Details of the Target

General Information of Target

Target ID LDTP06439
Target Name Thyroid receptor-interacting protein 6 (TRIP6)
Gene Name TRIP6
Gene ID 7205
Synonyms
OIP1; Thyroid receptor-interacting protein 6; TR-interacting protein 6; TRIP-6; Opa-interacting protein 1; OIP-1; Zyxin-related protein 1; ZRP-1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGG
PEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDR
QAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRG
CGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGG
EHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVF
HVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHP
GCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVA
LDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC
Target Bioclass
Other
Family
Zyxin/ajuba family
Subcellular location
Cytoplasm, cytoskeleton
Function
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Uniprot ID
Q15654
Ensemble ID
ENST00000200457.9
HGNC ID
HGNC:12311

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K394R DBIA    Probe Info 
HCC1954 SNV: p.G240V DBIA    Probe Info 
HCT15 SNV: p.P251H DBIA    Probe Info 
HELA SNV: p.S135C .
HSC3 SNV: p.E389Q DBIA    Probe Info 
LS123 SNV: p.T382R DBIA    Probe Info 
MDAMB468 SNV: p.E225Q DBIA    Probe Info 
MFE319 SNV: p.G197D DBIA    Probe Info 
OE33 SNV: p.C399Ter DBIA    Probe Info 
SNU1 SNV: p.A340T DBIA    Probe Info 
T24 SNV: p.F363L DBIA    Probe Info 
WM115 SNV: p.P345L DBIA    Probe Info 
WM2664 SNV: p.P345L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		5.14  LDD0215  [2]
Probe 1
 Probe Info  		Y123(20.88); Y131(13.32); Y213(15.98)  LDD3495  [3]
BTD
 Probe Info  		C429(0.67)  LDD2109  [4]
Sulforaphane-probe2
 Probe Info  		2.92  LDD0042  [5]
DA-P3
 Probe Info  		5.70  LDD0181  [6]
AHL-Pu-1
 Probe Info  		C47(2.00)  LDD0168  [7]
HHS-475
 Probe Info  		Y131(0.82); Y157(2.11); Y149(2.52)  LDD0264  [8]
DBIA
 Probe Info  		C328(1.06); C331(1.06); C310(1.04); C47(1.03)  LDD0078  [9]
IA-alkyne
 Probe Info  		C47(0.00); C328(0.00); C399(0.00); C339(0.00)  LDD0162  [10]
TFBX
 Probe Info  		C181(0.00); C476(0.00)  LDD0027  [11]
IPM
 Probe Info  		C328(0.00); C310(0.00); C181(0.00)  LDD0005  [12]
VSF
 Probe Info  		C54(0.00); C47(0.00)  LDD0007  [12]
Phosphinate-6
 Probe Info  		C362(0.00); C54(0.00); C181(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		C47(0.00); C429(0.00); C54(0.00); C331(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		C47(0.00); C429(0.00); C54(0.00)  LDD0218  [14]
AOyne
 Probe Info  		14.40  LDD0443  [15]
NAIA_5
 Probe Info  		C331(0.00); C328(0.00); C429(0.00)  LDD2223  [16]
HHS-465
 Probe Info  		Y131(0.00); Y157(0.00); Y149(0.00); K137(0.00)  LDD2240  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C47(2.00)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C54(2.17); C47(3.17)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C339(1.48); C342(1.40); C47(0.91); C279(1.05)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C339(1.02); C342(1.02); C47(0.97); C279(0.71)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C339(0.82); C342(0.82); C47(0.97); C304(0.95)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C339(0.84); C342(0.84); C47(0.91); C304(0.95)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C339(0.84); C342(0.84); C47(1.04); C304(0.96)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C339(0.95); C342(0.95); C47(1.36); C304(1.03)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C339(0.94); C342(0.94); C47(1.21); C304(0.92)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C339(1.02); C342(1.02); C47(1.23); C304(1.04)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C339(1.04); C342(1.04); C47(1.22); C304(0.98)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C339(1.02); C342(0.83); C47(1.17); C304(0.96)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C339(0.83); C342(0.89); C47(1.01); C304(0.93)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C339(0.83); C342(0.83); C47(1.07); C304(0.88)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C339(1.01); C342(1.01); C47(1.17); C279(0.97)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C339(0.81); C342(0.84); C47(1.18); C304(0.98)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C339(0.77); C342(0.87); C47(1.18); C304(1.05)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C339(0.87); C342(0.91); C47(1.27); C304(1.15)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C339(0.90); C342(0.90); C47(0.95); C279(1.03)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C339(1.30); C342(1.57); C47(1.19); C279(1.33)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C339(1.36); C342(1.40); C47(1.40); C279(1.30)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C339(1.07); C342(1.19); C47(1.46); C279(1.36)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C339(1.09); C342(1.12); C47(1.12); C279(0.92)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C339(1.29); C342(1.26); C47(1.07); C279(1.27)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C339(1.31); C342(1.41); C47(1.28); C279(0.97)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C339(1.10); C342(1.10); C47(0.98); C279(0.81)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C339(1.00); C342(1.25); C47(1.28); C279(1.21)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