Details of the Target

General Information of Target

Target ID LDTP14125
Target Name Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B)
Gene Name TIMM10B
Gene ID 26515
Synonyms
FXC1; TIM9B; TIMM9B; Mitochondrial import inner membrane translocase subunit Tim10 B; Fracture callus protein 1; FxC1; Mitochondrial import inner membrane translocase subunit Tim9 B; TIMM10B; Tim10b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKA
VECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSL
GTGTLVS
Target Bioclass
Other
Family
Small Tim family
Subcellular location
Mitochondrion inner membrane
Function
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.
Uniprot ID
Q9Y5J6
Ensemble ID
ENST00000254616.11
HGNC ID
HGNC:4022

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
5E-2FA
 Probe Info  		N.A.  LDD2235  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [1]
CY4
 Probe Info  		R12(0.00); R15(0.00)  LDD0247  [2]
NAIA_5
 Probe Info  		C32(0.00); C28(0.00)  LDD2223  [3]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		21.41  LDD1793  [4]
C108
 Probe Info  		8.06  LDD1795  [4]
C161
 Probe Info  		10.63  LDD1841  [4]
C201
 Probe Info  		36.50  LDD1877  [4]
C206
 Probe Info  		16.45  LDD1881  [4]
C218
 Probe Info  		11.47  LDD1892  [4]
C220
 Probe Info  		17.51  LDD1894  [4]
C289
 Probe Info  		32.00  LDD1959  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch-like protein 38 (KLHL38) . Q2WGJ6

References

1 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587