Details of the Target

General Information of Target

Target ID LDTP01522
Target Name Reticulon-3 (RTN3)
Gene Name RTN3
Gene ID 10313
Synonyms
ASYIP; NSPL2; Reticulon-3; Homolog of ASY protein; HAP; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEPSAATQSHSISSSSFGAEPSAPGGGGSPGACPALGTKSCSSSCADSFVSSSSSQPVS
LFSTSQEGLSSLCSDEPSSEIMTSSFLSSSEIHNTGLTILHGEKSHVLGSQPILAKEGKD
HLDLLDMKKMEKPQGTSNNVSDSSVSLAAGVHCDRPSIPASFPEHPAFLSKKIGQVEEQI
DKETKNPNGVSSREAKTALDADDRFTLLTAQKPPTEYSKVEGIYTYSLSPSKVSGDDVIE
KDSPESPFEVIIDKAAFDKEFKDSYKESTDDFGSWSVHTDKESSEDISETNDKLFPLRNK
EAGRYPMSALLSRQFSHTNAALEEVSRCVNDMHNFTNEILTWDLVPQVKQQTDKSSDCIT
KTTGLDMSEYNSEIPVVNLKTSTHQKTPVCSIDGSTPITKSTGDWAEASLQQENAITGKP
VPDSLNSTKEFSIKGVQGNMQKQDDTLAELPGSPPEKCDSLGSGVATVKVVLPDDHLKDE
MDWQSSALGEITEADSSGESDDTVIEDITADTSFENNKIQAEKPVSIPSAVVKTGEREIK
EIPSCEREEKTSKNFEELVSDSELHQDQPDILGRSPASEAACSKVPDTNVSLEDVSEVAP
EKPITTENPKLPSTVSPNVFNETEFSLNVTTSAYLESLHGKNVKHIDDSSPEDLIAAFTE
TRDKGIVDSERNAFKAISEKMTDFKTTPPVEVLHENESGGSEIKDIGSKYSEQSKETNGS
EPLGVFPTQGTPVASLDLEQEQLTIKALKELGERQVEKSTSAQRDAELPSEEVLKQTFTF
APESWPQRSYDILERNVKNGSDLGISQKPITIRETTRVDAVSSLSKTELVKKHVLARLLT
DFSVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVI
QAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKL
AVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQ
AKLPGIAKKKAE
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.; (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.
Uniprot ID
O95197
Ensemble ID
ENST00000339997.8
HGNC ID
HGNC:10469

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.D270Y DBIA    Probe Info 
GB1 SNV: p.S110R .
HCT15 SNV: p.R894G DBIA    Probe Info 
HEC1 SNV: p.G724C DBIA    Probe Info 
JURKAT SNV: p.A530V; p.T856I Compound 10    Probe Info 
MOLT4 SNV: p.G38W; p.G438D IA-alkyne    Probe Info 
NCIH661 SNV: p.I180M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 49 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.12  LDD0402  [1]
HDSF-alk
 Probe Info  		2.63  LDD0197  [2]
P3
 Probe Info  		10.00  LDD0450  [3]
EN219-alkyne
 Probe Info  		3.39  LDD0297  [4]
AZ-9
 Probe Info  		3.05  LDD0393  [5]
FBPP2
 Probe Info  		7.06  LDD0318  [6]
DA-P2
 Probe Info  		55.05  LDD0348  [7]
HRP
 Probe Info  		34.04  LDD0347  [7]
CHEMBL5175495
 Probe Info  		16.00  LDD0196  [8]
CY-1
 Probe Info  		100.00  LDD0243  [9]
CY4
 Probe Info  		100.00  LDD0244  [9]
N1
 Probe Info  		100.00  LDD0242  [9]
TG42
 Probe Info  		8.02  LDD0326  [10]
FBP2
 Probe Info  		6.08  LDD0317  [6]
TH211
 Probe Info  		Y1004(7.56)  LDD0257  [11]
TH214
 Probe Info  		Y1004(20.00)  LDD0258  [11]
TH216
 Probe Info  		Y1004(20.00)  LDD0259  [11]
ONAyne
 Probe Info  		K1022(0.34); K905(0.84)  LDD0274  [12]
OPA-S-S-alkyne
 Probe Info  		K998(4.14)  LDD3494  [13]
CCW36
 Probe Info  		1.97  LDD2215  [14]
DBIA
 Probe Info  		C582(1.23); C390(1.35)  LDD3310  [15]
P12
 Probe Info  		20.00  LDD0202  [16]
SAHA-CA-4PAP
 Probe Info  		9.30  LDD0269  [17]
BTD
 Probe Info  		C34(0.57)  LDD2089  [18]
Sulforaphane-probe2
 Probe Info  		3.00  LDD0042  [19]
Johansson_61
 Probe Info  		_(16.46)  LDD1485  [20]
DA-P3
 Probe Info  		15.24  LDD0179  [7]
HPAP
 Probe Info  		3.94  LDD0062  [21]
Alkyne-RA190
 Probe Info  		2.77  LDD0299  [22]
BDBM50514113
 Probe Info  		1.50  LDD0041  [23]
5E-2FA
 Probe Info  		N.A.  LDD2235  [24]