C339(1.14); C342(1.28); C47(0.94); C279(0.88)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C339(1.19); C342(1.27); C47(1.23); C279(0.91)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C339(1.09); C342(1.01); C47(1.03); C279(1.08)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C339(1.43); C342(1.47); C47(1.06); C279(1.02)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C339(1.24); C342(1.20); C47(1.18); C279(1.15)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C339(1.29); C342(1.42); C47(1.48); C279(1.16)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C339(1.11); C342(1.14); C47(1.45); C279(0.93)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C339(0.65); C342(0.65); C47(0.76); C279(0.98)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C339(0.60); C342(0.60); C47(0.69); C279(0.59)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C339(0.60); C342(0.60); C47(0.85); C279(0.86)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C339(0.56); C342(0.56); C47(0.76); C279(0.93)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C339(0.62); C342(0.62); C47(0.61); C279(0.77)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C339(0.55); C342(0.55); C47(0.65); C279(0.89)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C339(0.59); C342(0.59); C47(0.71); C279(0.93)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C339(0.70); C342(0.70); C47(0.67); C279(0.85)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C339(0.62); C342(0.62); C47(0.66); C279(0.91)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C339(0.64); C342(0.64); C47(0.71); C279(0.87)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C339(0.57); C342(0.57); C47(0.74); C279(0.94)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C339(0.70); C342(0.70); C47(0.68); C279(0.89)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C339(1.17); C342(1.17); C47(1.10); C279(0.98)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C339(0.68); C342(0.68); C47(0.77); C279(1.02)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C339(0.74); C342(0.74); C47(0.76); C279(0.96)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C339(0.62); C342(0.62); C47(0.54); C279(0.89)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C339(0.81); C342(0.69); C47(1.34); C457(0.82)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C339(0.75); C457(0.91); C342(0.95); C279(0.95)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C457(0.75); C339(0.81); C279(0.97); C282(0.97)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C279(1.00); C282(1.00); C362(1.02); C368(1.03)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C279(0.81); C282(0.81); C339(1.00); C365(1.06)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C339(0.88); C457(0.99); C279(1.03); C282(1.03)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C339(0.78); C457(1.05); C342(1.16); C402(1.23)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C279(0.96); C282(0.96); C365(0.96); C368(0.96)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C279(0.84); C282(0.84); C339(0.85); C457(0.98)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C457(0.74); C279(0.80); C282(0.80); C339(0.85)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C339(0.85); C279(0.97); C282(0.97); C402(0.99)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C339(0.90); C279(1.22); C282(1.22); C365(1.22)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C339(0.98); C342(1.23); C47(1.66); C279(1.15)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C339(1.00); C342(1.31); C47(1.74); C279(1.03)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C339(0.80); C342(1.08); C47(1.43); C279(1.16)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C339(0.90); C342(1.23); C47(1.49); C279(0.99)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C457(0.51); C432(0.68); C445(0.68); C339(0.73)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C339(0.66); C342(0.66); C457(0.72); C399(0.76)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C339(0.92); C342(0.92); C457(1.01); C402(1.03)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C54(0.82); C47(0.88); C399(0.91); C342(0.91)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C457(0.62); C339(0.89); C342(0.89); C432(0.98)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C457(0.43); C432(0.69); C445(0.69); C339(0.79)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C457(0.62); C432(0.84); C445(0.84); C339(0.87)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C457(0.51); C432(0.68); C445(0.68); C339(0.75)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C457(0.60); C432(0.75); C445(0.75); C435(0.91)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C279(0.64); C282(0.64); C445(0.88); C448(0.88)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C279(0.81); C282(0.81); C310(0.95); C304(1.11)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C365(1.03); C368(1.03); C310(1.05); C445(1.15)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C445(0.98); C448(0.98); C310(0.98); C365(1.09)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C279(0.93); C282(0.93); C307(1.12); C304(1.15)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C365(0.68); C368(0.87); C54(0.89); C304(0.91)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C279(1.02); C282(1.02); C310(1.09); C307(1.17)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C279(0.77); C282(0.77); C310(1.09); C304(1.14)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C279(1.05); C282(1.05); C310(1.28); C304(1.33)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C279(0.93); C282(0.93); C445(1.00); C448(1.00)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C279(0.87); C282(0.87); C476(1.13); C310(1.22)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C399(0.77); C402(0.80); C339(0.80); C342(0.80)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C279(0.71); C282(0.71); C339(0.75); C342(0.75)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C365(0.70); C368(0.70); C279(0.92); C282(0.92)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C365(0.66); C368(0.66); C279(0.77); C282(0.77)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C310(0.85); C365(0.86); C368(0.86); C304(0.90)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C365(0.61); C368(0.85); C54(0.87); C399(0.93)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C365(0.77); C368(0.77); C310(1.02); C304(1.05)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C339(0.54); C342(0.54); C365(0.76); C368(0.76)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C339(0.67); C342(0.67); C279(0.82); C282(0.82)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C365(0.74); C368(0.74); C339(0.79); C342(0.79)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C279(0.90); C282(0.90); C339(0.99); C342(0.99)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C339(0.56); C342(0.56); C365(1.03); C368(1.03)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C339(0.82); C342(0.82); C399(0.99); C365(1.00)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C339(0.82); C342(0.82); C365(0.83); C368(0.83)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C365(0.82); C368(0.82); C304(0.90); C339(0.92)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C339(1.07); C342(1.07); C365(1.18); C368(1.18)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C54(0.68); C365(0.69); C47(0.75); C399(0.82)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C304(1.10); C365(1.12); C368(1.12); C339(1.14)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C339(0.81); C342(0.81); C365(0.89); C368(0.89)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C339(0.93); C342(0.93); C362(0.97); C365(0.97)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C365(0.92); C368(0.92); C304(0.97); C362(0.97)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C304(1.03); C339(1.03); C342(1.03); C362(1.17)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C339(0.82); C342(0.82); C362(1.03); C365(1.10)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C339(0.90); C342(0.90); C362(1.22); C304(1.39)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C368(0.62); C365(0.72); C445(0.86); C448(0.86)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C445(0.66); C448(0.66); C368(0.80); C365(0.85)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C368(0.76); C365(0.82); C54(0.89); C445(0.99)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C445(0.77); C279(0.84); C282(0.84); C365(0.88)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C445(0.83); C448(0.83); C339(0.90); C342(0.90)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C368(0.79); C365(0.83); C54(0.92); C339(0.95)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C368(0.74); C365(0.82); C54(0.93); C47(0.97)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C368(0.79); C365(0.80); C445(0.87); C448(0.87)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C368(0.86); C365(0.97); C54(1.03); C445(1.04)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C445(0.78); C448(0.78); C339(0.87); C342(0.87)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C445(0.81); C448(0.81); C399(0.82); C402(0.82)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C368(0.89); C399(0.91); C402(0.91); C365(0.94)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C54(1.02); C304(1.02); C368(1.05); C310(1.06)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C365(0.95); C368(0.98); C328(1.03); C304(1.04)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C279(0.70); C282(0.70); C365(0.74); C368(0.74)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C368(0.90); C304(0.91); C365(0.92); C339(0.94)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C307(0.80); C310(0.82); C331(0.83); C328(0.84)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C304(1.01); C365(1.01); C331(1.03); C368(1.05)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C339(1.64); C342(1.64); C47(2.15); C368(0.97)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C279(1.01); C282(1.01); C362(1.02); C368(1.02)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C368(1.08); C362(1.10); C365(1.11); C339(1.22)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C368(0.89); C365(0.92); C304(0.97); C307(0.99)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C362(1.09); C328(1.12); C368(1.12); C307(1.13)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C365(0.81); C368(0.82); C339(0.83); C342(0.83)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C368(0.83); C365(0.86); C362(0.91); C328(0.93)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C365(0.81); C368