Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C238  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 99 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 99.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 56.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 45.6
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 43.7
 LDTP03813  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) 42.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 41.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 40.2
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 37.3
 LDTP02359  Heme oxygenase 1 (HMOX1) 36.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 33.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 32.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 31.6
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 29.9
 LDTP01560  NADH dehydrogenase 1 subunit C2 (NDUFC2) 29.9
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 29.7
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 29.2
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 25.8
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 25.8
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 25.6
 LDTP11127  ADP-dependent glucokinase (ADPGK) 24.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 24.6
 LDTP04456  Ubiquitin carboxyl-terminal hydrolase 11 (USP11) 24.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 24.1
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 22.9
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 22.3
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 20.8
 LDTP10329  Ceramide synthase 2 (CERS2) 20.7
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 20.7
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 20.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 20.1
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 19.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 19.4
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 19.0
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 19.0
 LDTP06720  Peroxisomal leader peptide-processing protease (TYSND1) 18.8
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 18.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 18.0
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 17.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 17.6
 LDTP15132  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (OGFOD3) 17.0
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 16.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 16.9
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 16.8
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 16.7
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 16.6
 LDTP01769  Dihydrofolate reductase (DHFR) 16.2
 LDTP07218  E3 ubiquitin-protein ligase BRE1A (RNF20) 15.6
 LDTP10020  Ras-related protein Rab-24 (RAB24) 15.6
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 15.5
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 15.3
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 14.8
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 14.5
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 14.4
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 14.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 14.1
 LDTP11247  Oxidoreductase HTATIP2 (HTATIP2) 14.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 13.8
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 13.8
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 13.6
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 13.5
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 13.5
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 13.2
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 13.2
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 13.2
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 13.0
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 12.9
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 12.9
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 12.8
 LDTP03145  Catechol O-methyltransferase (COMT) 12.6
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 12.6
 LDTP04531  Hexokinase-2 (HK2) 12.5
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 12.4
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 12.3
 LDTP11595  Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) 12.1
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 12.1
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 12.1
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 12.0
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 12.0
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 12.0
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 11.9
 LDTP12061  Ubiquitin carboxyl-terminal hydrolase MINDY-3 (MINDY3) 11.9
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 11.6
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 11.5
 LDTP11090  Mitochondrial genome maintenance exonuclease 1 (MGME1) 11.4
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 11.4
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 11.3
 LDTP09251  Atlastin-2 (ATL2) 11.2
 LDTP01513  NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) 11.2
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 11.2
 LDTP07961  Protein arginine methyltransferase NDUFAF7, mitochondrial (NDUFAF7) 11.2
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 11.2
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.1
 LDTP06142  Squalene monooxygenase (SQLE) 11.1
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 11.0
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 11.0
 LDTP00325  Pirin (PIR) 11.0
 LDTP13968  Exosome complex component CSL4 (EXOSC1) 10.9
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 10.9
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 10.9
Transporter and channel
Click to Show/Hide to Show 74 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 78.2
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 67.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 64.9
 LDTP15948  Transmembrane protein 126A (TMEM126A) 61.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 54.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 50.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 49.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 47.2
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 45.3
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 36.5
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 33.1
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 32.0
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 31.8
 LDTP01804  ATP synthase subunit a (MT-ATP6) 31.1
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 30.9
 LDTP09180  Zinc transporter 7 (SLC30A7) 27.9
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) 27.1
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 26.2
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 25.1
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 24.8
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 24.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 23.9
