Details of the Target

General Information of Target

Target ID LDTP03163
Target Name Sterol carrier protein 2 (SCP2)
Gene Name SCP2
Gene ID 6342
Synonyms
Sterol carrier protein 2; SCP-2; Acetyl-CoA C-myristoyltransferase; EC 2.3.1.155; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; EC 2.3.1.176; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; EC 2.3.1.16; SCP-chi; SCPX; Sterol carrier protein X; SCP-X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQA
CVGYVFGDSTCGQRAIYHSLGMTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALG
FEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEH
FAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEA
FVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDID
VIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGAT
GLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVVTLYKMGFPEAASSFRTHQIE
AVPTSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKN
GKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQL
QPGNAKL
Target Bioclass
Enzyme
Family
Thiolase-like superfamily, Thiolase family
Subcellular location
Peroxisome
Function
[Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.; [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Uniprot ID
P22307
Ensemble ID
ENST00000371509.8
HGNC ID
HGNC:10606
ChEMBL ID
CHEMBL5950

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1395 SNV: p.A155D .
HCT15 SNV: p.T176A .
KO52 SNV: p.K438R .
LN229 SNV: p.D298H .
TOV21G SNV: p.H355Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		12.50  LDD0122  [1]
C-Sul
 Probe Info  		4.44  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		K443(0.67)  LDD0274  [4]
STPyne
 Probe Info  		K132(10.00); K177(0.95); K26(1.07); K438(7.47)  LDD0277  [4]
AZ-9
 Probe Info  		E447(1.21)  LDD2208  [5]
Probe 1
 Probe Info  		Y35(7.26); Y245(85.36)  LDD3495  [6]
P11
 Probe Info  		18.96  LDD0201  [7]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0282  [8]
CCW36
 Probe Info  		5.09  LDD2215  [9]
Jackson_14
 Probe Info  		12.50  LDD0123  [1]
Johansson_61
 Probe Info  		_(9.11)  LDD1485  [10]
YY4-yne
 Probe Info  		3.58  LDD0400  [11]
EA-probe
 Probe Info  		C94(0.97)  LDD2210  [12]
DBIA
 Probe Info  		C71(1.06)  LDD0080  [13]
5E-2FA
 Probe Info  		H78(0.00); H156(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		K454(0.00); K522(0.00); K524(0.00)  LDD0199  [15]
m-APA
 Probe Info  		H156(0.00); H78(0.00); H143(0.00)  LDD2231  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C495(0.00); C94(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C495(0.00); C94(0.00); C115(0.00)  LDD0036  [16]
Lodoacetamide azide
 Probe Info  		C495(0.00); C94(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		K522(0.00); K453(0.00); K454(0.00)  LDD0035  [17]
IPM
 Probe Info  		N.A.  LDD0025  [18]
NHS
 Probe Info  		K470(0.00); K454(0.00)  LDD0010  [19]
SF
 Probe Info  		N.A.  LDD0028  [20]
Phosphinate-6
 Probe Info  		C94(0.00); C307(0.00); C71(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		K470(0.00); K534(0.00); K511(0.00)  LDD0228  [22]
AOyne
 Probe Info  		6.90  LDD0443  [23]
NAIA_5
 Probe Info  		C495(0.00); C115(0.00)  LDD2223  [24]
HHS-465
 Probe Info  		N.A.  LDD2240  [25]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		33.82  LDD1785  [26]
C235
 Probe Info  		19.16  LDD1908  [26]
FFF probe11
 Probe Info  		11.71  LDD0471  [27]
FFF probe13
 Probe Info  		20.00  LDD0475  [27]
FFF probe3
 Probe Info  		10.79  LDD0465  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C94(1.21); C495(1.04); C115(0.87); C71(1.36)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C94(1.07); C495(1.01); C115(1.03); C71(0.98)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C94(1.04); C495(1.14); C115(1.00); C71(0.79)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C94(0.90); C495(0.99); C71(0.89); C307(1.05)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C94(1.00); C495(1.01); C115(1.18); C71(0.89)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C94(0.92); C495(1.03); C115(1.10); C71(0.90)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C94(1.12); C495(0.98); C115(0.94); C71(1.04)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C94(0.98); C495(1.01); C115(0.94); C71(0.99)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C94(0.88); C495(0.94); C115(1.00); C71(0.87)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C94(1.10); C495(0.99); C115(1.01); C71(1.14)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C94(1.03); C495(1.00); C71(0.87); C307(0.89)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C94(0.94); C495(1.07); C71(0.93); C307(1.04)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C94(1.08); C495(1.00); C115(1.29); C71(0.91)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C94(0.89); C495(1.09); C115(0.99); C71(1.14)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C94(1.00); C495(0.92); C115(0.92); C71(0.89)