Details of the Target
General Information of Target
Target ID | LDTP06270 | |||||
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Target Name | Signal peptidase complex subunit 2 (SPCS2) | |||||
Gene Name | SPCS2 | |||||
Gene ID | 9789 | |||||
Synonyms |
KIAA0102; SPC25; Signal peptidase complex subunit 2; Microsomal signal peptidase 25 kDa subunit; SPase 25 kDa subunit |
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3D Structure | ||||||
Sequence |
MAAAAVQGGRSGGSGGCSGAGGASNCGTGSGRSGLLDKWKIDDKPVKIDKWDGSAVKNSL
DDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVIS YFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGR TKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK |
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Target Bioclass |
Enzyme
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Family |
SPCS2 family
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Subcellular location |
Endoplasmic reticulum membrane
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Function |
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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m-APA Probe Info |
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12.40 | LDD0402 | [1] | |
HDSF-alk Probe Info |
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1.88 | LDD0197 | [2] | |
DA-P2 Probe Info |
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26.01 | LDD0348 | [3] | |
HRP Probe Info |
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20.63 | LDD0347 | [3] | |
CHEMBL5175495 Probe Info |
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6.91 | LDD0196 | [4] | |
CY-1 Probe Info |
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100.00 | LDD0243 | [5] | |
W1 Probe Info |
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21.93 | LDD0235 | [6] | |
FBP2 Probe Info |
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2.17 | LDD0317 | [7] | |
ONAyne Probe Info |
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K71(0.40) | LDD0274 | [8] | |
STPyne Probe Info |
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K169(0.63); K191(9.43); K38(10.00); K40(9.72) | LDD0277 | [8] | |
P12 Probe Info |
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19.96 | LDD0202 | [9] | |
JZ128-DTB Probe Info |
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C26(0.00); C17(0.00) | LDD0462 | [10] | |
BTD Probe Info |
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C26(1.05) | LDD1700 | [11] | |
Sulforaphane-probe2 Probe Info |
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2.94 | LDD0042 | [12] | |
AHL-Pu-1 Probe Info |
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C26(2.55); C17(2.67) | LDD0171 | [13] | |
DBIA Probe Info |
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C17(5.30); C26(1.35) | LDD0080 | [14] | |
ATP probe Probe Info |
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K191(0.00); K195(0.00) | LDD0199 | [15] | |
IA-alkyne Probe Info |
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N.A. | LDD0162 | [16] | |
Lodoacetamide azide Probe Info |
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C26(0.00); C17(0.00) | LDD0037 | [17] | |
ATP probe Probe Info |
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N.A. | LDD0035 | [18] | |
NAIA_4 Probe Info |
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N.A. | LDD2226 | [19] | |
NAIA_5 Probe Info |
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C17(0.00); C26(0.00) | LDD2224 | [19] | |
TFBX Probe Info |
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C17(0.00); C26(0.00) | LDD0027 | [20] | |
WYneN Probe Info |
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N.A. | LDD0021 | [21] | |
DA-P3 Probe Info |
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N.A. | LDD0178 | [3] | |
aHNE Probe Info |
