Details of the Probe

General Information of Probe

Probe ID
LDPC0190
Probe Name
DA-P2
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 247.294
Lipid-water partition coefficient (xlogp) 1.56
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C14H17NO3
Canonical SMILES
C#CCCCC(=O)NCCc1ccc(O)c(O)c1
InChI
InChI=1S/C14H17NO3/c1-2-3-4-5-14(18)15-9-8-11-6-7-12(16)13(17)10-11/h1,6-7,10,16-17H,3-5,8-9H2,(H,15,18)
InChIKey
HUGNXIRRXRSXCS-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

31 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 12.82  LDD0348 
Acyl-CoA (8-3)-desaturase (FADS1) LDTP00968 15.50  LDD0348 
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) LDTP04622 4.02  LDD0348 
Cyclin-G-associated kinase (GAK) LDTP00497 4.61  LDD0348 
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) LDTP05874 11.55  LDD0348 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 8.77  LDD0348 
ERO1-like protein alpha (ERO1A) LDTP10386 4.73  LDD0348 
Glutamate--cysteine ligase regulatory subunit (GCLM) LDTP04186 4.56  LDD0348 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 6.66  LDD0348 
Glycerophosphodiester phosphodiesterase 1 (GDE1) LDTP12886 7.88  LDD0348 
Heme oxygenase 2 (HMOX2) LDTP03540 26.07  LDD0348 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 7.03  LDD0348 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 7.41  LDD0348 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) LDTP10930 4.19  LDD0348 
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) LDTP01004 11.65  LDD0348 
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) LDTP06104 5.88  LDD0348 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 8.10  LDD0348 
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) LDTP00285 4.12  LDD0348 
Protein disulfide-isomerase A5 (PDIA5) LDTP06145 6.71  LDD0348 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 5.57  LDD0348 
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (TYW1) LDTP16105 5.66  LDD0348 
Serine palmitoyltransferase 2 (SPTLC2) LDTP00598 22.78  LDD0348 
Serine/threonine-protein kinase VRK2 (VRK2) LDTP08378 17.76  LDD0348 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 26.01  LDD0348 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 6.81  LDD0348 
Squalene monooxygenase (SQLE) LDTP06142 4.27  LDD0348 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 11.76  LDD0348 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 30.03  LDD0348 
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) LDTP02935 6.96  LDD0348 
Ubiquitin carboxyl-terminal hydrolase 19 (USP19) LDTP01474 4.98  LDD0348 
Ubiquitin carboxyl-terminal hydrolase 33 (USP33) LDTP09517 38.11  LDD0348 
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⏷ Show the Full List of 31 Enzyme
26 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Cell cycle control protein 50A (TMEM30A) LDTP12665 9.03  LDD0348 
DnaJ homolog subfamily B member 14 (DNAJB14) LDTP09352 9.62  LDD0348 
Extended synaptotagmin-1 (ESYT1) LDTP11161 4.99  LDD0348 
Gap junction alpha-1 protein (GJA1) LDTP02894 4.01  LDD0348 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 7.84  LDD0348 
Integrin beta-1 (ITGB1) LDTP02122 10.92  LDD0348 
Macoilin (MACO1) LDTP08897 11.52  LDD0348 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 10.52  LDD0348 
mRNA export factor GLE1 (GLE1) LDTP06902 8.00  LDD0348 
Nuclear envelope pore membrane protein POM 121C (POM121C) LDTP00127 4.61  LDD0348 
Nuclear pore complex protein Nup153 (NUP153) LDTP04309 11.15  LDD0348 
Nuclear pore complex protein Nup50 (NUP50) LDTP13498 4.16  LDD0348 
Nuclear pore glycoprotein p62 (NUP62) LDTP03839 4.46  LDD0348 
Nucleoporin NUP35 (NUP35) LDTP09204 6.17  LDD0348 
Nucleoporin p58/p45 (NUP58) LDTP11293 7.18  LDD0348 
Protein Aster-A (GRAMD1A) LDTP10181 7.44  LDD0348 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 5.09  LDD0348 
Reticulon-1 (RTN1) LDTP06633 52.30  LDD0348 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 4.96  LDD0348 
Stromal interaction molecule 2 (STIM2) LDTP13018 18.24  LDD0348 
