Details of the Target

General Information of Target

Target ID LDTP00417
Target Name Programmed cell death protein 5 (PDCD5)
Gene Name PDCD5
Gene ID 9141
Synonyms
TFAR19; Programmed cell death protein 5; TF-1 cell apoptosis-related protein 19; Protein TFAR19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADEELEALRRQRLAELQAKHGDPGDAAQQEAKHREAEMRNSILAQVLDQSARARLSNLA
LVKPEKTKAVENYLIQMARYGQLSEKVSEQGLIEILKKVSQQTEKTTTVKFNRRKVMDSD
EDDDY
Target Bioclass
Other
Family
PDCD5 family
Function May function in the process of apoptosis.
Uniprot ID
O14737
Ensemble ID
ENST00000419343.7
HGNC ID
HGNC:8764

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SNGM SNV: p.Q12Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y73(17.42)  LDD0257  [1]
TH214
 Probe Info  		Y80(10.23)  LDD0258  [1]
TH216
 Probe Info  		Y73(13.09); Y80(10.80)  LDD0259  [1]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
OPA-S-S-alkyne
 Probe Info  		K33(4.82)  LDD3494  [3]
m-APA
 Probe Info  		10.57  LDD0403  [4]
HHS-482
 Probe Info  		Y73(1.27); Y80(1.33)  LDD0285  [5]
HHS-475
 Probe Info  		Y80(0.83); Y73(0.87)  LDD0264  [6]
HHS-465
 Probe Info  		Y73(9.01); Y80(9.55)  LDD2237  [7]
AMP probe
 Probe Info  		K63(0.00); K20(0.00)  LDD0200  [8]
ATP probe
 Probe Info  		K63(0.00); K20(0.00); K66(0.00); K68(0.00)  LDD0199  [8]
NHS
 Probe Info  		K97(0.00); K68(0.00); K33(0.00); K105(0.00)  LDD0010  [9]
OSF
 Probe Info  		N.A.  LDD0029  [10]
SF
 Probe Info  		K63(0.00); K66(0.00); Y80(0.00); K110(0.00)  LDD0028  [10]
STPyne
 Probe Info  		K97(0.00); K63(0.00); K33(0.00); K66(0.00)  LDD0009  [9]
1c-yne
 Probe Info  		K33(0.00); K20(0.00); K68(0.00)  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
PAL-AfBPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.39  LDD1711  [13]
C004
 Probe Info  		7.06  LDD1714  [13]
C022
 Probe Info  		7.46  LDD1728  [13]
C041
 Probe Info  		8.22  LDD1741  [13]
C052
 Probe Info  		4.92  LDD1750  [13]
C087
 Probe Info  		13.18  LDD1779  [13]
C106
 Probe Info  		36.76  LDD1793  [13]
C108
 Probe Info  		9.45  LDD1795  [13]
C112
 Probe Info  		17.51  LDD1799  [13]
C143
 Probe Info  		23.92  LDD1825  [13]
C153
 Probe Info  		22.01  LDD1834  [13]
C177
 Probe Info  		7.36  LDD1856  [13]
C178
 Probe Info  		25.63  LDD1857  [13]
C187
 Probe Info  		34.30  LDD1865  [13]
C191
 Probe Info  		23.10  LDD1868  [13]
C201
 Probe Info  		36.50  LDD1877  [13]
C210
 Probe Info  		39.12  LDD1884  [13]
C213
 Probe Info  		16.80  LDD1887  [13]
C220
 Probe Info  		15.03  LDD1894  [13]
C228
 Probe Info  		16.00  LDD1901  [13]
C232
 Probe Info  		38.85  LDD1905  [13]
C249
 Probe Info  		13.00  LDD1922  [13]
C252
 Probe Info  		9.00  LDD1925  [13]
C286
 Probe Info  		10.78  LDD1956  [13]
C293
 Probe Info  		24.42  LDD1963  [13]
C296
 Probe Info  		12.13  LDD1966  [13]
C305
 Probe Info  		12.04  LDD1974  [13]
C313
 Probe Info  		17.39  LDD1980  [13]
C314
 Probe Info  		16.91  LDD1981  [13]
C326
 Probe Info  		11.16  LDD1990  [13]
C328
 Probe Info  		9.19  LDD1992  [13]
C348
 Probe Info  		11.47  LDD2009  [13]
C350
 Probe Info  		41.64  LDD2011  [13]
C355
 Probe Info  		26.17  LDD2016  [13]
C364
 Probe Info  		16.56  LDD2025  [13]
C376
 Probe Info  		7.73  LDD2036  [13]
C383
 Probe Info  		10.85  LDD2042  [13]
C388
 Probe Info  		37.01  LDD2047  [13]
C391
 Probe Info  		19.29  LDD2050  [13]
C403
 Probe Info  		14.52  LDD2061  [13]
C407
 Probe Info  		11.47  LDD2064  [13]
C431
 Probe Info  		18.77  LDD2086  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe14
 Probe Info  		13.38  LDD0477  [14]
FFF probe2
 Probe Info  		16.39  LDD0463  [14]
OEA-DA
 Probe Info  		13.00  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 10.57  LDD0403  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0116  HHS-0101 DM93 Y80(0.83); Y73(0.87)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y80(0.74); Y73(0.77)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y80(0.87); Y73(1.00)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y80(0.69); Y73(0.81)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y80(0.80); Y73(0.96)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0123  JWB131 DM93 Y73(1.27); Y80(1.33)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y73(1.54); Y80(1.86)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y73(1.08); Y80(1.89)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y73(3.28); Y80(7.48)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y73(3.11); Y80(5.78)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y80(3.02)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y73(1.01); Y80(1.65)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y73(1.32); Y80(1.97)  LDD0292  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RAD18 (RAD18) RAD18 family Q9NS91
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570