Details of the Target

General Information of Target

Target ID LDTP11161
Target Name Extended synaptotagmin-1 (ESYT1)
Gene Name ESYT1
Gene ID 23344
Synonyms
FAM62A; KIAA0747; MBC2; Extended synaptotagmin-1; E-Syt1; Membrane-bound C2 domain-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRWQNMGTSVRRRSLQHQEQLEDSKELQPVVSHQETSVGALGSLCRQFQRRLPLRAVN
LNLRAGPSWKRLETPEPGQQGLQAAARSAKSALGAVSQRIQESCQSGTKWLVETQVKARR
RKRGAQKGSGSPTHSLSQKSTRLSGAAPAHSAADPWEKEHHRLSVRMGSHAHPLRRSRRE
AAFRSPYSSTEPLCSPSESDSDLEPVGAGIQHLQKLSQELDEAIMAEERKQALSDRQGFI
LKDVYASP
Target Bioclass
Transporter and channel
Family
Extended synaptotagmin family
Subcellular location
Endoplasmic reticulum membrane
Function
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
Uniprot ID
Q9BSJ8
Ensemble ID
ENST00000267113.4
HGNC ID
HGNC:29534
ChEMBL ID
CHEMBL3621033

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL120 Deletion: p.S12_P13del DBIA    Probe Info 
HCT116 Deletion: p.R771VfsTer7 .
HT SNV: p.L1033P DBIA    Probe Info 
HT3 SNV: p.C734G DBIA    Probe Info 
JURKAT SNV: p.Q381Ter Compound 10    Probe Info 
L428 SNV: p.A528V DBIA    Probe Info 
MDAMB453 SNV: p.S581C; p.L852F DBIA    Probe Info 
MM1S SNV: p.T739S .
MOLT4 SNV: p.Q903H IA-alkyne    Probe Info 
SBC5 SNV: p.A614S DBIA    Probe Info 
SNU1 SNV: p.S935R DBIA    Probe Info 
TOV21G SNV: p.A630V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.15  LDD0402  [1]
A-EBA
 Probe Info  		2.70  LDD0215  [2]
DA-P2
 Probe Info  		4.99  LDD0348  [3]
HRP
 Probe Info  		4.02  LDD0347  [3]
TH211
 Probe Info  		Y121(12.22); Y518(20.00); Y803(8.50); Y822(6.85)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
ONAyne
 Probe Info  		K197(0.58); K344(10.00); K662(8.33)  LDD0274  [6]
STPyne
 Probe Info  		K1018(8.33); K1054(10.00); K1060(6.14); K118(10.00)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K197(5.31)  LDD3494  [7]
DBIA
 Probe Info  		C532(2.36)  LDD3311  [8]
P12
 Probe Info  		10.62  LDD0202  [9]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [10]
BTD
 Probe Info  		C370(1.90)  LDD1700  [11]
Sulforaphane-probe2
 Probe Info  		1.36  LDD0160  [12]
DA-P3
 Probe Info  		7.18  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C635(4.35); C611(3.59); C604(4.21)  LDD0171  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
ATP probe
 Probe Info  		K1060(0.00); K662(0.00); K197(0.00); K671(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C522(0.00); C890(0.00); C635(0.00); C370(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C522(0.00); C635(0.00)  LDD0032  [17]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C522(0.00); C890(0.00); C995(0.00); C370(0.00)  LDD0037  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [19]
TFBX
 Probe Info  		C370(0.00); C995(0.00)  LDD0027  [19]
WYneN
 Probe Info  		C370(0.00); C635(0.00)  LDD0021  [20]
aHNE
 Probe Info  		N.A.  LDD0001  [20]
Compound 10
 Probe Info  		C370(0.00); C522(0.00)  LDD2216  [21]
Compound 11
 Probe Info  		C370(0.00); C522(0.00)  LDD2213  [21]
IPM
 Probe Info  		N.A.  LDD0005  [20]
PF-06672131
 Probe Info  		N.A.  LDD0017  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
Ox-W18
 Probe Info  		W750(0.00); W1043(0.00)  LDD2175  [25]
1c-yne
 Probe Info  		N.A.  LDD0228  [26]
Acrolein
 Probe Info  		C522(0.00); C635(0.00); H652(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		C522(0.00); C370(0.00); C995(0.00)  LDD0219  [27]