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C94(1.12); C495(0.96); C115(1.07); C71(1.12)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C94(0.94); C495(1.04); C115(1.08); C71(1.03)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C94(1.00); C495(1.02); C115(0.93); C71(0.93)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C94(1.07); C495(1.01); C71(1.02); C307(1.06)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C94(1.00); C495(1.02); C71(0.95); C307(0.97)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C94(1.20); C495(1.00); C115(1.08); C71(1.04)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C94(1.21); C495(1.00); C115(1.08); C71(1.20)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C94(0.94); C495(1.13); C115(1.00); C71(1.05)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C94(1.10); C495(0.89); C115(0.96); C71(1.03)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C94(1.23); C495(0.97); C115(1.05); C71(1.09)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C94(0.98); C495(1.05); C115(1.07); C71(0.81)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C94(0.98); C495(1.06); C115(0.94); C71(0.90)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C94(0.95); C495(0.98); C71(0.90); C307(0.99)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C94(0.99); C495(1.07); C71(1.01); C307(1.00)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C94(1.08); C495(1.19); C115(1.12); C71(1.53)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C94(1.04); C495(1.04); C115(1.07); C71(0.94)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C94(1.18); C495(1.00); C71(0.95); C307(0.96)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C94(1.19); C495(0.97); C115(0.95); C71(0.86)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C94(1.13); C495(0.99); C115(1.27); C71(1.24)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C94(1.16); C495(1.01); C115(1.07); C71(1.08)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C94(1.31); C495(1.13); C115(1.12); C71(0.76)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C94(1.13); C495(1.00); C71(0.91); C307(0.88)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C94(0.98); C495(1.07); C71(0.99); C307(1.00)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C94(1.07); C495(0.91); C115(1.09); C71(0.92)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C94(1.13); C495(1.12); C115(0.98); C71(1.13)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C94(1.09); C495(1.07); C115(1.02); C71(1.13)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C94(1.21); C495(0.99); C115(1.06); C71(1.09)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C94(0.94); C495(1.03); C71(1.18); C307(0.98)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C94(0.94); C495(1.04); C115(1.25); C71(1.21)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C94(1.01); C495(1.02); C115(0.99); C71(1.00)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C94(0.97); C495(0.95); C71(0.86); C307(0.85)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C94(0.97); C495(1.10); C71(1.06); C307(1.05)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C94(1.03); C495(0.99); C115(0.99); C71(1.39)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C94(0.95); C495(0.99); C115(0.97); C71(0.82)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C94(1.00); C495(1.13); C115(1.10); C71(0.84)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C94(1.12); C495(1.08); C115(0.99); C71(1.16)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C94(1.04); C495(1.05); C115(1.26); C71(0.95)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C94(1.00); C495(1.15); C115(1.08); C71(1.05)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C94(1.14); C495(1.05); C115(1.22); C71(0.86)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C94(1.04); C495(1.04); C71(0.95); C307(0.98)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C94(1.04); C495(1.09); C71(1.19); C307(0.96)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C94(1.14); C495(1.08); C115(1.09); C71(2.13)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C94(1.07); C495(0.98); C115(1.06); C71(1.08)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C94(1.13); C495(0.92); C115(1.15); C71(0.98)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C94(0.98); C495(1.02); C115(0.93); C71(0.77)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C94(1.02); C495(0.92); C115(1.08); C71(1.01)  LDD1569  [28]
 LDCM0248  AKOS034007472 HEK-293T C94(1.00); C495(1.09); C71(1.13); C307(1.06)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C94(1.32); C495(0.94); C115(1.00); C71(0.95)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C94(0.98); C495(0.93); C115(1.15); C71(0.84)  LDD1514  [28]
 LDCM0088  C45 HEK-293T 18.96  LDD0201  [7]
 LDCM0631  CCW16 231MFP 5.09  LDD2215  [9]
