Details of the Target

General Information of Target

Target ID LDTP01167
Target Name Reticulon-2 (RTN2)
Gene Name RTN2
Gene ID 6253
Synonyms
NSPL1; Reticulon-2; Neuroendocrine-specific protein-like 1; NSP-like protein 1; Neuroendocrine-specific protein-like I; NSP-like protein I; NSPLI
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR
ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE
PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE
TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE
KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLW
TAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVV
FTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVD
LTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTL
LILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGS
KAKAE
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface. Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell.
Uniprot ID
O75298
Ensemble ID
ENST00000245923.9
HGNC ID
HGNC:10468

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.L493CfsTer17 .
G361 Substitution: p.P412L .
JURKAT Deletion: p.D408MfsTer16 .
KYM1 SNV: p.E453Ter .
MEWO SNV: p.L463F .
TOV21G SNV: p.K352E .
UACC257 SNV: p.S334N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		N.A.  LDD0009  [1]
PAL-AfBPP Probe
Click To Hide/Show 52 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		9.65  LDD1733  [2]
C040
 Probe Info  		26.17  LDD1740  [2]
C041
 Probe Info  		6.54  LDD1741  [2]
C055
 Probe Info  		16.34  LDD1752  [2]
C056
 Probe Info  		37.53  LDD1753  [2]
C091
 Probe Info  		41.07  LDD1782  [2]
C092
 Probe Info  		64.00  LDD1783  [2]
C094
 Probe Info  		86.82  LDD1785  [2]
C095
 Probe Info  		5.94  LDD1786  [2]
C100
 Probe Info  		8.06  LDD1789  [2]
C112
 Probe Info  		38.59  LDD1799  [2]
C134
 Probe Info  		43.41  LDD1816  [2]
C135
 Probe Info  		12.47  LDD1817  [2]
C158
 Probe Info  		9.38  LDD1838  [2]
C159
 Probe Info  		10.70  LDD1839  [2]
C160
 Probe Info  		7.52  LDD1840  [2]
C161
 Probe Info  		16.56  LDD1841  [2]
C169
 Probe Info  		27.86  LDD1849  [2]
C201
 Probe Info  		26.54  LDD1877  [2]
C218
 Probe Info  		28.25  LDD1892  [2]
C219
 Probe Info  		5.90  LDD1893  [2]
C220
 Probe Info  		19.43  LDD1894  [2]
C225
 Probe Info  		5.13  LDD1898  [2]
C228
 Probe Info  		29.45  LDD1901  [2]
C231
 Probe Info  		16.91  LDD1904  [2]
C235
 Probe Info  		36.50  LDD1908  [2]
C238
 Probe Info  		11.16  LDD1911  [2]
C278
 Probe Info  		87.43  LDD1948  [2]
C282
 Probe Info  		15.67  LDD1952  [2]
C285
 Probe Info  		28.44  LDD1955  [2]
C287
 Probe Info  		15.03  LDD1957  [2]
C289
 Probe Info  		60.13  LDD1959  [2]
C299
 Probe Info  		8.69  LDD1968  [2]
C305
 Probe Info  		12.82  LDD1974  [2]
C314
 Probe Info  		14.32  LDD1981  [2]
C326
 Probe Info  		7.06  LDD1990  [2]
C343
 Probe Info  		14.52  LDD2005  [2]
C348
 Probe Info  		22.63  LDD2009  [2]
C349
 Probe Info  		37.53  LDD2010  [2]
C350
 Probe Info  		99.73  LDD2011  [2]
C353
 Probe Info  		9.00  LDD2014  [2]
C354
 Probe Info  		7.52  LDD2015  [2]
C376
 Probe Info  		7.78  LDD2036  [2]
C378
 Probe Info  		5.94  LDD2037  [2]
C380
 Probe Info  		5.28  LDD2039  [2]
C382
 Probe Info  		11.96  LDD2041  [2]
C388
 Probe Info  		99.73  LDD2047  [2]
C390
 Probe Info  		99.73  LDD2049  [2]
C391
 Probe Info  		13.74  LDD2050  [2]
C403
 Probe Info  		18.38  LDD2061  [2]
C407
 Probe Info  		12.13  LDD2064  [2]
OEA-DA
 Probe Info  		10.33  LDD0046  [3]

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570