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C26(0.00); C17(0.00) | LDD0001 | [21] | |
Compound 10 Probe Info |
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C17(0.00); C26(0.00) | LDD2216 | [22] | |
Compound 11 Probe Info |
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C17(0.00); C26(0.00) | LDD2213 | [22] | |
ENE Probe Info |
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C17(0.00); C26(0.00) | LDD0006 | [21] | |
IPM Probe Info |
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C17(0.00); C26(0.00) | LDD0005 | [21] | |
NHS Probe Info |
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N.A. | LDD0010 | [21] | |
VSF Probe Info |
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C17(0.00); C26(0.00) | LDD0007 | [21] | |
Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [23] | |
Acrolein Probe Info |
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C17(0.00); H216(0.00); C26(0.00) | LDD0217 | [24] | |
Crotonaldehyde Probe Info |
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C17(0.00); H216(0.00); C26(0.00); H144(0.00) | LDD0219 | [24] | |
Methacrolein Probe Info |
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C17(0.00); C26(0.00) | LDD0218 | [24] | |
AOyne Probe Info |
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15.00 | LDD0443 | [25] | |
TPP-AC Probe Info |
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N.A. | LDD0427 | [26] |
PAL-AfBPP Probe
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C26(0.75); C17(1.02) | LDD2142 | [11] |
LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C26(0.58); C17(1.02) | LDD2112 | [11] |
LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C26(0.62); C17(0.58) | LDD2117 | [11] |
LDCM0026 | 4SU-RNA+native RNA | DM93 | C26(2.55); C17(2.67) | LDD0171 | [13] |
LDCM0214 | AC1 | HCT 116 | C17(1.16); C26(1.11) | LDD0531 | [14] |
LDCM0215 | AC10 | HCT 116 | C17(1.17); C26(1.13) | LDD0532 | [14] |
LDCM0216 | AC100 | HCT 116 | C17(1.43); C26(1.44) | LDD0533 | [14] |
LDCM0217 | AC101 | HCT 116 | C17(1.52); C26(1.53) | LDD0534 | [14] |
LDCM0218 | AC102 | HCT 116 | C17(1.09); C26(1.06) | LDD0535 | [14] |
LDCM0219 | AC103 | HCT 116 | C17(1.34); C26(1.31) | LDD0536 | [14] |
LDCM0220 | AC104 | HCT 116 | C17(0.99); C26(0.96) | LDD0537 | [14] |
LDCM0221 | AC105 | HCT 116 | C17(1.34); C26(1.33) | LDD0538 | [14] |
LDCM0222 | AC106 | HCT 116 | C17(1.88); C26(1.81) | LDD0539 | [14] |
LDCM0223 | AC107 | HCT 116 | C17(1.26); C26(1.12) | LDD0540 | [14] |
LDCM0224 | AC108 | HCT 116 | C17(1.11); C26(1.07) | LDD0541 | [14] |
LDCM0225 | AC109 | HCT 116 | C17(1.15); C26(2.08) | LDD0542 | [14] |
LDCM0226 | AC11 | HCT 116 | C17(1.57); C26(1.36) | LDD0543 | [14] |
LDCM0227 | AC110 | HCT 116 | C17(1.12); C26(1.34) | LDD0544 | [14] |
LDCM0228 | AC111 | HCT 116 | C17(1.16); C26(1.30) | LDD0545 | [14] |
LDCM0229 | AC112 | HCT 116 | C17(1.42); C26(1.30) | LDD0546 | [14] |
LDCM0230 | AC113 | HCT 116 | C17(1.09); C26(1.12) | LDD0547 | [14] |
LDCM0231 | AC114 | HCT 116 | C17(0.85); C26(1.23) | LDD0548 | [14] |
LDCM0232 | AC115 | HCT 116 | C17(1.00); C26(1.31) | LDD0549 | [14] |
LDCM0233 | AC116 | HCT 116 | C17(1.11); C26(1.75) | LDD0550 | [14] |
LDCM0234 | AC117 | HCT 116 | C17(1.04); C26(1.30) | LDD0551 | [14] |
LDCM0235 | AC118 | HCT 116 | C17(0.90); C26(1.15) | LDD0552 | [14] |
LDCM0236 | AC119 | HCT 116 | C17(1.21); C26(1.17) | LDD0553 | [14] |
LDCM0237 | AC12 | HCT 116 | C17(1.23); C26(1.16) | LDD0554 | [14] |
LDCM0238 | AC120 | HCT 116 | C17(1.04); C26(1.02) | LDD0555 | [14] |
LDCM0239 | AC121 | HCT 116 | C17(0.89); C26(0.94) | LDD0556 | [14] |
LDCM0240 | AC122 | HCT 116 | C17(1.07); C26(1.02) | LDD0557 | [14] |
LDCM0241 | AC123 | HCT 116 | C17(0.95); C26(1.11) | LDD0558 | [14] |
LDCM0242 | AC124 | HCT 116 | C17(0.92); C26(1.01) | LDD0559 | [14] |
LDCM0243 | AC125 | HCT 116 | C17(0.90); C26(1.09) | LDD0560 | [14] |