Methacrolein
 Probe Info  		C370(0.00); C995(0.00)  LDD0218  [27]
W1
 Probe Info  		C370(0.00); C522(0.00)  LDD0236  [28]
AOyne
 Probe Info  		5.00  LDD0443  [29]
NAIA_5
 Probe Info  		C522(0.00); C890(0.00); C995(0.00); C370(0.00)  LDD2223  [30]
TPP-AC
 Probe Info  		N.A.  LDD0427  [31]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		10.26  LDD0471  [32]
FFF probe12
 Probe Info  		12.37  LDD0473  [32]
FFF probe13
 Probe Info  		20.00  LDD0475  [32]
FFF probe14
 Probe Info  		12.87  LDD0477  [32]
FFF probe2
 Probe Info  		17.00  LDD0463  [32]
FFF probe3
 Probe Info  		15.90  LDD0464  [32]
STS-1
 Probe Info  		N.A.  LDD0136  [33]
STS-2
 Probe Info  		N.A.  LDD0138  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]
DA-2
 Probe Info  		N.A.  LDD0072  [35]
OEA-DA
 Probe Info  		5.10  LDD0046  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C370(0.85); C995(1.17)  LDD2117  [11]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C370(1.36)  LDD2152  [11]
 LDCM0026  4SU-RNA+native RNA DM93 C635(4.35); C611(3.59); C604(4.21)  LDD0171  [13]
 LDCM0214  AC1 HEK-293T C635(0.91); C370(0.90); C995(1.04); C522(0.98)  LDD1507  [37]
 LDCM0215  AC10 HEK-293T C370(0.82); C995(0.96); C522(0.98); C890(1.00)  LDD1508  [37]
 LDCM0226  AC11 HEK-293T C635(0.99); C370(1.09); C995(0.95); C522(1.00)  LDD1509  [37]
 LDCM0237  AC12 HEK-293T C635(0.98); C370(0.98); C995(1.07); C522(0.97)  LDD1510  [37]
 LDCM0259  AC14 HEK-293T C635(1.06); C370(0.93); C995(1.05); C522(0.98)  LDD1512  [37]
 LDCM0270  AC15 HEK-293T C635(0.97); C370(0.79); C995(1.04); C522(0.98)  LDD1513  [37]
 LDCM0276  AC17 HEK-293T C635(0.95); C370(0.84); C995(1.05); C522(0.95)  LDD1515  [37]
 LDCM0277  AC18 HEK-293T C370(0.95); C995(0.97); C522(0.92); C890(0.80)  LDD1516  [37]
 LDCM0278  AC19 HEK-293T C635(0.88); C370(0.96); C995(0.99); C522(1.05)  LDD1517  [37]
 LDCM0279  AC2 HEK-293T C370(1.04); C995(0.98); C522(1.06); C890(1.18)  LDD1518  [37]
 LDCM0280  AC20 HEK-293T C635(1.04); C370(0.95); C995(0.97); C522(1.01)  LDD1519  [37]
 LDCM0281  AC21 HEK-293T C635(0.86); C370(0.81); C995(1.00); C522(1.03)  LDD1520  [37]
 LDCM0282  AC22 HEK-293T C635(1.07); C370(0.97); C995(1.05); C522(0.94)  LDD1521  [37]
 LDCM0283  AC23 HEK-293T C635(1.05); C370(0.85); C995(0.99); C522(0.98)  LDD1522  [37]
 LDCM0284  AC24 HEK-293T C635(1.01); C370(0.99); C995(1.01); C522(1.05)  LDD1523  [37]
 LDCM0285  AC25 HEK-293T C635(1.03); C370(0.86); C995(1.07); C522(1.01)  LDD1524  [37]
 LDCM0286  AC26 HEK-293T C370(0.92); C995(1.02); C522(1.08); C890(0.79)  LDD1525  [37]
 LDCM0287  AC27 HEK-293T C635(1.01); C370(1.05); C995(0.86); C522(1.00)  LDD1526  [37]
 LDCM0288  AC28 HEK-293T C635(0.89); C370(1.01); C995(0.96); C522(0.95)  LDD1527  [37]
 LDCM0289  AC29 HEK-293T C635(1.00); C370(0.84); C995(1.03); C522(0.94)  LDD1528  [37]
 LDCM0290  AC3 HEK-293T C635(0.98); C370(1.08); C995(0.85); C522(1.08)  LDD1529  [37]
 LDCM0291  AC30 HEK-293T C635(1.01); C370(1.03); C995(1.04); C522(1.01)  LDD1530  [37]
 LDCM0292  AC31 HEK-293T C635(0.91); C370(0.87); C995(1.02); C522(0.95)  LDD1531  [37]
 LDCM0293  AC32 HEK-293T C635(1.09); C370(1.02); C995(1.00); C522(1.13)  LDD1532  [37]
 LDCM0294  AC33 HEK-293T C635(1.08); C370(0.89); C995(1.07); C522(1.03)  LDD1533  [37]
 LDCM0295  AC34 HEK-293T C370(0.89); C995(0.96); C522(0.99); C890(0.99)  LDD1534  [37]
