Details of the Target

General Information of Target

Target ID LDTP15979
Target Name Transmembrane protein 245 (TMEM245)
Gene Name TMEM245
Gene ID 23731
Synonyms
C9orf5; Transmembrane protein 245; Protein CG-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEGTGLQPGAGEQLEAPATAEAVQERCEPETLRSKSLPVLSSASCRPSLSPTSGDANPA
FGCVDSSGHQELKQGPNPLAPSPSAPSTSAGLGDCNHRVDLSKTFSVSSALAMLQERRCL
YVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLV
VVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQIQELNASAPNDGLCQGG
NSTATLEPPACPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSL
YLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFL
VIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQADKKVSSMGFGKDVRD
LPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVP
SAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTT
GPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTE
CTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTF
ITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQEC
GVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQREFPLSTV
SERVGHPDNARTRSCPAFSTQGEFHEETGLQKGIQCAAQTYPGPFPEAISSSADPGLEES
PAALEPPS
Target Bioclass
Transporter and channel
Family
Autoinducer-2 exporter (AI-2E) (TC 2.A.86) family
Subcellular location
Membrane
Uniprot ID
Q9H330
Ensemble ID
ENST00000374586.8
HGNC ID
HGNC:1363

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		3.23  LDD0197  [1]
EN219-alkyne
 Probe Info  		3.65  LDD0297  [2]
CHEMBL5175495
 Probe Info  		7.40  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y533(9.83)  LDD0260  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K586(9.17)  LDD0277  [7]
Johansson_61
 Probe Info  		_(11.55)  LDD1485  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		11.96  LDD1752  [10]
C056
 Probe Info  		22.94  LDD1753  [10]
C063
 Probe Info  		17.88  LDD1760  [10]
C106
 Probe Info  		31.78  LDD1793  [10]
C107
 Probe Info  		7.06  LDD1794  [10]
C108
 Probe Info  		8.88  LDD1795  [10]
C112
 Probe Info  		23.26  LDD1799  [10]
C134
 Probe Info  		30.70  LDD1816  [10]
C153
 Probe Info  		16.56  LDD1834  [10]
C159
 Probe Info  		9.85  LDD1839  [10]
C160
 Probe Info  		10.70  LDD1840  [10]
C161
 Probe Info  		12.82  LDD1841  [10]
C169
 Probe Info  		42.22  LDD1849  [10]
C210
 Probe Info  		64.89  LDD1884  [10]
C225
 Probe Info  		6.77  LDD1898  [10]
C228
 Probe Info  		43.71  LDD1901  [10]
C246
 Probe Info  		18.38  LDD1919  [10]
C289
 Probe Info  		30.70  LDD1959  [10]
C293
 Probe Info  		24.76  LDD1963  [10]
C296
 Probe Info  		17.03  LDD1966  [10]
C349
 Probe Info  		12.38  LDD2010  [10]
C350
 Probe Info  		37.53  LDD2011  [10]
C362
 Probe Info  		28.84  LDD2023  [10]
C388
 Probe Info  		57.28  LDD2047  [10]
STS-1
 Probe Info  		N.A.  LDD0136  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0569  Fragment7 Jurkat _(11.55)  LDD1485  [8]

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.