ATP probe
 Probe Info  		K1018(0.00); K1022(0.00); K998(0.00)  LDD0199  [25]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [26]
IPM
 Probe Info  		N.A.  LDD0025  [27]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [27]
NAIA_4
 Probe Info  		C390(0.00); C34(0.00)  LDD2226  [28]
NAIA_5
 Probe Info  		C34(0.00); C390(0.00)  LDD2224  [28]
TFBX
 Probe Info  		N.A.  LDD0027  [27]
WYneN
 Probe Info  		N.A.  LDD0021  [29]
Compound 10
 Probe Info  		N.A.  LDD2216  [30]
PF-06672131
 Probe Info  		N.A.  LDD0017  [31]
PPMS
 Probe Info  		N.A.  LDD0008  [29]
STPyne
 Probe Info  		N.A.  LDD0009  [29]
VSF
 Probe Info  		N.A.  LDD0007  [29]
Acrolein
 Probe Info  		H1003(0.00); C34(0.00); H910(0.00)  LDD0217  [32]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [32]
Methacrolein
 Probe Info  		H1003(0.00); C34(0.00)  LDD0218  [32]
AOyne
 Probe Info  		11.90  LDD0443  [33]
TER-AC
 Probe Info  		N.A.  LDD0426  [34]
PAL-AfBPP Probe
Click To Hide/Show 159 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.84  LDD1714  [35]
C007
 Probe Info  		7.89  LDD1716  [35]
C010
 Probe Info  		7.46  LDD1719  [35]
C022
 Probe Info  		30.48  LDD1728  [35]
C026
 Probe Info  		6.59  LDD1732  [35]
C027
 Probe Info  		8.11  LDD1733  [35]
C040
 Probe Info  		41.64  LDD1740  [35]
C041
 Probe Info  		7.78  LDD1741  [35]
C049
 Probe Info  		12.13  LDD1747  [35]
C053
 Probe Info  		6.73  LDD1751  [35]
C055
 Probe Info  		47.84  LDD1752  [35]
C056
 Probe Info  		62.25  LDD1753  [35]
C063
 Probe Info  		23.10  LDD1760  [35]
C064
 Probe Info  		10.13  LDD1761  [35]
C067
 Probe Info  		8.28  LDD1763  [35]
C070
 Probe Info  		19.70  LDD1766  [35]
C071
 Probe Info  		8.63  LDD1767  [35]
C072
 Probe Info  		17.63  LDD1768  [35]
C082
 Probe Info  		7.94  LDD1774  [35]
C091
 Probe Info  		73.01  LDD1782  [35]
C092
 Probe Info  		99.73  LDD1783  [35]
C094
 Probe Info  		86.82  LDD1785  [35]
C095
 Probe Info  		21.71  LDD1786  [35]
C100
 Probe Info  		15.56  LDD1789  [35]
C106
 Probe Info  		59.71  LDD1793  [35]
C107
 Probe Info  		18.51  LDD1794  [35]
C108
 Probe Info  		13.93  LDD1795  [35]
C112
 Probe Info  		70.52  LDD1799  [35]
C129
 Probe Info  		6.59  LDD1811  [35]
C130
 Probe Info  		12.04  LDD1812  [35]
C134
 Probe Info  		99.73  LDD1816  [35]
C135
 Probe Info  		23.92  LDD1817  [35]
C139
 Probe Info  		14.22  LDD1821  [35]
C141
 Probe Info  		38.59  LDD1823  [35]
C143
 Probe Info  		68.12  LDD1825  [35]
C147
 Probe Info  		9.25  LDD1829  [35]
C153
 Probe Info  		39.12  LDD1834  [35]
C156
 Probe Info  		4.96  LDD1836  [35]
C158
 Probe Info  		9.51  LDD1838  [35]
C159
 Probe Info  		22.63  LDD1839  [35]
C160
 Probe Info  		19.97  LDD1840  [35]
C161
 Probe Info  		42.22  LDD1841  [35]
C163
 Probe Info  		28.64  LDD1843  [35]
C165
 Probe Info  		12.73  LDD1845  [35]
C166
 Probe Info  		9.51  LDD1846  [35]
C169
 Probe Info  		99.73  LDD1849  [35]
C172
 Probe Info  		7.26  LDD1852  [35]
C173
 Probe Info  		5.17  LDD1853  [35]
C174
 Probe Info  		4.99  LDD1854  [35]
C177
 Probe Info  		13.74  LDD1856  [35]
C178
 Probe Info  		33.36  LDD1857  [35]
C183
 Probe Info  		5.28  LDD1861  [35]
C186
 Probe Info  		13.83  LDD1864  [35]
C187
 Probe Info  		99.73  LDD1865  [35]
C191
 Probe Info  		49.18  LDD1868  [35]
