Details of the Target

General Information of Target

Target ID LDTP05874
Target Name Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15)
Gene Name ADAM15
Gene ID 8751
Synonyms
MDC15; Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; EC 3.4.24.-; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; Metargidin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVS
KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA
GIPPLVVPSRPAPPPPTVSSLYL
Target Bioclass
Enzyme
Subcellular location
Endomembrane system
Function
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Uniprot ID
Q13444
Ensemble ID
ENST00000271836.10
HGNC ID
HGNC:193
ChEMBL ID
CHEMBL2331050

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A713V DBIA    Probe Info 
COLO678 SNV: p.P415A DBIA    Probe Info 
FTC133 SNV: p.A788T .
JURKAT SNV: p.A824T .
MEWO SNV: p.P590S .
MFE319 SNV: p.R718C .
MOLT4 SNV: p.H722R .
NCIH661 SNV: p.Q530K .
TOV21G SNV: p.G362W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		11.55  LDD0348  [1]
HRP
 Probe Info  		7.90  LDD0347  [1]
STPyne
 Probe Info  		K729(9.09)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K660(4.34)  LDD3494  [3]
BTD
 Probe Info  		C733(1.06)  LDD2092  [4]
DBIA
 Probe Info  		C733(1.33); C134(1.12); C136(1.12)  LDD0078  [5]
IA-alkyne
 Probe Info  		C409(0.00); C571(0.00); C657(0.00)  LDD0162  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		C657(0.00); C409(0.00); C560(0.00); C830(0.00)  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [8]
AOyne
 Probe Info  		14.80  LDD0443  [10]
NAIA_5
 Probe Info  		C409(0.00); C571(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C733(1.02)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C733(1.00)  LDD2117  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C733(0.98)  LDD2103  [4]
 LDCM0214  AC1 HCT 116 C179(0.89); C409(1.07); C560(1.01); C571(1.10)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C179(1.05); C409(1.19); C560(1.21); C578(0.93)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C179(1.00); C409(1.03); C560(1.00); C571(0.71)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C179(1.22); C409(1.02); C560(0.96); C571(0.66)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C179(1.07); C409(1.04); C560(1.13); C571(0.65)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C179(1.45); C409(1.08); C560(1.17); C571(0.81)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C179(1.08); C409(0.97); C560(0.86); C571(0.87)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C179(1.25); C409(1.00); C560(1.13); C571(1.29)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C179(1.21); C409(1.26); C560(0.95); C571(0.89)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C179(1.21); C409(1.01); C560(1.08); C571(0.90)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C179(1.08); C409(1.10); C560(0.81); C571(0.70)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C179(0.99); C409(1.04); C560(0.81); C571(0.50)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C179(1.13); C409(1.11); C560(1.36); C578(0.92)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C179(1.15); C409(1.17); C560(1.04); C571(0.84)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C179(1.14); C409(1.09); C560(0.99); C571(0.63)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C179(1.19); C409(1.20); C560(1.02); C571(0.60)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C179(1.07); C409(1.02); C560(0.92); C571(1.01)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C179(1.20); C409(1.07); C560(1.07); C571(0.99)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C179(1.31); C409(1.16); C560(1.13); C571(1.06)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C179(1.33); C409(1.22); C560(1.01); C571(0.92)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C179(1.12); C409(1.11); C560(1.07); C571(0.97)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C179(1.06); C409(1.07); C560(1.12); C571(0.87)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C179(1.22); C409(1.15); C560(1.02); C571(0.92)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C179(0.90); C409(1.09); C560(1.05); C578(0.89)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C179(1.39); C409(1.24); C560(0.94); C571(0.95)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C179(1.03); C409(1.10); C560(0.97); C571(0.98)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C179(0.97); C409(1.07); C560(1.02); C571(1.08)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C179(0.97); C409(1.21); C560(1.05); C571(0.75)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C179(1.05); C409(1.05); C560(1.01); C571(0.98)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C179(1.05); C409(1.08); C560(1.19); C571(0.93)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C179(1.46); C409(1.16); C560(1.10); C571(0.81)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C179(1.34); C409(1.17); C560(0.93); C571(0.78)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C179(1.32); C409(1.11); C560(1.03); C578(0.90)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C179(0.96); C409(0.87); C560(0.83); C578(0.73)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C179(1.05); C409(1.01); C560(1.09); C578(0.85)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C179(1.12); C409(0.97); C560(0.80); C578(0.91)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C179(0.84); C409(0.96); C560(1.12); C578(1.06)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C179(0.96); C409(1.