Details of the Target

General Information of Target

Target ID LDTP10804
Target Name Chloride channel CLIC-like protein 1 (CLCC1)
Gene Name CLCC1
Gene ID 23155
Synonyms
KIAA0761; MCLC; Chloride channel CLIC-like protein 1; Mid-1-related chloride channel protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWDSEEEGPWDQMPLPDRD
FCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMALRHSAC
RRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGVPQAEAGLPPVVDAIDDASV
EEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCH
CDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRL
QLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASS
SASGTSEAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFGGEEEEEEEGSVGNLDNL
SCFHPADIFGTSDPGGLASWTHSYSGCSFTSGVLDENANLDASCFLNGGLEGSREGSLPG
TSVPPSMDAGRSSSVDLSLSSCDSFELLQALPDYSLGPHYTSQKVSDSLDNIEAPHFPLP
GLSPPGDASSCFLESLMGFSEPAAEALDPFIDSQFEDTVPASLMEPVPV
Target Bioclass
Transporter and channel
Family
Chloride channel MCLC family
Subcellular location
Endoplasmic reticulum membrane
Function Seems to act as a chloride ion channel. Plays a role in retina development.
Uniprot ID
Q96S66
Ensemble ID
ENST00000302500.5
HGNC ID
HGNC:29675

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.V338M .
KMCH1 SNV: p.E126Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		3.69  LDD0066  [2]
STPyne
 Probe Info  		K103(5.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y531(7.88)  LDD3495  [4]
DBIA
 Probe Info  		C254(1.23)  LDD3315  [5]
P12
 Probe Info  		12.54  LDD0202  [6]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [7]
Acrolein
 Probe Info  		N.A.  LDD0227  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [11]
TFBX
 Probe Info  		C550(0.00); C254(0.00)  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		17.75  LDD1753  [15]
C091
 Probe Info  		12.55  LDD1782  [15]
C092
 Probe Info  		25.63  LDD1783  [15]
C094
 Probe Info  		23.10  LDD1785  [15]
C112
 Probe Info  		17.03  LDD1799  [15]
C134
 Probe Info  		24.76  LDD1816  [15]
C201
 Probe Info  		31.56  LDD1877  [15]
C210
 Probe Info  		43.11  LDD1884  [15]
C218
 Probe Info  		16.11  LDD1892  [15]
C220
 Probe Info  		13.27  LDD1894  [15]
C228
 Probe Info  		19.29  LDD1901  [15]
C231
 Probe Info  		12.21  LDD1904  [15]
C289
 Probe Info  		31.12  LDD1959  [15]
C343
 Probe Info  		13.93  LDD2005  [15]
C348
 Probe Info  		10.06  LDD2009  [15]
C349
 Probe Info  		11.96  LDD2010  [15]
C350
 Probe Info  		29.86  LDD2011  [15]
C362
 Probe Info  		38.05  LDD2023  [15]
C388
 Probe Info  		54.95  LDD2047  [15]
C407
 Probe Info  		13.55  LDD2064  [15]
FFF probe11
 Probe Info  		20.00  LDD0471  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
FFF probe3
 Probe Info  		16.71  LDD0464  [16]
Alk-rapa
 Probe Info  		5.06  LDD0213  [17]
OEA-DA
 Probe Info  		11.06  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C254(1.04)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C254(1.09); C550(1.06)  LDD0813  [20]
 LDCM0226  AC11 HEK-293T C254(0.99); C550(1.15)  LDD0824  [20]
 LDCM0230  AC113 HEK-293T C254(0.91)  LDD0828  [20]
 LDCM0231  AC114 HEK-293T C254(0.89)  LDD0829  [20]
