Details of the Probe

General Information of Probe

Probe ID
LDPC0355
Probe Name
C108
Synonyms
Z3426152213
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 327.4
Lipid-water partition coefficient (xlogp) 2.8
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C18H21N3OS
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-1-(1-thiophen-2-yl-2-azabicyclo[3.2.0]heptan-2-yl)propan-1-one
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)N2CCC3C2(CC3)C4=CC=CS4
InChI
InChI=1S/C18H21N3OS/c1-2-3-9-17(19-20-17)10-7-16(22)21-12-8-14-6-11-18(14,21)15-5-4-13-23-15/h1,4-5,13-14H,3,6-12H2
InChIKey
VBOXFFVOBGGHKD-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

134 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) LDTP06657 8.82  LDD1795 
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (BCKDHB) LDTP03144 9.92  LDD1795 
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 10.06  LDD1795 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 13.09  LDD1795 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 15.35  LDD1795 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 17.63  LDD1795 
Acid ceramidase (ASAH1) LDTP05905 25.46  LDD1795 
Actin-histidine N-methyltransferase (SETD3) LDTP08206 13.83  LDD1795 
ADP-dependent glucokinase (ADPGK) LDTP11127 10.27  LDD1795 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 15.35  LDD1795 
Alpha-galactosidase A (GLA) LDTP02141 9.58  LDD1795 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 11.79  LDD1795 
ATP-binding cassette sub-family D member 1 (ABCD1) LDTP03676 13.45  LDD1795 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 9.25  LDD1795 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 9.92  LDD1795 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 8.00  LDD1795 
Atypical kinase COQ8B, mitochondrial (COQ8B) LDTP10201 8.94  LDD1795 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 10.78  LDD1795 
Beta-galactosidase (GLB1) LDTP02837 12.13  LDD1795 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 10.06  LDD1795 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 13.18  LDD1795 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 17.51  LDD1795 
Calcyclin-binding protein (CACYBP) LDTP12163 15.45  LDD1795 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 10.20  LDD1795 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 22.32  LDD1795 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 13.09  LDD1795 
Ceramide glucosyltransferase (UGCG) LDTP06617 9.58  LDD1795 
Ceramide synthase 1 (CERS1) LDTP03394 10.27  LDD1795 
Ceramide synthase 2 (CERS2) LDTP10329 14.12  LDD1795 
Ceramide synthase 5 (CERS5) LDTP08891 8.06  LDD1795 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 24.93  LDD1795 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 34.06  LDD1795 
Cytochrome b5 type B (CYB5B) LDTP00697 30.70  LDD1795 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 18.77  LDD1795 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 8.57  LDD1795 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 13.74  LDD1795 
Delta(24)-sterol reductase (DHCR24) LDTP06375 15.67  LDD1795 
Dihydrofolate reductase (DHFR) LDTP01769 45.25  LDD1795 
DNA polymerase epsilon subunit 2 (POLE2) LDTP04737 12.73  LDD1795 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 10.06  LDD1795 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 9.92  LDD1795 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 8.28  LDD1795 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 9.06  LDD1795 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 13.00  LDD1795 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 15.24  LDD1795 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 15.45  LDD1795 
Epoxide hydrolase 1 (EPHX1) LDTP02175 13.74  LDD1795 
Ethanolamine kinase 1 (ETNK1) LDTP12197 14.32  LDD1795 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 36.25  LDD1795 
Fumarylacetoacetase (FAH) LDTP02868 12.64  LDD1795 
Glutaminyl-peptide cyclotransferase-like protein (QPCTL) LDTP12790 16.56  LDD1795 
Glutathione hydrolase 7 (GGT7) LDTP13367 10.41  LDD1795 
Glutathione S-transferase A4 (GSTA4) LDTP00575 32.22  LDD1795 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 10.48  LDD1795 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 8.51  LDD1795 
GPI ethanolamine phosphate transferase 2 (PIGG) LDTP06977 8.06  LDD1795 
Heme A synthase COX15 (COX15) LDTP07931 11.31  LDD1795 
Heme oxygenase 1 (HMOX1) LDTP02359 11.96  LDD1795 
Heme oxygenase 2 (HMOX2) LDTP03540 37.27  LDD1795 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 10.70  LDD1795 