 LDCM0296  AC35 HEK-293T C635(1.13); C370(1.00); C995(0.99); C522(1.05)  LDD1535  [37]
 LDCM0297  AC36 HEK-293T C635(1.17); C370(0.95); C995(0.95); C522(1.07)  LDD1536  [37]
 LDCM0298  AC37 HEK-293T C635(1.05); C370(0.86); C995(0.99); C522(1.06)  LDD1537  [37]
 LDCM0299  AC38 HEK-293T C635(0.97); C370(0.93); C995(1.00); C522(0.96)  LDD1538  [37]
 LDCM0300  AC39 HEK-293T C635(0.88); C370(0.79); C995(1.01); C522(1.03)  LDD1539  [37]
 LDCM0301  AC4 HEK-293T C635(0.96); C370(1.07); C995(1.06); C522(1.01)  LDD1540  [37]
 LDCM0302  AC40 HEK-293T C635(1.01); C370(1.00); C995(1.02); C522(0.99)  LDD1541  [37]
 LDCM0303  AC41 HEK-293T C635(1.06); C370(0.83); C995(1.03); C522(0.92)  LDD1542  [37]
 LDCM0304  AC42 HEK-293T C370(0.87); C995(1.01); C522(0.92); C890(1.02)  LDD1543  [37]
 LDCM0305  AC43 HEK-293T C635(1.09); C370(1.08); C995(0.94); C522(1.03)  LDD1544  [37]
 LDCM0306  AC44 HEK-293T C635(0.84); C370(0.97); C995(0.98); C522(1.16)  LDD1545  [37]
 LDCM0307  AC45 HEK-293T C635(1.08); C370(0.76); C995(1.04); C522(0.96)  LDD1546  [37]
 LDCM0308  AC46 HEK-293T C635(0.96); C370(0.93); C995(1.01); C522(1.04)  LDD1547  [37]
 LDCM0309  AC47 HEK-293T C635(0.97); C370(0.79); C995(1.00); C522(1.05)  LDD1548  [37]
 LDCM0310  AC48 HEK-293T C635(1.07); C370(0.99); C995(1.05); C522(1.01)  LDD1549  [37]
 LDCM0311  AC49 HEK-293T C635(0.81); C370(0.70); C995(1.03); C522(1.03)  LDD1550  [37]
 LDCM0312  AC5 HEK-293T C635(0.95); C370(1.02); C995(0.96); C522(0.94)  LDD1551  [37]
 LDCM0313  AC50 HEK-293T C370(0.84); C995(0.98); C522(1.05); C890(0.95)  LDD1552  [37]
 LDCM0314  AC51 HEK-293T C635(0.95); C370(1.06); C995(0.89); C522(1.07)  LDD1553  [37]
 LDCM0315  AC52 HEK-293T C635(0.91); C370(0.97); C995(0.98); C522(0.96)  LDD1554  [37]
 LDCM0316  AC53 HEK-293T C635(0.93); C370(0.70); C995(0.99); C522(0.96)  LDD1555  [37]
 LDCM0317  AC54 HEK-293T C635(0.95); C370(0.93); C995(0.89); C522(1.01)  LDD1556  [37]
 LDCM0318  AC55 HEK-293T C635(0.80); C370(0.68); C995(0.96); C522(1.08)  LDD1557  [37]
 LDCM0319  AC56 HEK-293T C635(0.98); C370(1.01); C995(0.96); C522(0.99)  LDD1558  [37]
 LDCM0320  AC57 HEK-293T C635(0.86); C370(0.96); C995(0.95); C522(1.09)  LDD1559  [37]
 LDCM0321  AC58 HEK-293T C370(1.01); C995(0.88); C522(1.00); C890(0.86)  LDD1560  [37]
 LDCM0322  AC59 HEK-293T C635(0.92); C370(1.09); C995(0.91); C522(1.04)  LDD1561  [37]
 LDCM0323  AC6 HEK-293T C635(1.08); C370(0.98); C995(0.99); C522(1.06)  LDD1562  [37]
 LDCM0324  AC60 HEK-293T C635(0.93); C370(1.04); C995(0.97); C522(0.98)  LDD1563  [37]
 LDCM0325  AC61 HEK-293T C635(1.00); C370(0.93); C995(0.88); C522(0.99)  LDD1564  [37]
 LDCM0326  AC62 HEK-293T C635(0.86); C370(1.01); C995(0.89); C522(0.99)  LDD1565  [37]
 LDCM0327  AC63 HEK-293T C635(0.92); C370(1.06); C995(0.95); C522(1.06)  LDD1566  [37]
 LDCM0328  AC64 HEK-293T C635(0.98); C370(1.01); C995(0.85); C522(0.97)  LDD1567  [37]
 LDCM0334  AC7 HEK-293T C635(0.86); C370(0.95); C995(0.94); C522(1.04)  LDD1568  [37]
 LDCM0345  AC8 HEK-293T C635(1.10); C370(0.96); C995(0.92); C522(1.03)  LDD1569  [37]
 LDCM0520  AKOS000195272 MDA-MB-231 C995(0.71)  LDD2113  [11]
 LDCM0248  AKOS034007472 HEK-293T C635(0.94); C370(0.78); C995(0.97); C522(0.96)  LDD1511  [37]
 LDCM0356  AKOS034007680 HEK-293T C635(0.95); C370(0.84); C995(1.05); C522(0.95)  LDD1570  [37]