 LDCM0232  AC115 HEK-293T C254(0.93)  LDD0830  [20]
 LDCM0233  AC116 HEK-293T C254(0.91)  LDD0831  [20]
 LDCM0234  AC117 HEK-293T C254(0.86)  LDD0832  [20]
 LDCM0235  AC118 HEK-293T C254(0.96)  LDD0833  [20]
 LDCM0236  AC119 HEK-293T C254(0.92)  LDD0834  [20]
 LDCM0237  AC12 HEK-293T C254(0.77); C550(1.18)  LDD0835  [20]
 LDCM0238  AC120 HEK-293T C254(1.02)  LDD0836  [20]
 LDCM0239  AC121 HEK-293T C254(0.81)  LDD0837  [20]
 LDCM0240  AC122 HEK-293T C254(0.83)  LDD0838  [20]
 LDCM0241  AC123 HEK-293T C254(0.83)  LDD0839  [20]
 LDCM0242  AC124 HEK-293T C254(0.87)  LDD0840  [20]
 LDCM0243  AC125 HEK-293T C254(0.84)  LDD0841  [20]
 LDCM0244  AC126 HEK-293T C254(0.94)  LDD0842  [20]
 LDCM0245  AC127 HEK-293T C254(0.92)  LDD0843  [20]
 LDCM0246  AC128 HEK-293T C254(0.89)  LDD0844  [20]
 LDCM0247  AC129 HEK-293T C254(0.90)  LDD0845  [20]
 LDCM0249  AC130 HEK-293T C254(0.98)  LDD0847  [20]
 LDCM0250  AC131 HEK-293T C254(1.22)  LDD0848  [20]
 LDCM0251  AC132 HEK-293T C254(0.93)  LDD0849  [20]
 LDCM0252  AC133 HEK-293T C254(0.99)  LDD0850  [20]
 LDCM0253  AC134 HEK-293T C254(0.86)  LDD0851  [20]
 LDCM0254  AC135 HEK-293T C254(0.80)  LDD0852  [20]
 LDCM0255  AC136 HEK-293T C254(0.84)  LDD0853  [20]
 LDCM0256  AC137 HEK-293T C254(0.89)  LDD0854  [20]
 LDCM0257  AC138 HEK-293T C254(0.73)  LDD0855  [20]
 LDCM0258  AC139 HEK-293T C254(1.05)  LDD0856  [20]
 LDCM0259  AC14 HEK-293T C254(0.82); C550(1.47)  LDD0857  [20]
 LDCM0260  AC140 HEK-293T C254(1.01)  LDD0858  [20]
 LDCM0261  AC141 HEK-293T C254(0.87)  LDD0859  [20]
 LDCM0262  AC142 HEK-293T C254(0.97)  LDD0860  [20]
 LDCM0263  AC143 HEK-293T C550(0.68)  LDD0861  [20]
 LDCM0264  AC144 HEK-293T C550(0.59)  LDD0862  [20]
 LDCM0265  AC145 HEK-293T C550(0.57)  LDD0863  [20]
 LDCM0266  AC146 HEK-293T C550(0.67)  LDD0864  [20]
 LDCM0267  AC147 HEK-293T C550(0.65)  LDD0865  [20]
 LDCM0268  AC148 HEK-293T C550(0.60)  LDD0866  [20]
 LDCM0269  AC149 HEK-293T C550(0.61)  LDD0867  [20]
 LDCM0270  AC15 HEK-293T C254(0.84); C550(1.20)  LDD0868  [20]
 LDCM0271  AC150 HEK-293T C550(0.58)  LDD0869  [20]
 LDCM0272  AC151 HEK-293T C550(0.65)  LDD0870  [20]
 LDCM0273  AC152 HEK-293T C550(0.61)  LDD0871  [20]
 LDCM0274  AC153 HEK-293T C550(0.61)  LDD0872  [20]
 LDCM0621  AC154 HEK-293T C550(0.69)  LDD2162  [20]
 LDCM0622  AC155 HEK-293T C550(0.72)  LDD2163  [20]
 LDCM0623  AC156 HEK-293T C550(0.73)  LDD2164  [20]
 LDCM0624  AC157 HEK-293T C550(0.60)  LDD2165  [20]
 LDCM0276  AC17 HEK-293T C254(0.82)  LDD0874  [20]
 LDCM0277  AC18 HEK-293T C254(0.75)  LDD0875  [20]
 LDCM0278  AC19 HEK-293T C254(0.75)  LDD0876  [20]
 LDCM0279  AC2 HEK-293T C254(0.91)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C254(0.84)  LDD0878  [20]
 LDCM0281  AC21 HEK-293T C254(0.78)  LDD0879  [20]
 LDCM0282  AC22 HEK-293T C254(0.73)  LDD0880  [20]
 LDCM0283  AC23 HEK-293T C254(0.88)  LDD0881  [20]
 LDCM0284  AC24 HEK-293T C254(0.89)  LDD0882  [20]
 LDCM0285  AC25 HEK-293T C254(0.60)  LDD0883  [20]
 LDCM0286  AC26 HEK-293T C254(0.67)  LDD0884  [20]
 LDCM0287  AC27 HEK-293T C254(0.55)  LDD0885  [20]
 LDCM0288  AC28 HEK-293T C254(0.52)  LDD0886  [20]