 LDCM0367  CL1 HEK-293T C94(1.14); C495(1.01); C71(0.74); C307(1.36)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C94(1.32); C495(1.01); C115(1.11); C71(1.11)  LDD1572  [28]
 LDCM0369  CL100 HEK-293T C94(1.70); C495(1.01); C115(0.97); C71(0.88)  LDD1573  [28]
 LDCM0370  CL101 HEK-293T C94(1.33); C495(1.02); C71(0.90); C307(1.07)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C94(1.82); C495(0.88); C115(1.05); C71(1.83)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C94(1.36); C495(0.94); C115(1.07); C71(0.79)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C94(1.48); C495(0.96); C115(1.02); C71(0.95)  LDD1577  [28]
 LDCM0374  CL105 HEK-293T C94(1.24); C495(1.05); C71(0.95); C307(1.29)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C94(1.58); C495(0.92); C115(1.05); C71(1.36)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C94(1.26); C495(0.95); C115(1.09); C71(0.80)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C94(1.61); C495(0.99); C115(1.13); C71(1.11)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C94(1.34); C495(0.87); C71(0.84); C307(0.95)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C94(1.45); C495(1.03); C115(0.96); C71(0.76)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C94(1.52); C495(0.91); C115(1.05); C71(1.09)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C94(1.48); C495(0.90); C115(1.17); C71(0.83)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C94(1.85); C495(0.95); C115(0.95); C71(0.77)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C94(1.01); C495(1.01); C71(0.96); C307(1.31)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C94(1.42); C495(1.02); C115(0.85); C71(1.26)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C94(1.34); C495(0.96); C115(1.04); C71(1.13)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C94(1.46); C495(1.01); C115(1.17); C71(0.84)  LDD1590  [28]
 LDCM0387  CL117 HEK-293T C94(1.32); C495(1.05); C71(0.97); C307(1.05)  LDD1591  [28]
 LDCM0388  CL118 HEK-293T C94(1.33); C495(0.99); C115(0.98); C71(1.40)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C94(1.15); C495(1.07); C115(1.15); C71(0.79)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C94(1.45); C495(1.02); C115(1.14); C71(0.93)  LDD1594  [28]
 LDCM0391  CL120 HEK-293T C94(1.20); C495(1.05); C115(1.07); C71(0.89)  LDD1595  [28]
 LDCM0392  CL121 HEK-293T C94(1.27); C495(1.01); C71(0.67); C307(1.00)  LDD1596  [28]
 LDCM0393  CL122 HEK-293T C94(1.44); C495(1.00); C115(0.80); C71(1.61)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C94(1.45); C495(0.89); C115(1.23); C71(0.99)  LDD1598  [28]
 LDCM0395  CL124 HEK-293T C94(1.34); C495(0.94); C115(0.97); C71(0.87)  LDD1599  [28]
 LDCM0396  CL125 HEK-293T C94(1.39); C495(1.08); C71(0.81); C307(1.12)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C94(1.84); C495(0.97); C115(0.83); C71(1.75)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C94(1.54); C495(0.92); C115(1.18); C71(1.04)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C94(1.32); C495(1.13); C115(0.98); C71(1.00)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C94(1.18); C495(0.91); C71(0.99); C307(0.84)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C94(2.08); C495(0.97); C115(0.85); C71(1.81)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C94(1.34); C495(0.84); C115(1.07); C71(0.69)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C94(1.83); C495(0.99); C115(1.07); C71(0.75)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C94(1.89); C495(0.95); C115(1.03); C71(1.04)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C94(1.51); C495(1.04); C115(1.09); C71(0.98)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C94(1.61); C495(1.12); C115(1.05); C71(0.73)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C94(1.76); C495(1.02); C115(0.91); C71(1.20)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C94(0.97); C495(1.00); C71(0.83); C307(1.13)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C94(1.05); C495(0.75); C71(0.67); C307(1.50)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C94(1.65); C495(1.09); C115(1.24); C71(0.77)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C94(0.88); C495(1.02); C115(0.87); C71(0.84)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C94(1.19); C495(1.02); C115(0.91); C71(0.76)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C94(1.21); C495(0.91); C71(0.76); C307(1.00)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C94(1.25); C495(0.93); C115(0.89); C71(1.90)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C94(1.50); C495(0.98); C115(1.11); C71(0.85)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C94(1.55); C495(0.98); C115(1.17); C71(0.97)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C94(1.22); C495(0.99); C115(1.21); C71(0.95)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C94(1.67); C495(0.94); C115(1.14); C71(1.00)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C94(1.01); C495(1.08); C115(1.17); C71