Details of the Target

General Information of Target

Target ID LDTP13241
Target Name LIM domain-containing protein 1 (LIMD1)
Gene Name LIMD1
Gene ID 8994
Synonyms
LIM domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
Target Bioclass
Other
Family
Zyxin/ajuba family
Subcellular location
Cytoplasm
Function
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation.
Uniprot ID
Q9UGP4
Ensemble ID
ENST00000273317.5
HGNC ID
HGNC:6612

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		9.56  LDD0348  [2]
HRP
 Probe Info  		5.38  LDD0347  [2]
BTD
 Probe Info  		C305(1.14)  LDD2090  [3]
DA-P3
 Probe Info  		19.45  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C401(20.00); C305(5.75); C148(20.00)  LDD0169  [4]
DBIA
 Probe Info  		C305(0.95)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C472(0.00); C148(0.00); C560(0.00); C431(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C472(0.00); C148(0.00); C560(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		C305(0.00); C374(0.00); C401(0.00); C431(0.00)  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
aHNE
 Probe Info  		N.A.  LDD0001  [9]
Compound 10
 Probe Info  		C305(0.00); C431(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		C305(0.00); C431(0.00)  LDD2213  [10]
IPM
 Probe Info  		C431(0.00); C401(0.00); C305(0.00)  LDD0005  [9]
VSF
 Probe Info  		C148(0.00); C374(0.00); C305(0.00); C401(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C305(0.00); C431(0.00); C374(0.00); C401(0.00)  LDD0018  [11]
Methacrolein
 Probe Info  		C222(0.00); C148(0.00)  LDD0218  [12]
W1
 Probe Info  		C305(0.00); C148(0.00)  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C401(20.00); C305(5.75); C148(20.00)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C222(1.13)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C222(0.72)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C222(0.96)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C222(1.09)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C222(0.75)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C222(1.29)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C222(1.03)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C222(1.44)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C222(0.98)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C222(1.40)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C222(0.88)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C222(0.78)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C222(1.14)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C222(0.88)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C222(0.81)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C222(1.08)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C222(0.97)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C222(0.95)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C222(1.09)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C222(0.90)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C222(1.63)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C222(1.05)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C222(1.05)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C222(0.82)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C222(0.75)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C222(1.72)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C222(1.00)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C222(2.54)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C222(1.28)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C222(0.76)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C222(0.87)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C222(1.02)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C597(1.52); C222(1.09)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C597(0.61); C222(1.09)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C597(0.75); C222(1.24)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C597(0.73); C222(0.96)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C597(0.75); C222(1.33)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C597(0.48); C222(0.73)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C597(0.54); C222(0.98)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C597(0.54); C222(0.82)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C597(0.70); C222(1.26)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C597(0.45); C222(1.13)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C597(0.44); C222(1.13)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C597(0.43); C222(1.27)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C222(0.68)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C597(0.54); C222(0.97)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C597(0.41); C222(1.22)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C597(0.53); C222(1.19)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C222(0.91)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C222(1.10)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C222(1.03)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C222(0.90)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C222(0.90)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C222(0.94)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C222(1.04)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C222(1.01)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C222(0.92)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C222(1.07)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C222(0.80)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C222(0.90)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C222(0.86)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C222(1.04)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C222(0.94)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C222(0.85)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C222(1.18)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C222(0.68)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C222(1.11)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C222(1.06)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C222(1.22)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C222(1.10)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C222(1.01)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C222(1.14)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C222(1.19)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C597(1.07); C600(0.84)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C597(1.05); C600(0.99)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C597(0.95); C600(1.11)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C597(0.80); C600(1.11)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C597(0.79); C600(1.27)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C222(0.99)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C597(1.06); C600(0.75)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C597(0.85); C600(0.99)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C597(0.89); C600(1.15)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C597(0.94); C600(0.97)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C597(0.96); C600(1.16)  LDD0893  [5]
 LDCM0296  AC35 HCT 116 C222(1.11)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C222(1.28)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C222(1.41)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C222(1.08)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C222(1.21)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C222(1.21)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C222(1.46)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C222(1.52)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C222(1.36)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C222(1.50)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C222(1.34)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C222(1.52)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C222(1.36)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C222(1.45)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C222(1.97)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C222(1.78)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C222(0.91)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C222(1.37)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C222(1.04)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C222(1.35)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C222(1.32)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C222(1.58)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C222(1.69)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C222(2.11)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C222(1.38)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C222(1.48)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C222(1.48)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C222(1.05)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C222(1.71)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C222(1.54)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C222(2.25)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C222(1.09)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C222(1.60)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C222(0.56)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C222(0.61)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C222(0.63)  LDD0648  [5]
 LDCM0332  AC68 HEK-293T C597(1.39); C222(0.86)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C597(1.65); C222(0.99)  LDD0931  [5]
 LDCM0334  AC7 HCT 116 C222(0.99)  LDD0651  [5]
 LDCM0335  AC70 HEK-293T C597(1.02); C222(0.81)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C597(1.10); C222(0.83)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C597(2.57); C222(0.91)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C597(0.81); C222(0.62)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C597(1.29); C222(0.79)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C597(1.96); C222(0.83)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C597(1.58); C222(1.20)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C597(1.43); C222(0.99)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C597(1.61); C222(0.98)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C597(1.33); C222(0.99)  LDD0942  [5]
 LDCM0345  AC8 HCT 116 C222(0.88)  LDD0662  [5]
 LDCM0346  AC80 HEK-293T C597(1.23); C222(1.03)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C597(1.22); C222(1.18)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C597(1.06); C222(1.20)  LDD0946  [5]
