C691(1.22); C477(1.12)  LDD1520  [26]
 LDCM0282  AC22 HEK-293T C301(1.12); C477(1.18); C618(1.33); C553(0.76)  LDD1521  [26]
 LDCM0283  AC23 HEK-293T C301(1.03); C261(0.89); C500(0.87); C618(1.15)  LDD1522  [26]
 LDCM0284  AC24 HEK-293T C301(1.20); C500(1.38); C553(1.03); C636(1.13)  LDD1523  [26]
 LDCM0285  AC25 HEK-293T C301(0.93); C477(1.07); C553(1.00); C633(1.03)  LDD1524  [26]
 LDCM0286  AC26 HEK-293T C301(0.97); C261(0.90); C691(1.42); C477(1.11)  LDD1525  [26]
 LDCM0287  AC27 HEK-293T C301(0.99); C261(1.16); C477(0.99); C553(1.00)  LDD1526  [26]
 LDCM0288  AC28 HEK-293T C301(0.97); C64(0.94); C477(1.04); C500(1.06)  LDD1527  [26]
 LDCM0289  AC29 HEK-293T C301(0.94); C261(1.00); C691(1.40); C477(1.10)  LDD1528  [26]
 LDCM0290  AC3 HEK-293T C301(0.96); C261(1.20); C477(1.05); C553(1.37)  LDD1529  [26]
 LDCM0291  AC30 HEK-293T C301(1.01); C477(1.09); C618(1.52); C553(1.00)  LDD1530  [26]
 LDCM0292  AC31 HEK-293T C301(1.00); C261(1.24); C500(0.97); C618(0.87)  LDD1531  [26]
 LDCM0293  AC32 HEK-293T C301(1.12); C500(1.00); C553(0.97); C636(1.02)  LDD1532  [26]
 LDCM0294  AC33 HEK-293T C301(0.97); C477(1.13); C553(1.06); C633(1.05)  LDD1533  [26]
 LDCM0295  AC34 HEK-293T C301(1.30); C261(0.97); C691(1.45); C477(1.10)  LDD1534  [26]
 LDCM0296  AC35 HEK-293T C301(1.02); C261(1.14); C477(1.11); C553(1.12)  LDD1535  [26]
 LDCM0297  AC36 HEK-293T C301(1.01); C64(0.89); C477(1.21); C500(0.85)  LDD1536  [26]
 LDCM0298  AC37 HEK-293T C301(0.94); C261(1.07); C691(1.38); C477(1.29)  LDD1537  [26]
 LDCM0299  AC38 HEK-293T C301(0.99); C477(1.16); C618(1.30); C553(1.55)  LDD1538  [26]
 LDCM0300  AC39 HEK-293T C301(0.94); C261(0.83); C500(1.00); C618(1.09)  LDD1539  [26]
 LDCM0301  AC4 HEK-293T C301(1.08); C64(0.92); C477(1.12); C500(1.00)  LDD1540  [26]
 LDCM0302  AC40 HEK-293T C301(1.13); C500(0.84); C553(0.99); C636(1.72)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C301(1.03); C477(1.06); C553(1.43); C633(1.06)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C301(0.90); C261(1.16); C691(1.48); C477(1.08)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C301(0.90); C261(1.13); C477(1.17); C553(1.00)  LDD1544  [26]
 LDCM0306  AC44 HEK-293T C301(0.98); C64(1.05); C477(1.04); C500(0.84)  LDD1545  [26]
 LDCM0307  AC45 HEK-293T C301(1.03); C261(1.11); C691(1.29); C477(1.21)  LDD1546  [26]
 LDCM0308  AC46 HEK-293T C301(0.93); C477(1.39); C618(1.58); C553(1.24)  LDD1547  [26]
 LDCM0309  AC47 HEK-293T C301(0.99); C261(0.88); C500(1.04); C618(0.87)  LDD1548  [26]
 LDCM0310  AC48 HEK-293T C301(1.25); C500(0.91); C553(1.08); C636(1.15)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C301(0.90); C477(0.97); C553(1.28); C633(1.02)  LDD1550  [26]
 LDCM0312  AC5 HEK-293T C301(1.02); C261(1.02); C691(1.38); C477(0.95)  LDD1551  [26]
 LDCM0313  AC50 HEK-293T C301(1.18); C261(1.00); C691(1.25); C477(0.97)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C301(0.92); C261(1.05); C477(1.04); C553(0.85)  LDD1553  [26]
 LDCM0315  AC52 HEK-293T C301(1.02); C64(0.72); C477(0.96); C500(0.94)  LDD1554  [26]
 LDCM0316  AC53 HEK-293T C301(0.94); C261(1.17); C691(1.22); C477(1.17)  LDD1555  [26]
 LDCM0317  AC54 HEK-293T C301(1.00); C477(1.09); C618(1.12); C553(1.05)  LDD1556  [26]
 LDCM0318  AC55 HEK-293T C301(1.00); C261(0.83); C500(1.15); C618(0.95)  LDD1557  [26]
 LDCM0319  AC56 HEK-293T C301(1.06); C500(1.07); C553(1.06); C636(1.28)  LDD1558  [26]
 LDCM0320  AC57 HEK-293T C301(1.11); C477(1.06); C553(1.16); C633(0.99)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C301(0.90); C261(1.16); C691(1.24); C477(1.07)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C301(0.88); C261(1.15); C477(1.09); C553(1.04)  LDD1561  [26]