 LDCM0275  AKOS034007705 HEK-293T C635(1.02); C370(0.95); C995(0.99); C522(1.01)  LDD1514  [37]
 LDCM0498  BS-3668 MDA-MB-231 C370(0.58)  LDD2091  [11]
 LDCM0088  C45 HEK-293T 10.62  LDD0202  [9]
 LDCM0087  Capsaicin HEK-293T 14.41  LDD0185  [3]
 LDCM0630  CCW28-3 231MFP C611(1.45)  LDD2214  [38]
 LDCM0108  Chloroacetamide HeLa C522(0.00); C995(0.00); H652(0.00); K855(0.00)  LDD0222  [27]
 LDCM0367  CL1 HEK-293T C635(0.97); C370(0.92); C995(1.06); C522(1.25)  LDD1571  [37]
 LDCM0368  CL10 HEK-293T C635(1.33); C370(0.79); C995(1.61); C522(1.06)  LDD1572  [37]
 LDCM0369  CL100 HEK-293T C635(1.07); C370(0.96); C995(1.03); C522(1.00)  LDD1573  [37]
 LDCM0370  CL101 HEK-293T C635(0.94); C370(0.96); C995(0.91); C522(1.12)  LDD1574  [37]
 LDCM0371  CL102 HEK-293T C370(0.97); C995(1.05); C522(1.02); C611(1.19)  LDD1575  [37]
 LDCM0372  CL103 HEK-293T C635(1.05); C370(0.76); C995(1.01); C522(1.03)  LDD1576  [37]
 LDCM0373  CL104 HEK-293T C635(0.98); C370(0.80); C995(1.07); C522(1.01)  LDD1577  [37]
 LDCM0374  CL105 HEK-293T C635(0.97); C370(1.04); C995(0.94); C522(1.14)  LDD1578  [37]
 LDCM0375  CL106 HEK-293T C370(0.99); C995(0.93); C522(1.04); C611(1.37)  LDD1579  [37]
 LDCM0376  CL107 HEK-293T C635(0.89); C370(0.73); C995(1.05); C522(0.98)  LDD1580  [37]
 LDCM0377  CL108 HEK-293T C635(0.99); C370(0.78); C995(1.03); C522(0.96)  LDD1581  [37]
 LDCM0378  CL109 HEK-293T C635(0.99); C370(1.05); C995(1.03); C522(1.10)  LDD1582  [37]
 LDCM0379  CL11 HEK-293T C635(0.99); C370(1.02); C995(1.48); C522(1.26)  LDD1583  [37]
 LDCM0380  CL110 HEK-293T C370(0.97); C995(1.22); C522(1.13); C611(0.83)  LDD1584  [37]
 LDCM0381  CL111 HEK-293T C635(1.11); C370(0.87); C995(1.09); C522(1.04)  LDD1585  [37]
 LDCM0382  CL112 HEK-293T C635(1.06); C370(0.81); C995(1.10); C522(1.03)  LDD1586  [37]
 LDCM0383  CL113 HEK-293T C635(0.92); C370(1.00); C995(0.93); C522(1.02)  LDD1587  [37]
 LDCM0384  CL114 HEK-293T C370(1.04); C995(1.04); C522(1.04); C611(1.69)  LDD1588  [37]
 LDCM0385  CL115 HEK-293T C635(1.08); C370(0.82); C995(1.05); C522(1.02)  LDD1589  [37]
 LDCM0386  CL116 HEK-293T C635(1.04); C370(0.82); C995(1.02); C522(0.97)  LDD1590  [37]
 LDCM0387  CL117 HEK-293T C635(0.84); C370(1.02); C995(0.95); C522(0.96)  LDD1591  [37]
 LDCM0388  CL118 HEK-293T C370(0.91); C995(0.95); C522(1.07); C611(0.97)  LDD1592  [37]
 LDCM0389  CL119 HEK-293T C635(1.01); C370(0.76); C995(1.04); C522(1.02)  LDD1593  [37]
 LDCM0390  CL12 HEK-293T C635(1.31); C370(0.87); C995(1.39); C522(1.03)  LDD1594  [37]
 LDCM0391  CL120 HEK-293T C635(1.04); C370(0.92); C995(1.13); C522(1.03)  LDD1595  [37]
 LDCM0392  CL121 HEK-293T C635(0.80); C370(1.10); C995(0.94); C522(1.08)  LDD1596  [37]
 LDCM0393  CL122 HEK-293T C370(0.91); C995(0.92); C522(1.02); C611(0.91)  LDD1597  [37]
 LDCM0394  CL123 HEK-293T C635(0.80); C370(0.72); C995(0.97); C522(1.09)  LDD1598  [37]
 LDCM0395  CL124 HEK-293T C635(0.99); C370(0.61); C995(0.94); C522(1.06)  LDD1599  [37]
 LDCM0396  CL125 HEK-293T C635(0.59); C370(1.03); C995(0.77); C522(1.11)  LDD1600  [37]
 LDCM0397  CL126 HEK-293T C370(1.05); C995(0.82); C522(1.01); C611(1.29)  LDD1601  [37]
 LDCM0398  CL127 HEK-293T C635(0.78); C370(1.04); C995(0.88); C522(1.10)  LDD1602  [37]
 LDCM0399  CL128 HEK-293T C635(1.01); C370(0.99); C995(0.88); C522(0.92)  LDD1603  [37]
 LDCM0400  CL13 HEK-293T C635(0.91); C370(0.91); C995(0.99); C522(0.95)  LDD1604  [37]