(0.89)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C94(1.59); C495(1.08); C115(0.95); C71(0.74)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C94(1.40); C495(0.97); C71(0.94); C307(1.21)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C94(1.26); C495(0.91); C71(0.63); C307(1.04)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C94(1.27); C495(1.10); C115(1.09); C71(0.98)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C94(1.08); C495(1.10); C115(0.97); C71(0.75)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C94(1.25); C495(1.11); C115(1.01); C71(0.78)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C94(1.28); C495(0.97); C71(0.94); C307(0.99)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C94(1.44); C495(1.06); C115(1.16); C71(0.96)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C94(1.85); C495(0.93); C115(1.14); C71(0.94)  LDD1633  [28]
 LDCM0430  CL40 HEK-293T C94(1.08); C495(0.97); C115(0.91); C71(0.82)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C94(1.55); C495(1.06); C115(0.89); C71(1.05)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C94(1.47); C495(1.06); C115(1.06); C71(0.78)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C94(1.66); C495(1.32); C115(0.96); C71(0.64)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C94(1.33); C495(1.08); C71(0.88); C307(1.27)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C94(1.02); C495(1.05); C71(0.84); C307(1.09)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C94(0.22); C495(1.19); C115(1.02); C71(0.22)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C94(1.06); C495(1.11); C115(0.91); C71(0.87)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C94(1.33); C495(0.89); C115(1.06); C71(0.81)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C94(1.36); C495(1.00); C71(1.04); C307(0.95)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C94(1.63); C495(0.99); C115(1.07); C71(0.92)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C94(2.13); C495(0.98); C115(0.91); C71(1.16)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C94(1.19); C495(1.03); C115(1.09); C71(0.94)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C94(1.53); C495(1.06); C115(1.05); C71(0.97)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C94(1.63); C495(0.77); C115(1.10); C71(0.78)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C94(1.23); C495(1.19); C115(1.09); C71(0.69)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C94(1.98); C495(1.20); C71(0.97); C307(1.04)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C94(1.22); C495(1.01); C71(0.72); C307(1.14)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C94(1.90); C495(1.12); C115(1.22); C71(0.97)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C94(1.06); C495(1.00); C115(0.91); C71(0.74)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C94(1.82); C495(0.84); C115(1.16); C71(0.76)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C94(1.61); C495(0.96); C115(1.02); C71(0.87)  LDD1655  [28]
 LDCM0453  CL61 HEK-293T C94(1.27); C495(1.00); C71(0.94); C307(0.84)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C94(2.03); C495(0.93); C115(0.93); C71(1.22)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C94(1.58); C495(0.99); C115(1.04); C71(1.02)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C94(1.42); C495(0.91); C115(1.03); C71(0.77)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C94(1.75); C495(1.09); C115(1.04); C71(1.20)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C94(1.39); C495(1.07); C115(1.20); C71(0.88)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C94(0.94); C495(1.17); C115(0.94); C71(0.74)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C94(1.88); C495(0.94); C71(0.91); C307(1.13)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C94(1.10); C495(1.22); C71(0.72); C307(1.16)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C94(0.62); C495(1.12); C115(1.22); C71(0.80)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C94(1.73); C495(1.13); C115(1.09); C71(1.42)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C94(1.15); C495(1.06); C115(0.89); C71(0.69)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C94(1.57); C495(1.04); C115(0.92); C71(0.86)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C94(0.50); C495(0.86); C71(0.88); C307(1.36)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C94(1.58); C495(0.98); C115(1.02); C71(1.59)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C94(1.39); C495(1.03); C115(0.87); C71(0.80)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C94(1.51); C495(0.94); C115(0.98); C71(1.01)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C94(1.10); C495(1.06); C115(1.01); C71(0.85)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C94(1.35); C495(1.12); C115(1.01); C71(0.66)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C94(2.03); C495(0.96); C71