Histone-lysine N-methyltransferase NSD2 (NSD2) LDTP01759 9.19  LDD1795 
Histone-lysine N-methyltransferase NSD3 (NSD3) LDTP11518 8.75  LDD1795 
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) LDTP06645 9.25  LDD1795 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 12.73  LDD1795 
Lactadherin (MFGE8) LDTP05561 8.28  LDD1795 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 18.77  LDD1795 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 14.03  LDD1795 
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) LDTP13486 11.39  LDD1795 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 10.48  LDD1795 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 11.55  LDD1795 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 14.62  LDD1795 
Lysosomal alpha-glucosidase (GAA) LDTP02486 10.78  LDD1795 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 8.22  LDD1795 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 17.03  LDD1795 
Lysosomal protective protein (CTSA) LDTP02505 19.97  LDD1795 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 26.72  LDD1795 
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) LDTP00975 12.82  LDD1795 
Metalloendopeptidase OMA1, mitochondrial (OMA1) LDTP10249 15.14  LDD1795 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 25.46  LDD1795 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 11.63  LDD1795 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 10.63  LDD1795 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 9.99  LDD1795 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 11.88  LDD1795 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 32.90  LDD1795 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 17.63  LDD1795 
NADPH--cytochrome P450 reductase (POR) LDTP02848 8.28  LDD1795 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 33.82  LDD1795 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 11.55  LDD1795 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 11.55  LDD1795 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 11.16  LDD1795 
Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) LDTP03374 9.06  LDD1795 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 11.63  LDD1795 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 11.24  LDD1795 
Peroxisomal trans-2-enoyl-CoA reductase (PECR) LDTP11437 8.22  LDD1795 
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) LDTP06638 16.68  LDD1795 
Phospholipase A2 group XV (PLA2G15) LDTP09088 13.64  LDD1795 
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (PHKA1) LDTP04080 8.51  LDD1795 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 9.78  LDD1795 
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) LDTP03024 8.51  LDD1795 
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) LDTP03249 8.28  LDD1795 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 9.32  LDD1795 
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) LDTP08859 17.03  LDD1795 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 16.34  LDD1795 
Presequence protease, mitochondrial (PITRM1) LDTP07003 9.78  LDD1795 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 11.39  LDD1795 
Prostaglandin reductase 3 (PTGR3) LDTP15422 8.06  LDD1795 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 14.42  LDD1795 
Proteasome subunit beta type-3 (PSMB3) LDTP04284 9.51  LDD1795 
Proteasome subunit beta type-4 (PSMB4) LDTP03417 9.51  LDD1795 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 17.88  LDD1795 
Protein disulfide-isomerase (P4HB) LDTP02188 9.78  LDD1795 
Protein O-mannosyl-transferase TMTC3 (TMTC3) LDTP07868 8.28  LDD1795 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 15.24  LDD1795 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 15.24  LDD1795 
Ras-related protein Ral-A (RALA) LDTP02557 12.13  LDD1795 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 34.06  LDD1795 
Ribitol 5-phosphate transferase FKRP (FKRP) LDTP12109 8.34  LDD1795 
Ribonuclease T2 (RNASET2) LDTP00316 8.11  LDD1795 
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) LDTP07989 12.82  LDD1795 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 31.12  LDD1795 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 8.22  LDD1795 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 8.11  LDD1795 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 15.45  LDD1795 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 34.78  LDD1795 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 13.36  LDD1795 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 8.06  LDD1795 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 19.03  LDD1795 