LDCM0244 | AC126 | HCT 116 | C17(1.00); C26(1.31) | LDD0561 | [14] |
LDCM0245 | AC127 | HCT 116 | C17(0.89); C26(1.48) | LDD0562 | [14] |
LDCM0246 | AC128 | HCT 116 | C17(1.06); C26(1.29) | LDD0563 | [14] |
LDCM0247 | AC129 | HCT 116 | C17(0.80); C26(0.99) | LDD0564 | [14] |
LDCM0249 | AC130 | HCT 116 | C17(1.16); C26(1.42) | LDD0566 | [14] |
LDCM0250 | AC131 | HCT 116 | C17(0.77); C26(0.94) | LDD0567 | [14] |
LDCM0251 | AC132 | HCT 116 | C17(0.81); C26(0.97) | LDD0568 | [14] |
LDCM0252 | AC133 | HCT 116 | C17(0.87); C26(0.95) | LDD0569 | [14] |
LDCM0253 | AC134 | HCT 116 | C17(1.03); C26(1.33) | LDD0570 | [14] |
LDCM0254 | AC135 | HCT 116 | C17(0.92); C26(1.26) | LDD0571 | [14] |
LDCM0255 | AC136 | HCT 116 | C17(0.93); C26(0.98) | LDD0572 | [14] |
LDCM0256 | AC137 | HCT 116 | C17(0.88); C26(0.95) | LDD0573 | [14] |
LDCM0257 | AC138 | HCT 116 | C17(1.13); C26(1.31) | LDD0574 | [14] |
LDCM0258 | AC139 | HCT 116 | C17(1.00); C26(1.26) | LDD0575 | [14] |
LDCM0259 | AC14 | HCT 116 | C17(1.28); C26(1.15) | LDD0576 | [14] |
LDCM0260 | AC140 | HCT 116 | C17(0.99); C26(1.23) | LDD0577 | [14] |
LDCM0261 | AC141 | HCT 116 | C17(0.98); C26(1.25) | LDD0578 | [14] |
LDCM0262 | AC142 | HCT 116 | C17(0.86); C26(0.95) | LDD0579 | [14] |
LDCM0263 | AC143 | HCT 116 | C17(1.10); C26(1.18) | LDD0580 | [14] |
LDCM0264 | AC144 | HCT 116 | C17(1.14); C26(1.39) | LDD0581 | [14] |
LDCM0265 | AC145 | HCT 116 | C17(1.03); C26(1.20) | LDD0582 | [14] |
LDCM0266 | AC146 | HCT 116 | C17(1.84); C26(1.85) | LDD0583 | [14] |
LDCM0267 | AC147 | HCT 116 | C17(1.23); C26(1.28) | LDD0584 | [14] |
LDCM0268 | AC148 | HCT 116 | C17(1.60); C26(1.93) | LDD0585 | [14] |
LDCM0269 | AC149 | HCT 116 | C17(1.50); C26(1.61) | LDD0586 | [14] |
LDCM0270 | AC15 | HCT 116 | C26(1.09); C17(1.11) | LDD0587 | [14] |
LDCM0271 | AC150 | HCT 116 | C17(1.17); C26(1.25) | LDD0588 | [14] |
LDCM0272 | AC151 | HCT 116 | C17(1.15); C26(1.32) | LDD0589 | [14] |
LDCM0273 | AC152 | HCT 116 | C26(1.45); C17(1.52) | LDD0590 | [14] |
LDCM0274 | AC153 | HCT 116 | C17(1.63); C26(1.76) | LDD0591 | [14] |
LDCM0621 | AC154 | HCT 116 | C17(1.25); C26(1.47) | LDD2158 | [14] |
LDCM0622 | AC155 | HCT 116 | C17(1.60); C26(1.59) | LDD2159 | [14] |
LDCM0623 | AC156 | HCT 116 | C17(1.14); C26(1.09) | LDD2160 | [14] |
LDCM0624 | AC157 | HCT 116 | C17(1.20); C26(1.16) | LDD2161 | [14] |
LDCM0276 | AC17 | HCT 116 | C17(1.13); C26(1.23) | LDD0593 | [14] |
LDCM0277 | AC18 | HCT 116 | C26(1.80); C17(1.96) | LDD0594 | [14] |
LDCM0278 | AC19 | HCT 116 | C26(1.45); C17(1.55) | LDD0595 | [14] |
LDCM0279 | AC2 | HCT 116 | C26(1.36); C17(1.77) | LDD0596 | [14] |
LDCM0280 | AC20 | HCT 116 | C17(1.21); C26(1.24) | LDD0597 | [14] |
LDCM0281 | AC21 | HCT 116 | C26(1.32); C17(1.38) | LDD0598 | [14] |
LDCM0282 | AC22 | HCT 116 | C17(1.09); C26(1.17) | LDD0599 | [14] |
LDCM0283 | AC23 | HCT 116 | C26(1.40); C17(1.44) | LDD0600 | [14] |
LDCM0284 | AC24 | HCT 116 | C17(0.99); C26(1.08) | LDD0601 | [14] |
LDCM0285 | AC25 | HCT 116 | C26(1.25); C17(1.29) | LDD0602 | [14] |
LDCM0286 | AC26 | HCT 116 | C26(1.53); C17(1.54) | LDD0603 | [14] |
LDCM0287 | AC27 | HCT 116 | C26(1.58); C17(1.60) | LDD0604 | [14] |
LDCM0288 | AC28 | HCT 116 | C26(1.57); C17(1.66) | LDD0605 | [14] |
LDCM0289 | AC29 | HCT 116 | C17(1.66); C26(1.75) | LDD0606 | [14] |
LDCM0290 | AC3 | HCT 116 | C26(1.07); C17(1.08) | LDD0607 | [14] |
LDCM0291 | AC30 | HCT 116 | C26(1.69); C17(1.84) | LDD0608 | [14] |
LDCM0292 | AC31 | HCT 116 | C17(1.35); C26(1.46) | LDD0609 | [14] |
LDCM0293 | AC32 | HCT 116 | C26(1.89); C17(1.94) | LDD0610 | [14] |
LDCM0294 | AC33 | HCT 116 | C17(1.66); C26(1.68) | LDD0611 | [14] |
LDCM0295 | AC34 | HCT 116 | C26(1.87); C17(1.96) | LDD0612 | [14] |
LDCM0296 | AC35 | HCT 116 | C26(0.83); C17(0.85) | LDD0613 | [14] |
LDCM0297 | AC36 | HCT 116 | C17(0.91); C26(0.91) | LDD0614 | [14] |