 LDCM0401  CL14 HEK-293T C370(1.01); C995(0.92); C522(0.98); C611(1.14)  LDD1605  [37]
 LDCM0402  CL15 HEK-293T C635(0.90); C370(0.77); C995(1.02); C522(1.17)  LDD1606  [37]
 LDCM0403  CL16 HEK-293T C635(1.04); C370(0.85); C995(0.95); C522(0.97)  LDD1607  [37]
 LDCM0404  CL17 HEK-293T C635(0.85); C370(0.82); C995(1.15); C522(1.13)  LDD1608  [37]
 LDCM0405  CL18 HEK-293T C370(0.80); C995(0.95); C522(1.04); C890(1.08)  LDD1609  [37]
 LDCM0406  CL19 HEK-293T C635(1.02); C370(0.94); C995(0.83); C522(1.07)  LDD1610  [37]
 LDCM0407  CL2 HEK-293T C370(0.98); C995(0.95); C522(1.01); C611(1.14)  LDD1611  [37]
 LDCM0408  CL20 HEK-293T C635(0.98); C370(0.85); C995(1.21); C522(1.13)  LDD1612  [37]
 LDCM0409  CL21 HEK-293T C635(1.00); C370(0.76); C995(1.28); C522(1.21)  LDD1613  [37]
 LDCM0410  CL22 HEK-293T C635(1.07); C370(0.78); C995(1.48); C522(0.97)  LDD1614  [37]
 LDCM0411  CL23 HEK-293T C635(1.04); C370(0.81); C995(1.38); C522(1.05)  LDD1615  [37]
 LDCM0412  CL24 HEK-293T C635(1.16); C370(0.86); C995(1.28); C522(1.05)  LDD1616  [37]
 LDCM0413  CL25 HEK-293T C635(0.73); C370(1.09); C995(0.93); C522(1.00)  LDD1617  [37]
 LDCM0414  CL26 HEK-293T C370(0.99); C995(0.96); C522(0.93); C611(1.19)  LDD1618  [37]
 LDCM0415  CL27 HEK-293T C635(0.92); C370(0.80); C995(1.08); C522(1.00)  LDD1619  [37]
 LDCM0416  CL28 HEK-293T C635(1.01); C370(0.76); C995(1.02); C522(1.16)  LDD1620  [37]
 LDCM0417  CL29 HEK-293T C635(0.94); C370(0.82); C995(1.10); C522(0.91)  LDD1621  [37]
 LDCM0418  CL3 HEK-293T C635(0.99); C370(0.94); C995(1.02); C522(1.10)  LDD1622  [37]
 LDCM0419  CL30 HEK-293T C370(0.84); C995(1.07); C522(0.99); C890(1.08)  LDD1623  [37]
 LDCM0420  CL31 HEK-293T C635(0.87); C370(0.99); C995(1.04); C522(1.05)  LDD1624  [37]
 LDCM0421  CL32 HEK-293T C635(0.82); C370(0.94); C995(1.09); C522(1.20)  LDD1625  [37]
 LDCM0422  CL33 HEK-293T C635(0.86); C370(0.78); C995(1.26); C522(1.15)  LDD1626  [37]
 LDCM0423  CL34 HEK-293T C635(0.96); C370(0.83); C995(1.28); C522(1.13)  LDD1627  [37]
 LDCM0424  CL35 HEK-293T C635(0.94); C370(0.80); C995(1.45); C522(1.00)  LDD1628  [37]
 LDCM0425  CL36 HEK-293T C635(1.15); C370(0.91); C995(1.35); C522(1.08)  LDD1629  [37]
 LDCM0426  CL37 HEK-293T C635(0.76); C370(1.00); C995(0.91); C522(1.19)  LDD1630  [37]
 LDCM0428  CL39 HEK-293T C635(1.13); C370(0.90); C995(1.08); C522(1.08)  LDD1632  [37]
 LDCM0429  CL4 HEK-293T C635(1.02); C370(1.02); C995(0.96); C522(0.97)  LDD1633  [37]
 LDCM0430  CL40 HEK-293T C635(0.95); C370(1.00); C995(0.95); C522(0.92)  LDD1634  [37]
 LDCM0431  CL41 HEK-293T C635(1.10); C370(0.91); C995(1.12); C522(1.00)  LDD1635  [37]
 LDCM0432  CL42 HEK-293T C370(0.98); C995(0.97); C522(0.95); C890(1.20)  LDD1636  [37]
 LDCM0433  CL43 HEK-293T C635(1.06); C370(1.12); C995(1.06); C522(1.02)  LDD1637  [37]
 LDCM0434  CL44 HEK-293T C635(1.01); C370(0.94); C995(1.17); C522(0.93)  LDD1638  [37]
 LDCM0435  CL45 HEK-293T C635(1.04); C370(0.76); C995(1.17); C522(1.08)  LDD1639  [37]
 LDCM0436  CL46 HEK-293T C635(1.09); C370(0.87); C995(1.39); C522(1.07)  LDD1640  [37]
 LDCM0437  CL47 HEK-293T C635(1.10); C370(0.91); C995(1.32); C522(1.12)  LDD1641  [37]
 LDCM0438  CL48 HEK-293T C635(1.13); C370(0.89); C995(1.34); C522(1.01)  LDD1642  [37]
 LDCM0439  CL49 HEK-293T C635(0.72); C370(1.05); C995(0.94); C522(0.96)  LDD1643  [37]
 LDCM0440  CL5 HEK-293T C635(0.80); C370(0.94); C995(1.05); C522(1.00)  LDD1644  [37]
