Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name EV-93  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01394  DNA fragmentation factor subunit beta (DFFB) C194 20.0
 LDTP05943  Myotubularin-related protein 1 (MTMR1) C117 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 20.0
 LDTP13302  Nuclear prelamin A recognition factor (NARF) C99 16.5
 LDTP14535  6-phosphogluconolactonase (PGLS) C32, C33 15.3
 LDTP03540  Heme oxygenase 2 (HMOX2) C265 15.0
 LDTP06211  Caspase-8 (CASP8) C360 13.7
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 12.5
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 11.0
 LDTP03230  Tyrosine-protein kinase JAK1 (JAK1) C810, C817, C818 10.7
 LDTP10874  Platelet-activating factor acetylhydrolase 2, cytoplasmic (PAFAH2) C72 9.6
 LDTP00577  Dihydroxyacetone phosphate acyltransferase (GNPAT) C54 9.5
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 9.4
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 9.0
 LDTP09841  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) C21 7.6
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 7.4
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 7.2
 LDTP09344  Prostamide/prostaglandin F synthase (PRXL2B) C44 7.1
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) C287 6.5
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120, C124 5.9
 LDTP08619  Probable ATP-dependent RNA helicase DDX60 (DDX60) C1051 5.9
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 5.9
 LDTP06486  Serine/threonine-protein kinase STK11 (STK11) C418 5.7
 LDTP05845  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (PDE3B) C297, C311 5.6
 LDTP00514  Apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1) C382 5.5
 LDTP11127  ADP-dependent glucokinase (ADPGK) C40 4.8
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) C293 4.8
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) C616, C624 4.3
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) C499 4.2
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) C335 4.2
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119, C123, C126 4.1
 LDTP15477  tRNA-uridine aminocarboxypropyltransferase 2 (DTWD2) C220, C226 4.1
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04007  Huntingtin (HTT) C1441 17.4
 LDTP01060  PRA1 family protein 2 (PRAF2) C28 5.0
 LDTP12548  Phospholipid scramblase 3 (PLSCR3) C125, C126 4.7
 LDTP07456  Molybdate-anion transporter (MFSD5) C33 4.4
 LDTP08344  Stimulator of interferon genes protein (STING1) C88, C91 4.4
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 4.4
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C440 12.5
 LDTP02338  CD48 antigen (CD48) C148 8.1
 LDTP02338  CD48 antigen (CD48) C193, C196 6.9
Other
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1000, C1001 14.6
 LDTP15887  Lipase maturation factor 2 (LMF2) C659 9.9
 LDTP17481  Uncharacterized protein C15orf39 (C15orf39) C367 9.6
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 9.3
 LDTP19499  UPF0598 protein C8orf82 (C8orf82) C98 9.2
 LDTP00239  DNA fragmentation factor subunit alpha (DFFA) C165 7.4
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C673 6.1
 LDTP00809  Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) C305 5.9
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) C288 5.7
 LDTP14041  TRPM8 channel-associated factor 1 (TCAF1) C487, C488 5.6
 LDTP19634  Uncharacterized protein ZSWIM9 (ZSWIM9) C403 5.6
 LDTP14369  Coiled-coil domain-containing protein 69 (CCDC69) C11 4.9
 LDTP07755  Dynamin-binding protein (DNMBP) C691 4.8
 LDTP14042  Malignant fibrous histiocytoma-amplified sequence 1 (MFHAS1) C1040 4.7
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C259 4.7
 LDTP17157  OCIA domain-containing protein 2 (OCIAD2) C27 4.6
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) C140 4.6
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 4.4
 LDTP11895  Lck-interacting transmembrane adapter 1 (LIME1) C69 4.3
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C135 4.3
 LDTP07204  Phosphoinositide 3-kinase regulatory subunit 6 (PIK3R6) C709, C713 4.1
 LDTP13721  TBC1 domain family member 2B (TBC1D2B) C726 4.1
 LDTP11924  Golgi-associated plant pathogenesis-related protein 1 (GLIPR2) C32 4.0

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.