LDCM0298 | AC37 | HCT 116 | C26(0.85); C17(0.94) | LDD0615 | [14] |
LDCM0299 | AC38 | HCT 116 | C17(0.96); C26(0.97) | LDD0616 | [14] |
LDCM0300 | AC39 | HCT 116 | C17(1.07); C26(1.12) | LDD0617 | [14] |
LDCM0301 | AC4 | HCT 116 | C17(1.30); C26(1.49) | LDD0618 | [14] |
LDCM0302 | AC40 | HCT 116 | C17(1.08); C26(1.26) | LDD0619 | [14] |
LDCM0303 | AC41 | HCT 116 | C17(1.11); C26(1.12) | LDD0620 | [14] |
LDCM0304 | AC42 | HCT 116 | C17(1.09); C26(1.19) | LDD0621 | [14] |
LDCM0305 | AC43 | HCT 116 | C26(1.20); C17(1.25) | LDD0622 | [14] |
LDCM0306 | AC44 | HCT 116 | C17(0.99); C26(1.12) | LDD0623 | [14] |
LDCM0307 | AC45 | HCT 116 | C17(1.30); C26(1.32) | LDD0624 | [14] |
LDCM0308 | AC46 | HCT 116 | C26(1.03); C17(1.17) | LDD0625 | [14] |
LDCM0309 | AC47 | HCT 116 | C26(1.07); C17(1.13) | LDD0626 | [14] |
LDCM0310 | AC48 | HCT 116 | C26(1.05); C17(1.17) | LDD0627 | [14] |
LDCM0311 | AC49 | HCT 116 | C17(1.60); C26(1.61) | LDD0628 | [14] |
LDCM0312 | AC5 | HCT 116 | C17(1.38); C26(1.52) | LDD0629 | [14] |
LDCM0313 | AC50 | HCT 116 | C26(1.60); C17(1.78) | LDD0630 | [14] |
LDCM0314 | AC51 | HCT 116 | C26(0.93); C17(0.99) | LDD0631 | [14] |
LDCM0315 | AC52 | HCT 116 | C26(1.10); C17(1.19) | LDD0632 | [14] |
LDCM0316 | AC53 | HCT 116 | C26(1.37); C17(1.39) | LDD0633 | [14] |
LDCM0317 | AC54 | HCT 116 | C26(1.19); C17(1.26) | LDD0634 | [14] |
LDCM0318 | AC55 | HCT 116 | C17(1.54); C26(1.58) | LDD0635 | [14] |
LDCM0319 | AC56 | HCT 116 | C26(2.01); C17(2.09) | LDD0636 | [14] |
LDCM0320 | AC57 | HCT 116 | C17(1.67); C26(1.78) | LDD0637 | [14] |
LDCM0321 | AC58 | HCT 116 | C17(1.40); C26(1.62) | LDD0638 | [14] |
LDCM0322 | AC59 | HCT 116 | C17(1.50); C26(1.83) | LDD0639 | [14] |
LDCM0323 | AC6 | HCT 116 | C26(1.31); C17(1.36) | LDD0640 | [14] |
LDCM0324 | AC60 | HCT 116 | C17(1.54); C26(1.72) | LDD0641 | [14] |
LDCM0325 | AC61 | HCT 116 | C17(1.21); C26(1.34) | LDD0642 | [14] |
LDCM0326 | AC62 | HCT 116 | C17(1.62); C26(1.63) | LDD0643 | [14] |
LDCM0327 | AC63 | HCT 116 | C17(1.39); C26(1.69) | LDD0644 | [14] |
LDCM0328 | AC64 | HCT 116 | C17(1.41); C26(1.72) | LDD0645 | [14] |
LDCM0329 | AC65 | HCT 116 | C17(1.00); C26(1.15) | LDD0646 | [14] |
LDCM0330 | AC66 | HCT 116 | C17(0.99); C26(1.16) | LDD0647 | [14] |
LDCM0331 | AC67 | HCT 116 | C17(1.19); C26(1.38) | LDD0648 | [14] |
LDCM0332 | AC68 | HCT 116 | C17(1.15); C26(1.23) | LDD0649 | [14] |
LDCM0333 | AC69 | HCT 116 | C17(1.11); C26(1.41) | LDD0650 | [14] |
LDCM0334 | AC7 | HCT 116 | C26(1.06); C17(1.06) | LDD0651 | [14] |
LDCM0335 | AC70 | HCT 116 | C17(1.28); C26(1.42) | LDD0652 | [14] |
LDCM0336 | AC71 | HCT 116 | C17(0.89); C26(1.19) | LDD0653 | [14] |
LDCM0337 | AC72 | HCT 116 | C17(1.18); C26(1.35) | LDD0654 | [14] |
LDCM0338 | AC73 | HCT 116 | C17(1.64); C26(1.95) | LDD0655 | [14] |
LDCM0339 | AC74 | HCT 116 | C17(1.25); C26(1.80) | LDD0656 | [14] |
LDCM0340 | AC75 | HCT 116 | C17(1.92); C26(2.62) | LDD0657 | [14] |
LDCM0341 | AC76 | HCT 116 | C17(1.26); C26(1.36) | LDD0658 | [14] |
LDCM0342 | AC77 | HCT 116 | C17(1.45); C26(1.49) | LDD0659 | [14] |
LDCM0343 | AC78 | HCT 116 | C17(1.14); C26(1.33) | LDD0660 | [14] |
LDCM0344 | AC79 | HCT 116 | C17(1.17); C26(1.36) | LDD0661 | [14] |
LDCM0345 | AC8 | HCT 116 | C17(1.07); C26(1.14) | LDD0662 | [14] |
LDCM0346 | AC80 | HCT 116 | C17(1.18); C26(1.35) | LDD0663 | [14] |
LDCM0347 | AC81 | HCT 116 | C17(1.09); C26(1.24) | LDD0664 | [14] |
LDCM0348 | AC82 | HCT 116 | C17(1.49); C26(1.92) | LDD0665 | [14] |
LDCM0349 | AC83 | HCT 116 | C17(1.46); C26(1.90) | LDD0666 | [14] |
LDCM0350 | AC84 | HCT 116 | C17(1.28); C26(1.40) | LDD0667 | [14] |
LDCM0351 | AC85 | HCT 116 | C17(1.31); C26(1.39) | LDD0668 | [14] |
LDCM0352 | AC86 | HCT 116 | C17(1.36); C26(1.42) | LDD0669 | [14] |
LDCM0353 | AC87 | HCT 116 | C26(1.08); C17(1.25) | LDD0670 | [14] |