(0.81); C304(1.05); C47(1.06)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C368(0.85); C365(0.87); C307(0.96); C362(0.97)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C339(0.73); C342(0.73); C362(0.80); C368(0.80)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C339(0.93); C342(0.93); C368(0.97); C362(0.99)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C339(0.75); C342(0.75); C368(1.18); C365(1.22)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C339(0.86); C342(0.86); C368(1.11); C365(1.12)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C368(0.93); C365(0.94); C399(0.96); C339(0.97)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C368(0.92); C279(0.95); C282(0.95); C339(0.96)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C279(0.88); C282(0.88); C368(0.88); C365(0.91)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C435(0.77); C339(0.97); C342(0.97); C448(0.99)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C279(0.82); C282(0.82); C368(1.00); C365(1.03)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C368(0.60); C365(0.64); C435(0.68); C448(0.74)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C339(1.17); C342(1.17); C368(1.29); C365(1.33)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C368(0.72); C365(0.75); C445(1.02); C448(1.03)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C368(0.76); C365(0.78); C445(0.86); C339(0.86)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C339(0.89); C342(0.89); C399(0.94); C368(0.94)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C279(0.80); C282(0.80); C368(0.90); C365(0.92)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C365(0.92); C368(0.93); C279(0.94); C282(0.94)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C476(1.10); C279(1.17); C282(1.17); C368(1.19)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C476(0.84); C339(0.96); C342(0.96); C432(1.01)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C339(0.67); C342(0.67); C432(0.77); C399(0.82)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C339(1.17); C342(1.17); C47(0.92); C279(0.84)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C365(0.79); C368(0.79); C54(0.96); C328(0.97)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C365(0.91); C368(0.91); C339(1.11); C342(1.11)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.90  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C328(1.06); C331(1.06); C310(1.04); C47(1.03)  LDD0078  [9]
 LDCM0087  Capsaicin HEK-293T 8.85  LDD0185  [6]
 LDCM0108  Chloroacetamide HeLa C331(0.00); C429(0.00); C47(0.00)  LDD0222  [14]
 LDCM0367  CL1 HCT 116 C339(0.46); C342(0.46); C279(0.54); C282(0.54)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C339(0.45); C342(0.45); C279(0.58); C282(0.58)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C339(0.72); C365(0.72); C342(0.81); C399(0.82)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C279(1.06); C282(1.06); C328(1.08); C54(1.11)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C279(0.75); C282(0.75); C339(0.85); C342(0.85)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C279(0.78); C282(0.78); C328(0.93); C47(0.96)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C279(0.86); C282(0.86); C328(0.93); C331(0.96)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C457(0.50); C339(0.83); C342(0.83); C399(0.92)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C457(0.52); C339(0.67); C342(0.67); C399(0.99)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C457(0.51); C432(0.98); C445(0.98); C399(1.05)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C457(0.85); C399(1.01); C339(1.03); C342(1.03)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C457(0.71); C339(0.91); C342(0.91); C432(0.96)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C339(0.55); C342(0.55); C365(0.90); C445(0.91)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C457(0.60); C402(0.78); C399(0.79); C339(0.83)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C339(0.62); C342(0.62); C457(0.63); C399(0.76)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C310(0.83); C399(0.88); C279(0.89); C282(0.89)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C279(0.88); C282(0.88); C310(1.09); C304(1.15)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C365(0.83); C368(0.83); C476(0.92); C279(0.93)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C279(0.94); C282(0.94); C310(1.11); C304(1.17)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C279(0.77); C282(0.77); C310(1.04); C476(1.04)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C339(0.87); C342(0.87); C365(1.07); C368(1.07)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C339(0.59); C342(0.59); C365(0.88); C368(0.88)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C365(0.83); C368(0.83); C279(0.89); C282(0.89)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C339(0.93); C342(0.93); C365(0.94); C368(0.99)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C365(0.66); C368(0.66); C304(0.94); C279(0.94)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C339(0.77); C342(0.77); C362(1.14); C328(1.71)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C304(0.81); C339(0.89); C342(0.89); C54(0.91)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C339(0.64); C342(0.64); C399(0.76); C402