 LDCM0323  AC6 HEK-293T C301(1.02); C477(1.10); C618(1.42); C553(1.12)  LDD1562  [26]
 LDCM0324  AC60 HEK-293T C301(1.11); C64(0.94); C477(1.09); C500(1.04)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C301(0.95); C261(1.11); C691(1.16); C477(1.08)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C301(0.94); C477(1.19); C618(1.17); C553(1.24)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C301(0.99); C261(1.06); C500(1.41); C618(1.19)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C301(1.14); C500(0.86); C553(1.02); C636(1.41)  LDD1567  [26]
 LDCM0334  AC7 HEK-293T C301(1.07); C261(0.97); C500(1.44); C618(0.92)  LDD1568  [26]
 LDCM0345  AC8 HEK-293T C301(1.15); C500(1.15); C553(1.07); C636(1.49)  LDD1569  [26]
 LDCM0545  Acetamide MDA-MB-231 C691(0.59)  LDD2138  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C691(0.72)  LDD2113  [11]
 LDCM0248  AKOS034007472 HEK-293T C301(0.95); C261(0.99); C691(1.19); C477(1.09)  LDD1511  [26]
 LDCM0356  AKOS034007680 HEK-293T C301(1.03); C477(1.09); C553(0.81); C633(0.99)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C301(1.09); C500(0.94); C553(1.08); C636(1.43)  LDD1514  [26]
 LDCM0498  BS-3668 MDA-MB-231 C691(0.84)  LDD2091  [11]
 LDCM0108  Chloroacetamide HeLa C691(0.00); C75(0.00); H499(0.00); C555(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C301(1.28); C261(1.29); C477(1.14); C500(1.06)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C301(2.46); C477(1.03); C618(1.37); C553(1.15)  LDD1572  [26]
 LDCM0369  CL100 HEK-293T C477(0.95); C636(1.24)  LDD1573  [26]
 LDCM0370  CL101 HEK-293T C301(1.04); C261(1.10); C477(1.18); C500(0.89)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C301(1.21); C261(0.76); C691(1.07); C636(1.03)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C301(1.01); C261(1.00); C64(0.98); C477(1.08)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C477(1.00); C636(1.13)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C301(0.98); C261(0.85); C477(1.15); C500(0.90)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C301(1.05); C261(0.84); C691(0.95); C636(1.29)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C301(1.03); C261(0.92); C64(1.07); C477(0.98)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C477(1.26); C636(1.13)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C301(0.94); C261(0.91); C477(1.06); C500(1.24)  LDD1582  [26]
 LDCM0379  CL11 HEK-293T C301(1.21); C261(0.97); C500(1.21); C618(0.87)  LDD1583  [26]
 LDCM0380  CL110 HEK-293T C301(1.19); C261(0.70); C691(1.19); C636(1.04)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C301(1.07); C261(1.04); C64(0.95); C477(0.98)  LDD1585  [26]
 LDCM0382  CL112 HEK-293T C477(1.01); C636(1.07)  LDD1586  [26]
 LDCM0383  CL113 HEK-293T C301(1.05); C261(0.97); C477(1.14); C500(1.16)  LDD1587  [26]
 LDCM0384  CL114 HEK-293T C301(1.27); C261(0.85); C691(1.29); C636(1.24)  LDD1588  [26]
 LDCM0385  CL115 HEK-293T C301(0.99); C261(1.00); C64(1.04); C477(1.13)  LDD1589  [26]
 LDCM0386  CL116 HEK-293T C477(1.21); C636(1.33)  LDD1590  [26]
 LDCM0387  CL117 HEK-293T C301(1.10); C261(1.06); C477(1.12); C500(0.92)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C301(1.12); C261(1.03); C691(0.95); C636(1.21)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C301(1.01); C261(0.95); C64(0.97); C477(1.01)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C301(1.32); C500(1.47); C553(1.17); C636(1.47)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C477(0.93); C636(1.14)  LDD1595  [26]