C193
 Probe Info  		22.47  LDD1869  [35]
C194
 Probe Info  		17.51  LDD1870  [35]
C196
 Probe Info  		36.25  LDD1872  [35]
C198
 Probe Info  		28.05  LDD1874  [35]
C201
 Probe Info  		99.73  LDD1877  [35]
C206
 Probe Info  		58.89  LDD1881  [35]
C207
 Probe Info  		40.22  LDD1882  [35]
C210
 Probe Info  		99.73  LDD1884  [35]
C213
 Probe Info  		17.88  LDD1887  [35]
C216
 Probe Info  		6.82  LDD1890  [35]
C217
 Probe Info  		5.17  LDD1891  [35]
C218
 Probe Info  		82.71  LDD1892  [35]
C219
 Probe Info  		24.76  LDD1893  [35]
C220
 Probe Info  		90.51  LDD1894  [35]
C225
 Probe Info  		19.70  LDD1898  [35]
C226
 Probe Info  		15.35  LDD1899  [35]
C228
 Probe Info  		99.73  LDD1901  [35]
C229
 Probe Info  		16.56  LDD1902  [35]
C231
 Probe Info  		99.73  LDD1904  [35]
C232
 Probe Info  		74.03  LDD1905  [35]
C233
 Probe Info  		25.63  LDD1906  [35]
C234
 Probe Info  		11.16  LDD1907  [35]
C235
 Probe Info  		99.73  LDD1908  [35]
C238
 Probe Info  		46.21  LDD1911  [35]
C240
 Probe Info  		21.71  LDD1913  [35]
C243
 Probe Info  		61.82  LDD1916  [35]
C246
 Probe Info  		83.87  LDD1919  [35]
C251
 Probe Info  		59.30  LDD1924  [35]
C252
 Probe Info  		29.86  LDD1925  [35]
C258
 Probe Info  		7.26  LDD1931  [35]
C264
 Probe Info  		45.89  LDD1935  [35]
C265
 Probe Info  		28.44  LDD1936  [35]
C270
 Probe Info  		8.82  LDD1940  [35]
C271
 Probe Info  		8.69  LDD1941  [35]
C273
 Probe Info  		13.27  LDD1943  [35]
C275
 Probe Info  		6.06  LDD1945  [35]
C277
 Probe Info  		22.16  LDD1947  [35]
C278
 Probe Info  		99.73  LDD1948  [35]
C280
 Probe Info  		12.64  LDD1950  [35]
C282
 Probe Info  		50.56  LDD1952  [35]
C284
 Probe Info  		27.10  LDD1954  [35]
C285
 Probe Info  		76.64  LDD1955  [35]
C287
 Probe Info  		45.57  LDD1957  [35]
C288
 Probe Info  		21.86  LDD1958  [35]
C289
 Probe Info  		99.73  LDD1959  [35]
C290
 Probe Info  		8.63  LDD1960  [35]
C293
 Probe Info  		58.49  LDD1963  [35]
C296
 Probe Info  		19.84  LDD1966  [35]
C299
 Probe Info  		15.14  LDD1968  [35]
C304
 Probe Info  		5.35  LDD1973  [35]
C305
 Probe Info  		18.38  LDD1974  [35]
C307
 Probe Info  		6.28  LDD1975  [35]
C310
 Probe Info  		27.47  LDD1977  [35]
C314
 Probe Info  		15.24  LDD1981  [35]
C322
 Probe Info  		15.67  LDD1988  [35]
C326
 Probe Info  		11.31  LDD1990  [35]
C339
 Probe Info  		19.16  LDD2002  [35]
C343
 Probe Info  		60.13  LDD2005  [35]
C348
 Probe Info  		18.00  LDD2009  [35]
C349
 Probe Info  		49.18  LDD2010  [35]
C350
 Probe Info  		88.03  LDD2011  [35]
C355
 Probe Info  		36.50  LDD2016  [35]
C356
 Probe Info  		24.25  LDD2017  [35]
C357
 Probe Info  		8.82  LDD2018  [35]
C362
 Probe Info  		99.73  LDD2023  [35]
C363
 Probe Info  		43.71  LDD2024  [35]
C364
 Probe Info  		47.50  LDD2025  [35]
C366
 Probe Info  		51.98  LDD2027  [35]
C367
 Probe Info  		32.67  LDD2028  [35]
C373
 Probe Info  		11.55  LDD2033  [35]
C376
 Probe Info  		14.62  LDD2036  [35]
C378
 Probe Info  		6.59  LDD2037  [35]
C380
 Probe Info  		7.36  LDD2039  [35]
C382
 Probe Info  		21.11  LDD2041  [35]
C383
 Probe Info  		13.36  LDD2042  [35]
C386
 Probe Info  		9.85  LDD2045  [35]
C388
 Probe Info  		99.73  LDD2047  [35]
C390
 Probe Info  		82.14  LDD2049  [35]
C399
 Probe Info  		19.16  LDD2058  [35]
C403