 LDCM0441  CL50 HEK-293T C370(1.01); C995(1.02); C522(0.93); C611(0.90)  LDD1645  [37]
 LDCM0443  CL52 HEK-293T C635(1.03); C370(0.92); C995(1.20); C522(1.00)  LDD1646  [37]
 LDCM0444  CL53 HEK-293T C635(0.96); C370(0.93); C995(1.13); C522(1.11)  LDD1647  [37]
 LDCM0445  CL54 HEK-293T C370(0.68); C995(1.04); C522(1.15); C890(0.77)  LDD1648  [37]
 LDCM0446  CL55 HEK-293T C635(0.99); C370(0.96); C995(0.96); C522(1.13)  LDD1649  [37]
 LDCM0447  CL56 HEK-293T C635(1.02); C370(0.94); C995(1.26); C522(1.11)  LDD1650  [37]
 LDCM0448  CL57 HEK-293T C635(1.02); C370(0.81); C995(1.39); C522(1.12)  LDD1651  [37]
 LDCM0449  CL58 HEK-293T C635(0.95); C370(0.86); C995(1.50); C522(1.05)  LDD1652  [37]
 LDCM0450  CL59 HEK-293T C635(0.98); C370(0.77); C995(1.32); C522(1.11)  LDD1653  [37]
 LDCM0451  CL6 HEK-293T C370(1.01); C995(0.98); C522(1.12); C890(1.06)  LDD1654  [37]
 LDCM0452  CL60 HEK-293T C635(1.30); C370(0.89); C995(1.33); C522(1.20)  LDD1655  [37]
 LDCM0453  CL61 HEK-293T C635(0.87); C370(1.02); C995(0.85); C522(0.97)  LDD1656  [37]
 LDCM0454  CL62 HEK-293T C370(1.07); C995(0.91); C522(1.04); C611(0.89)  LDD1657  [37]
 LDCM0455  CL63 HEK-293T C635(0.92); C370(0.88); C995(1.03); C522(0.94)  LDD1658  [37]
 LDCM0456  CL64 HEK-293T C635(1.04); C370(0.89); C995(1.10); C522(1.17)  LDD1659  [37]
 LDCM0457  CL65 HEK-293T C635(1.03); C370(0.85); C995(1.04); C522(0.91)  LDD1660  [37]
 LDCM0458  CL66 HEK-293T C370(0.92); C995(0.99); C522(1.13); C890(1.12)  LDD1661  [37]
 LDCM0459  CL67 HEK-293T C635(0.97); C370(1.12); C995(0.90); C522(1.01)  LDD1662  [37]
 LDCM0460  CL68 HEK-293T C635(0.89); C370(0.97); C995(1.14); C522(1.20)  LDD1663  [37]
 LDCM0461  CL69 HEK-293T C635(1.05); C370(0.69); C995(1.11); C522(1.17)  LDD1664  [37]
 LDCM0462  CL7 HEK-293T C635(0.96); C370(0.93); C995(0.97); C522(1.06)  LDD1665  [37]
 LDCM0463  CL70 HEK-293T C635(1.05); C370(0.86); C995(1.37); C522(0.96)  LDD1666  [37]
 LDCM0464  CL71 HEK-293T C635(0.88); C370(0.72); C995(1.29); C522(1.07)  LDD1667  [37]
 LDCM0465  CL72 HEK-293T C635(1.12); C370(0.89); C995(1.24); C522(0.99)  LDD1668  [37]
 LDCM0466  CL73 HEK-293T C635(0.80); C370(1.00); C995(0.95); C522(1.05)  LDD1669  [37]
 LDCM0467  CL74 HEK-293T C370(0.94); C995(0.90); C522(1.06); C611(0.87)  LDD1670  [37]
 LDCM0469  CL76 HEK-293T C635(1.03); C370(0.88); C995(0.86); C522(0.96)  LDD1672  [37]
 LDCM0470  CL77 HEK-293T C635(0.82); C370(0.84); C995(1.09); C522(1.02)  LDD1673  [37]
 LDCM0471  CL78 HEK-293T C370(0.84); C995(1.01); C522(0.98); C890(0.96)  LDD1674  [37]
 LDCM0472  CL79 HEK-293T C635(0.95); C370(1.02); C995(0.94); C522(1.09)  LDD1675  [37]
 LDCM0473  CL8 HEK-293T C635(0.74); C370(0.87); C995(1.20); C522(1.09)  LDD1676  [37]
 LDCM0474  CL80 HEK-293T C635(0.82); C370(0.91); C995(1.11); C522(1.00)  LDD1677  [37]
 LDCM0475  CL81 HEK-293T C635(1.00); C370(0.62); C995(1.02); C522(1.01)  LDD1678  [37]
 LDCM0476  CL82 HEK-293T C635(0.96); C370(0.90); C995(1.26); C522(1.12)  LDD1679  [37]
 LDCM0477  CL83 HEK-293T C635(0.99); C370(0.85); C995(1.26); C522(1.04)  LDD1680  [37]
 LDCM0478  CL84 HEK-293T C635(0.95); C370(0.91); C995(1.12); C522(1.26)  LDD1681  [37]
 LDCM0479  CL85 HEK-293T C635(0.70); C370(1.03); C995(0.81); C522(0.99)  LDD1682  [37]
 LDCM0480  CL86 HEK-293T C370(1.04); C995(0.76); C522(1.13); C611(1.99)  LDD1683  [37]
