Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DA-P3  Probe Info 
Probe concentration 15 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Capsaicin  Competitor Info 
Competitor Concentration 150 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00598  Serine palmitoyltransferase 2 (SPTLC2) 108.4
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 69.1
 LDTP03481  DNA-3-methyladenine glycosylase (MPG) 45.8
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 42.5
 LDTP08231  E3 ubiquitin-protein ligase ZNF598 (ZNF598) 36.6
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 32.3
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 31.4
 LDTP06214  Kinesin-like protein KIF22 (KIF22) 29.3
 LDTP00497  Cyclin-G-associated kinase (GAK) 24.3
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 24.1
 LDTP02984  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) 18.6
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 18.6
 LDTP04398  Ras-related protein Rab-5C (RAB5C) 17.7
 LDTP00491  Aurora kinase A (AURKA) 16.2
 LDTP04229  MAP kinase-activated protein kinase 2 (MAPKAPK2) 15.6
 LDTP07515  tRNA N(3)-methylcytidine methyltransferase METTL2B (METTL2B) 15.3
 LDTP03003  Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) 13.1
 LDTP12599  Ubiquitin-like-conjugating enzyme ATG3 (ATG3) 12.9
 LDTP10935  Kinesin-like protein KIF2C (KIF2C) 12.8
 LDTP09251  Atlastin-2 (ATL2) 12.7
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) 12.5
 LDTP11571  Uridine-cytidine kinase 2 (UCK2) 12.5
 LDTP00366  Dihydropyrimidinase-related protein 4 (DPYSL4) 12.1
 LDTP00952  Germinal-center associated nuclear protein (MCM3AP) 12.0
 LDTP00837  Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) 11.8
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 11.1
 LDTP03577  S-adenosylmethionine synthase isoform type-2 (MAT2A) 10.9
 LDTP19838  Immunity-related GTPase family Q protein (IRGQ) 10.8
 LDTP11299  Serine/threonine-protein kinase RIO2 (RIOK2) 10.5
 LDTP13589  RNA-binding protein NOB1 (NOB1) 9.9
 LDTP06104  Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) 9.9
 LDTP02333  Glutathione S-transferase P (GSTP1) 9.8
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) 9.5
 LDTP05639  Kinesin-like protein KIF1A (KIF1A) 9.4
 LDTP11996  3'-5' RNA helicase YTHDC2 (YTHDC2) 8.8
 LDTP00225  26S proteasome non-ATPase regulatory subunit 9 (PSMD9) 8.6
 LDTP13682  Transcription termination factor 2 (TTF2) 8.3
 LDTP04435  Interleukin-1 receptor-associated kinase 1 (IRAK1) 8.2
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 7.8
 LDTP08023  Elongation factor-like GTPase 1 (EFL1) 7.7
 LDTP04310  E3 SUMO-protein ligase RanBP2 (RANBP2) 7.0
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) 6.9
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) 6.7
 LDTP14535  6-phosphogluconolactonase (PGLS) 6.6
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 6.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.8
 LDTP00611  E3 ubiquitin-protein ligase Midline-1 (MID1) 5.2
 LDTP00442  DNA-directed RNA polymerase III subunit RPC1 (POLR3A) 5.1
 LDTP08826  Activating signal cointegrator 1 complex subunit 3 (ASCC3) 5.0
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL) 4.9
 LDTP18530  Protein NDRG3 (NDRG3) 4.9
 LDTP01374  Glutaredoxin-3 (GLRX3) 4.9
 LDTP00747  Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) 4.8
 LDTP03946  Glycine--tRNA ligase (GARS1) 4.6
 LDTP05812  Ras GTPase-activating protein-binding protein 1 (G3BP1) 4.5
 LDTP07290  Lysophospholipid acyltransferase LPCAT4 (LPCAT4) 4.3
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) 4.2
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 4.2
 LDTP04542  Thimet oligopeptidase (THOP1) 4.1
 LDTP05344  Kinesin-like protein KIF23 (KIF23) 4.1
 LDTP11909  Serine/threonine-protein kinase WNK1 (WNK1) 4.0
Transporter and channel