 Probe Info  		48.50  LDD2061  [35]
C407
 Probe Info  		50.21  LDD2064  [35]
C408
 Probe Info  		5.54  LDD2065  [35]
C409
 Probe Info  		5.66  LDD2066  [35]
C413
 Probe Info  		30.70  LDD2069  [35]
C419
 Probe Info  		31.56  LDD2074  [35]
C420
 Probe Info  		14.03  LDD2075  [35]
C422
 Probe Info  		11.00  LDD2077  [35]
C423
 Probe Info  		19.97  LDD2078  [35]
C424
 Probe Info  		19.16  LDD2079  [35]
C426
 Probe Info  		48.84  LDD2081  [35]
C429
 Probe Info  		45.89  LDD2084  [35]
C431
 Probe Info  		72.00  LDD2086  [35]
FFF probe11
 Probe Info  		20.00  LDD0471  [36]
FFF probe13
 Probe Info  		20.00  LDD0476  [36]
FFF probe14
 Probe Info  		18.48  LDD0477  [36]
FFF probe2
 Probe Info  		20.00  LDD0463  [36]
FFF probe3
 Probe Info  		20.00  LDD0464  [36]
JN0003
 Probe Info  		18.81  LDD0469  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
DFG-out-4
 Probe Info  		7.10  LDD0075  [39]
A-DA
 Probe Info  		4.54  LDD0145  [40]
Alk-rapa
 Probe Info  		5.08  LDD0213  [41]
OEA-DA
 Probe Info  		4.00  LDD0046  [42]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C34(1.02)  LDD2142  [18]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C34(1.06)  LDD2112  [18]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C34(1.10)  LDD2117  [18]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C34(1.23)  LDD2103  [18]
 LDCM0214  AC1 HEK-293T C390(1.00); C582(1.15)  LDD1507  [43]
 LDCM0215  AC10 HEK-293T C390(1.04); C582(1.01)  LDD1508  [43]
 LDCM0226  AC11 HEK-293T C390(1.07); C582(1.09)  LDD1509  [43]
 LDCM0237  AC12 HEK-293T C390(1.03); C582(1.05)  LDD1510  [43]
 LDCM0259  AC14 HEK-293T C390(1.05); C582(1.00); C458(1.15); C545(0.97)  LDD1512  [43]
 LDCM0270  AC15 HEK-293T C390(1.03); C582(1.06)  LDD1513  [43]
 LDCM0276  AC17 HEK-293T C390(1.02); C582(1.05)  LDD1515  [43]
 LDCM0277  AC18 HEK-293T C390(1.13); C582(1.10)  LDD1516  [43]
 LDCM0278  AC19 HEK-293T C390(1.61); C582(1.03)  LDD1517  [43]
 LDCM0279  AC2 HEK-293T C390(0.93); C582(0.97)  LDD1518  [43]
 LDCM0280  AC20 HEK-293T C390(1.03); C582(0.93)  LDD1519  [43]
 LDCM0281  AC21 HEK-293T C390(1.08); C458(1.06)  LDD1520  [43]
 LDCM0282  AC22 HEK-293T C390(1.12); C582(1.09); C458(1.14); C545(0.93)  LDD1521  [43]
 LDCM0283  AC23 HEK-293T C390(1.07); C582(1.05)  LDD1522  [43]
 LDCM0284  AC24 HEK-293T C390(0.95)  LDD1523  [43]
 LDCM0285  AC25 HEK-293T C390(1.09); C582(1.01)  LDD1524  [43]
 LDCM0286  AC26 HEK-293T C390(1.01); C582(1.06)  LDD1525  [43]
 LDCM0287  AC27 HEK-293T C390(0.81); C582(1.03)  LDD1526  [43]
 LDCM0288  AC28 HEK-293T C390(0.94); C582(1.01)  LDD1527  [43]
 LDCM0289  AC29 HEK-293T C390(0.98); C458(1.14)  LDD1528  [43]
 LDCM0290  AC3 HEK-293T C390(0.82); C582(1.15)  LDD1529  [43]
 LDCM0291  AC30 HEK-293T C390(0.89); C582(0.99); C458(1.00); C545(0.92)  LDD1530  [43]
 LDCM0292  AC31 HEK-293T C390(1.01); C582(1.04)  LDD1531  [43]
 LDCM0293  AC32 HEK-293T C390(1.06)  LDD1532  [43]
 LDCM0294  AC33 HEK-293T C390(1.31); C582(1.18)  LDD1533  [43]
 LDCM0295  AC34 HEK-293T C390(1.16); C582(1.17)  LDD1534  [43]
 LDCM0296  AC35 HEK-293T C390(1.04); C582(1.18)  LDD1535  [43]
 LDCM0297  AC36 HEK-293T C390(1.14); C582(1.13)  LDD1536  [43]
 LDCM0298  AC37 HEK-293T C390(1.09); C458(1.44)  LDD1537  [43]
 LDCM0299  AC38 HEK-293T C390(1.01); C582(1.11); C458(1.02); C545(1.13)  LDD1538  [43]