LDCM0354 | AC88 | HCT 116 | C26(1.33); C17(1.34) | LDD0671 | [14] |
LDCM0355 | AC89 | HCT 116 | C26(1.40); C17(1.50) | LDD0672 | [14] |
LDCM0357 | AC90 | HCT 116 | C26(1.05); C17(1.19) | LDD0674 | [14] |
LDCM0358 | AC91 | HCT 116 | C17(1.54); C26(1.91) | LDD0675 | [14] |
LDCM0359 | AC92 | HCT 116 | C17(1.39); C26(1.61) | LDD0676 | [14] |
LDCM0360 | AC93 | HCT 116 | C26(1.17); C17(1.22) | LDD0677 | [14] |
LDCM0361 | AC94 | HCT 116 | C17(1.11); C26(1.12) | LDD0678 | [14] |
LDCM0362 | AC95 | HCT 116 | C17(1.25); C26(1.34) | LDD0679 | [14] |
LDCM0363 | AC96 | HCT 116 | C26(1.40); C17(1.55) | LDD0680 | [14] |
LDCM0364 | AC97 | HCT 116 | C17(1.57); C26(1.66) | LDD0681 | [14] |
LDCM0365 | AC98 | HCT 116 | C26(1.51); C17(1.52) | LDD0682 | [14] |
LDCM0366 | AC99 | HCT 116 | C26(1.06); C17(1.09) | LDD0683 | [14] |
LDCM0520 | AKOS000195272 | MDA-MB-231 | C26(0.79); C17(0.90) | LDD2113 | [11] |
LDCM0248 | AKOS034007472 | HCT 116 | C17(1.02); C26(0.96) | LDD0565 | [14] |
LDCM0356 | AKOS034007680 | HCT 116 | C17(1.32); C26(1.35) | LDD0673 | [14] |
LDCM0275 | AKOS034007705 | HCT 116 | C17(1.69); C26(1.85) | LDD0592 | [14] |
LDCM0156 | Aniline | NCI-H1299 | 11.93 | LDD0403 | [1] |
LDCM0088 | C45 | HEK-293T | 19.96 | LDD0202 | [9] |
LDCM0087 | Capsaicin | HEK-293T | 6.38 | LDD0185 | [3] |
LDCM0108 | Chloroacetamide | HeLa | H216(0.00); H199(0.00); H144(0.00); C26(0.00) | LDD0222 | [24] |
LDCM0632 | CL-Sc | Hep-G2 | C17(0.66) | LDD2227 | [19] |
LDCM0367 | CL1 | HCT 116 | C26(0.89); C17(1.04) | LDD0684 | [14] |
LDCM0368 | CL10 | HCT 116 | C17(1.65); C26(1.70) | LDD0685 | [14] |
LDCM0369 | CL100 | HCT 116 | C26(1.39); C17(1.59) | LDD0686 | [14] |
LDCM0370 | CL101 | HCT 116 | C26(1.47); C17(1.51) | LDD0687 | [14] |
LDCM0371 | CL102 | HCT 116 | C26(1.12); C17(1.17) | LDD0688 | [14] |
LDCM0372 | CL103 | HCT 116 | C26(1.11); C17(1.17) | LDD0689 | [14] |
LDCM0373 | CL104 | HCT 116 | C26(1.09); C17(1.15) | LDD0690 | [14] |
LDCM0374 | CL105 | HCT 116 | C26(1.61); C17(1.73) | LDD0691 | [14] |
LDCM0375 | CL106 | HCT 116 | C26(2.28); C17(2.37) | LDD0692 | [14] |
LDCM0376 | CL107 | HCT 116 | C17(1.74); C26(1.91) | LDD0693 | [14] |
LDCM0377 | CL108 | HCT 116 | C17(1.72); C26(1.81) | LDD0694 | [14] |
LDCM0378 | CL109 | HCT 116 | C26(1.45); C17(1.46) | LDD0695 | [14] |
LDCM0379 | CL11 | HCT 116 | C26(1.57); C17(1.68) | LDD0696 | [14] |
LDCM0380 | CL110 | HCT 116 | C26(1.81); C17(2.02) | LDD0697 | [14] |
LDCM0381 | CL111 | HCT 116 | C26(1.49); C17(1.49) | LDD0698 | [14] |
LDCM0382 | CL112 | HCT 116 | C26(1.43); C17(1.44) | LDD0699 | [14] |
LDCM0383 | CL113 | HCT 116 | C26(1.60); C17(1.70) | LDD0700 | [14] |
LDCM0384 | CL114 | HCT 116 | C26(1.90); C17(1.94) | LDD0701 | [14] |
LDCM0385 | CL115 | HCT 116 | C26(1.64); C17(1.70) | LDD0702 | [14] |
LDCM0386 | CL116 | HCT 116 | C17(1.48); C26(1.53) | LDD0703 | [14] |
LDCM0387 | CL117 | HCT 116 | C17(1.65); C26(1.82) | LDD0704 | [14] |
LDCM0388 | CL118 | HCT 116 | C17(1.04); C26(1.12) | LDD0705 | [14] |
LDCM0389 | CL119 | HCT 116 | C26(1.13); C17(1.29) | LDD0706 | [14] |
LDCM0390 | CL12 | HCT 116 | C17(1.31); C26(1.90) | LDD0707 | [14] |
LDCM0391 | CL120 | HCT 116 | C17(1.01); C26(1.01) | LDD0708 | [14] |
LDCM0392 | CL121 | HCT 116 | C26(1.53); C17(2.47) | LDD0709 | [14] |
LDCM0393 | CL122 | HCT 116 | C26(1.13); C17(1.18) | LDD0710 | [14] |
LDCM0394 | CL123 | HCT 116 | C26(1.45); C17(1.63) | LDD0711 | [14] |
LDCM0395 | CL124 | HCT 116 | C26(1.67); C17(1.79) | LDD0712 | [14] |
LDCM0396 | CL125 | HCT 116 | C17(1.01); C26(1.10) | LDD0713 | [14] |
LDCM0397 | CL126 | HCT 116 | C26(1.10); C17(1.13) | LDD0714 | [14] |
LDCM0398 | CL127 | HCT 116 | C17(0.98); C26(1.05) | LDD0715 | [14] |
LDCM0399 | CL128 | HCT 116 | C17(1.48); C26(1.75) | LDD0716 | [14] |
LDCM0400 | CL13 | HCT 116 | C17(0.99); C26(1.22) | LDD0717 | [14] |
LDCM0401 | CL14 | HCT 116 | C17(0.80); C26(0.98) | LDD0718 | [14] |
