Probe Name	P12					Probe Info
Probe concentration	1 mM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	SILAC
Competitor Name	C45					Competitor Info
Competitor Concentration	1 mM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Peripheral blood
	Disease Model		Normal
	Model Name		Human normal cells (HEK-293T)

Target ID	Target Name					Binding Ratio
LDTP10215	Carboxymethylenebutenolidase homolog (CMBL)					20.0
LDTP11558	ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3)					20.0
LDTP05795	Nucleoside diphosphate kinase 3 (NME3)					20.0
LDTP09364	Retinol dehydrogenase 11 (RDH11)					20.0
LDTP07227	Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1)					20.0
LDTP06270	Signal peptidase complex subunit 2 (SPCS2)					20.0
LDTP01707	Thioredoxin domain-containing protein 12 (TXNDC12)					18.9
LDTP05652	Aspartyl/asparaginyl beta-hydroxylase (ASPH)					18.4
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)					18.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)					17.3
LDTP11874	Thioredoxin-related transmembrane protein 1 (TMX1)					16.6
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)					16.4
LDTP13367	Glutathione hydrolase 7 (GGT7)					15.4
LDTP14064	TNF receptor-associated factor 6 (TRAF6)					13.2
LDTP02022	Thymidine kinase, cytosolic (TK1)					12.1
LDTP10386	ERO1-like protein alpha (ERO1A)					11.7
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)					11.2
LDTP02770	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)					7.7
LDTP05773	Peroxiredoxin-4 (PRDX4)					7.2
LDTP02188	Protein disulfide-isomerase (P4HB)					7.1
LDTP06104	Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)					6.1
LDTP09251	Atlastin-2 (ATL2)					5.4

Target ID	Target Name					Binding Ratio
LDTP09742	Protein ELYS (AHCTF1)					20.0
LDTP01454	SUN domain-containing protein 1 (SUN1)					16.9
LDTP04309	Nuclear pore complex protein Nup153 (NUP153)					16.8
LDTP07002	Transport and Golgi organization protein 1 homolog (MIA3)					13.4
LDTP10804	Chloride channel CLIC-like protein 1 (CLCC1)					12.5
LDTP03559	High affinity cationic amino acid transporter 1 (SLC7A1)					11.5
LDTP02330	Signal recognition particle 19 kDa protein (SRP19)					11.1
LDTP11161	Extended synaptotagmin-1 (ESYT1)					10.6
LDTP13498	Nuclear pore complex protein Nup50 (NUP50)					6.4
LDTP00958	TBC1 domain family member 4 (TBC1D4)					6.0

Target ID	Target Name					Binding Ratio
LDTP06748	Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)					10.5

Target ID	Target Name					Binding Ratio
LDTP02491	HLA class I histocompatibility antigen, C alpha chain (HLA-C)					16.4
LDTP02040	HLA class I histocompatibility antigen, A alpha chain (HLA-A)					12.6
LDTP01913	HLA class I histocompatibility antigen, B alpha chain (HLA-B)					12.6

Target ID	Target Name					Binding Ratio
LDTP16116	BSD domain-containing protein 1 (BSDC1)					20.0
LDTP14085	Protein PRRC2C (PRRC2C)					20.0
LDTP00512	Protein transport protein Sec16A (SEC16A)					20.0
LDTP01522	Reticulon-3 (RTN3)					20.0
LDTP09837	A-kinase anchor protein 1, mitochondrial (AKAP1)					17.4
LDTP06378	Disks large-associated protein 5 (DLGAP5)					15.6
LDTP07205	Telomere-associated protein RIF1 (RIF1)					11.9
LDTP09655	Ataxin-2-like protein (ATXN2L)					11.6
LDTP03151	Oxysterol-binding protein 1 (OSBP)					9.5
LDTP13088	Protein IMPACT (IMPACT)					9.4
LDTP15840	Tetratricopeptide repeat protein 1 (TTC1)					9.4
LDTP04356	Emerin (EMD)					9.0
LDTP08639	Stromal membrane-associated protein 1 (SMAP1)					7.8
LDTP13913	Inner nuclear membrane protein Man1 (LEMD3)					7.3
LDTP12640	Gamma-taxilin (TXLNG)					6.8

1	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.