 LDCM0349  AC83 HCT 116 C222(1.29)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C222(1.12)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C222(0.92)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C222(0.97)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C222(0.99)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C222(1.12)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C222(1.05)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C222(1.20)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C222(0.94)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C222(1.14)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C222(1.03)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C222(0.65)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C222(1.29)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C222(0.85)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C222(1.12)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C222(1.95)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C222(0.94)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C222(0.70)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C222(1.19)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C222(0.80)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C305(0.95)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C431(0.57)  LDD2091  [3]
 LDCM0087  Capsaicin HEK-293T 6.42  LDD0185  [2]
 LDCM0632  CL-Sc Hep-G2 C431(1.32); C431(0.79); C401(0.44)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C222(1.10)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C222(0.88)  LDD0966  [5]
 LDCM0369  CL100 HCT 116 C222(1.09)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C222(0.79)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C222(0.81)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C222(0.69)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C222(0.69)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C222(1.41)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C222(1.44)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C222(1.37)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C222(1.31)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C222(1.46)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C222(0.85)  LDD0977  [5]
 LDCM0380  CL110 HCT 116 C222(1.69)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C222(1.23)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C597(1.02); C600(1.34)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C597(0.90); C600(1.09)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C597(0.73); C600(1.11)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C597(0.92); C600(1.56)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C597(0.91); C600(1.04)  LDD0984  [5]
 LDCM0387  CL117 HCT 116 C222(1.13)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C222(1.15)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C222(1.35)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C222(0.90)  LDD0988  [5]
 LDCM0391  CL120 HCT 116 C222(1.51)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C222(1.00)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C222(1.17)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C222(1.30)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C222(1.42)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C222(1.05)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C222(1.00)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C222(0.85)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C222(1.27)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C222(0.84)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C222(1.00)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C222(0.89)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C222(1.25)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C222(1.06)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C222(1.08)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C222(1.07)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C222(0.98)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C222(1.18)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C222(1.44)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C222(1.28)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C222(1.38)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C222(1.06)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C222(1.03)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C222(1.66)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C222(1.08)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C222(1.32)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C222(1.16)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C222(0.80)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C222(1.70)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C597(2.03)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C597(1.01)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C597(0.91)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C597(0.87)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C597(1.13)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C597(0.69)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C597(0.67)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C597(0.49)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C222(1.19)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C597(0.97)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C597(0.64)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C597(0.68)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C597(0.64)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C597(0.93)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C597(0.70)  LDD1033  [5]
 LDCM0436  CL46 HCT 116 C222(1.11)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C222(0.76)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C222(0.85)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C222(1.03)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C222(0.96)  LDD1038  [5]
 LDCM0441  CL50 HCT 116 C222(0.84)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C222(1.01)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C222(1.04)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C222(1.25)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C222(0.98)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C222(0.83)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C222(0.78)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C222(0.89)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C222(0.91)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C222(1.10)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C222(0.90)  LDD1049  [5]
 LDCM0452  CL60 HCT 116 C222(0.94)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C222(1.01)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C222(1.06)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C222(0.85)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C222(0.52)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C222(0.72)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C222(0.77)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C222(0.67)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C222(0.82)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C222(0.83)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C222(0.93)  LDD1060  [5]
 LDCM0463  CL70 HCT 116 C222(0.90)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C222(0.67)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C222(1.08)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C222(0.71)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C222(0.91)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C222(1.00)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C222(0.89)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C222(0.96)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C222(0.86)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C222(1.71)  LDD1071  [5]
 LDCM0474  CL80 HCT 116 C222(0.83)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C222(0.88)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C222(0.76)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C222(0.90)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C222(0.92)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C222(0.91)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C222(0.98)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C222(0.84)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C222(0.81)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C222(0.98)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C222(0.75)  LDD1082  [5]
 LDCM0485  CL90 HCT 116 C222(0.87)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C222(1.18)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C222(1.05)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C222(1.08)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C222(1.41)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C222(1.45)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C222(1.05)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C222(1.15)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C222(1.22)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C222(1.09)  LDD0811  [5]
 LDCM0027  Dopamine HEK-293T 19.45  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C148(1.15); C222(1.05); C374(1.29); C305(1.06)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C222(1.22); C374(1.12); C431(1.06); C305(0.73)  LDD1702  [3]
 LDCM0031  Epigallocatechin gallate HEK-293T 25.59  LDD0183  [2]
 LDCM0468  Fragment33 HCT 116 C222(0.71)  LDD0785  [5]
 LDCM0427  Fragment51 HEK-293T C597(1.17)  LDD1025  [5]
 LDCM0022  KB02 HCT 116 C305(2.34)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C305(1.42)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C305(1.74)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C431(0.55)  LDD2121  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C305(1.14)  LDD2090  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C305(1.24)  LDD2096  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C374(1.05); C560(1.10)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C431(1.12); C374(0.66)  LDD2107  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C374(0.98)  LDD2111  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C305(0.91)  LDD2118  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C431(0.92)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C560(1.03)  LDD2123  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C305(1.21)  LDD2126  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C560(1.00)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C374(0.74)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C305(0.89)  LDD2143  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C431(0.41)  LDD2150  [3]
 LDCM0032  Oleacein HEK-293T 5.76  LDD0184  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C305(1.04)  LDD2207  [16]
 LDCM0029  Quercetin HEK-293T 6.24  LDD0181  [2]
 LDCM0131  RA190 MM1.R C305(2.65); C374(1.87)  LDD0304  [17]
 LDCM0021  THZ1 HCT 116 C305(1.07)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-1 (AGO1) Argonaute family Q9UL18

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.