LDCM0402 | CL15 | HCT 116 | C17(0.90); C26(1.18) | LDD0719 | [14] |
LDCM0403 | CL16 | HCT 116 | C26(1.15); C17(1.38) | LDD0720 | [14] |
LDCM0404 | CL17 | HCT 116 | C26(1.47); C17(1.68) | LDD0721 | [14] |
LDCM0405 | CL18 | HCT 116 | C26(1.29); C17(1.37) | LDD0722 | [14] |
LDCM0406 | CL19 | HCT 116 | C26(1.25); C17(1.40) | LDD0723 | [14] |
LDCM0407 | CL2 | HCT 116 | C26(0.85); C17(0.91) | LDD0724 | [14] |
LDCM0408 | CL20 | HCT 116 | C26(1.70); C17(1.76) | LDD0725 | [14] |
LDCM0409 | CL21 | HCT 116 | C26(2.11); C17(2.20) | LDD0726 | [14] |
LDCM0410 | CL22 | HCT 116 | C17(2.29); C26(2.65) | LDD0727 | [14] |
LDCM0411 | CL23 | HCT 116 | C26(1.50); C17(1.61) | LDD0728 | [14] |
LDCM0412 | CL24 | HCT 116 | C17(1.81); C26(1.72) | LDD0729 | [14] |
LDCM0413 | CL25 | HCT 116 | C17(2.14); C26(1.95) | LDD0730 | [14] |
LDCM0414 | CL26 | HCT 116 | C17(1.48); C26(1.42) | LDD0731 | [14] |
LDCM0415 | CL27 | HCT 116 | C17(1.94); C26(1.61) | LDD0732 | [14] |
LDCM0416 | CL28 | HCT 116 | C17(1.49); C26(1.36) | LDD0733 | [14] |
LDCM0417 | CL29 | HCT 116 | C17(1.69); C26(1.62) | LDD0734 | [14] |
LDCM0418 | CL3 | HCT 116 | C17(1.28); C26(1.01) | LDD0735 | [14] |
LDCM0419 | CL30 | HCT 116 | C17(1.28); C26(1.23) | LDD0736 | [14] |
LDCM0420 | CL31 | HCT 116 | C17(1.37); C26(1.32) | LDD0737 | [14] |
LDCM0421 | CL32 | HCT 116 | C17(1.45); C26(1.42) | LDD0738 | [14] |
LDCM0422 | CL33 | HCT 116 | C17(2.02); C26(1.73) | LDD0739 | [14] |
LDCM0423 | CL34 | HCT 116 | C17(2.19); C26(1.96) | LDD0740 | [14] |
LDCM0424 | CL35 | HCT 116 | C17(2.31); C26(2.06) | LDD0741 | [14] |
LDCM0425 | CL36 | HCT 116 | C17(1.97); C26(1.81) | LDD0742 | [14] |
LDCM0426 | CL37 | HCT 116 | C17(2.55); C26(2.47) | LDD0743 | [14] |
LDCM0428 | CL39 | HCT 116 | C17(2.09); C26(2.06) | LDD0745 | [14] |
LDCM0429 | CL4 | HCT 116 | C17(0.63); C26(0.79) | LDD0746 | [14] |
LDCM0430 | CL40 | HCT 116 | C17(2.20); C26(1.88) | LDD0747 | [14] |
LDCM0431 | CL41 | HCT 116 | C17(1.75); C26(1.84) | LDD0748 | [14] |
LDCM0432 | CL42 | HCT 116 | C17(3.55); C26(3.81) | LDD0749 | [14] |
LDCM0433 | CL43 | HCT 116 | C17(2.54); C26(2.36) | LDD0750 | [14] |
LDCM0434 | CL44 | HCT 116 | C17(1.93); C26(1.88) | LDD0751 | [14] |
LDCM0435 | CL45 | HCT 116 | C17(2.67); C26(2.36) | LDD0752 | [14] |
LDCM0436 | CL46 | HCT 116 | C17(0.84); C26(0.90) | LDD0753 | [14] |
LDCM0437 | CL47 | HCT 116 | C17(0.84); C26(0.90) | LDD0754 | [14] |
LDCM0438 | CL48 | HCT 116 | C17(0.87); C26(0.98) | LDD0755 | [14] |
LDCM0439 | CL49 | HCT 116 | C17(0.95); C26(1.00) | LDD0756 | [14] |
LDCM0440 | CL5 | HCT 116 | C17(1.02); C26(0.95) | LDD0757 | [14] |
LDCM0441 | CL50 | HCT 116 | C17(0.97); C26(0.95) | LDD0758 | [14] |
LDCM0442 | CL51 | HCT 116 | C17(0.99); C26(1.06) | LDD0759 | [14] |
LDCM0443 | CL52 | HCT 116 | C17(1.01); C26(1.09) | LDD0760 | [14] |
LDCM0444 | CL53 | HCT 116 | C17(0.89); C26(0.92) | LDD0761 | [14] |
LDCM0445 | CL54 | HCT 116 | C17(0.94); C26(0.99) | LDD0762 | [14] |
LDCM0446 | CL55 | HCT 116 | C17(0.93); C26(0.99) | LDD0763 | [14] |
LDCM0447 | CL56 | HCT 116 | C17(0.98); C26(1.05) | LDD0764 | [14] |
LDCM0448 | CL57 | HCT 116 | C17(0.85); C26(0.84) | LDD0765 | [14] |
LDCM0449 | CL58 | HCT 116 | C17(0.76); C26(0.84) | LDD0766 | [14] |
LDCM0450 | CL59 | HCT 116 | C17(0.94); C26(1.01) | LDD0767 | [14] |
LDCM0451 | CL6 | HCT 116 | C17(1.17); C26(1.22) | LDD0768 | [14] |
LDCM0452 | CL60 | HCT 116 | C17(0.88); C26(0.95) | LDD0769 | [14] |
LDCM0453 | CL61 | HCT 116 | C17(1.23); C26(1.31) | LDD0770 | [14] |
LDCM0454 | CL62 | HCT 116 | C17(1.20); C26(1.37) | LDD0771 | [14] |
LDCM0455 | CL63 | HCT 116 | C17(1.72); C26(1.82) | LDD0772 | [14] |
LDCM0456 | CL64 | HCT 116 | C17(2.34); C26(2.01) | LDD0773 | [14] |
LDCM0457 | CL65 | HCT 116 | C17(1.17); C26(1.32) | LDD0774 | [14] |
LDCM0458 | CL66 | HCT 116 | C17(1.91); C26(2.44) | LDD0775 | [14] |