02); C560(1.04); C578(0.84)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C179(1.10); C409(1.06); C560(1.17); C578(1.00)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C179(1.02); C409(1.02); C560(1.03); C578(1.10)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C179(1.12); C409(1.06); C560(1.14); C578(0.92)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C179(0.91); C409(1.01); C560(1.09); C578(1.09)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C179(0.93); C409(1.07); C560(1.14); C578(1.17)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C179(0.95); C409(1.02); C560(1.10); C578(1.13)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C179(0.83); C409(1.02); C560(1.09); C578(0.95)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C179(1.14); C409(1.08); C560(1.16); C578(1.22)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C179(0.97); C409(1.03); C560(1.12); C578(1.08)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C179(0.78); C409(0.97); C560(1.06); C578(0.96)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C179(1.08); C409(1.07); C560(0.87); C571(0.78)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C571(0.93); C409(0.94); C661(1.16); C667(1.16)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C409(0.93); C560(1.02); C571(1.02); C578(1.09)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C571(0.87); C409(0.96); C661(0.97); C667(0.97)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C571(0.88); C560(0.95); C409(1.02); C661(1.10)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C571(0.86); C409(1.14); C578(1.19); C583(1.24)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C578(1.03); C409(1.03); C583(1.08); C571(1.14)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C578(0.84); C583(0.86); C560(0.98); C179(1.01)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C409(0.89); C578(0.96); C583(0.98); C571(1.03)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C560(0.83); C661(0.88); C667(0.88); C571(0.96)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C560(0.91); C661(1.01); C667(1.01); C571(1.05)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C571(1.08); C578(1.14); C583(1.20); C560(1.24)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C179(1.39); C409(0.96); C560(0.89); C571(0.99)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C179(1.43); C409(1.06); C560(1.23); C571(1.05)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C179(1.22); C409(0.92); C560(1.02); C571(1.01)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C179(1.20); C409(0.93); C560(0.86); C571(1.20)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C733(1.06); C409(1.11); C571(1.15); C179(1.16)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C409(1.03); C571(1.05); C733(1.09); C578(1.25)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C733(1.00); C571(1.03); C409(1.04); C179(1.15)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C657(0.80); C179(0.88); C560(0.88); C409(0.98)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C571(0.99); C733(1.05); C409(1.09); C179(1.16)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C733(0.78); C571(1.02); C409(1.07); C560(1.32)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C409(1.01); C733(1.05); C571(1.06); C179(1.16)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C571(0.98); C409(1.12); C560(1.19); C179(1.21)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C733(0.98); C571(0.99); C409(1.03); C179(1.07)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C733(0.85); C409(0.92); C179(1.13); C583(1.23)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C733(0.84); C409(1.03); C571(1.04); C179(1.06)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C733(0.95); C409(1.09); C571(1.24); C179(1.24)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C733(0.94); C409(1.00); C571(1.20); C560(1.24)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C179(1.19); C733(1.22); C409(1.27); C571(1.32)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C657(0.82); C733(0.88); C560(0.89); C179(0.94)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C733(0.76); C179(1.15); C409(1.22); C571(1.29)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C733(0.64); C409(1.13); C578(1.28); C583(1.28)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C733(0.64); C409(1.22); C583(1.26); C578(1.27)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C409(1.12); C733(1.17); C578(1.37); C560(1.40)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C733(0.82); C409(1.19); C583(1.28); C578(1.31)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C661(0.66); C667(0.67); C657(0.75); C409(0.90)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C571(0.99); C657(1.01); C409(1.05); C560(1.07)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C571(0.93); C657(0.97); C560(1.01); C409(1.11)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C571(0.97); C657(1.01); C578(1.11); C583(1.11)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C661(0.92); C667(0.94); C657(1.09); C571(1.09)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C657(0.97); C179(0.97); C578(0.98); C583(0.98)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C571(0.97); C560(1.04); C578(1.09); C583(1.09)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C657(0.96); C409(1.08); C571(1.09); C661(1.11)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C571(0.91); C657(0.98); C409(1.11); C667(1.13)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