 LDCM0392  CL121 HEK-293T C301(0.99); C261(1.06); C477(1.26); C500(1.53)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C301(1.05); C261(0.90); C691(1.19); C636(0.99)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C301(1.38); C261(0.98); C64(0.88); C477(1.08)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C477(1.05); C636(1.05)  LDD1599  [26]
 LDCM0396  CL125 HEK-293T C301(0.95); C261(1.14); C477(1.13); C500(1.04)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C301(1.01); C261(0.83); C691(1.18); C636(1.16)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C301(0.99); C261(1.00); C64(0.97); C477(1.03)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C477(1.10); C636(1.37)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C301(1.14); C261(1.13); C477(1.18); C500(1.22)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C301(1.07); C261(0.99); C691(1.14); C636(1.26)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C301(1.25); C261(0.97); C64(1.00); C477(0.97)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C477(1.05); C636(1.29)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C301(1.13); C477(1.13); C553(1.07); C633(1.08)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C301(0.96); C261(1.06); C691(1.12); C477(1.15)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C301(0.84); C261(1.32); C477(1.18); C553(1.20)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C301(1.01); C261(0.78); C691(1.14); C636(1.14)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C301(0.88); C64(0.54); C477(1.11); C500(0.85)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C301(1.31); C261(0.83); C691(0.72); C477(0.99)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C301(0.92); C477(1.12); C618(1.29); C553(0.95)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C301(1.04); C261(0.85); C500(0.84); C618(1.02)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C301(1.05); C500(1.20); C553(1.19); C636(1.30)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C301(1.05); C261(0.80); C477(0.88); C500(0.94)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C301(0.89); C261(1.03); C691(1.43); C636(1.17)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C301(0.92); C261(0.94); C64(1.08); C477(1.02)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C477(1.09); C636(1.10)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C301(0.89); C477(0.91); C553(1.18); C633(0.99)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C301(0.93); C261(1.24); C64(0.97); C477(1.04)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C301(0.85); C261(0.95); C691(1.29); C477(1.18)  LDD1623  [26]
 LDCM0420  CL31 HEK-293T C301(0.94); C261(1.11); C477(1.18); C553(1.42)  LDD1624  [26]
 LDCM0421  CL32 HEK-293T C301(0.98); C64(1.22); C477(1.02); C500(0.70)  LDD1625  [26]
 LDCM0422  CL33 HEK-293T C301(1.83); C261(1.07); C691(0.70); C477(0.83)  LDD1626  [26]
 LDCM0423  CL34 HEK-293T C301(0.98); C477(1.13); C618(1.33); C553(0.91)  LDD1627  [26]
 LDCM0424  CL35 HEK-293T C301(0.98); C261(0.89); C500(1.41); C618(0.93)  LDD1628  [26]
 LDCM0425  CL36 HEK-293T C301(1.11); C500(0.70); C553(1.10); C636(1.24)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C301(0.96); C261(1.02); C477(1.11); C500(0.89)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C301(1.04); C261(1.09); C64(1.00); C477(1.11)  LDD1632  [26]
 LDCM0429  CL4 HEK-293T C477(0.80); C636(1.13)  LDD1633  [26]