LDCM0459 | CL67 | HCT 116 | C17(1.59); C26(1.60) | LDD0776 | [14] |
LDCM0460 | CL68 | HCT 116 | C17(1.64); C26(1.64) | LDD0777 | [14] |
LDCM0461 | CL69 | HCT 116 | C17(1.50); C26(1.51) | LDD0778 | [14] |
LDCM0462 | CL7 | HCT 116 | C17(1.28); C26(1.43) | LDD0779 | [14] |
LDCM0463 | CL70 | HCT 116 | C17(1.47); C26(1.60) | LDD0780 | [14] |
LDCM0464 | CL71 | HCT 116 | C17(1.80); C26(1.83) | LDD0781 | [14] |
LDCM0465 | CL72 | HCT 116 | C17(1.23); C26(1.25) | LDD0782 | [14] |
LDCM0466 | CL73 | HCT 116 | C17(1.71); C26(1.75) | LDD0783 | [14] |
LDCM0467 | CL74 | HCT 116 | C17(1.74); C26(1.74) | LDD0784 | [14] |
LDCM0469 | CL76 | HCT 116 | C17(1.44); C26(1.46) | LDD0786 | [14] |
LDCM0470 | CL77 | HCT 116 | C17(1.30); C26(1.44) | LDD0787 | [14] |
LDCM0471 | CL78 | HCT 116 | C17(1.61); C26(1.59) | LDD0788 | [14] |
LDCM0472 | CL79 | HCT 116 | C17(1.92); C26(2.02) | LDD0789 | [14] |
LDCM0473 | CL8 | HCT 116 | C17(3.10); C26(2.42) | LDD0790 | [14] |
LDCM0474 | CL80 | HCT 116 | C17(1.18); C26(1.24) | LDD0791 | [14] |
LDCM0475 | CL81 | HCT 116 | C17(1.38); C26(1.45) | LDD0792 | [14] |
LDCM0476 | CL82 | HCT 116 | C17(3.29); C26(3.38) | LDD0793 | [14] |
LDCM0477 | CL83 | HCT 116 | C17(2.11); C26(2.21) | LDD0794 | [14] |
LDCM0478 | CL84 | HCT 116 | C17(3.06); C26(3.05) | LDD0795 | [14] |
LDCM0479 | CL85 | HCT 116 | C17(1.45); C26(1.47) | LDD0796 | [14] |
LDCM0480 | CL86 | HCT 116 | C17(1.09); C26(1.15) | LDD0797 | [14] |
LDCM0481 | CL87 | HCT 116 | C17(1.43); C26(1.45) | LDD0798 | [14] |
LDCM0482 | CL88 | HCT 116 | C17(2.25); C26(2.12) | LDD0799 | [14] |
LDCM0483 | CL89 | HCT 116 | C17(3.55); C26(3.53) | LDD0800 | [14] |
LDCM0484 | CL9 | HCT 116 | C17(1.17); C26(1.41) | LDD0801 | [14] |
LDCM0485 | CL90 | HCT 116 | C17(1.01); C26(1.10) | LDD0802 | [14] |
LDCM0486 | CL91 | HCT 116 | C17(1.53); C26(1.41) | LDD0803 | [14] |
LDCM0487 | CL92 | HCT 116 | C17(1.46); C26(1.24) | LDD0804 | [14] |
LDCM0488 | CL93 | HCT 116 | C17(1.42); C26(1.14) | LDD0805 | [14] |
LDCM0489 | CL94 | HCT 116 | C17(1.63); C26(1.67) | LDD0806 | [14] |
LDCM0490 | CL95 | HCT 116 | C17(1.30); C26(1.71) | LDD0807 | [14] |
LDCM0491 | CL96 | HCT 116 | C17(1.22); C26(1.15) | LDD0808 | [14] |
LDCM0492 | CL97 | HCT 116 | C17(1.89); C26(1.42) | LDD0809 | [14] |
LDCM0493 | CL98 | HCT 116 | C17(1.27); C26(1.31) | LDD0810 | [14] |
LDCM0494 | CL99 | HCT 116 | C17(1.20); C26(1.22) | LDD0811 | [14] |
LDCM0017 | DFG-out-2 | A431 | 4.80 | LDD0075 | [31] |
LDCM0028 | Dobutamine | HEK-293T | 5.11 | LDD0180 | [3] |
LDCM0027 | Dopamine | HEK-293T | 6.88 | LDD0179 | [3] |
LDCM0495 | E2913 | HEK-293T | C26(0.96); C17(1.04) | LDD1698 | [33] |
LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C17(2.72); C26(1.98) | LDD1702 | [11] |
LDCM0031 | Epigallocatechin gallate | HEK-293T | 5.24 | LDD0183 | [3] |
LDCM0625 | F8 | Ramos | 0.56; C17(1.85) | LDD2187 | [34] |
LDCM0572 | Fragment10 | Ramos | 2.89; C17(2.48) | LDD2189 | [34] |
LDCM0573 | Fragment11 | Ramos | 1.30; C17(2.24) | LDD2190 | [34] |
LDCM0574 | Fragment12 | Ramos | 1.92; C17(1.66) | LDD2191 | [34] |
LDCM0575 | Fragment13 | Ramos | 0.96; C17(0.85) | LDD2192 | [34] |
LDCM0576 | Fragment14 | Ramos | 0.30; C17(1.67) | LDD2193 | [34] |
LDCM0579 | Fragment20 | Ramos | 1.48; C17(1.14) | LDD2194 | [34] |
LDCM0580 | Fragment21 | Ramos | 0.66; C17(0.96) | LDD2195 | [34] |
LDCM0582 | Fragment23 | Ramos | 1.34; C17(0.56) | LDD2196 | [34] |
LDCM0578 | Fragment27 | Ramos | 0.87; C17(1.29) | LDD2197 | [34] |
LDCM0586 | Fragment28 | Ramos | 0.95; C17(0.81) | LDD2198 | [34] |
LDCM0588 | Fragment30 | Ramos | 1.64; C17(1.65) | LDD2199 | [34] |
LDCM0589 | Fragment31 | Ramos | 1.26; C17(0.72) | LDD2200 | [34] |
LDCM0590 | Fragment32 | Ramos | 2.81; C17(1.65) | LDD2201 | [34] |
LDCM0468 | Fragment33 | HCT 116 | C17(1.82); C26(1.51) | LDD0785 | [14] |
LDCM0596 | Fragment38 | Ramos | 1.06; C17(0.38) | LDD2203 | [34] |