SUN domain-containing protein 1 (SUN1) LDTP01454 6.42  LDD0348 
Synaptosomal-associated protein 23 (SNAP23) LDTP00198 4.03  LDD0348 
Syntaxin-17 (STX17) LDTP04770 15.88  LDD0348 
Transport and Golgi organization protein 1 homolog (MIA3) LDTP07002 5.66  LDD0348 
Vezatin (VEZT) LDTP12191 46.27  LDD0348 
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) LDTP08040 10.67  LDD0348 
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⏷ Show the Full List of 26 Transporter and channel
3 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) LDTP02970 13.00  LDD0348 
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) LDTP06748 5.63  LDD0348 
Transcription regulator protein BACH1 (BACH1) LDTP00461 11.59  LDD0348 
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46 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
A-kinase anchor protein 1, mitochondrial (AKAP1) LDTP09837 12.79  LDD0348 
A-kinase anchor protein 12 (AKAP12) LDTP05382 14.51  LDD0348 
Anamorsin (CIAPIN1) LDTP07385 5.24  LDD0348 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 22.73  LDD0348 
BAG family molecular chaperone regulator 5 (BAG5) LDTP13507 7.64  LDD0348 
Calcium-regulated heat-stable protein 1 (CARHSP1) LDTP13916 4.84  LDD0348 
CDGSH iron-sulfur domain-containing protein 2 (CISD2) LDTP08902 8.99  LDD0348 
Cell division cycle-associated protein 2 (CDCA2) LDTP07345 8.65  LDD0348 
Collagen alpha-2(IV) chain (COL4A2) LDTP02282 8.20  LDD0348 
Dynactin subunit 4 (DCTN4) LDTP13402 5.60  LDD0348 
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) LDTP05915 6.44  LDD0348 
Galectin-3-binding protein (LGALS3BP) LDTP05558 4.39  LDD0348 
Inner nuclear membrane protein Man1 (LEMD3) LDTP13913 6.55  LDD0348 
Laminin subunit beta-1 (LAMB1) LDTP02230 9.94  LDD0348 
Laminin subunit gamma-1 (LAMC1) LDTP02535 19.11  LDD0348 
LIM domain-containing protein 1 (LIMD1) LDTP13241 9.56  LDD0348 
Lipase maturation factor 2 (LMF2) LDTP15887 6.16  LDD0348 
Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) LDTP14217 6.25  LDD0348 
MAP7 domain-containing protein 1 (MAP7D1) LDTP14910 5.05  LDD0348 
MAP7 domain-containing protein 3 (MAP7D3) LDTP08535 5.61  LDD0348 
Membralin (TMEM259) LDTP14939 5.79  LDD0348 
Nesprin-2 (SYNE2) LDTP09702 23.42  LDD0348 
Nicastrin (NCSTN) LDTP09787 13.56  LDD0348 
Opioid growth factor receptor (OGFR) LDTP16155 4.71  LDD0348 
Oxysterol-binding protein-related protein 11 (OSBPL11) LDTP11367 4.25  LDD0348 
Protein ITPRID2 (ITPRID2) LDTP03426 12.01  LDD0348 
Protein LTV1 homolog (LTV1) LDTP15727 4.24  LDD0348 
Protein transport protein Sec16A (SEC16A) LDTP00512 35.65  LDD0348 
RAD50-interacting protein 1 (RINT1) LDTP07476 4.41  LDD0348 
Reticulon-3 (RTN3) LDTP01522 55.05  LDD0348 
Signal recognition particle receptor subunit alpha (SRPRA) LDTP02263 4.68  LDD0348 
Spartin (SPART) LDTP08735 4.33  LDD0348 
Tetratricopeptide repeat protein 1 (TTC1) LDTP15840 6.15  LDD0348 
Torsin-1A-interacting protein 2 (TOR1AIP2) LDTP09215 10.04  LDD0348 
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) LDTP14426 4.08  LDD0348 
Transducin beta-like protein 2 (TBL2) LDTP16285 5.14  LDD0348 
Transforming acidic coiled-coil-containing protein 1 (TACC1) LDTP01210 180.99  LDD0348 
Transforming acidic coiled-coil-containing protein 3 (TACC3) LDTP14228 7.20  LDD0348 
Transmembrane protein 209 (TMEM209) LDTP18272 17.82  LDD0348 
Trinucleotide repeat-containing gene 6A protein (TNRC6A) LDTP09137 6.15  LDD0348 
UBX domain-containing protein 4 (UBXN4) LDTP09806 53.07  LDD0348 
Uncharacterized protein FAM241A (FAM241A) LDTP19744 6.21  LDD0348 
Uncharacterized protein KIAA0930 (KIAA0930) LDTP17325 4.42  LDD0348 
UPF0488 protein C8orf33 (C8orf33) LDTP12025 4.21  LDD0348 
Vesicle-trafficking protein SEC22a (SEC22A) LDTP10431 4.46  LDD0348 
WD repeat-containing protein 41 (WDR41) LDTP12123 4.19  LDD0348 
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⏷ Show the Full List of 46 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
15 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0348 
Download The Altas

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348