(0.78)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C339(0.81); C342(0.81); C304(1.02); C365(1.07)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C445(0.64); C448(0.64); C368(0.73); C365(0.81)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C339(0.65); C342(0.65); C47(0.84); C54(0.88)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C54(0.87); C339(0.95); C342(0.95); C365(0.99)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C368(0.67); C365(0.72); C54(0.79); C47(1.17)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C339(0.55); C342(0.55); C279(0.76); C282(0.76)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C279(0.54); C282(0.54); C365(0.80); C368(0.82)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C339(0.59); C342(0.59); C279(0.76); C282(0.76)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C339(1.00); C342(1.00); C328(1.01); C47(1.11)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C339(0.83); C342(0.83); C399(0.92); C402(0.92)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C339(0.94); C342(0.94); C54(0.99); C47(1.02)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C339(0.89); C342(0.89); C47(1.01); C54(1.03)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C339(0.52); C342(0.52); C368(0.86); C365(0.91)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C54(1.19); C328(1.32); C47(1.35); C339(1.41)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C339(1.07); C342(1.07); C54(1.10); C365(1.12)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C47(0.86); C54(0.93); C365(1.51); C368(1.51)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C47(0.97); C54(1.03); C328(1.11); C365(1.18)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C47(0.98); C339(1.35); C342(1.35); C279(2.03)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C339(1.17); C342(1.17); C47(0.98); C279(2.06)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C339(1.18); C342(1.18); C47(1.05); C279(1.78)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C339(1.82); C342(1.82); C47(0.88); C279(1.46)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C339(1.38); C342(1.38); C47(1.23); C279(2.00)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C339(1.20); C342(1.20); C47(1.45); C279(2.11)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C339(0.60); C342(0.60); C47(1.15); C279(1.19)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C339(1.17); C342(1.17); C47(1.39); C279(1.44)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C339(1.25); C342(1.16); C47(1.04); C279(1.02)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C339(0.86); C342(0.87); C47(1.13); C279(1.09)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C339(0.51); C342(0.65); C47(1.38); C279(0.50)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C339(1.02); C342(1.02); C47(1.24); C279(1.11)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C339(1.06); C342(1.11); C47(1.76); C279(1.05)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C339(1.15); C342(1.11); C47(1.19); C279(1.25)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C339(1.23); C342(1.24); C47(1.64); C279(1.04)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C339(1.35); C342(1.39); C47(1.22); C279(0.92)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C339(1.09); C342(1.09); C47(1.33); C279(0.97)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C339(1.07); C342(1.10); C47(1.80); C279(1.03)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C339(1.19); C342(1.23); C47(1.34); C279(1.16)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C339(1.25); C342(1.31); C47(2.14); C279(1.52)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C339(1.18); C342(1.21); C47(1.59); C279(1.12)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C339(0.88); C342(0.86); C47(1.47); C279(0.98)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C339(1.04); C342(0.96); C47(1.72); C279(0.98)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C339(0.72); C342(0.72); C47(0.82); C279(0.87)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C339(0.83); C342(0.83); C47(0.79); C279(0.81)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C339(1.18); C342(1.18); C47(1.08); C279(0.82)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C339(0.92); C342(0.92); C47(1.24); C279(0.85)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C339(0.91); C342(0.91); C47(1.20); C279(0.96)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C339(0.98); C342(0.98); C47(1.17); C279(0.83)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C339(1.76); C342(1.76); C47(1.06); C279(0.75)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C339(1.28); C342(1.28); C47(1.18); C279(0.96)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C339(0.80); C342(0.80); C47(1.18); C279(0.80)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C339(1.05); C342(1.05); C47(1.09); C279(0.96)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C339(1.19); C342(1.19); C47(1.05); C279(0.92)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C339(1.12); C342(1.12); C47(1.08); C279(0.96)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C339(1.11); C342(1.11); C47(0.93); C279(0.92)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C339(1.04); C342(1.04); C47(0.96); C279(0.96)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