Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C305  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 120 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01803  Adenosine deaminase (ADA) 83.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 65.3
 LDTP07683  Carboxylesterase 3 (CES3) 44.6
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 40.5
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 38.9
 LDTP13972  Oligoribonuclease, mitochondrial (REXO2) 36.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 34.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 32.0
 LDTP12509  N-lysine methyltransferase SMYD2 (SMYD2) 31.1
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 30.1
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 28.1
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 26.5
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 26.5
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 25.8
 LDTP04114  E3 ubiquitin-protein ligase NEDD4 (NEDD4) 24.9
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 24.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 24.4
 LDTP02713  Macrophage migration inhibitory factor (MIF) 23.9
 LDTP05905  Acid ceramidase (ASAH1) 23.3
 LDTP06986  Rab-like protein 3 (RABL3) 23.3
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 22.3
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 22.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 21.7
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 21.7
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 21.4
 LDTP02359  Heme oxygenase 1 (HMOX1) 21.4
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 21.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 20.7
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 20.7
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 19.4
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 19.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 19.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 18.6
 LDTP11127  ADP-dependent glucokinase (ADPGK) 18.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 18.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 18.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 17.8
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 17.4
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 17.4
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 16.8
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 16.3
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 16.2
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 16.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 15.9
 LDTP02505  Lysosomal protective protein (CTSA) 15.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.6
 LDTP00988  Protein O-GlcNAcase (OGA) 15.6
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 15.5
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 15.5
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 15.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 14.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 14.8
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 14.8
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 14.6
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 14.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 14.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 14.1
 LDTP04893  Ras-related protein Rab-5B (RAB5B) 14.0
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 13.8
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 13.7
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 13.5
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 13.5
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 13.5
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 13.5
 LDTP03145  Catechol O-methyltransferase (COMT) 13.4
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 13.4
 LDTP04032  Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) 13.4
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 13.4
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 13.3
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 13.2
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 13.2
 LDTP09355  Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) 13.2
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 12.9
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 12.8
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 12.8
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 12.7
 LDTP02223  Cathepsin B (CTSB) 12.7
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 12.7
 LDTP09074  UDP-glucuronic acid decarboxylase 1 (UXS1) 12.6
 LDTP06617  Ceramide glucosyltransferase (UGCG) 12.3
 LDTP02837  Beta-galactosidase (GLB1) 12.2
 LDTP00422  Serine/threonine-protein kinase Chk1 (CHEK1) 12.2
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 12.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 12.0
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 12.0
 LDTP05446  Ubiquitin-protein ligase E3A (UBE3A) 11.8
 LDTP10329  Ceramide synthase 2 (CERS2) 11.7
 LDTP01788  Adenylate kinase isoenzyme 1 (AK1) 11.6
 LDTP06371  GTP-binding protein Rheb (RHEB) 11.6
 LDTP03787  Choline kinase alpha (CHKA) 11.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 11.5
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 11.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 11.4
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 11.2
 LDTP02539  Lysosomal acid phosphatase (ACP2) 11.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 11.0
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 10.9
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 10.9
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 10.8
 LDTP14801  Di-N-acetylchitobiase (CTBS) 10.7
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 10.7
 LDTP03688  Serine hydroxymethyltransferase, cytosolic (SHMT1) 10.7
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 10.7
 LDTP06427  Translin (TSN) 10.6
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 10.4
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 10.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 10.3
 LDTP02141  Alpha-galactosidase A (GLA) 10.1
 LDTP10322  Abasic site processing protein HMCES (HMCES) 10.0
 LDTP07503  Endoplasmic reticulum aminopeptidase 2 (ERAP2) 9.9
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 9.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.8
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 9.8
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 9.7
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 9.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 9.6
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 9.6
 LDTP00639  ATP-binding cassette sub-family C member 4 (ABCC4) 9.6
 LDTP07054  Exosome complex component MTR3 (EXOSC6) 9.6
Transporter and channel
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09180  Zinc transporter 7 (SLC30A7) 77.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 62.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 46.2
 LDTP01804  ATP synthase subunit a (MT-ATP6) 45.6
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 42.5
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 38.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 35.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 32.9
