Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DA-P2  Probe Info 
Probe concentration 15 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09517  Ubiquitin carboxyl-terminal hydrolase 33 (USP33) 38.1
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 30.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 26.1
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 26.0
 LDTP00598  Serine palmitoyltransferase 2 (SPTLC2) 22.8
 LDTP08378  Serine/threonine-protein kinase VRK2 (VRK2) 17.8
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) 15.5
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 12.8
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 11.8
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 11.6
 LDTP05874  Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) 11.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 8.8
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 8.1
 LDTP12886  Glycerophosphodiester phosphodiesterase 1 (GDE1) 7.9
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 7.4
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 7.0
 LDTP02935  Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) 7.0
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 6.8
 LDTP06145  Protein disulfide-isomerase A5 (PDIA5) 6.7
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) 6.7
 LDTP06104  Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) 5.9
 LDTP16105  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (TYW1) 5.7
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 5.6
 LDTP01474  Ubiquitin carboxyl-terminal hydrolase 19 (USP19) 5.0
 LDTP10386  ERO1-like protein alpha (ERO1A) 4.7
 LDTP00497  Cyclin-G-associated kinase (GAK) 4.6
 LDTP04186  Glutamate--cysteine ligase regulatory subunit (GCLM) 4.6
 LDTP06142  Squalene monooxygenase (SQLE) 4.3
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 4.2
 LDTP00285  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) 4.1
 LDTP04622  Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) 4.0
Transporter and channel
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06633  Reticulon-1 (RTN1) 52.3
 LDTP12191  Vezatin (VEZT) 46.3
 LDTP13018  Stromal interaction molecule 2 (STIM2) 18.2
 LDTP04770  Syntaxin-17 (STX17) 15.9
 LDTP08897  Macoilin (MACO1) 11.5
 LDTP04309  Nuclear pore complex protein Nup153 (NUP153) 11.2
 LDTP02122  Integrin beta-1 (ITGB1) 10.9
 LDTP08040  Zinc finger FYVE domain-containing protein 16 (ZFYVE16) 10.7
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 10.5
 LDTP09352  DnaJ homolog subfamily B member 14 (DNAJB14) 9.6
 LDTP12665  Cell cycle control protein 50A (TMEM30A) 9.0
 LDTP06902  mRNA export factor GLE1 (GLE1) 8.0
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 7.8
 LDTP10181  Protein Aster-A (GRAMD1A) 7.4
 LDTP11293  Nucleoporin p58/p45 (NUP58) 7.2
 LDTP01454  SUN domain-containing protein 1 (SUN1) 6.4
 LDTP09204  Nucleoporin NUP35 (NUP35) 6.2
 LDTP07002  Transport and Golgi organization protein 1 homolog (MIA3) 5.7
 LDTP04866  Protein transport protein Sec61 subunit beta (SEC61B) 5.1
 LDTP11161  Extended synaptotagmin-1 (ESYT1) 5.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 5.0
 LDTP00127  Nuclear envelope pore membrane protein POM 121C (POM121C) 4.6
 LDTP03839  Nuclear pore glycoprotein p62 (NUP62) 4.5
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) 4.2
 LDTP00198  Synaptosomal-associated protein 23 (SNAP23) 4.0
 LDTP02894  Gap junction alpha-1 protein (GJA1) 4.0
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02970  Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) 13.0
 LDTP00461  Transcription regulator protein BACH1 (BACH1) 11.6
 LDTP06748  Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) 5.6
Other
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) 181.0
 LDTP01522  Reticulon-3 (RTN3) 55.0
 LDTP09806  UBX domain-containing protein 4 (UBXN4) 53.1
 LDTP00512  Protein transport protein Sec16A (SEC16A) 35.6
 LDTP09702  Nesprin-2 (SYNE2) 23.4
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 22.7
 LDTP02535  Laminin subunit gamma-1 (LAMC1) 19.1
 LDTP18272  Transmembrane protein 209 (TMEM209) 17.8
 LDTP05382  A-kinase anchor protein 12 (AKAP12) 14.5
 LDTP09787  Nicastrin (NCSTN) 13.6
 LDTP09837  A-kinase anchor protein 1, mitochondrial (AKAP1) 12.8
 LDTP03426  Protein ITPRID2 (ITPRID2) 12.0
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) 10.0
 LDTP02230  Laminin subunit beta-1 (LAMB1) 9.9
 LDTP13241  LIM domain-containing protein 1 (LIMD1) 9.6
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) 9.0
 LDTP07345  Cell division cycle-associated protein 2 (CDCA2) 8.7
 LDTP02282  Collagen alpha-2(IV) chain (COL4A2) 8.2
 LDTP13507  BAG family molecular chaperone regulator 5 (BAG5) 7.6
 LDTP14228  Transforming acidic coiled-coil-containing protein 3 (TACC3) 7.2
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 6.6
 LDTP05915  Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) 6.4
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 6.3
 LDTP19744  Uncharacterized protein FAM241A (FAM241A) 6.2
 LDTP15887  Lipase maturation factor 2 (LMF2) 6.2
 LDTP15840  Tetratricopeptide repeat protein 1 (TTC1) 6.2
 LDTP09137  Trinucleotide repeat-containing gene 6A protein (TNRC6A) 6.1
 LDTP14939  Membralin (TMEM259) 5.8
 LDTP08535  MAP7 domain-containing protein 3 (MAP7D3) 5.6
 LDTP13402  Dynactin subunit 4 (DCTN4) 5.6
 LDTP07385  Anamorsin (CIAPIN1) 5.2
 LDTP16285  Transducin beta-like protein 2 (TBL2) 5.1
 LDTP14910  MAP7 domain-containing protein 1 (MAP7D1) 5.0
 LDTP13916  Calcium-regulated heat-stable protein 1 (CARHSP1) 4.8
 LDTP16155  Opioid growth factor receptor (OGFR) 4.7
 LDTP02263  Signal recognition particle receptor subunit alpha (SRPRA) 4.7
 LDTP10431  Vesicle-trafficking protein SEC22a (SEC22A) 4.5
 LDTP17325  Uncharacterized protein KIAA0930 (KIAA0930) 4.4
 LDTP07476  RAD50-interacting protein 1 (RINT1) 4.4
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 4.4
 LDTP08735  Spartin (SPART) 4.3
 LDTP11367  Oxysterol-binding protein-related protein 11 (OSBPL11) 4.2
 LDTP15727  Protein LTV1 homolog (LTV1) 4.2
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 4.2
 LDTP12123  WD repeat-containing protein 41 (WDR41) 4.2
 LDTP14426  TRAF-type zinc finger domain-containing protein 1 (TRAFD1) 4.1

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348