 LDCM0289  AC29 HEK-293T C254(0.53)  LDD0887  [20]
 LDCM0290  AC3 HEK-293T C254(1.04)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C254(0.61)  LDD0889  [20]
 LDCM0292  AC31 HEK-293T C254(0.69)  LDD0890  [20]
 LDCM0293  AC32 HEK-293T C254(0.54)  LDD0891  [20]
 LDCM0294  AC33 HEK-293T C254(0.59)  LDD0892  [20]
 LDCM0295  AC34 HEK-293T C254(0.77)  LDD0893  [20]
 LDCM0296  AC35 HEK-293T C254(0.98)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C254(0.96)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C254(1.03)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C254(0.99); C279(1.26)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C254(0.97); C279(1.16)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C254(0.97)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C254(0.95); C279(1.18)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C254(1.09)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C254(1.04)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C254(1.02)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C254(1.04)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C254(1.12)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C254(1.01); C279(1.14)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C254(0.96); C279(1.20)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C254(0.81); C279(0.97)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C254(1.05)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C254(1.07)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C254(0.94)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C254(0.97)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C254(1.01)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C254(0.97)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C254(0.99); C279(1.19)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C254(1.00); C279(1.10)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C254(0.88); C279(1.21)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C550(0.97)  LDD0918  [20]
 LDCM0321  AC58 HEK-293T C550(0.96)  LDD0919  [20]
 LDCM0322  AC59 HEK-293T C550(0.74)  LDD0920  [20]
 LDCM0323  AC6 HEK-293T C254(1.43); C550(1.11)  LDD0921  [20]
 LDCM0324  AC60 HEK-293T C550(1.03)  LDD0922  [20]
 LDCM0325  AC61 HEK-293T C550(0.85)  LDD0923  [20]
 LDCM0326  AC62 HEK-293T C550(0.81)  LDD0924  [20]
 LDCM0327  AC63 HEK-293T C550(0.97)  LDD0925  [20]
 LDCM0328  AC64 HEK-293T C550(0.78)  LDD0926  [20]
 LDCM0329  AC65 HEK-293T C550(1.06)  LDD0927  [20]
 LDCM0330  AC66 HEK-293T C550(0.83)  LDD0928  [20]
 LDCM0331  AC67 HEK-293T C550(0.97)  LDD0929  [20]
 LDCM0332  AC68 HEK-293T C550(0.61)  LDD0930  [20]
 LDCM0333  AC69 HEK-293T C550(0.81)  LDD0931  [20]
 LDCM0334  AC7 HEK-293T C254(1.28); C550(0.95)  LDD0932  [20]
 LDCM0335  AC70 HEK-293T C550(1.62)  LDD0933  [20]
 LDCM0336  AC71 HEK-293T C550(0.94)  LDD0934  [20]
 LDCM0337  AC72 HEK-293T C550(1.12)  LDD0935  [20]
 LDCM0338  AC73 HEK-293T C550(1.11)  LDD0936  [20]
 LDCM0339  AC74 HEK-293T C550(1.48)  LDD0937  [20]
 LDCM0340  AC75 HEK-293T C550(0.94)  LDD0938  [20]
 LDCM0341  AC76 HEK-293T C550(1.01)  LDD0939  [20]