C667(0.87); C657(1.08); C661(1.08); C578(1.09)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C560(0.94); C571(0.97); C409(1.12); C657(1.12)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C667(1.08); C560(1.13); C661(1.14); C571(1.14)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C733(0.64); C560(0.81); C583(0.97); C179(1.00)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C578(0.98); C560(1.03); C583(1.03); C733(1.07)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C179(0.86); C733(0.99); C560(1.05); C409(1.05)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C733(0.93); C560(1.08); C571(1.24); C409(1.27)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C179(0.90); C578(0.98); C583(0.98); C571(1.05)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C733(1.06); C409(1.20); C583(1.23); C560(1.23)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C179(0.79); C733(0.90); C583(1.10); C560(1.11)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C733(0.79); C409(1.05); C179(1.06); C571(1.11)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C733(0.97); C560(1.00); C571(1.07); C583(1.10)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C733(0.78); C560(0.89); C583(1.03); C578(1.05)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C560(1.01); C733(1.04); C583(1.15); C578(1.21)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C560(0.98); C583(1.03); C571(1.04); C578(1.15)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C179(0.83); C571(0.92); C578(1.04); C560(1.05)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C560(0.79); C578(0.97); C409(1.06); C571(1.06)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C571(1.02); C179(1.03); C560(1.09); C409(1.12)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C578(0.89); C583(0.91); C179(1.07); C560(1.15)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C179(0.99); C409(1.00); C578(1.07); C733(1.17)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C179(0.95); C409(1.09); C560(1.13); C578(1.18)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C179(0.93); C560(1.01); C409(1.04); C578(1.10)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C179(0.87); C578(1.07); C571(1.11); C583(1.21)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C179(0.74); C571(1.05); C578(1.14); C409(1.20)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C571(0.97); C578(1.08); C583(1.13); C409(1.20)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C571(0.92); C179(0.98); C409(0.98); C578(1.01)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C179(0.83); C571(0.87); C578(0.88); C583(0.99)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C733(0.85); C578(1.05); C571(1.05); C583(1.09)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C733(0.81); C560(0.85); C578(0.92); C583(0.97)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C583(0.96); C179(0.96); C578(0.97); C409(1.08)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C409(1.02); C733(1.02); C560(1.12); C578(1.14)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C733(0.89); C578(1.12); C560(1.13); C583(1.14)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C578(0.90); C661(0.96); C667(0.96); C733(1.00)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C733(0.89); C578(1.02); C583(1.17); C409(1.22)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C578(0.95); C560(0.99); C733(1.05); C583(1.07)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C733(1.00); C578(1.02); C583(1.13); C560(1.17)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C560(0.94); C733(0.95); C578(1.06); C583(1.14)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C560(1.07); C409(1.11); C733(1.12); C578(1.15)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C733(0.78); C578(0.95); C583(1.03); C560(1.04)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C661(0.95); C667(0.95); C578(0.96); C733(1.00)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C583(0.84); C578(0.85); C560(1.10); C409(1.12)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C560(1.02); C409(1.05); C733(1.05); C578(1.06)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C661(0.76); C667(0.76); C409(0.85); C571(0.89)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C578(0.87); C560(0.93); C733(0.94); C583(0.94)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C578(1.05); C583(1.05); C560(1.28); C409(1.48)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C578(1.11); C583(1.11); C661(1.26); C667(1.26)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C661(1.04); C667(1.04); C571(1.15); C560(1.17)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C560(1.11); C179(1.22); C571(1.29); C657(1.32)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C560(1.03); C661(1.06); C667(1.06); C179(1.08)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C409(1.08); C560(1.10); C578(1.19); C583(1.19)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C409(1.16); C560(1.24); C571(1.28); C657(1.41)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C179(0.92); C560(1.10); C571(1.13); C661(1.22)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C578(1.31); C583(1.31); C409(1.45); C560(1.46)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C578(1.03); C583(1.03); C571(1.24); C409(1.31)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C661(1.06); C667(1.06); C571(1.18); C409(1.22)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C661(0.95); C667(0.95); C560(1.12); C409(1.13)