(0.82); C307(1.76)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C94(1.35); C495(1.09); C71(0.98); C307(0.87)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C94(1.14); C495(1.17); C71(0.75); C307(0.81)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C94(1.25); C495(1.16); C115(1.07); C71(0.88)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C94(1.29); C495(1.18); C115(1.00); C71(0.79)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C94(1.20); C495(1.08); C115(1.03); C71(0.76)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C94(1.49); C495(1.14); C71(0.74); C307(0.96)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C94(1.18); C495(0.90); C115(0.94); C71(1.19)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C94(1.68); C495(0.82); C115(1.31); C71(0.90)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C94(1.84); C495(1.08); C115(1.28); C71(1.13)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C94(1.92); C495(0.93); C115(0.95); C71(1.01)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C94(1.13); C495(1.03); C71(0.82); C307(1.12)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C94(1.61); C495(0.62); C115(1.08); C71(0.97)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C94(1.93); C495(1.13); C115(1.13); C71(0.94)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C94(0.48); C495(0.99); C71(0.82); C307(1.06)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C94(1.14); C495(0.32); C71(0.79); C307(1.03)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C94(1.57); C495(1.12); C115(1.07); C71(0.90)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C94(1.02); C495(1.03); C115(0.98); C71(0.80)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C94(1.61); C495(0.90); C115(1.11); C71(0.91)  LDD1694  [28]
 LDCM0492  CL97 HEK-293T C94(1.16); C495(0.92); C71(0.80); C307(1.03)  LDD1695  [28]
 LDCM0493  CL98 HEK-293T C94(1.50); C495(0.98); C115(0.87); C71(1.21)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C94(1.57); C495(1.01); C115(1.28); C71(0.87)  LDD1697  [28]
 LDCM0495  E2913 HEK-293T C94(1.56); C495(1.10); C115(1.22); C71(0.96)  LDD1698  [28]
 LDCM0175  Ethacrynic acid HeLa C94(0.97)  LDD2210  [12]
 LDCM0201  EV-3 T cell C71(4.41)  LDD0515  [29]
 LDCM0202  EV-93 T cell C94(20.00)  LDD0514  [29]
 LDCM0572  Fragment10 MDA-MB-231 C71(8.27)  LDD1465  [10]
 LDCM0573  Fragment11 MDA-MB-231 C94(20.00)  LDD1391  [10]
 LDCM0574  Fragment12 MDA-MB-231 C94(20.00)  LDD1393  [10]
 LDCM0575  Fragment13 MDA-MB-231 C71(4.89)  LDD1469  [10]
 LDCM0576  Fragment14 MDA-MB-231 C71(1.11); C307(0.93); C94(0.99)  LDD1471  [10]
 LDCM0579  Fragment20 MDA-MB-231 C94(20.00)  LDD1402  [10]
 LDCM0580  Fragment21 MDA-MB-231 C71(8.26); C307(20.00)  LDD1473  [10]
 LDCM0582  Fragment23 MDA-MB-231 C94(1.56)  LDD1408  [10]
 LDCM0578  Fragment27 MDA-MB-231 C71(20.00)  LDD1474  [10]
 LDCM0586  Fragment28 MDA-MB-231 C94(20.00)  LDD1475  [10]
 LDCM0590  Fragment32 MDA-MB-231 C94(12.98)  LDD1423  [10]
 LDCM0468  Fragment33 HEK-293T C94(1.79); C495(0.97); C115(1.17); C71(0.99)  LDD1671  [28]
 LDCM0596  Fragment38 MDA-MB-231 C94(0.96)  LDD1433  [10]
 LDCM0597  Fragment39 MDA-MB-231 C94(20.00)  LDD1435  [10]
 LDCM0566  Fragment4 MDA-MB-231 C94(20.00)  LDD1378  [10]
 LDCM0598  Fragment40 MDA-MB-231 C94(0.86)  LDD1436  [10]
 LDCM0599  Fragment41 MDA-MB-231 C94(1.01)  LDD1438  [10]
 LDCM0601  Fragment43 MDA-MB-231 C94(20.00)  LDD1441  [10]
 LDCM0603  Fragment45 MDA-MB-231 C71(16.75); C94(20.00)  LDD1482  [10]
 LDCM0604  Fragment46 MDA-MB-231 C94(1.06)  LDD1445  [10]
 LDCM0427  Fragment51 MDA-MB-231 C71(5.56)  LDD1483  [10]
 LDCM0610  Fragment52 MDA-MB-231 C94(20.00)  LDD1452  [10]
 LDCM0568  Fragment6 MDA-MB-231 C94(0.97)  LDD1382  [10]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [10]
 LDCM0615  Fragment63-R Jurkat _(16.55)  LDD1487  [10]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [10]
 LDCM0569  Fragment7 Jurkat _(9.11)  LDD1485  [10]
 LDCM0570  Fragment8 MDA-MB-231 C94(20.00)  LDD1385  [10]
 LDCM0571  Fragment9 MDA-MB-231 C94(20.00)  LDD1387  [10]
 LDCM0022  KB02 HCT 116 C71(1.06)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C71(0.95)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C71(1.71)  LDD0082  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C94(0.44)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C71(0.50); C94(0.40)  LDD2207  [30]
 LDCM0099  Phenelzine HEK-293T 20.00  LDD0282  [8]
 LDCM0131  RA190 MM1.R C495(1.36); C71(1.04)  LDD0304  [31]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 12.50  LDD0123  [1]
 LDCM0154  YY4 T cell 3.58  LDD0400  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Caspase-6 (CASP6) Peptidase C14A family P55212
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
9 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
10 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
11 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.