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 22.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 21.9
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 21.9
 LDTP15648  BRI3-binding protein (BRI3BP) 21.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 21.3
 LDTP12383  Protein GPR108 (GPR108) 21.1
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 20.1
 LDTP05900  Metaxin-1 (MTX1) 19.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 19.8
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 18.8
 LDTP11245  Derlin-1 (DERL1) 18.4
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 18.4
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 18.1
 LDTP07236  Protein GPR107 (GPR107) 18.1
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 17.9
 LDTP10065  Transmembrane protein 230 (TMEM230) 17.9
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 17.6
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 17.6
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 16.9
 LDTP15481  Transmembrane protein 87A (TMEM87A) 16.2
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 16.0
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 16.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 15.1
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 14.8
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 14.8
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 14.7
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 13.4
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 13.2
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 13.1
 LDTP07583  Transmembrane protein 65 (TMEM65) 12.9
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 12.8
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 12.6
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 12.6
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 12.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 12.5
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 12.5
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 12.0
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 12.0
 LDTP11250  MICOS complex subunit MIC26 (APOO) 12.0
 LDTP03869  Protein Mpv17 (MPV17) 12.0
 LDTP04787  Transmembrane protein 33 (TMEM33) 12.0
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 11.7
 LDTP14717  ATP synthase subunit e, mitochondrial (ATP5ME) 11.6
 LDTP10513  Exocyst complex component 2 (EXOC2) 11.4
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 11.4
 LDTP07531  Sideroflexin-4 (SFXN4) 11.3
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 11.2
 LDTP12979  Transmembrane protein 14C (TMEM14C) 11.2
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 11.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 11.0
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 10.9
 LDTP05780  Syntaxin-5 (STX5) 10.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 14.2
Other
Click to Show/Hide to Show 81 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 99.7
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 91.8
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 75.1
 LDTP18569  PRELI domain containing protein 3B (PRELID3B) 65.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 50.9
 LDTP01522  Reticulon-3 (RTN3) 46.2
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 45.3
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 36.3
 LDTP10056  Protein FAM162A (FAM162A) 36.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 35.0
 LDTP05160  Nucleobindin-2 (NUCB2) 33.8
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 31.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 30.9
 LDTP00105  Protein unc-119 homolog B (UNC119B) 30.5
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 28.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 27.3
 LDTP08224  Protein LYRIC (MTDH) 27.1
 LDTP16080  Protein FAM114A2 (FAM114A2) 26.2
 LDTP19859  Small integral membrane protein 12 (SMIM12) 23.6
 LDTP08606  Nurim (NRM) 23.1
 LDTP13086  Syntaxin-18 (STX18) 22.9
 LDTP00986  Syntaxin-10 (STX10) 21.3
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 21.3
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 21.1
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 20.1
 LDTP18272  Transmembrane protein 209 (TMEM209) 19.6
 LDTP10924  Prohibitin-2 (PHB2) 19.4
 LDTP19963  TraB domain-containing protein (TRABD) 19.4
 LDTP08081  Hepatoma-derived growth factor-related protein 2 (HDGFL2) 19.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 19.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 18.1
 LDTP12412  Reticulon-4 (RTN4) 18.1
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 18.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 17.4
 LDTP02913  Desmin (DES) 17.1
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 16.9
 LDTP02297  Vimentin (VIM) 15.8
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 15.7
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 15.1
 LDTP08594  Negative elongation factor C/D (NELFCD) 14.6
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 14.5
 LDTP03926  Centrin-2 (CETN2) 14.5
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 14.4
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 14.1
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 13.8
 LDTP03612  Bifunctional purine biosynthesis protein ATIC (ATIC) 13.6
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 13.6
 LDTP01652  Centrosomal protein 43 (CEP43) 13.5
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 13.5
 LDTP05375  Nucleobindin-1 (NUCB1) 13.5
 LDTP15057  TBC1 domain family member 9B (TBC1D9B) 13.5
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 13.2
 LDTP15863  Large ribosomal subunit protein mL45 (MRPL45) 13.2
 LDTP09773  Protein FAM3C (FAM3C) 13.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 13.1
 LDTP02180  Neurofilament light polypeptide (NEFL) 12.8
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 12.8
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 12.7
 LDTP06391  Protein transport protein Sec23B (SEC23B) 12.6
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 12.4
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 12.3
 LDTP01494  Protein YIF1A (YIF1A) 12.2
 LDTP10849  Regulator of microtubule dynamics protein 3 (RMDN3) 12.2
 LDTP02443  Calmodulin-3 (CALM3) 12.0
 LDTP04356  Emerin (EMD) 12.0
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 12.0
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 11.9
 LDTP13412  Anaphase-promoting complex subunit 2 (ANAPC2) 11.8
 LDTP13273  Ubiquilin-2 (UBQLN2) 11.6
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 11.4
 LDTP15283  Nucleolar protein 9 (NOP9) 11.4
 LDTP00859  Synaptogyrin-2 (SYNGR2) 11.4
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 11.2
 LDTP12192  Kinetochore protein Spc25 (SPC25) 11.2
 LDTP13901  Ragulator complex protein LAMTOR2 (LAMTOR2) 11.2
 LDTP01167  Reticulon-2 (RTN2) 11.2
 LDTP05641  WASH complex subunit 5 (WASHC5) 11.1
 LDTP06097  Reticulocalbin-2 (RCN2) 11.0
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 11.0
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 10.9
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 10.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587