Squalene monooxygenase (SQLE) LDTP06142 8.22  LDD1795 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 8.46  LDD1795 
TLC domain-containing protein 1 (TLCD1) LDTP10182 14.93  LDD1795 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 19.56  LDD1795 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 10.06  LDD1795 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 9.71  LDD1795 
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) LDTP12960 18.90  LDD1795 
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⏷ Show the Full List of 134 Enzyme
104 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 12.73  LDD1795 
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 14.32  LDD1795 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 16.45  LDD1795 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 8.51  LDD1795 
Amyloid-beta precursor protein (APP) LDTP02071 8.11  LDD1795 
Annexin A1 (ANXA1) LDTP02010 9.51  LDD1795 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 10.70  LDD1795 
ATP synthase subunit a (MT-ATP6) LDTP01804 45.89  LDD1795 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 33.82  LDD1795 
BRI3-binding protein (BRI3BP) LDTP15648 25.99  LDD1795 
Calcium uptake protein 1, mitochondrial (MICU1) LDTP11041 8.82  LDD1795 
Calcium uptake protein 2, mitochondrial (MICU2) LDTP08673 9.51  LDD1795 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 9.13  LDD1795 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 12.13  LDD1795 
Derlin-1 (DERL1) LDTP11245 10.27  LDD1795 
Derlin-2 (DERL2) LDTP11634 10.13  LDD1795 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 99.73  LDD1795 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 9.85  LDD1795 
Etoposide-induced protein 2.4 homolog (EI24) LDTP00405 7.94  LDD1795 
H(+)/Cl(-) exchange transporter 6 (CLCN6) LDTP04462 28.25  LDD1795 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 8.69  LDD1795 
Hsp90 co-chaperone Cdc37 (CDC37) LDTP06549 11.24  LDD1795 
Importin subunit alpha-1 (KPNA2) LDTP04501 12.21  LDD1795 
Integral membrane protein 2B (ITM2B) LDTP13833 10.41  LDD1795 
Integral membrane protein 2C (ITM2C) LDTP12451 11.63  LDD1795 
Intermembrane lipid transfer protein VPS13A (VPS13A) LDTP10769 11.16  LDD1795 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 11.39  LDD1795 
Lysosome membrane protein 2 (SCARB2) LDTP06034 24.25  LDD1795 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 42.81  LDD1795 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 9.51  LDD1795 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 9.06  LDD1795 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 13.36  LDD1795 
Metal cation symporter ZIP14 (SLC39A14) LDTP06293 7.94  LDD1795 
Metal transporter CNNM3 (CNNM3) LDTP09144 7.94  LDD1795 
Metaxin-1 (MTX1) LDTP05900 9.65  LDD1795 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 8.22  LDD1795 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 14.93  LDD1795 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 12.21  LDD1795 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 43.41  LDD1795 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD1795 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 22.01  LDD1795 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 20.39  LDD1795 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 9.32  LDD1795 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 12.64  LDD1795 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 22.16  LDD1795 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 9.38  LDD1795 
Mpv17-like protein 2 (MPV17L2) LDTP14952 14.72  LDD1795 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 13.27  LDD1795 
Nucleoporin NDC1 (NDC1) LDTP11213 12.55  LDD1795 
Occludin (OCLN) LDTP06581 9.58  LDD1795 
Osteopetrosis-associated transmembrane protein 1 (OSTM1) LDTP08327 8.40  LDD1795 
Prosaposin (PSAP) LDTP02215 21.41  LDD1795 
Protein ARV1 (ARV1) LDTP11812 12.73  LDD1795 
Protein GPR107 (GPR107) LDTP07236 24.59  LDD1795 
Protein GPR108 (GPR108) LDTP12383 14.62  LDD1795 
Protein OS-9 (OS9) LDTP05871 10.06  LDD1795 
Protein RFT1 homolog (RFT1) LDTP10073 8.94  LDD1795 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 11.55  LDD1795 
Protein spinster homolog 1 (SPNS1) LDTP11844 13.00  LDD1795 
Protein tweety homolog 3 (TTYH3) LDTP11615 28.84  LDD1795 
Protein wntless homolog (WLS) LDTP07156 15.89  LDD1795 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 13.55  LDD1795 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 21.56  LDD1795 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 11.00  LDD1795 