 LDCM0300  AC39 HEK-293T C390(1.03); C582(1.15)  LDD1539  [43]
 LDCM0301  AC4 HEK-293T C390(1.12); C582(0.99)  LDD1540  [43]
 LDCM0302  AC40 HEK-293T C390(0.99)  LDD1541  [43]
 LDCM0303  AC41 HEK-293T C390(1.08); C582(1.17)  LDD1542  [43]
 LDCM0304  AC42 HEK-293T C390(1.14); C582(1.21)  LDD1543  [43]
 LDCM0305  AC43 HEK-293T C390(1.09); C582(1.13)  LDD1544  [43]
 LDCM0306  AC44 HEK-293T C390(1.14); C582(1.04)  LDD1545  [43]
 LDCM0307  AC45 HEK-293T C390(1.09); C458(1.10)  LDD1546  [43]
 LDCM0308  AC46 HEK-293T C390(1.03); C582(0.95); C458(0.99); C545(1.17)  LDD1547  [43]
 LDCM0309  AC47 HEK-293T C390(1.04); C582(1.09)  LDD1548  [43]
 LDCM0310  AC48 HEK-293T C390(1.05)  LDD1549  [43]
 LDCM0311  AC49 HEK-293T C390(1.01); C582(1.01)  LDD1550  [43]
 LDCM0312  AC5 HEK-293T C390(1.04); C458(1.30)  LDD1551  [43]
 LDCM0313  AC50 HEK-293T C390(1.12); C582(1.14)  LDD1552  [43]
 LDCM0314  AC51 HEK-293T C390(1.07); C582(1.12)  LDD1553  [43]
 LDCM0315  AC52 HEK-293T C390(1.03); C582(1.05)  LDD1554  [43]
 LDCM0316  AC53 HEK-293T C390(1.14); C458(1.26)  LDD1555  [43]
 LDCM0317  AC54 HEK-293T C390(1.04); C582(1.11); C458(0.99); C545(1.11)  LDD1556  [43]
 LDCM0318  AC55 HEK-293T C390(1.17); C582(1.12)  LDD1557  [43]
 LDCM0319  AC56 HEK-293T C390(1.07)  LDD1558  [43]
 LDCM0320  AC57 HEK-293T C390(1.17); C582(1.08)  LDD1559  [43]
 LDCM0321  AC58 HEK-293T C390(1.04); C582(1.25)  LDD1560  [43]
 LDCM0322  AC59 HEK-293T C390(1.06); C582(1.20)  LDD1561  [43]
 LDCM0323  AC6 HEK-293T C390(1.01); C582(1.01); C458(1.14); C545(1.01)  LDD1562  [43]
 LDCM0324  AC60 HEK-293T C390(1.03); C582(1.00)  LDD1563  [43]
 LDCM0325  AC61 HEK-293T C390(1.11); C458(1.34)  LDD1564  [43]
 LDCM0326  AC62 HEK-293T C390(0.99); C582(1.13); C458(0.97); C545(1.04)  LDD1565  [43]
 LDCM0327  AC63 HEK-293T C390(1.17); C582(1.09)  LDD1566  [43]
 LDCM0328  AC64 HEK-293T C390(0.98)  LDD1567  [43]
 LDCM0334  AC7 HEK-293T C390(0.85); C582(1.05)  LDD1568  [43]
 LDCM0345  AC8 HEK-293T C390(0.91)  LDD1569  [43]
 LDCM0520  AKOS000195272 MDA-MB-231 C34(0.73)  LDD2113  [18]
 LDCM0248  AKOS034007472 HEK-293T C390(1.10); C458(1.32)  LDD1511  [43]
 LDCM0356  AKOS034007680 HEK-293T C390(1.09); C582(1.06)  LDD1570  [43]
 LDCM0275  AKOS034007705 HEK-293T C390(0.96)  LDD1514  [43]
 LDCM0156  Aniline NCI-H1299 13.01  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0202  [16]
 LDCM0631  CCW16 231MFP 1.97  LDD2215  [14]
 LDCM0108  Chloroacetamide HeLa H1003(0.00); C34(0.00)  LDD0222  [32]
 LDCM0367  CL1 HEK-293T C390(1.03)  LDD1571  [43]
 LDCM0368  CL10 HEK-293T C390(1.03); C582(0.66); C458(2.82); C545(1.18)  LDD1572  [43]
 LDCM0369  CL100 HEK-293T C390(0.86); C582(0.98)  LDD1573  [43]
 LDCM0370  CL101 HEK-293T C390(0.99)  LDD1574  [43]
 LDCM0373  CL104 HEK-293T C390(0.81); C582(1.05)  LDD1577  [43]
 LDCM0374  CL105 HEK-293T C390(1.03)  LDD1578  [43]
 LDCM0377  CL108 HEK-293T C390(0.87); C582(0.99)  LDD1581  [43]
 LDCM0378  CL109 HEK-293T C390(0.84)  LDD1582  [43]
 LDCM0379  CL11 HEK-293T C390(0.93); C582(0.86)  LDD1583  [43]
 LDCM0382  CL112 HEK-293T C390(0.88); C582(0.97)  LDD1586  [43]
 LDCM0383  CL113 HEK-293T C390(0.95)  LDD1587  [43]
 LDCM0386  CL116 HEK-293T C390(0.90); C582(1.08)  LDD1590  [43]