C339(1.09); C342(1.09); C47(1.02); C279(1.06)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C339(0.41); C342(0.41); C47(1.45); C279(1.08)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C339(0.99); C342(0.99); C47(1.12); C279(0.89)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C47(0.96); C279(1.10); C282(1.10); C304(1.07)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C47(1.05); C279(1.10); C282(1.10); C304(0.95)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C47(1.00); C279(1.21); C282(1.21); C304(0.97)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C47(1.29); C279(1.29); C282(1.29); C304(1.13)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C47(0.86); C279(1.12); C282(1.12); C304(0.99)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C47(1.01); C279(1.36); C282(1.36); C304(1.20)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C47(1.16); C279(1.68); C282(1.68); C304(1.27)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C47(1.02); C279(1.26); C282(1.26); C304(1.04)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C47(1.05); C279(1.07); C282(1.07); C304(0.98)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C339(0.86); C342(0.86); C47(1.25); C279(1.13)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C47(1.16); C279(1.15); C282(1.15); C304(1.06)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C47(1.37); C279(1.14); C282(1.14); C304(1.06)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C47(1.14); C279(1.33); C282(1.33); C304(0.95)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C47(1.19); C279(1.00); C282(1.00); C304(0.99)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C47(1.28); C279(1.12); C282(1.12); C304(1.02)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C339(0.66); C342(0.66); C47(1.01); C279(0.94)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C339(0.69); C342(0.69); C47(0.81); C279(0.86)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C339(0.73); C342(0.73); C47(1.14); C279(0.97)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C339(0.96); C342(0.96); C47(1.15); C279(1.05)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C339(0.90); C342(0.90); C47(2.28); C279(0.88)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C339(0.90); C342(0.90); C47(0.75); C279(0.76)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C339(0.93); C342(0.93); C47(1.09); C279(0.76)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C339(0.91); C342(0.91); C47(0.88); C279(1.00)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C339(0.95); C342(0.95); C47(0.98); C279(0.86)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C339(0.80); C342(0.80); C47(1.14); C279(1.04)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C339(0.73); C342(0.73); C47(1.23); C279(0.98)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C339(0.76); C342(0.76); C47(0.77); C279(1.03)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C339(0.91); C342(0.91); C47(0.76); C279(0.92)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C339(1.12); C342(1.12); C47(0.94); C279(0.96)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C339(0.98); C342(0.98); C47(1.35); C279(1.31)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C339(0.87); C342(0.87); C47(1.13); C279(0.81)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C339(0.64); C342(0.64); C47(0.96); C279(0.69)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C339(0.46); C342(0.83); C47(1.13); C279(0.90)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C339(0.82); C342(0.82); C47(1.04); C279(0.73)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C339(1.25); C342(0.90); C47(0.94); C279(0.99)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C339(1.26); C342(0.94); C47(1.06); C279(1.11)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C339(1.25); C342(0.91); C47(1.16); C279(1.09)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C339(2.01); C342(1.34); C47(1.02); C279(1.09)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C339(1.70); C342(1.27); C47(0.97); C279(1.10)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C339(1.91); C342(1.18); C47(0.95); C279(0.99)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C339(1.46); C342(1.05); C47(1.08); C279(1.16)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C476(0.52)  LDD2228  [16]
 LDCM0495  E2913 HEK-293T C429(1.03); C387(0.90); C47(0.79); C328(0.71)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C328(1.09); C429(1.08); C460(0.90)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C47(1.13); C279(1.23); C282(1.23); C304(1.08)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C339(1.37); C342(1.30); C47(2.18); C279(1.18)  LDD0744  [9]
 LDCM0116  HHS-0101 DM93 Y131(0.82); Y157(2.11); Y149(2.52)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y131(0.64); Y149(2.53); Y157(8.34)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y157(0.14); Y131(0.75); Y149(2.06)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y131(0.70); Y327(1.76); Y149(4.60)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y131(1.08); Y149(1.40); Y157(2.39)  LDD0268  [8]
 LDCM0107  IAA HeLa H41(0.00); C429(0.00)  LDD0221  [14]
 LDCM0022  KB02 HCT 116 C47(3.13); C54(3.13); C304(2.02); C339(1.76)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C47(1.76); C54(1.76); C304(2.71); C339(2.29)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C47(2.59); C54(2.59); C304(2.15); C339(1.77)  LDD0082  [9]