Renin receptor (ATP6AP2) LDTP01309 7.94  LDD1795 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 16.80  LDD1795 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 14.22  LDD1795 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 8.11  LDD1795 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 21.11  LDD1795 
Sodium bicarbonate cotransporter 3 (SLC4A7) LDTP14275 8.17  LDD1795 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 13.45  LDD1795 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 23.26  LDD1795 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 10.06  LDD1795 
Sorting nexin-27 (SNX27) LDTP10533 33.59  LDD1795 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 8.82  LDD1795 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 17.27  LDD1795 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 9.45  LDD1795 
Stomatin (STOM) LDTP03380 11.08  LDD1795 
Stromal interaction molecule 1 (STIM1) LDTP05934 9.13  LDD1795 
Surfeit locus protein 4 (SURF4) LDTP00592 12.13  LDD1795 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 12.91  LDD1795 
Syntaxin-6 (STX6) LDTP00857 11.47  LDD1795 
Tetraspanin-10 (TSPAN10) LDTP15967 18.64  LDD1795 
Tetraspanin-3 (TSPAN3) LDTP16813 13.93  LDD1795 
Transferrin receptor protein 1 (TFRC) LDTP01969 8.63  LDD1795 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 24.93  LDD1795 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 29.86  LDD1795 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 7.89  LDD1795 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 16.91  LDD1795 
Transmembrane protein 126A (TMEM126A) LDTP15948 18.77  LDD1795 
Transmembrane protein 160 (TMEM160) LDTP20002 19.29  LDD1795 
Transmembrane protein 199 (TMEM199) LDTP08881 48.50  LDD1795 
Transmembrane protein 245 (TMEM245) LDTP15979 8.88  LDD1795 
Transmembrane protein 70, mitochondrial (TMEM70) LDTP11229 8.46  LDD1795 
Transmembrane protein 87A (TMEM87A) LDTP15481 8.22  LDD1795 
Transportin-1 (TNPO1) LDTP09949 9.06  LDD1795 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 8.57  LDD1795 
Vang-like protein 1 (VANGL1) LDTP09288 9.32  LDD1795 
Vesicular integral-membrane protein VIP36 (LMAN2) LDTP05690 9.38  LDD1795 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 29.24  LDD1795 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 24.08  LDD1795 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 8.63  LDD1795 
Wolframin (WFS1) LDTP01380 7.94  LDD1795 
Zinc transporter ZIP11 (SLC39A11) LDTP17682 8.51  LDD1795 
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⏷ Show the Full List of 104 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DNA polymerase epsilon subunit 4 (POLE4) LDTP12471 7.89  LDD1795 
Protein Wiz (WIZ) LDTP01674 15.14  LDD1795 
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2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 9.25  LDD1795 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 34.30  LDD1795 
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99 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 10.93  LDD1795 
Apolipoprotein L2 (APOL2) LDTP11076 51.63  LDD1795 
BRISC complex subunit Abraxas 2 (ABRAXAS2) LDTP06278 14.93  LDD1795 
Calumenin (CALU) LDTP00887 9.58  LDD1795 
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) LDTP02511 21.41  LDD1795 
Centrin-2 (CETN2) LDTP03926 7.89  LDD1795 
Centromere protein K (CENPK) LDTP11143 17.75  LDD1795 
Clustered mitochondria protein homolog (CLUH) LDTP14486 14.52  LDD1795 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 8.22  LDD1795 
Collectin-12 (COLEC12) LDTP07031 11.24  LDD1795 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 40.22  LDD1795 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 13.55  LDD1795 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 11.08  LDD1795 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 21.56  LDD1795 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 8.82  LDD1795 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 12.91  LDD1795 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 22.47  LDD1795 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 24.93  LDD1795 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 10.85  LDD1795 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 8.22  LDD1795 
Galectin-3-binding protein (LGALS3BP) LDTP05558 8.28  LDD1795 
Ganglioside GM2 activator (GM2A) LDTP02927 16.91  LDD1795 
Golgi apparatus protein 1 (GLG1) LDTP09920 8.88  LDD1795 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 17.03  LDD1795 