 LDCM0481  CL87 HEK-293T C635(0.74); C370(1.03); C995(0.83); C522(1.08)  LDD1684  [37]
 LDCM0482  CL88 HEK-293T C635(1.05); C370(1.04); C995(0.87); C522(1.01)  LDD1685  [37]
 LDCM0483  CL89 HEK-293T C635(0.67); C370(0.94); C995(0.83); C522(1.02)  LDD1686  [37]
 LDCM0484  CL9 HEK-293T C635(1.11); C370(0.99); C995(1.19); C522(1.00)  LDD1687  [37]
 LDCM0485  CL90 HEK-293T C370(0.92); C995(1.11); C522(1.10); C890(1.19)  LDD1688  [37]
 LDCM0486  CL91 HEK-293T C635(0.74); C370(1.03); C995(0.78); C522(1.08)  LDD1689  [37]
 LDCM0487  CL92 HEK-293T C635(0.78); C370(0.96); C995(0.98); C522(1.08)  LDD1690  [37]
 LDCM0488  CL93 HEK-293T C635(0.80); C370(0.79); C995(1.08); C522(1.04)  LDD1691  [37]
 LDCM0489  CL94 HEK-293T C635(1.18); C370(0.88); C995(1.16); C522(1.08)  LDD1692  [37]
 LDCM0490  CL95 HEK-293T C635(0.84); C370(0.97); C995(1.27); C522(1.00)  LDD1693  [37]
 LDCM0491  CL96 HEK-293T C635(0.78); C370(0.90); C995(0.80); C522(1.12)  LDD1694  [37]
 LDCM0492  CL97 HEK-293T C635(0.91); C370(1.01); C995(0.99); C522(1.27)  LDD1695  [37]
 LDCM0493  CL98 HEK-293T C370(1.03); C995(1.04); C522(1.03); C611(1.02)  LDD1696  [37]
 LDCM0494  CL99 HEK-293T C635(1.04); C370(1.11); C995(0.97); C522(1.04)  LDD1697  [37]
 LDCM0028  Dobutamine HEK-293T 6.02  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 7.18  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C635(1.13); C370(0.88); C995(1.05); C522(1.01)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C995(2.33); C370(2.04); C635(1.22)  LDD1702  [11]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.87  LDD0183  [3]
 LDCM0625  F8 Ramos C635(2.84)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C635(1.09)  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C522(3.87); C635(5.58)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C635(0.46)  LDD2191  [39]
 LDCM0576  Fragment14 Ramos C522(1.27); C635(0.55)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C635(0.40)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C635(0.59)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C635(1.11)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C635(0.93)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C635(0.66)  LDD2198  [39]
 LDCM0590  Fragment32 Ramos C635(0.87)  LDD2201  [39]
 LDCM0468  Fragment33 HEK-293T C635(0.91); C370(0.80); C995(0.96); C522(1.01)  LDD1671  [37]
 LDCM0596  Fragment38 Ramos C635(0.77)  LDD2203  [39]
 LDCM0427  Fragment51 HEK-293T C370(1.04); C995(0.98); C522(0.96); C611(1.26)  LDD1631  [37]
 LDCM0610  Fragment52 Ramos C635(1.24)  LDD2204  [39]
 LDCM0569  Fragment7 Ramos C522(0.77); C635(0.65)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C635(0.45)  LDD2188  [39]
 LDCM0107  IAA HeLa C522(0.00); H652(0.00); H960(0.00)  LDD0221  [27]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [10]
 LDCM0022  KB02 HEK-293T C635(1.26); C370(1.00); C995(1.01); C522(0.79)  LDD1492  [37]
 LDCM0023  KB03 HEK-293T C635(0.99); C370(0.99); C995(0.96); C522(0.90)  LDD1497  [37]
 LDCM0024  KB05 G361 C532(2.36)  LDD3311  [8]
 LDCM0030  Luteolin HEK-293T 14.42  LDD0182  [3]