 LDCM0342  AC77 HEK-293T C550(1.99)  LDD0940  [20]
 LDCM0343  AC78 HEK-293T C550(1.04)  LDD0941  [20]
 LDCM0344  AC79 HEK-293T C550(0.66)  LDD0942  [20]
 LDCM0345  AC8 HEK-293T C254(0.75); C550(1.07)  LDD0943  [20]
 LDCM0346  AC80 HEK-293T C550(1.03)  LDD0944  [20]
 LDCM0347  AC81 HEK-293T C550(1.00)  LDD0945  [20]
 LDCM0348  AC82 HEK-293T C550(1.43)  LDD0946  [20]
 LDCM0349  AC83 HEK-293T C550(1.14)  LDD0947  [20]
 LDCM0350  AC84 HEK-293T C550(1.37)  LDD0948  [20]
 LDCM0351  AC85 HEK-293T C550(1.15)  LDD0949  [20]
 LDCM0352  AC86 HEK-293T C550(1.40)  LDD0950  [20]
 LDCM0353  AC87 HEK-293T C550(1.46)  LDD0951  [20]
 LDCM0354  AC88 HEK-293T C550(1.97)  LDD0952  [20]
 LDCM0355  AC89 HEK-293T C550(1.84)  LDD0953  [20]
 LDCM0357  AC90 HEK-293T C550(2.05)  LDD0955  [20]
 LDCM0358  AC91 HEK-293T C550(1.57)  LDD0956  [20]
 LDCM0359  AC92 HEK-293T C550(1.28)  LDD0957  [20]
 LDCM0360  AC93 HEK-293T C550(1.35)  LDD0958  [20]
 LDCM0361  AC94 HEK-293T C550(1.87)  LDD0959  [20]
 LDCM0362  AC95 HEK-293T C550(1.34)  LDD0960  [20]
 LDCM0363  AC96 HEK-293T C550(1.81)  LDD0961  [20]
 LDCM0364  AC97 HEK-293T C550(1.80)  LDD0962  [20]
 LDCM0248  AKOS034007472 HEK-293T C254(1.03); C550(1.53)  LDD0846  [20]
 LDCM0356  AKOS034007680 HEK-293T C254(0.86); C550(1.20)  LDD0954  [20]
 LDCM0275  AKOS034007705 HEK-293T C254(0.80); C550(1.87)  LDD0873  [20]
 LDCM0156  Aniline NCI-H1299 12.63  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C550(1.12)  LDD2171  [20]
 LDCM0088  C45 HEK-293T 12.54  LDD0202  [6]
 LDCM0367  CL1 HEK-293T C254(0.74)  LDD0965  [20]
 LDCM0368  CL10 HEK-293T C254(0.31)  LDD0966  [20]
 LDCM0369  CL100 HEK-293T C254(1.02)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C254(0.76); C550(1.14)  LDD0968  [20]
 LDCM0371  CL102 HEK-293T C254(0.93); C550(1.24)  LDD0969  [20]
 LDCM0372  CL103 HEK-293T C254(1.17); C550(1.33)  LDD0970  [20]
 LDCM0373  CL104 HEK-293T C254(0.79); C550(1.37)  LDD0971  [20]
 LDCM0374  CL105 HEK-293T C254(0.82)  LDD0972  [20]
 LDCM0375  CL106 HEK-293T C254(0.89)  LDD0973  [20]
 LDCM0376  CL107 HEK-293T C254(0.84)  LDD0974  [20]
 LDCM0377  CL108 HEK-293T C254(0.66)  LDD0975  [20]
 LDCM0378  CL109 HEK-293T C254(0.82)  LDD0976  [20]
 LDCM0379  CL11 HEK-293T C254(0.30)  LDD0977  [20]
 LDCM0380  CL110 HEK-293T C254(0.84)  LDD0978  [20]
 LDCM0381  CL111 HEK-293T C254(0.77)  LDD0979  [20]
 LDCM0382  CL112 HEK-293T C254(0.53)  LDD0980  [20]
 LDCM0383  CL113 HEK-293T C254(0.67)  LDD0981  [20]
 LDCM0384  CL114 HEK-293T C254(0.44)  LDD0982  [20]
 LDCM0385  CL115 HEK-293T C254(0.57)  LDD0983  [20]
 LDCM0386  CL116 HEK-293T C254(0.56)  LDD0984  [20]
 LDCM0387  CL117 HEK-293T C254(1.08)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C254(1.03)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C254(0.97)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C254(0.53)  LDD0988  [20]
 LDCM0391  CL120 HEK-293T C254(0.96)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C254(1.02)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C254(1.02)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C254(1.21)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C254(1.02)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C550(0.96)  LDD0994  [20]
