Details of the Target

General Information of Target

Target ID LDTP06051
Target Name Kelch-like ECH-associated protein 1 (KEAP1)
Gene Name KEAP1
Gene ID 9817
Synonyms
INRF2; KIAA0132; KLHL19; Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
Target Type
Clinical trial
Target Bioclass
Other
Family
KEAP1 family
Subcellular location
Cytoplasm
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination . KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation. The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome.
TTD ID
T83198
Uniprot ID
Q14145
DrugMap ID
TT3Z6Y9
Ensemble ID
ENST00000171111.10
HGNC ID
HGNC:23177
ChEMBL ID
CHEMBL2069156

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.49  LDD0402  [1]
Alkylaryl probe 1
 Probe Info  		17.00  LDD0385  [2]
Alkylaryl probe 2
 Probe Info  		12.00  LDD0391  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
STPyne
 Probe Info  		K323(10.00)  LDD0277  [4]
P13
 Probe Info  		20.00  LDD0203  [5]
BTD
 Probe Info  		C13(0.66)  LDD2117  [6]
Sulforaphane-probe2
 Probe Info  		5.88  LDD0160  [7]
Curcusone 37
 Probe Info  		2.04  LDD0188  [8]
Johansson_61
 Probe Info  		_(5.06)  LDD1485  [9]
DA-P3
 Probe Info  		4.32  LDD0179  [10]
AHL-Pu-1
 Probe Info  		C288(10.67)  LDD0168  [11]
DBIA
 Probe Info  		C624(1.00)  LDD0078  [12]
IA-alkyne
 Probe Info  		C77(0.00); C368(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C368(0.00); C297(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
IPM
 Probe Info  		N.A.  LDD0005  [15]
VSF
 Probe Info  		C288(0.00); C257(0.00)  LDD0007  [15]
Phosphinate-6
 Probe Info  		C319(0.00); C434(0.00)  LDD0018  [16]
AOyne
 Probe Info  		7.90  LDD0443  [17]
NAIA_5
 Probe Info  		C151(0.00); C489(0.00); C368(0.00); C613(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		16.68  LDD1838  [18]
C174
 Probe Info  		5.31  LDD1854  [18]
C240
 Probe Info  		15.03  LDD1913  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C13(0.66)  LDD2117  [6]
 LDCM0025  4SU-RNA HEK-293T C288(10.67)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C288(10.81)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C288(0.91); C23(0.96); C38(0.96); C249(0.75)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C151(5.55); C288(1.15); C23(0.96); C38(0.96)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C288(1.24); C23(0.78); C38(0.78); C249(0.81)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C288(1.18); C23(0.86); C38(0.86); C249(0.80)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C288(1.01); C23(0.93); C38(0.93); C249(0.83)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C288(1.52); C23(1.09); C38(1.09); C249(0.69)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C288(1.20); C23(0.91); C38(0.91); C249(0.73)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C288(1.55); C23(0.97); C38(0.97); C249(0.62)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C288(1.70); C23(1.09); C38(1.09); C249(0.80)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C288(1.44); C23(0.96); C38(0.98); C249(0.76)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C288(1.37); C23(0.78); C38(0.89); C249(0.91)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C288(1.22); C23(0.92); C38(0.98); C249(0.84)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C151(3.95); C288(1.23); C23(1.11); C38(1.11)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C288(1.20); C23(1.02); C38(1.04); C249(0.89)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C288(1.31); C23(0.97); C38(1.12); C249(0.81)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C288(1.28); C23(1.12); C38(1.08); C249(0.94)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C288(1.05); C23(0.99); C38(0.99); C249(1.04)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C288(1.21); C23(1.01); C38(1.01); C249(0.97)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C288(1.54); C23(1.02); C38(1.02); C249(1.01)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C288(2.06); C23(1.10); C38(1.10); C249(0.93)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C288(1.23); C23(1.04); C38(1.04); C249(1.05)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C288(1.24); C23(0.92); C38(0.92); C249(0.98)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C288(1.14); C23(1.03); C38(1.03); C249(1.08)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C151(1.14); C288(0.93); C23(0.84); C38(0.84)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C288(0.92); C23(1.23); C38(1.23); C249(0.99)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C288(1.22); C23(0.91); C38(0.91); C249(1.01)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C288(1.21); C23(1.09); C38(1.09); C249(1.11)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C288(1.40); C23(0.91); C38(0.91); C249(1.26)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C288(0.90); C23(0.85); C38(0.85); C249(1.10)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C288(1.13); C23(1.26); C38(1.26); C249(1.15)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C288(1.88); C23(1.17); C38(1.17); C249(1.03)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C288(1.45); C23(1.18); C38(1.18); C249(1.08)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C288(1.31); C23(1.05); C38(1.05); C249(0.94)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C288(1.31); C23(0.96); C38(0.96); C249(1.25)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C288(1.90); C23(0.97); C38(0.97); C249(0.75)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C288(1.27); C23(1.17); C38(1.17); C249(1.30)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C288(1.58); C23(0.89); C38(0.89); C249(0.79)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C288(1.40); C23(0.85); C38(0.85); C249(0.78)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C288(1.77); C23(0.98); C38(0.98); C249(0.86)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C288(1.75); C23(0.91); C38(0.91); C249(0.88)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C288(1.27); C23(0.92); C38(0.92); C249(0.78)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C288(1.19); C23(0.93); C38(0.93); C249(0.98)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C288(1.76); C23(1.18); C38(1.18); C249(0.78)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C288(1.72); C23(1.05); C38(1.05); C249(0.90)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C151(1.05); C288(0.96); C23(1.11); C38(1.11)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C288(2.02); C23(1.05); C38(1.05); C249(0.77)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C288(1.92); C23(1.08); C38(1.08); C249(0.84)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C288(1.15); C23(0.82); C38(0.82); C249(0.83)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C288(1.23); C23(1.11); C38(1.11); C249(0.99)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C319(0.90); C249(0.98); C241(0.98); C613(1.07)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C319(0.88); C249(0.91); C241(0.91); C273(1.02)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C249(0.77); C241(0.77); C613(1.16); C23(1.18)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C249(0.84); C241(0.84); C319(0.88); C613(1.16)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