 LDCM0387  CL117 HEK-293T C390(1.21)  LDD1591  [43]
 LDCM0390  CL12 HEK-293T C390(1.01)  LDD1594  [43]
 LDCM0391  CL120 HEK-293T C390(0.91); C582(1.03)  LDD1595  [43]
 LDCM0392  CL121 HEK-293T C390(0.90)  LDD1596  [43]
 LDCM0395  CL124 HEK-293T C390(0.86); C582(1.05)  LDD1599  [43]
 LDCM0396  CL125 HEK-293T C390(0.97)  LDD1600  [43]
 LDCM0399  CL128 HEK-293T C390(1.05); C582(1.04)  LDD1603  [43]
 LDCM0400  CL13 HEK-293T C390(1.08)  LDD1604  [43]
 LDCM0403  CL16 HEK-293T C390(1.03); C582(1.16)  LDD1607  [43]
 LDCM0404  CL17 HEK-293T C390(1.06); C582(1.14)  LDD1608  [43]
 LDCM0405  CL18 HEK-293T C390(1.08); C582(1.34)  LDD1609  [43]
 LDCM0406  CL19 HEK-293T C390(1.07); C582(1.09)  LDD1610  [43]
 LDCM0408  CL20 HEK-293T C390(1.04); C582(0.88)  LDD1612  [43]
 LDCM0409  CL21 HEK-293T C390(1.04); C458(1.15)  LDD1613  [43]
 LDCM0410  CL22 HEK-293T C390(1.07); C582(0.73); C458(1.96); C545(1.10)  LDD1614  [43]
 LDCM0411  CL23 HEK-293T C390(1.08); C582(0.94)  LDD1615  [43]
 LDCM0412  CL24 HEK-293T C390(0.96)  LDD1616  [43]
 LDCM0413  CL25 HEK-293T C390(0.90)  LDD1617  [43]
 LDCM0416  CL28 HEK-293T C390(0.89); C582(0.98)  LDD1620  [43]
 LDCM0417  CL29 HEK-293T C390(1.12); C582(1.02)  LDD1621  [43]
 LDCM0419  CL30 HEK-293T C390(1.15); C582(1.19)  LDD1623  [43]
 LDCM0420  CL31 HEK-293T C390(0.96); C582(0.99)  LDD1624  [43]
 LDCM0421  CL32 HEK-293T C390(0.99); C582(0.85)  LDD1625  [43]
 LDCM0422  CL33 HEK-293T C390(1.01); C458(1.21)  LDD1626  [43]
 LDCM0423  CL34 HEK-293T C390(0.96); C582(0.77); C458(2.32); C545(1.06)  LDD1627  [43]
 LDCM0424  CL35 HEK-293T C390(0.96); C582(0.85)  LDD1628  [43]
 LDCM0425  CL36 HEK-293T C390(0.96)  LDD1629  [43]
 LDCM0426  CL37 HEK-293T C390(0.82)  LDD1630  [43]
 LDCM0429  CL4 HEK-293T C390(0.91); C582(1.14)  LDD1633  [43]
 LDCM0430  CL40 HEK-293T C390(0.89); C582(1.05)  LDD1634  [43]
 LDCM0431  CL41 HEK-293T C390(0.97); C582(1.00)  LDD1635  [43]
 LDCM0432  CL42 HEK-293T C390(0.93); C582(1.18)  LDD1636  [43]
 LDCM0433  CL43 HEK-293T C390(0.91); C582(0.98)  LDD1637  [43]
 LDCM0434  CL44 HEK-293T C390(1.01); C582(0.94)  LDD1638  [43]
 LDCM0435  CL45 HEK-293T C390(0.98); C458(1.19)  LDD1639  [43]
 LDCM0436  CL46 HEK-293T C390(0.96); C582(0.73); C458(1.75); C545(1.25)  LDD1640  [43]
 LDCM0437  CL47 HEK-293T C390(0.99); C582(0.92)  LDD1641  [43]
 LDCM0438  CL48 HEK-293T C390(0.99)  LDD1642  [43]
 LDCM0439  CL49 HEK-293T C390(0.77)  LDD1643  [43]
 LDCM0440  CL5 HEK-293T C390(1.12); C582(1.18)  LDD1644  [43]
 LDCM0443  CL52 HEK-293T C390(0.93); C582(0.99)  LDD1646  [43]
 LDCM0444  CL53 HEK-293T C390(1.03); C582(1.14)  LDD1647  [43]
 LDCM0445  CL54 HEK-293T C390(1.02); C582(1.22)  LDD1648  [43]
 LDCM0446  CL55 HEK-293T C390(1.12); C582(0.94)  LDD1649  [43]
 LDCM0447  CL56 HEK-293T C390(0.94); C582(0.91)  LDD1650  [43]
 LDCM0448  CL57 HEK-293T C390(1.10); C458(1.81)  LDD1651  [43]
 LDCM0449  CL58 HEK-293T C390(0.93); C582(0.78); C458(1.87); C545(1.05)  LDD1652  [43]
 LDCM0450  CL59 HEK-293T C390(0.95); C582(0.94)  LDD1653  [43]
 LDCM0451  CL6 HEK-293T C390(1.04); C582(1.32)  LDD1654  [43]
 LDCM0452  CL60 HEK-293T C390(1.04)  LDD1655  [43]
 LDCM0453  CL61 HEK-293T C390(0.89)  LDD1656  [43]
 LDCM0456  CL64 HEK-293T C390(0.93); C582(0.93)  LDD1659  [43]
 LDCM0457  CL65 HEK-293T C390(1.00); C582(1.18)  LDD1660  [43]