 LDCM0397  CL126 HEK-293T C550(1.32)  LDD0995  [20]
 LDCM0398  CL127 HEK-293T C550(1.17)  LDD0996  [20]
 LDCM0399  CL128 HEK-293T C550(1.13)  LDD0997  [20]
 LDCM0400  CL13 HEK-293T C254(0.50)  LDD0998  [20]
 LDCM0401  CL14 HEK-293T C254(0.46)  LDD0999  [20]
 LDCM0402  CL15 HEK-293T C254(0.38)  LDD1000  [20]
 LDCM0403  CL16 HEK-293T C254(0.76)  LDD1001  [20]
 LDCM0404  CL17 HEK-293T C254(0.66)  LDD1002  [20]
 LDCM0405  CL18 HEK-293T C254(0.53)  LDD1003  [20]
 LDCM0406  CL19 HEK-293T C254(0.77)  LDD1004  [20]
 LDCM0407  CL2 HEK-293T C254(0.41)  LDD1005  [20]
 LDCM0408  CL20 HEK-293T C254(0.76)  LDD1006  [20]
 LDCM0409  CL21 HEK-293T C254(0.62)  LDD1007  [20]
 LDCM0410  CL22 HEK-293T C254(0.59)  LDD1008  [20]
 LDCM0411  CL23 HEK-293T C254(0.73)  LDD1009  [20]
 LDCM0412  CL24 HEK-293T C254(0.58)  LDD1010  [20]
 LDCM0413  CL25 HEK-293T C254(0.55)  LDD1011  [20]
 LDCM0414  CL26 HEK-293T C254(0.55)  LDD1012  [20]
 LDCM0415  CL27 HEK-293T C254(0.55)  LDD1013  [20]
 LDCM0416  CL28 HEK-293T C254(0.62)  LDD1014  [20]
 LDCM0417  CL29 HEK-293T C254(0.62)  LDD1015  [20]
 LDCM0418  CL3 HEK-293T C254(0.60)  LDD1016  [20]
 LDCM0419  CL30 HEK-293T C254(0.48)  LDD1017  [20]
 LDCM0420  CL31 HEK-293T C254(0.83)  LDD1018  [20]
 LDCM0421  CL32 HEK-293T C254(0.74)  LDD1019  [20]
 LDCM0422  CL33 HEK-293T C254(0.62)  LDD1020  [20]
 LDCM0423  CL34 HEK-293T C254(0.89)  LDD1021  [20]
 LDCM0424  CL35 HEK-293T C254(0.77)  LDD1022  [20]
 LDCM0425  CL36 HEK-293T C254(0.61)  LDD1023  [20]
 LDCM0426  CL37 HEK-293T C254(0.72)  LDD1024  [20]
 LDCM0428  CL39 HEK-293T C254(0.61)  LDD1026  [20]
 LDCM0429  CL4 HEK-293T C254(0.43)  LDD1027  [20]
 LDCM0430  CL40 HEK-293T C254(0.73)  LDD1028  [20]
 LDCM0431  CL41 HEK-293T C254(0.59)  LDD1029  [20]
 LDCM0432  CL42 HEK-293T C254(0.62)  LDD1030  [20]
 LDCM0433  CL43 HEK-293T C254(0.62)  LDD1031  [20]
 LDCM0434  CL44 HEK-293T C254(0.76)  LDD1032  [20]
 LDCM0435  CL45 HEK-293T C254(0.66)  LDD1033  [20]
 LDCM0436  CL46 HEK-293T C254(0.69)  LDD1034  [20]
 LDCM0437  CL47 HEK-293T C254(0.72)  LDD1035  [20]
 LDCM0438  CL48 HEK-293T C254(0.80)  LDD1036  [20]
 LDCM0439  CL49 HEK-293T C254(0.71)  LDD1037  [20]
 LDCM0440  CL5 HEK-293T C254(0.33)  LDD1038  [20]
 LDCM0441  CL50 HEK-293T C254(0.52)  LDD1039  [20]
 LDCM0442  CL51 HEK-293T C254(0.63)  LDD1040  [20]
 LDCM0443  CL52 HEK-293T C254(1.15)  LDD1041  [20]
 LDCM0444  CL53 HEK-293T C254(0.90)  LDD1042  [20]
 LDCM0445  CL54 HEK-293T C254(0.66)  LDD1043  [20]
 LDCM0446  CL55 HEK-293T C254(0.68)  LDD1044  [20]
 LDCM0447  CL56 HEK-293T C254(0.83)  LDD1045  [20]
 LDCM0448  CL57 HEK-293T C254(0.79)  LDD1046  [20]
 LDCM0449  CL58 HEK-293T C254(0.82)  LDD1047  [20]
 LDCM0450  CL59 HEK-293T C254(0.60)  LDD1048  [20]
 LDCM0451  CL6 HEK-293T C254(0.54)  LDD1049  [20]
 LDCM0452  CL60 HEK-293T C254(0.60)  LDD1050  [20]
