Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	EN219-alkyne			Probe Info
Probe concentration	2 uM
Criteria	Quantification: Probe vs DMSO
Quantitative Method	TMT
*In Vivo* Experiment Model**	Model Type		Cell lysate
	Derived Tissue		Breast
	Disease Model	Breast cancer [ICD-11:2C82]
	Model Name	Human breast cancer cell lysate (231MFP)

Interaction Altas of This Experiment [1]

Enzyme

Click to Show/Hide to Show 5 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP12040	Prostaglandin E synthase 2 (PTGES2)	5.0
LDTP06787	Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1)	4.0
LDTP07591	Neutral cholesterol ester hydrolase 1 (NCEH1)	3.9
LDTP03540	Heme oxygenase 2 (HMOX2)	3.8
LDTP03831	Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)	3.7

Transporter and channel

Click to Show/Hide to Show 1 Protein Related to This Bioclass

Target ID	Target Name					Binding Ratio
LDTP15979	Transmembrane protein 245 (TMEM245)					3.6

Other

Click to Show/Hide to Show 4 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP06302	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (ACAP2)	5.7
LDTP11140	Peroxiredoxin-like 2A (PRXL2A)	4.9
LDTP01522	Reticulon-3 (RTN3)	3.4
LDTP12412	Reticulon-4 (RTN4)	3.4

References

1	Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.