 LDTP05900  Metaxin-1 (MTX1) 32.0
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 30.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 29.9
 LDTP02215  Prosaposin (PSAP) 28.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 28.4
 LDTP20002  Transmembrane protein 160 (TMEM160) 28.4
 LDTP11844  Protein spinster homolog 1 (SPNS1) 28.2
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 25.8
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 24.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 23.8
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 22.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 21.7
 LDTP16813  Tetraspanin-3 (TSPAN3) 21.4
 LDTP15648  BRI3-binding protein (BRI3BP) 21.3
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 20.3
 LDTP00592  Surfeit locus protein 4 (SURF4) 19.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 18.9
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 18.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 18.4
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 18.3
 LDTP15481  Transmembrane protein 87A (TMEM87A) 18.0
 LDTP09949  Transportin-1 (TNPO1) 17.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 16.8
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 16.8
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 16.0
 LDTP07236  Protein GPR107 (GPR107) 15.6
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 15.3
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 15.2
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 14.6
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 14.6
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 13.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 13.7
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 13.5
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 13.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 12.9
 LDTP11615  Protein tweety homolog 3 (TTYH3) 12.8
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 12.7
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) 12.7
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 12.7
 LDTP11116  45 kDa calcium-binding protein (SDF4) 12.0
 LDTP01217  Metaxin-2 (MTX2) 12.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 11.9
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 11.6
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 11.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 11.5
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 11.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 11.2
 LDTP12451  Integral membrane protein 2C (ITM2C) 10.7
 LDTP11245  Derlin-1 (DERL1) 10.6
 LDTP14970  Metaxin-3 (MTX3) 10.6
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 10.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 10.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 10.2
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 10.1
 LDTP10065  Transmembrane protein 230 (TMEM230) 9.8
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 9.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 9.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 15.1
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 9.6
Other
Click to Show/Hide to Show 77 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 53.1
 LDTP11076  Apolipoprotein L2 (APOL2) 46.2
 LDTP03926  Centrin-2 (CETN2) 38.3
 LDTP05160  Nucleobindin-2 (NUCB2) 34.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 33.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 28.8
 LDTP00105  Protein unc-119 homolog B (UNC119B) 25.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 24.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 23.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 22.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 21.6
 LDTP06097  Reticulocalbin-2 (RCN2) 21.0
 LDTP18883  Protein CEBPZOS (CEBPZOS) 20.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 19.7
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 19.6
 LDTP13086  Syntaxin-18 (STX18) 19.6
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 18.6
 LDTP05375  Nucleobindin-1 (NUCB1) 18.4
 LDTP01522  Reticulon-3 (RTN3) 18.4
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 18.4
 LDTP12891  Glycolipid transfer protein (GLTP) 17.8
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 17.0
 LDTP10056  Protein FAM162A (FAM162A) 16.1
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 15.8
 LDTP12192  Kinetochore protein Spc25 (SPC25) 15.7
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 14.9
 LDTP09069  Kinetochore protein Spc24 (SPC24) 14.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 14.5
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 14.4
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 14.3
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 14.3
 LDTP14939  Membralin (TMEM259) 14.3
 LDTP01279  Protein CREG1 (CREG1) 14.1
 LDTP02927  Ganglioside GM2 activator (GM2A) 14.0
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 14.0
 LDTP03775  RNA-binding protein FUS (FUS) 13.9
 LDTP05922  Dynactin subunit 2 (DCTN2) 13.3
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 13.3
 LDTP15623  Neuferricin (CYB5D2) 13.0
 LDTP01167  Reticulon-2 (RTN2) 12.8
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 12.6
 LDTP06527  Alpha-internexin (INA) 12.4
 LDTP01652  Centrosomal protein 43 (CEP43) 12.4
 LDTP05226  RNA-binding protein 3 (RBM3) 12.3
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 12.2
 LDTP00417  Programmed cell death protein 5 (PDCD5) 12.0
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 12.0
 LDTP15398  Protein FAM177A1 (FAM177A1) 11.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 11.6
 LDTP00859  Synaptogyrin-2 (SYNGR2) 11.6
 LDTP01359  Dynactin subunit 3 (DCTN3) 11.6
 LDTP10452  Conserved oligomeric Golgi complex subunit 3 (COG3) 11.3
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 11.3
 LDTP13507  BAG family molecular chaperone regulator 5 (BAG5) 11.0
 LDTP02297  Vimentin (VIM) 11.0
 LDTP13630  Neudesin (NENF) 10.9
 LDTP12412  Reticulon-4 (RTN4) 10.9
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 10.8
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 10.7
 LDTP19963  TraB domain-containing protein (TRABD) 10.7
 LDTP00887  Calumenin (CALU) 10.5
 LDTP13309  Prefoldin subunit 2 (PFDN2) 10.5
 LDTP18309  Protein HGH1 homolog (HGH1) 10.5
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 10.2
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 10.1
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 10.1
 LDTP00573  Prefoldin subunit 6 (PFDN6) 10.1
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 10.0
 LDTP08594  Negative elongation factor C/D (NELFCD) 9.9
 LDTP02205  Tubulin beta chain (TUBB) 9.9
 LDTP10823  Paired amphipathic helix protein Sin3a (SIN3A) 9.8
 LDTP05960  Trophoblast glycoprotein (TPBG) 9.8
 LDTP06548  Large ribosomal subunit protein uL23m (MRPL23) 9.8
 LDTP14192  MORF4 family-associated protein 1 (MRFAP1) 9.8
 LDTP04980  U6 snRNA-associated Sm-like protein LSm6 (LSM6) 9.7
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 9.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 9.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587