 LDCM0430  CL40 HEK-293T C477(1.04); C636(1.23)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C301(0.92); C477(1.04); C553(1.01); C633(1.02)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C301(0.96); C261(1.02); C691(0.91); C477(1.08)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C301(0.86); C261(1.19); C477(1.04); C553(0.93)  LDD1637  [26]
 LDCM0434  CL44 HEK-293T C301(0.96); C64(0.88); C477(0.94); C500(0.88)  LDD1638  [26]
 LDCM0435  CL45 HEK-293T C301(1.06); C261(1.05); C691(0.82); C477(0.95)  LDD1639  [26]
 LDCM0436  CL46 HEK-293T C301(1.00); C477(1.18); C618(1.55); C553(0.89)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C301(0.94); C261(0.90); C500(0.89); C618(1.40)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C301(1.18); C500(0.84); C553(1.19); C636(1.43)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C301(1.01); C261(1.20); C477(1.15); C500(1.14)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C301(0.91); C477(1.14); C553(1.10); C633(1.08)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C301(1.07); C261(0.91); C691(0.91); C636(1.08)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C477(1.11); C636(1.22)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C301(1.12); C477(1.12); C553(1.05); C633(1.00)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C301(1.39); C261(0.98); C691(1.10); C477(1.20)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C301(0.83); C261(1.04); C477(1.02); C553(1.03)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C301(0.97); C64(1.16); C477(1.02); C500(0.78)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C301(1.09); C261(0.94); C691(0.79); C477(1.14)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C301(0.98); C477(1.13); C618(1.50); C553(0.77)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C301(0.98); C261(1.03); C500(1.36); C618(1.19)  LDD1653  [26]
 LDCM0451  CL6 HEK-293T C301(1.28); C261(1.01); C691(1.23); C477(1.18)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C301(1.02); C500(1.09); C553(1.24); C636(1.12)  LDD1655  [26]
 LDCM0453  CL61 HEK-293T C301(0.96); C261(1.03); C477(1.07); C500(1.25)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C301(1.01); C261(1.14); C691(1.08); C636(0.87)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C301(0.92); C261(1.05); C64(1.12); C477(1.03)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C477(0.98); C636(1.18)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C301(0.91); C477(1.05); C553(0.99); C633(0.94)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C301(0.92); C261(1.27); C691(1.15); C477(1.00)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C301(0.91); C261(1.14); C477(1.08); C553(1.06)  LDD1662  [26]
 LDCM0460  CL68 HEK-293T C301(1.02); C64(1.43); C477(1.01); C500(1.06)  LDD1663  [26]
 LDCM0461  CL69 HEK-293T C301(0.98); C261(1.16); C691(0.79); C477(1.07)  LDD1664  [26]
 LDCM0462  CL7 HEK-293T C301(0.95); C261(1.54); C477(1.20); C553(1.06)  LDD1665  [26]
 LDCM0463  CL70 HEK-293T C301(1.01); C477(0.99); C618(1.42); C553(1.26)  LDD1666  [26]
 LDCM0464  CL71 HEK-293T C301(0.90); C261(0.92); C500(2.22); C618(1.01)  LDD1667  [26]
 LDCM0465  CL72 HEK-293T C301(0.97); C500(0.86); C553(1.09); C636(1.00)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C301(1.05); C261(0.85); C477(1.10); C500(0.78)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C301(0.91); C261(0.89); C691(1.55); C636(1.02)  LDD1670  [26]
 LDCM0469  CL76 HEK-293T C477(1.05); C636(1.14)  LDD1672  [26]
