Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name CCW36  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name CCW16  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast cancer [ICD-11:2C82]
Model Name Human breast cancer cell lysate (231MFP)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03831  Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) 6.3
 LDTP03163  Sterol carrier protein 2 (SCP2) 5.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.6
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 2.3
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 10.2
 LDTP14236  Selenoprotein K (SELENOK) 3.7
 LDTP01522  Reticulon-3 (RTN3) 2.0

References

1 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.