 LDCM0453  CL61 HEK-293T C254(0.90)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C254(0.99)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C254(0.98)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C254(1.04)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C254(1.01)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C254(1.07)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C254(1.06)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C254(1.06)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C254(1.11)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C254(0.37)  LDD1060  [20]
 LDCM0463  CL70 HEK-293T C254(1.06); C279(0.68)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C254(1.16); C279(0.51)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C254(1.08); C279(0.40)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C254(1.07)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C254(0.95)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C254(0.98)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C254(1.12)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C254(1.02)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C254(1.07)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C254(0.83)  LDD1071  [20]
 LDCM0474  CL80 HEK-293T C254(1.02)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C254(1.05)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C254(1.09); C279(0.72)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C254(1.11); C279(0.58)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C254(1.00); C279(0.57)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C254(0.97)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C254(0.96)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C254(1.05)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C254(0.95)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C254(1.02)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C254(0.85)  LDD1082  [20]
 LDCM0485  CL90 HEK-293T C254(1.52)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C254(1.03)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C254(1.14)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C254(1.27)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C254(1.10); C279(0.84)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C254(1.45); C279(1.06)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C254(1.02); C279(0.82)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C254(1.11)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C254(1.01)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C254(1.07)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C254(1.10)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C254(1.03)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C254(0.69)  LDD1025  [20]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [7]
 LDCM0022  KB02 HEK-293T C550(0.93); C254(0.86)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C550(1.11); C254(0.94)  LDD1497  [19]
 LDCM0024  KB05 IGR39 C254(1.23)  LDD3315  [5]
 LDCM0109  NEM HeLa N.A.  LDD0227  [8]
 LDCM0090  Rapamycin JHH-7 5.06  LDD0213  [17]
 LDCM0021  THZ1 HCT 116 C550(1.12)  LDD2173  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein PIGBOS1 (PIGBOS1) . A0A0B4J2F0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.