Click to Show/Hide to Show 30 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07002  Transport and Golgi organization protein 1 homolog (MIA3) 100.7
 LDTP08040  Zinc finger FYVE domain-containing protein 16 (ZFYVE16) 49.9
 LDTP09204  Nucleoporin NUP35 (NUP35) 28.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 27.7
 LDTP04770  Syntaxin-17 (STX17) 27.1
 LDTP06633  Reticulon-1 (RTN1) 23.1
 LDTP02330  Signal recognition particle 19 kDa protein (SRP19) 23.1
 LDTP11161  Extended synaptotagmin-1 (ESYT1) 14.4
 LDTP03839  Nuclear pore glycoprotein p62 (NUP62) 14.0
 LDTP12272  Prolactin regulatory element-binding protein (PREB) 10.8
 LDTP12191  Vezatin (VEZT) 8.8
 LDTP12510  Aladin (AAAS) 7.9
 LDTP07152  Acyl-CoA-binding domain-containing protein 5 (ACBD5) 7.2
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 6.9
 LDTP06902  mRNA export factor GLE1 (GLE1) 6.8
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 6.6
 LDTP14174  Sorting nexin-5 (SNX5) 6.6
 LDTP04597  Methylosome subunit pICln (CLNS1A) 6.0
 LDTP12292  Junctophilin-1 (JPH1) 5.9
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) 5.6
 LDTP02547  Protein 4.1 (EPB41) 5.6
 LDTP00127  Nuclear envelope pore membrane protein POM 121C (POM121C) 5.5
 LDTP11531  Oxysterol-binding protein-related protein 8 (OSBPL8) 5.4
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 5.1
 LDTP01380  Wolframin (WFS1) 4.9
 LDTP09742  Protein ELYS (AHCTF1) 4.7
 LDTP04800  Nuclear pore complex protein Nup107 (NUP107) 4.4
 LDTP07203  ER membrane protein complex subunit 10 (EMC10) 4.4
 LDTP02307  Annexin A5 (ANXA5) 4.1
 LDTP00198  Synaptosomal-associated protein 23 (SNAP23) 4.1
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 36.1
 LDTP06748  Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) 23.3
 LDTP09564  Zinc finger CCCH domain-containing protein 15 (ZC3H15) 21.4
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3) 21.3
 LDTP03043  Transcription factor BTF3 (BTF3) 13.9
 LDTP02970  Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) 6.2
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09680  Palladin (PALLD) 16.5
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 5.2
Other
Click to Show/Hide to Show 100 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 111.7
 LDTP03151  Oxysterol-binding protein 1 (OSBP) 83.4
 LDTP07522  Centrosomal protein of 85 kDa (CEP85) 82.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 67.8
 LDTP01684  BAG family molecular chaperone regulator 3 (BAG3) 63.3
 LDTP12432  Inner centromere protein (INCENP) 60.6
 LDTP01177  Hyaluronan mediated motility receptor (HMMR) 57.3
 LDTP08535  MAP7 domain-containing protein 3 (MAP7D3) 55.8
 LDTP04112  Microtubule-associated protein 1B (MAP1B) 44.5
 LDTP01021  Perilipin-3 (PLIN3) 43.5
 LDTP09806  UBX domain-containing protein 4 (UBXN4) 43.2
 LDTP16285  Transducin beta-like protein 2 (TBL2) 39.6
 LDTP04199  Protein PRRC2A (PRRC2A) 38.0
 LDTP05172  TATA element modulatory factor (TMF1) 38.0
 LDTP09820  La-related protein 4B (LARP4B) 34.7
 LDTP13383  Protein Hook homolog 1 (HOOK1) 30.5
 LDTP19787  RING finger protein 214 (RNF214) 29.0
 LDTP10656  Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) 28.6
 LDTP10753  Sperm-associated antigen 5 (SPAG5) 28.0
 LDTP15727  Protein LTV1 homolog (LTV1) 28.0
 LDTP09702  Nesprin-2 (SYNE2) 27.2
 LDTP07297  Microtubule-associated protein 1S (MAP1S) 25.6
 LDTP09049  NHL repeat-containing protein 2 (NHLRC2) 25.5
 LDTP11530  Tether containing UBX domain for GLUT4 (ASPSCR1) 23.3
 LDTP08069  HAUS augmin-like complex subunit 6 (HAUS6) 23.0
 LDTP13304  Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) 18.3
 LDTP00019  Shootin-1 (SHTN1) 17.5
 LDTP15057  TBC1 domain family member 9B (TBC1D9B) 17.1
 LDTP13507  BAG family molecular chaperone regulator 5 (BAG5) 16.4
 LDTP05750  Chromatin assembly factor 1 subunit A (CHAF1A) 16.3