 LDCM0109  NEM HeLa H652(0.00); H857(0.00); H960(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C635(0.42)  LDD2089  [11]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C370(1.63)  LDD2090  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C370(0.86); C635(0.96)  LDD2093  [11]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C635(1.26)  LDD2094  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C370(0.97)  LDD2099  [11]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C370(0.77)  LDD2101  [11]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C370(1.85)  LDD2105  [11]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C635(0.74)  LDD2106  [11]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C370(0.91); C635(1.15); C995(1.14)  LDD2107  [11]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C370(0.66); C995(0.71)  LDD2109  [11]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C370(0.90)  LDD2111  [11]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C370(0.47)  LDD2115  [11]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C635(0.90)  LDD2116  [11]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C370(0.49)  LDD2118  [11]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C370(0.97)  LDD2120  [11]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C635(1.14)  LDD2122  [11]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C370(0.73); C635(0.97); C995(1.34)  LDD2123  [11]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C370(0.22); C635(1.30)  LDD2124  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C370(0.74); C995(1.07)  LDD2125  [11]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C370(0.18)  LDD2126  [11]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C370(0.96)  LDD2127  [11]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C370(0.99); C635(0.86)  LDD2129  [11]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C370(0.38)  LDD2134  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C370(1.13); C635(1.12)  LDD2135  [11]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C370(1.15)  LDD2136  [11]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C370(0.97)  LDD2137  [11]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C370(1.90)  LDD1700  [11]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C995(0.94)  LDD2140  [11]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C370(0.34)  LDD2141  [11]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C370(0.97)  LDD2143  [11]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C370(2.57)  LDD2144  [11]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C995(1.10)  LDD2146  [11]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C370(0.45)  LDD2148  [11]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C370(0.35)  LDD2149  [11]
 LDCM0032  Oleacein HEK-293T 5.27  LDD0184  [3]
 LDCM0029  Quercetin HEK-293T 12.83  LDD0181  [3]
 LDCM0003  Sulforaphane MDA-MB-231 1.36  LDD0160  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Extended synaptotagmin-1 (ESYT1) Extended synaptotagmin family Q9BSJ8
Extended synaptotagmin-2 (ESYT2) Extended synaptotagmin family A0FGR8
Extended synaptotagmin-3 (ESYT3) Extended synaptotagmin family A0FGR9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
29 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
30 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
31 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
34 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
35 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
36 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578