 LDCM0470  CL77 HEK-293T C301(1.16); C477(1.15); C553(1.02); C633(0.92)  LDD1673  [26]
 LDCM0471  CL78 HEK-293T C301(0.85); C261(1.05); C691(1.09); C477(1.14)  LDD1674  [26]
 LDCM0472  CL79 HEK-293T C301(0.84); C261(1.09); C477(1.08); C553(0.98)  LDD1675  [26]
 LDCM0473  CL8 HEK-293T C301(2.01); C64(1.01); C477(1.04); C500(1.26)  LDD1676  [26]
 LDCM0474  CL80 HEK-293T C301(0.94); C64(1.30); C477(1.05); C500(0.67)  LDD1677  [26]
 LDCM0475  CL81 HEK-293T C301(0.84); C261(0.85); C691(0.84); C477(1.08)  LDD1678  [26]
 LDCM0476  CL82 HEK-293T C301(0.86); C477(0.98); C618(1.39); C553(1.27)  LDD1679  [26]
 LDCM0477  CL83 HEK-293T C301(1.02); C261(0.86); C500(1.03); C618(1.14)  LDD1680  [26]
 LDCM0478  CL84 HEK-293T C301(1.24); C500(0.90); C553(1.28); C636(1.22)  LDD1681  [26]
 LDCM0479  CL85 HEK-293T C301(0.93); C261(0.94); C477(1.13); C500(1.03)  LDD1682  [26]
 LDCM0480  CL86 HEK-293T C301(0.87); C261(0.81); C691(1.10); C636(1.23)  LDD1683  [26]
 LDCM0481  CL87 HEK-293T C301(1.13); C261(1.12); C64(1.00); C477(1.12)  LDD1684  [26]
 LDCM0482  CL88 HEK-293T C477(0.91); C636(1.09)  LDD1685  [26]
 LDCM0483  CL89 HEK-293T C301(0.91); C477(1.05); C553(1.36); C633(1.25)  LDD1686  [26]
 LDCM0484  CL9 HEK-293T C301(1.07); C261(1.21); C691(0.84); C477(1.06)  LDD1687  [26]
 LDCM0485  CL90 HEK-293T C301(1.75); C261(0.97); C691(1.03); C477(1.00)  LDD1688  [26]
 LDCM0486  CL91 HEK-293T C301(0.77); C261(1.11); C477(1.04); C553(1.05)  LDD1689  [26]
 LDCM0487  CL92 HEK-293T C301(0.99); C64(0.67); C477(1.01); C500(0.86)  LDD1690  [26]
 LDCM0488  CL93 HEK-293T C301(1.00); C261(0.83); C691(0.84); C477(0.90)  LDD1691  [26]
 LDCM0489  CL94 HEK-293T C301(1.03); C477(1.10); C618(1.57); C553(0.86)  LDD1692  [26]
 LDCM0490  CL95 HEK-293T C301(1.95); C261(1.38); C500(1.41); C618(0.81)  LDD1693  [26]
 LDCM0491  CL96 HEK-293T C301(1.22); C500(1.41); C553(1.25); C636(1.26)  LDD1694  [26]
 LDCM0492  CL97 HEK-293T C301(1.16); C261(1.13); C477(1.09); C500(1.17)  LDD1695  [26]
 LDCM0493  CL98 HEK-293T C301(1.05); C261(0.83); C691(1.03); C636(1.12)  LDD1696  [26]
 LDCM0494  CL99 HEK-293T C301(1.00); C261(0.99); C64(0.96); C477(1.01)  LDD1697  [26]
 LDCM0097  Dasatinib K562 7.40  LDD0270  [8]
 LDCM0495  E2913 HEK-293T C301(0.93); C261(1.04); C64(0.88); C477(1.16)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C618(0.95)  LDD1702  [11]
 LDCM0468  Fragment33 HEK-293T C301(0.88); C261(0.79); C64(0.97); C477(1.08)  LDD1671  [26]
 LDCM0427  Fragment51 HEK-293T C301(0.98); C261(1.04); C691(1.25); C636(1.14)  LDD1631  [26]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [10]
 LDCM0022  KB02 HEK-293T C301(0.98); C477(1.06)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C301(1.01); C477(1.10)  LDD1497  [26]
 LDCM0024  KB05 COLO792 C691(1.69); C75(1.44)  LDD3310  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C691(0.88)  LDD2121  [11]
 LDCM0109  NEM HeLa N.A.  LDD0227  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C691(0.93)  LDD2089  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C691(0.98)  LDD2093  [11]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C691(0.84)  LDD2097  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C691(1.09); C649(1.14)  LDD2099  [11]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C691(1.46)  LDD2101  [11]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C691(0.35)  LDD2104  [11]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C691(0.35)  LDD2106  [11]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C691(0.94); C649(0.89)  LDD2107  [11]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C691(0.62)  