LDCM0566 | Fragment4 | Ramos | 1.09; C17(0.78) | LDD2184 | [34] |
LDCM0427 | Fragment51 | HCT 116 | C17(4.03); C26(3.40) | LDD0744 | [14] |
LDCM0610 | Fragment52 | Ramos | 2.69; C17(3.12) | LDD2204 | [34] |
LDCM0614 | Fragment56 | Ramos | 2.22; C17(1.33) | LDD2205 | [34] |
LDCM0569 | Fragment7 | Ramos | C17(1.17) | LDD2186 | [34] |
LDCM0571 | Fragment9 | Ramos | 2.83; C17(3.35) | LDD2188 | [34] |
LDCM0107 | IAA | HeLa | H144(0.00); H199(0.00); H216(0.00) | LDD0221 | [24] |
LDCM0179 | JZ128 | PC-3 | C26(0.00); C17(0.00) | LDD0462 | [10] |
LDCM0022 | KB02 | HCT 116 | C17(5.30); C26(1.35) | LDD0080 | [14] |
LDCM0023 | KB03 | HCT 116 | C17(3.96); C26(1.50) | LDD0081 | [14] |
LDCM0024 | KB05 | HCT 116 | C17(15.88); C26(1.47) | LDD0082 | [14] |
LDCM0030 | Luteolin | HEK-293T | 14.25 | LDD0182 | [3] |
LDCM0109 | NEM | HeLa | H216(0.00); H144(0.00); H199(0.00) | LDD0223 | [24] |
LDCM0497 | Nucleophilic fragment 11b | MDA-MB-231 | C26(1.22) | LDD2090 | [11] |
LDCM0501 | Nucleophilic fragment 13b | MDA-MB-231 | C17(1.41) | LDD2094 | [11] |
LDCM0504 | Nucleophilic fragment 15a | MDA-MB-231 | C26(1.22) | LDD2097 | [11] |
LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C26(0.75) | LDD2099 | [11] |
LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C26(0.47) | LDD2100 | [11] |
LDCM0508 | Nucleophilic fragment 17a | MDA-MB-231 | C26(0.88); C17(0.94) | LDD2101 | [11] |
LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C26(0.36) | LDD2104 | [11] |
LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C17(1.30) | LDD2105 | [11] |
LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C26(0.84) | LDD2107 | [11] |
LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C26(0.47) | LDD2108 | [11] |
LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C26(1.06); C17(0.85) | LDD2109 | [11] |
LDCM0518 | Nucleophilic fragment 22a | MDA-MB-231 | C26(0.78) | LDD2111 | [11] |
LDCM0522 | Nucleophilic fragment 24a | MDA-MB-231 | C26(0.58); C17(0.63) | LDD2115 | [11] |
LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C26(0.65); C17(0.57) | LDD2123 | [11] |
LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C26(0.59); C17(0.61) | LDD2125 | [11] |
LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C26(0.70); C17(0.74) | LDD2127 | [11] |
LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C26(0.74) | LDD2129 | [11] |
LDCM0540 | Nucleophilic fragment 35 | MDA-MB-231 | C26(0.69); C17(0.77) | LDD2133 | [11] |
LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C26(0.72); C17(0.84) | LDD2134 | [11] |
LDCM0542 | Nucleophilic fragment 37 | MDA-MB-231 | C26(0.70) | LDD2135 | [11] |
LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C26(0.99); C17(1.14) | LDD2136 | [11] |
LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C26(0.98); C17(1.03) | LDD2137 | [11] |
LDCM0211 | Nucleophilic fragment 3b | MDA-MB-231 | C26(1.05) | LDD1700 | [11] |
LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C26(0.70) | LDD2140 | [11] |
LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C26(0.68); C17(0.81) | LDD2141 | [11] |
LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C26(1.01) | LDD2145 | [11] |
LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C26(0.91) | LDD2146 | [11] |
LDCM0554 | Nucleophilic fragment 7a | MDA-MB-231 | C26(0.56); C17(0.66) | LDD2148 | [11] |
LDCM0559 | Nucleophilic fragment 9b | MDA-MB-231 | C26(1.84) | LDD2153 | [11] |
LDCM0627 | NUDT7-COV-1 | HEK-293T | C17(0.64) | LDD2206 | [35] |
LDCM0032 | Oleacein | HEK-293T | 4.80 | LDD0184 | [3] |
LDCM0628 | OTUB2-COV-1 | HEK-293T | C17(0.68) | LDD2207 | [35] |
LDCM0029 | Quercetin | HEK-293T | 9.25 | LDD0181 | [3] |
LDCM0131 | RA190 | MM1.R | C17(2.05); C26(2.05) | LDD0304 | [36] |
LDCM0003 | Sulforaphane | MCF-7 | 2.94 | LDD0042 | [12] |
LDCM0112 | W16 | Hep-G2 | C26(0.75); C17(0.79) | LDD0239 | [6] |
References