 LDCM0030  Luteolin HEK-293T 10.85  LDD0182  [6]
 LDCM0109  NEM HeLa H41(0.00); H34(0.00)  LDD0223  [14]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C429(0.67)  LDD2109  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C429(1.10)  LDD2119  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C429(1.00)  LDD2129  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C429(1.45)  LDD2136  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C429(1.32)  LDD2144  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C328(0.34)  LDD2206  [20]
 LDCM0032  Oleacein HEK-293T 5.08  LDD0184  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C328(0.74)  LDD2207  [20]
 LDCM0029  Quercetin HEK-293T 5.70  LDD0181  [6]
 LDCM0003  Sulforaphane MCF-7 2.92  LDD0042  [5]
 LDCM0021  THZ1 HCT 116 C304(1.34); C307(1.34); C310(1.34); C47(1.23)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Inositol hexakisphosphate kinase 3 (IP6K3) Inositol phosphokinase (IPK) family Q96PC2
Methyltransferase-like protein 17, mitochondrial (METTL17) Rsm22 family Q9H7H0
Methionine-R-sulfoxide reductase B3 (MSRB3) MsrB Met sulfoxide reductase family Q8IXL7
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Kallikrein-15 (KLK15) Peptidase S1 family Q9H2R5
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Tyrosine-protein kinase receptor Tie-1 (TIE1) Tyr protein kinase family P35590
Tyrosine-protein phosphatase non-receptor type 14 (PTPN14) Protein-tyrosine phosphatase family Q15678
Transforming protein RhoA (RHOA) Rho family P61586
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
E3 ubiquitin ligase TRAF3IP2 (TRAF3IP2) . O43734
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Tripartite motif-containing protein 29 (TRIM29) . Q14134
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit O, mitochondrial (ATP5PO) ATPase delta chain family P48047
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Huntingtin (HTT) Huntingtin family P42858
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
ADP/ATP translocase 3 (SLC25A6) Mitochondrial carrier (TC 2.A.29) family P12236
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A9 (HOXA9) Abd-B homeobox family P31269
Homeobox protein Hox-B9 (HOXB9) Abd-B homeobox family P17482
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Zinc finger protein 785 (ZNF785) Krueppel C2H2-type zinc-finger protein family A8K8V0
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Transcription factor RFX3 (RFX3) RFX family P48380
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Forkhead box protein D4-like 1 (FOXD4L1) . Q9NU39
Zinc finger protein 541 (ZNF541) . Q9H0D2
Zinc finger protein 580 (ZNF580) . Q9UK33
Zinc finger protein 581 (ZNF581) . Q9P0T4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) Immunoglobulin superfamily Q99706
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ciliary neurotrophic factor (CNTF) CNTF family P26441
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Other
Click To Hide/Show 50 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Ataxin-1 (ATXN1) ATXN1 family P54253
Beta-crystallin A4 (CRYBA4) Beta/gamma-crystallin family P53673
Protein BEX2 (BEX2) BEX family Q9BXY8
Bystin (BYSL) Bystin family Q13895
Enhancer of filamentation 1 (NEDD9) CAS family Q14511
Cancer/testis antigen 2 (CTAG2) CTAG/PCC1 family O75638
Mammalian ependymin-related protein 1 (EPDR1) Ependymin family Q9UM22
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) G-alpha family P04899
Protein INCA1 (INCA1) INCA family Q0VD86
Protein MEMO1 (MEMO1) MEMO1 family Q9Y316
Protein Mis18-beta (OIP5) Mis18 family O43482
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
GPI transamidase component PIG-S (PIGS) PIGS family Q96S52
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Putative POM121-like protein 1 (POM121L1P) POM121 family Q3SYA9
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
Migration and invasion enhancer 1 (MIEN1) SelWTH family Q9BRT3
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
TRPM8 channel-associated factor 1 (TCAF1) TCAF family Q9Y4C2
Tektin-4 (TEKT4) Tektin family Q8WW24
Trafficking protein particle complex subunit 2-like protein (TRAPPC2L) TRAPP small subunits family Q9UL33
Atrophin-1 (ATN1) . P54259
Axin-1 (AXIN1) . O15169
BAG family molecular chaperone regulator 3 (BAG3) . O95817
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
Cytoplasmic protein NCK2 (NCK2) . O43639
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
G protein pathway suppressor 2 (GPS2) . Q13227
Genetic suppressor element 1 (GSE1) . Q14687
Inactive polyglycylase TTLL10 (TTLL10) . Q6ZVT0
Keratinocyte proline-rich protein (KPRP) . Q5T749
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Putative uncharacterized protein MGC163334 . Q5W150
Putative Wilms tumor upstream neighbor 1 gene protein (WT1-AS) . Q06250
Ran-binding protein 3-like (RANBP3L) . Q86VV4
Rhombotin-2 (LMO2) . P25791
SCAN domain-containing protein 1 (SCAND1) . P57086
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Uncharacterized protein C11orf87 (C11orf87) . Q6NUJ2
Uncharacterized protein EXOC3-AS1 (EXOC3-AS1) . Q8N2X6
Vasorin (VASN) . Q6EMK4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.