LDD2108  [11]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C691(0.94); C649(1.55)  LDD2109  [11]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C691(1.06); C649(0.78)  LDD2111  [11]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C691(0.49)  LDD2114  [11]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C691(0.51)  LDD2115  [11]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C691(1.88); C649(1.04)  LDD2119  [11]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C691(1.01); C649(0.69)  LDD2123  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C691(0.96); C649(0.85)  LDD2125  [11]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C691(1.06); C649(0.79)  LDD2127  [11]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C691(1.04)  LDD2129  [11]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C691(0.57)  LDD2133  [11]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C691(0.42); C649(1.97)  LDD2134  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C691(1.15)  LDD2135  [11]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C691(1.26); C649(1.03)  LDD2136  [11]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C691(1.38); C649(0.99)  LDD2137  [11]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C691(2.35)  LDD1700  [11]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C691(0.72)  LDD2140  [11]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C691(0.97)  LDD2141  [11]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C691(4.15); C649(1.29)  LDD2144  [11]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C691(0.29)  LDD2145  [11]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C691(0.97); C649(1.00)  LDD2146  [11]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C691(0.52); C649(0.84); C574(0.98)  LDD2148  [11]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C691(0.58)  LDD2150  [11]
 LDCM0014  Panhematin hPBMC 3.19  LDD0064  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiotensin-converting enzyme 2 (ACE2) Peptidase M2 family Q9BYF1
Insulin-like growth factor 1 receptor (IGF1R) Tyr protein kinase family P08069
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) . P78536
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Filamin-A (FLNA) Filamin family P21333
Integrin alpha-5 (ITGA5) Integrin alpha chain family P08648
Talin-1 (TLN1) . Q9Y490
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fractalkine (CX3CL1) Intercrine delta family P78423
Cytokine receptor common subunit beta (CSF2RB) Type I cytokine receptor family P32927
Endoglin (ENG) . P17813
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Crk-like protein (CRKL) CRK family P46109
Integrin alpha-2 (ITGA2) Integrin alpha chain family P17301
Integrin alpha-4 (ITGA4) Integrin alpha chain family P13612
Paxillin (PXN) Paxillin family P49023
Angiopoietin-related protein 4 (ANGPTL4) . Q9BY76

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Antithymocyte Immunoglobulin (Rabbit) BiotechDrug DB00098
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
131i-radretumab Antibody D0H4GT
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Os2966 Antibody DB8MR6
Jsm 6427 . D0ZT4J
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
C(-grgdfl-) Small molecular drug D0B4JU
Mk-0668 Small molecular drug D09XED
Sb-265123 Small molecular drug D0R3CY
Pln-74809 . DB16515

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
12 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD014175
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402