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C661(1.09); C667(1.09); C179(1.10); C571(1.18)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C578(1.07); C583(1.07); C560(1.21); C409(1.22)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C661(1.26); C667(1.26); C571(1.29); C409(1.34)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C571(0.59); C661(0.70); C667(0.70); C657(0.71)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C571(0.83); C661(0.84); C667(0.84); C560(0.89)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C179(0.89); C409(1.07); C560(0.97); C578(0.89)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C583(0.86); C578(0.87); C179(1.08); C560(1.11)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C578(0.94); C583(1.03); C560(1.21); C409(1.30)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C733(1.33); C134(1.12); C136(1.12)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C657(0.88); C667(0.91); C560(0.94); C409(1.00)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C560(0.65); C667(0.83); C571(1.02); C657(1.08)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C657(0.77); C179(0.94); C409(0.98); C571(1.04)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C578(0.94); C583(0.95); C179(1.12); C560(1.12)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C179(0.90); C578(0.93); C583(0.98); C409(1.05)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C560(0.86); C578(0.93); C583(0.93); C409(1.08)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C578(0.88); C583(0.88); C409(1.01); C179(1.07)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C571(1.01); C733(1.07); C409(1.12); C560(1.25)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C571(1.12); C409(1.24); C560(1.49); C733(1.51)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C733(0.88); C571(1.06); C409(1.13); C560(1.43)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C733(0.96); C571(1.05); C409(1.25); C560(1.45)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C409(1.11); C571(1.13); C733(1.18); C560(1.29)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C560(0.66); C667(0.78); C571(1.15); C409(1.16)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C733(0.97); C571(1.03); C409(1.10); C560(1.19)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C571(0.99); C409(1.00); C733(1.10); C560(1.26)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C571(0.94); C733(0.98); C409(1.12); C583(1.12)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C733(0.65); C409(1.12); C571(1.24); C560(1.32)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C571(1.05); C733(1.06); C409(1.19); C179(1.29)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C733(0.83); C571(1.04); C560(1.15); C583(1.21)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C733(0.96); C409(1.14); C179(1.16); C578(1.36)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C571(0.97); C560(1.00); C657(1.20); C578(1.21)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C571(0.92); C409(1.04); C661(1.19); C560(1.19)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C667(0.79); C661(0.91); C657(0.93); C560(1.09)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C560(0.80); C667(0.89); C571(1.26); C409(1.28)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C667(0.87); C657(0.94); C661(0.97); C571(0.99)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C179(0.65); C560(0.86); C583(0.94); C733(0.94)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C733(0.97); C409(1.08); C583(1.11); C179(1.26)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C583(0.91); C560(0.93); C578(0.99); C571(1.02)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C733(1.04); C578(1.09); C583(1.11); C571(1.15)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C409(0.96); C571(1.03); C583(1.11); C179(1.12)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C571(0.93); C409(0.97); C578(1.04); C560(1.07)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C179(1.02); C560(1.06); C409(1.09); C733(1.11)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C409(0.95); C179(1.00); C578(1.01); C560(1.10)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C560(0.66); C667(1.09); C571(1.13); C657(1.18)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C560(0.76); C667(0.87); C657(0.99); C409(1.05)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C560(0.55); C667(1.04); C571(1.07); C657(1.08)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C733(0.70); C409(0.92); C661(1.18); C667(1.18)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C657(0.82); C661(0.90); C667(0.90); C571(0.92)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C733(0.91); C409(0.97); C657(1.08); C578(1.11)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C733(0.77); C409(1.04); C578(1.11); C583(1.11)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C667(0.88); C657(1.02); C409(1.07); C571(1.13)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C733(0.92); C409(1.01); C657(1.05); C578(1.17)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C571(1.00); C661(1.04); C667(1.04); C657(1.10)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C571(0.91); C657(1.08); C578(1.09); C583(1.09)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C657(0.85); C571(0.92); C733(0.92); C578(1.11)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C409(1.04); C571(1.04); C657(1.09); C733(1.12)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C409(1.14); C560(1.24); C571(0.81); C578(1.22)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C409(1.10); C560(1.32); C571(1.04); C578(1.20)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C409(1.00); C560(1.46); C571(1.12); C578(1.40)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C409(1.04); C560(1.12); C571(1.27); C578(1.13)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C409(0.98); C560(1.38); C571(1.15); C578(1.17)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C409(0.99); C560(0.84); C571(1.06); C578(1.26)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C409(0.91); C560(1.33); C571(0.97); C578(1.09)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C179(1.09); C409(1.08); C560(1.16); C571(1.02)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C179(0.98); C409(1.22); C560(1.13); C571(1.48)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C179(1.01); C409(1.10); C560(1.04); C571(1.41)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C179(1.02); C409(1.11); C560(1.26); C571(1.17)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C179(1.14); C409(1.18); C560(1.28); C571(1.36)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C179(1.24); C409(1.19); C560(1.14); C571(1.23)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C179(1.20); C409(1.24); C560(1.14); C571(1.70)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C179(1.25); C409(1.13); C560(1.69); C571(1.09)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C409(1.00); C560(0.83); C571(0.85); C578(1.11)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C179(1.46); C409(1.31); C560(1.11); C571(1.34)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C179(1.06); C409(1.01); C560(1.13); C571(1.41)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C179(1.28); C409(1.20); C560(1.17); C571(1.24)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C179(0.99); C409(1.30); C560(1.26); C571(1.34)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C179(1.12); C409(1.27); C560(1.51); C571(1.26)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C179(1.17); C409(1.05); C560(1.25); C571(1.52)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C409(0.96); C560(1.02); C571(0.77); C578(1.14)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C409(0.99); C560(0.88); C571(0.83); C578(1.13)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C409(1.00); C560(0.92); C571(0.78); C578(1.17)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C409(1.05); C560(1.08); C571(0.78); C578(1.33)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C409(1.16); C560(0.89); C571(1.34); C578(1.01)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C409(1.09); C560(0.94); C571(0.83); C578(1.07)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C409(0.98); C560(1.04); C571(1.29); C578(1.00)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C409(0.98); C560(0.94); C571(0.76); C578(0.78)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C409(1.14); C560(0.96); C571(1.11); C578(1.19)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C409(0.90); C560(0.88); C571(1.03); C578(0.77)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C409(0.92); C560(1.02); C571(0.94); C578(0.95)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C409(0.97); C560(0.97); C571(0.96); C578(0.85)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C409(0.87); C560(0.85); C571(0.92); C578(1.02)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C409(1.04); C560(0.99); C571(0.82); C578(0.85)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C409(1.13); C560(1.08); C571(0.98); C578(1.07)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C409(1.14); C560(0.79); C571(1.01); C578(1.26)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C409(0.95); C560(1.05); C571(0.89); C578(0.98)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C179(1.27); C409(1.02); C560(1.07); C571(1.25)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C179(1.06); C409(1.08); C560(1.31); C571(1.23)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C179(1.26); C409(0.96); C560(1.36); C571(1.16)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C179(1.17); C409(1.08); C560(1.16); C571(1.60)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C179(1.06); C409(1.06); C560(1.58); C571(1.10)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C179(1.04); C409(1.14); C560(1.20); C571(1.01)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C179(1.31); C409(1.03); C560(1.30); C571(1.31)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C179(1.18); C409(1.20); C560(1.31); C571(1.21)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C179(1.36); C409(1.21); C560(1.24); C571(1.01)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C409(1.13); C560(1.02); C571(1.41); C578(1.48)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C179(0.93); C409(1.12); C560(1.29); C571(1.14)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C179(1.06); C409(1.22); C560(1.46); C571(1.29)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C179(1.18); C409(1.14); C560(1.74); C571(1.04)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C179(1.19); C409(1.14); C560(1.36); C571(1.13)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C179(1.16); C409(1.30); C560(1.49); C571(1.45)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C179(1.16); C409(1.03); C560(1.18); C571(1.06)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C179(1.42); C409(1.00); C560(1.19); C571(0.93)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