Heat shock 70 kDa protein 13 (HSPA13) LDTP04207 7.89  LDD1795 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 8.75  LDD1795 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 11.31  LDD1795 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 14.22  LDD1795 
Kinetochore protein Spc24 (SPC24) LDTP09069 11.96  LDD1795 
Large proline-rich protein BAG6 (BAG6) LDTP04094 10.85  LDD1795 
Large ribosomal subunit protein bL28m (MRPL28) LDTP05741 8.34  LDD1795 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 13.36  LDD1795 
MAU2 chromatid cohesion factor homolog (MAU2) LDTP14304 9.19  LDD1795 
Mediator of RNA polymerase II transcription subunit 25 (MED25) LDTP07906 8.28  LDD1795 
Membralin (TMEM259) LDTP14939 20.68  LDD1795 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 7.89  LDD1795 
MICOS complex subunit MIC19 (CHCHD3) LDTP12764 12.04  LDD1795 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 37.53  LDD1795 
Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B) LDTP14125 8.06  LDD1795 
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) LDTP00913 8.46  LDD1795 
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) LDTP16322 8.57  LDD1795 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 8.46  LDD1795 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 29.86  LDD1795 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 21.41  LDD1795 
Neudesin (NENF) LDTP13630 9.25  LDD1795 
Neurofilament light polypeptide (NEFL) LDTP02180 8.22  LDD1795 
Neurofilament medium polypeptide (NEFM) LDTP02181 10.27  LDD1795 
Nucleobindin-1 (NUCB1) LDTP05375 9.06  LDD1795 
Nucleobindin-2 (NUCB2) LDTP05160 33.13  LDD1795 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 9.06  LDD1795 
Nurim (NRM) LDTP08606 13.74  LDD1795 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 8.22  LDD1795 
Optic atrophy 3 protein (OPA3) LDTP16006 13.45  LDD1795 
Periphilin-1 (PPHLN1) LDTP09183 8.22  LDD1795 
Plexin-B2 (PLXNB2) LDTP00513 10.41  LDD1795 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 11.55  LDD1795 
Pre-mRNA-splicing factor 38B (PRPF38B) LDTP17266 8.82  LDD1795 
Programmed cell death protein 5 (PDCD5) LDTP00417 9.45  LDD1795 
Proline-rich protein PRCC (PRCC) LDTP09850 8.75  LDD1795 
Protein CEBPZOS (CEBPZOS) LDTP18883 32.45  LDD1795 
Protein FAM114A2 (FAM114A2) LDTP16080 14.12  LDD1795 
Protein FAM162A (FAM162A) LDTP10056 14.83  LDD1795 
Protein flightless-1 homolog (FLII) LDTP05734 22.32  LDD1795 
Protein jagunal homolog 1 (JAGN1) LDTP08904 9.19  LDD1795 
Protein LYRIC (MTDH) LDTP08224 10.63  LDD1795 
Protein SET (SET) LDTP05277 8.82  LDD1795 
Protein SYS1 homolog (SYS1) LDTP08796 11.24  LDD1795 
Protein unc-119 homolog B (UNC119B) LDTP00105 21.26  LDD1795 
Protein UXT (UXT) LDTP13125 8.82  LDD1795 
Protein YIF1A (YIF1A) LDTP01494 10.34  LDD1795 
Rab9 effector protein with kelch motifs (RABEPK) LDTP08130 14.72  LDD1795 
RAD50-interacting protein 1 (RINT1) LDTP07476 14.62  LDD1795 
Receptor expression-enhancing protein 3 (REEP3) LDTP15095 8.82  LDD1795 
Reticulocalbin-2 (RCN2) LDTP06097 20.68  LDD1795 
Reticulon-3 (RTN3) LDTP01522 13.93  LDD1795 
Reticulon-4 (RTN4) LDTP12412 8.82  LDD1795 
RNA-binding protein 10 (RBM10) LDTP05224 8.82  LDD1795 
RNA-binding protein 5 (RBM5) LDTP04527 8.00  LDD1795 
RNA-binding protein EWS (EWSR1) LDTP05318 8.17  LDD1795 
RNA-binding protein FUS (FUS) LDTP03775 10.78  LDD1795 
RNA-binding protein FXR1 (FXR1) LDTP04395 9.25  LDD1795 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 11.31  LDD1795 
Small integral membrane protein 12 (SMIM12) LDTP19859 10.20  LDD1795 
Splicing factor U2AF 65 kDa subunit (U2AF2) LDTP03352 12.91  LDD1795 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 7.94  LDD1795 
Syntaxin-10 (STX10) LDTP00986 8.75  LDD1795 
Syntaxin-18 (STX18) LDTP13086 15.78  LDD1795 
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) LDTP14263 18.38  LDD1795 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 9.06  LDD1795 
Tetraspanin-6 (TSPAN6) LDTP14458 35.51  LDD1795 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 10.34  LDD1795 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 14.12  LDD1795 
TraB domain-containing protein (TRABD) LDTP19963 12.30  LDD1795 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 13.27  LDD1795 
U3 small nucleolar RNA-associated protein 6 homolog (UTP6) LDTP12830 10.27  LDD1795 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 25.11  LDD1795 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 19.43  LDD1795 
Uncharacterized protein KIAA2013 (KIAA2013) LDTP17652 9.45  LDD1795 
Vimentin (VIM) LDTP02297 9.99  LDD1795 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1795 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587