 LDCM0458  CL66 HEK-293T C390(1.08); C582(1.25)  LDD1661  [43]
 LDCM0459  CL67 HEK-293T C390(1.15); C582(1.00)  LDD1662  [43]
 LDCM0460  CL68 HEK-293T C390(1.21); C582(0.94)  LDD1663  [43]
 LDCM0461  CL69 HEK-293T C390(1.09); C458(1.29)  LDD1664  [43]
 LDCM0462  CL7 HEK-293T C390(0.91); C582(1.01)  LDD1665  [43]
 LDCM0463  CL70 HEK-293T C390(0.96); C582(0.73); C458(1.69); C545(1.16)  LDD1666  [43]
 LDCM0464  CL71 HEK-293T C390(0.91); C582(0.92)  LDD1667  [43]
 LDCM0465  CL72 HEK-293T C390(1.16)  LDD1668  [43]
 LDCM0466  CL73 HEK-293T C390(1.08)  LDD1669  [43]
 LDCM0469  CL76 HEK-293T C390(0.87); C582(1.06)  LDD1672  [43]
 LDCM0470  CL77 HEK-293T C390(1.08); C582(1.01)  LDD1673  [43]
 LDCM0471  CL78 HEK-293T C390(0.99); C582(1.31)  LDD1674  [43]
 LDCM0472  CL79 HEK-293T C390(0.90); C582(1.03)  LDD1675  [43]
 LDCM0473  CL8 HEK-293T C390(0.88); C582(0.74)  LDD1676  [43]
 LDCM0474  CL80 HEK-293T C390(0.97); C582(0.95)  LDD1677  [43]
 LDCM0475  CL81 HEK-293T C390(1.06); C458(1.56)  LDD1678  [43]
 LDCM0476  CL82 HEK-293T C390(1.01); C582(0.79); C458(1.55); C545(1.09)  LDD1679  [43]
 LDCM0477  CL83 HEK-293T C390(0.99); C582(0.86)  LDD1680  [43]
 LDCM0478  CL84 HEK-293T C390(0.98)  LDD1681  [43]
 LDCM0479  CL85 HEK-293T C390(0.91)  LDD1682  [43]
 LDCM0482  CL88 HEK-293T C390(0.99); C582(1.07)  LDD1685  [43]
 LDCM0483  CL89 HEK-293T C390(1.29); C582(1.17)  LDD1686  [43]
 LDCM0484  CL9 HEK-293T C390(1.13); C458(1.31)  LDD1687  [43]
 LDCM0485  CL90 HEK-293T C390(1.13); C582(1.04)  LDD1688  [43]
 LDCM0486  CL91 HEK-293T C390(0.97); C582(1.15)  LDD1689  [43]
 LDCM0487  CL92 HEK-293T C390(1.05); C582(0.97)  LDD1690  [43]
 LDCM0488  CL93 HEK-293T C390(1.07); C458(1.37)  LDD1691  [43]
 LDCM0489  CL94 HEK-293T C390(1.22); C582(0.81); C458(1.55); C545(1.07)  LDD1692  [43]
 LDCM0490  CL95 HEK-293T C390(0.97); C582(0.81)  LDD1693  [43]
 LDCM0491  CL96 HEK-293T C390(0.93)  LDD1694  [43]
 LDCM0492  CL97 HEK-293T C390(0.65)  LDD1695  [43]
 LDCM0185  Compound 17 HEK-293T 11.26  LDD0512  [36]
 LDCM0191  Compound 21 HEK-293T 8.10  LDD0508  [36]
 LDCM0190  Compound 34 HEK-293T 11.83  LDD0510  [36]
 LDCM0192  Compound 35 HEK-293T 5.99  LDD0509  [36]
 LDCM0193  Compound 36 HEK-293T 5.87  LDD0511  [36]
 LDCM0634  CY-0357 Hep-G2 C34(0.77)  LDD2228  [28]
 LDCM0017  DFG-out-2 A431 7.10  LDD0075  [39]
 LDCM0028  Dobutamine HEK-293T 7.03  LDD0180  [7]
 LDCM0027  Dopamine HEK-293T 15.24  LDD0179  [7]
 LDCM0100  EN219 231MFP 3.47  LDD0298  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 16.41  LDD0183  [7]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [20]
 LDCM0615  Fragment63-R Jurkat _(13.45)  LDD1487  [20]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [20]
 LDCM0569  Fragment7 Jurkat _(16.46)  LDD1485  [20]
 LDCM0107  IAA HeLa N.A.  LDD0221  [32]
 LDCM0022  KB02 HEK-293T C390(1.08)  LDD1492  [43]
 LDCM0023  KB03 HEK-293T C390(1.01)  LDD1497  [43]
 LDCM0024  KB05 COLO792 C582(1.23); C390(1.35)  LDD3310  [15]
 LDCM0030  Luteolin HEK-293T 28.62  LDD0182  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C34(0.99)  LDD2102  [18]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C34(0.51)  LDD2121  [18]
