General Information of Target

Target ID LDTP18569
Target Name PRELI domain containing protein 3B (PRELID3B)
Gene Name PRELID3B
Gene ID 51012
Synonyms
C20orf45; SLMO2; PRELI domain containing protein 3B; Protein slowmo homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVYIPSFRYEESDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPS
KHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDET
ESEESSKLSHQPVLLFLRDPYVLPAASDFPNVVIEGVLHGIFYPHLQPR
Target Bioclass
Other
Family
Slowmo family
Uniprot ID
Q9Y3B1
Ensemble ID
ENST00000355937.9
HGNC ID
HGNC:15892

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.P45L .
NCIH358 SNV: p.R109Ter .
OVK18 SNV: p.P116H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
5E-2FA
 Probe Info 
N.A.  LDD2235  [1]
m-APA
 Probe Info 
N.A.  LDD2231  [1]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info 
30.48  LDD1752  [2]
C056
 Probe Info 
26.17  LDD1753  [2]
C064
 Probe Info 
8.34  LDD1761  [2]
C091
 Probe Info 
16.11  LDD1782  [2]
C092
 Probe Info 
33.13  LDD1783  [2]
C094
 Probe Info 
45.89  LDD1785  [2]
C134
 Probe Info 
75.58  LDD1816  [2]
C135
 Probe Info 
17.63  LDD1817  [2]
C139
 Probe Info 
19.43  LDD1821  [2]
C140
 Probe Info 
9.45  LDD1822  [2]
C238
 Probe Info 
65.80  LDD1911  [2]
C243
 Probe Info 
12.64  LDD1916  [2]
C246
 Probe Info 
13.74  LDD1919  [2]
BD-F
 Probe Info 
P26(0.00); N27(0.00); Y25(0.00)  LDD0024  [3]

References

1 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652