 LDTP07005  WD repeat-containing protein 44 (WDR44) 16.3
 LDTP13525  Muskelin (MKLN1) 15.4
 LDTP18272  Transmembrane protein 209 (TMEM209) 15.2
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 14.8
 LDTP04092  Crk-like protein (CRKL) 14.4
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) 14.1
 LDTP01677  Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) 13.9
 LDTP07132  Ubiquitin-associated protein 2 (UBAP2) 13.6
 LDTP13710  Trinucleotide repeat-containing gene 6B protein (TNRC6B) 13.6
 LDTP00737  Centriolar coiled-coil protein of 110 kDa (CCP110) 13.2
 LDTP07345  Cell division cycle-associated protein 2 (CDCA2) 13.0
 LDTP07742  Rab11 family-interacting protein 1 (RAB11FIP1) 12.8
 LDTP04903  Actin-related protein 2 (ACTR2) 12.5
 LDTP15947  Mitochondrial fission regulator 1-like (MTFR1L) 12.2
 LDTP06868  Angiomotin (AMOT) 11.8
 LDTP06268  Condensin complex subunit 2 (NCAPH) 11.5
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) 11.0
 LDTP17214  Protein odr-4 homolog (ODR4) 10.5
 LDTP14104  NEDD8 ultimate buster 1 (NUB1) 10.3
 LDTP12948  Charged multivesicular body protein 5 (CHMP5) 10.0
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) 10.0
 LDTP01105  SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) 9.8
 LDTP08795  GH3 domain-containing protein (GHDC) 9.6
 LDTP06383  Calponin-3 (CNN3) 9.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 9.0
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) 9.0
 LDTP03079  Calpastatin (CAST) 8.9
 LDTP06439  Thyroid receptor-interacting protein 6 (TRIP6) 8.8
 LDTP05556  Golgin subfamily A member 3 (GOLGA3) 8.6
 LDTP01932  Prelamin-A/C (LMNA) 8.1
 LDTP08735  Spartin (SPART) 7.8
 LDTP09837  A-kinase anchor protein 1, mitochondrial (AKAP1) 7.8
 LDTP13817  Nuclear migration protein nudC (NUDC) 7.7
 LDTP00778  Band 4.1-like protein 2 (EPB41L2) 7.4
 LDTP04356  Emerin (EMD) 7.3
 LDTP06042  Desmoglein-2 (DSG2) 7.1
 LDTP07903  La-related protein 4 (LARP4) 7.1
 LDTP01233  PC4 and SFRS1-interacting protein (PSIP1) 6.8
 LDTP07605  La-related protein 1 (LARP1) 6.7
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) 6.6
 LDTP08770  Serine/threonine-protein kinase 11-interacting protein (STK11IP) 6.6
 LDTP18115  Transmembrane protein 131 (TMEM131) 6.6
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 6.4
 LDTP13241  LIM domain-containing protein 1 (LIMD1) 6.4
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) 6.4
 LDTP14978  Protein PRRC2B (PRRC2B) 6.4
 LDTP05821  Polyadenylate-binding protein 4 (PABPC4) 6.1
 LDTP15235  G protein-regulated inducer of neurite outgrowth 1 (GPRIN1) 5.8
 LDTP03778  Protein DEK (DEK) 5.7
 LDTP08888  Oxidation resistance protein 1 (OXR1) 5.6
 LDTP03404  Microtubule-associated protein 4 (MAP4) 5.6
 LDTP01118  WD repeat-containing protein 1 (WDR1) 5.4
 LDTP09266  Protein NEDD1 (NEDD1) 5.4
 LDTP14910  MAP7 domain-containing protein 1 (MAP7D1) 5.3
 LDTP14545  Heat shock 70 kDa protein 4L (HSPA4L) 5.2
 LDTP09655  Ataxin-2-like protein (ATXN2L) 5.1
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 5.1
 LDTP15840  Tetratricopeptide repeat protein 1 (TTC1) 5.0
 LDTP11019  Endophilin-A2 (SH3GL1) 5.0
 LDTP00720  Centromere/kinetochore protein zw10 homolog (ZW10) 4.9
 LDTP18273  MAP7 domain-containing protein 2 (MAP7D2) 4.6
 LDTP11695  Kinesin light chain 2 (KLC2) 4.5
 LDTP08523  Centrosomal protein of 97 kDa (CEP97) 4.5
 LDTP03426  Protein ITPRID2 (ITPRID2) 4.5
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 4.5
 LDTP04395  RNA-binding protein FXR1 (FXR1) 4.4
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) 4.4
 LDTP00766  Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) 4.4
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) 4.1
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) 4.1

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348