 LDCM0109  NEM HeLa N.A.  LDD0223  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C34(0.57)  LDD2089  [18]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C34(0.94)  LDD2090  [18]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C34(0.94)  LDD2094  [18]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C34(0.78)  LDD2098  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C34(0.96)  LDD2099  [18]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C34(0.96)  LDD2101  [18]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C34(0.98)  LDD2105  [18]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C34(0.96)  LDD2106  [18]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C34(0.80)  LDD2107  [18]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C34(0.94)  LDD2108  [18]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C34(1.08)  LDD2109  [18]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C34(1.79)  LDD2110  [18]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C34(1.09)  LDD2111  [18]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C34(0.69)  LDD2114  [18]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C34(0.70)  LDD2115  [18]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C34(2.77)  LDD2119  [18]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C34(1.00)  LDD2125  [18]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C34(0.95)  LDD2129  [18]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C34(0.57)  LDD2134  [18]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C34(1.01)  LDD2135  [18]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C34(1.48)  LDD2136  [18]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C34(0.81)  LDD2140  [18]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C34(0.88)  LDD2141  [18]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C34(1.09)  LDD2146  [18]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C34(0.72)  LDD2148  [18]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C34(0.50)  LDD2150  [18]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C34(1.45)  LDD2153  [18]
 LDCM0627  NUDT7-COV-1 HEK-293T C34(0.95)  LDD2206  [44]
 LDCM0628  OTUB2-COV-1 HEK-293T C34(0.75)  LDD2207  [44]
 LDCM0014  Panhematin HEK-293T 3.94  LDD0062  [21]
 LDCM0029  Quercetin HEK-293T 29.51  LDD0181  [7]
 LDCM0131  RA190 MM1.R 2.77  LDD0299  [22]
 LDCM0090  Rapamycin JHH-7 5.08  LDD0213  [41]
 LDCM0084  Ro 48-8071 A-549 4.54  LDD0145  [40]
 LDCM0096  SAHA K562 9.30  LDD0269  [17]
 LDCM0003  Sulforaphane MCF-7 3.00  LDD0042  [19]
 LDCM0002  Ward_cp1 U2OS 1.50  LDD0041  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (PPP2R3C) . Q969Q6
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Cardiac phospholamban (PLN) Phospholamban family P26678
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Ceramide transfer protein (CERT1) . Q9Y5P4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Regulator of microtubule dynamics protein 2 (RMDN2) RMDN family Q96LZ7
MIT domain-containing protein 1 (MITD1) . Q8WV92
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
4 Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.
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6 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
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