C179(1.07); C409(1.26); C560(1.39); C571(1.05)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C179(1.26); C409(1.18); C560(1.76); C571(0.89)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C409(1.34); C560(1.13); C571(1.14); C578(1.18)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C179(1.11); C409(1.05); C560(1.27); C571(0.93)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C179(1.05); C409(1.23); C560(1.62); C571(0.96)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C179(0.94); C409(1.39); C560(1.16); C571(0.88)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C179(1.13); C409(1.23); C560(1.15); C571(0.96)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C179(1.29); C409(1.46); C560(1.46); C571(0.89)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C179(1.14); C409(1.28); C560(1.19); C571(0.84)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C179(1.10); C409(1.06); C560(1.21); C571(1.02)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C179(1.45); C409(1.28); C560(1.23); C571(0.85)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C179(1.33); C409(1.28); C560(1.28); C571(0.82)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C179(0.99); C409(1.49); C560(1.26); C571(1.03)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C409(1.19); C560(1.00); C571(1.30); C578(1.59)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C179(1.91); C409(1.05); C560(0.82); C571(0.71)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C179(1.02); C409(1.12); C560(0.98); C571(1.08)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C179(1.10); C409(1.03); C560(0.88); C571(0.93)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C179(0.98); C409(1.11); C560(0.95); C571(0.97)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C179(1.17); C409(1.20); C560(1.06); C571(1.09)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C179(1.19); C409(1.22); C560(1.00); C571(0.92)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C179(1.05); C409(1.08); C560(1.02); C571(1.05)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C179(1.01); C409(1.03); C560(0.86); C571(1.02)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C179(0.93); C409(1.19); C560(1.06); C571(1.01)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C179(0.89); C409(1.01); C560(0.98); C571(0.95)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C830(1.38); C409(1.14); C667(1.13)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C661(2.56)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C179(1.11); C409(1.06); C560(1.10); C571(1.08)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C179(2.97); C409(1.31); C560(1.09); C571(1.50)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C560(2.54)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C560(2.70)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C560(2.95)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C733(1.20)  LDD2102  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C733(1.06)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C733(0.94)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C733(1.34)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C733(1.65)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C733(0.99)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C733(0.96)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C733(0.69)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C733(1.17)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C733(0.94)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C733(0.89)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C733(0.80)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C733(1.24)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C733(0.77)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C733(0.88)  LDD2114  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C733(0.96)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C733(1.07)  LDD2127  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C733(0.47)  LDD2133  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C733(1.44)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C733(1.02)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C733(0.71)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C733(1.08)  LDD2141  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C733(3.13)  LDD2153  [4]
 LDCM0021  THZ1 HCT 116 C733(0.94); C409(1.01); C560(1.03); C578(0.98)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Tyrosine-protein kinase HCK (HCK) Tyr protein kinase family P08631
Tyrosine-protein kinase Lck (LCK) Tyr protein kinase family P06239
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
Tyrosine-protein kinase BTK (BTK) Tyr protein kinase family Q06187
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Sorting nexin-33 (SNX33) Sorting nexin family Q8WV41
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Endophilin-A1 (SH3GL2) Endophilin family Q99962
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Nephrocystin-1 (NPHP1) Nephrocystin-1 family O15259
Odontogenic ameloblast-associated protein (ODAM) ODAM family A1E959
Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3) PACSIN family Q9UKS6
SH3 and PX domain-containing protein 2A (SH3PXD2A) SH3PXD2 family Q5TCZ1
Sorting nexin-9 (SNX9) Sorting nexin family Q9Y5X1
Four and a half LIM domains protein 3 (FHL3) . Q13643
Osteoclast-stimulating factor 1 (OSTF1) . Q92882
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402