C319(0.92); C249(1.02); C241(1.02); C23(1.43)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C249(0.76); C241(0.76); C319(1.15); C613(1.31)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C395(0.42); C406(0.42); C171(0.43); C196(0.43)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C249(0.77); C241(0.77); C273(0.97); C613(0.99)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C613(1.01); C273(1.02); C249(1.07); C241(1.07)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C249(1.00); C241(1.00); C319(1.05); C613(1.21)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C249(1.02); C241(1.02); C319(1.13); C613(1.64)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C288(1.59); C23(1.24); C38(1.18); C249(0.99)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C288(1.33); C23(1.30); C38(1.31); C249(0.93)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C288(1.10); C23(1.13); C38(1.16); C249(0.97)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C288(1.11); C23(1.24); C38(1.22); C249(0.93)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C489(0.66); C395(0.71); C406(0.71); C624(1.00)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C489(0.37); C171(0.48); C196(0.48); C249(0.90)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C489(0.72); C395(1.01); C406(1.01); C249(1.01)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C171(0.47); C196(0.47); C14(0.49); C249(0.78)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C489(0.52); C273(0.95); C395(0.95); C406(0.95)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C489(0.54); C395(0.68); C406(0.68); C151(0.95)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C489(0.56); C395(0.90); C406(0.90); C249(0.97)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C489(0.46); C273(0.93); C319(1.01); C395(1.06)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C489(0.72); C395(0.95); C406(0.95); C624(1.09)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C489(0.44); C171(0.61); C196(0.61); C319(0.66)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C171(0.37); C196(0.37); C489(0.47); C249(0.79)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C489(0.47); C171(0.55); C196(0.55); C319(0.75)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C489(0.49); C249(0.78); C241(0.78); C319(0.84)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C489(0.52); C171(0.64); C196(0.64); C319(0.72)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C14(0.45); C171(0.49); C196(0.49); C226(0.80)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C489(0.37); C171(0.63); C196(0.63); C249(0.75)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C489(0.58); C319(0.78); C249(0.79); C241(0.79)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C489(0.38); C171(0.41); C196(0.41); C249(0.77)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C489(0.46); C171(0.55); C196(0.55); C151(0.72)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C489(0.44); C171(0.73); C196(0.73); C319(0.77)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C288(0.66); C226(0.70); C273(0.81); C624(0.86)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C226(0.62); C288(0.88); C273(0.88); C613(0.90)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C288(0.74); C226(0.80); C249(0.86); C241(0.86)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C226(0.86); C288(0.89); C624(0.93); C249(0.93)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C288(0.79); C226(0.83); C249(0.85); C241(0.85)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C171(0.31); C196(0.31); C14(0.57); C319(0.81)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C489(0.77); C395(0.81); C406(0.81); C624(0.95)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C226(0.77); C288(0.82); C613(0.93); C273(0.95)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C489(0.85); C226(0.91); C249(0.98); C241(0.98)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C226(0.81); C489(0.98); C395(1.01); C406(1.01)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C489(0.84); C288(0.91); C624(0.95); C226(0.97)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C489(0.83); C288(0.84); C226(0.92); C249(1.01)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C241(0.99); C395(1.04); C406(1.04); C613(1.07)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C395(0.78); C406(0.78); C241(0.91); C23(0.95)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C319(0.82); C241(0.86); C249(0.90); C23(0.94)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C395(0.51); C406(0.51); C489(0.73); C249(0.81)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C171(0.25); C196(0.25); C14(0.62); C249(0.75)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C395(0.59); C406(0.59); C489(0.71); C226(0.98)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C395(0.91); C406(0.91); C249(0.93); C241(0.94)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C241(0.78); C249(0.79); C395(0.87); C406(0.87)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C395(0.67); C406(0.67); C489(0.75); C249(0.86)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C395(0.65); C406(0.65); C489(0.72); C249(0.87)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C249(0.60); C489(0.63); C395(0.76); C406(0.76)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C395(0.54); C406(0.54); C249(0.57); C489(0.58)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C241(0.78); C249(0.81); C489(0.85); C23(1.01)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C241(0.89); C489(0.92); C249(0.92); C288(1.05)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C489(0.87); C241(0.87); C249(0.87); C395(0.90)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C171(0.39); C196(0.39); C489(0.58); C395(0.61)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C249(0.72); C241(0.73); C489(0.94); C395(0.95)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C241(0.75); C249(0.78); C624(0.92); C226(0.97)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C489(0.54); C241(0.90); C249(0.91); C226(0.92)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C249(0.77); C241(0.79); C395(1.00); C406(1.00)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C395(0.64); C406(0.64); C489(0.68); C249(0.86)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C395(0.80); C406(0.80); C241(0.86); C249(0.87)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C395(0.72); C406(0.72); C241(0.87); C249(0.92)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C395(0.57); C406(0.57); C241(0.79); C249(0.80)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C171(0.68); C196(0.68); C249(0.76); C241(0.84)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C395(0.79); C406(0.79); C613(0.80); C249(0.83)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C395(0.44); C406(0.44); C171(0.59); C196(0.59)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C395(0.68); C406(0.68); C171(0.69); C196(0.69)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C613(0.76); C395(0.77); C406(0.77); C171(0.83)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C395(0.84); C406(0.84); C249(0.85); C613(0.86)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C395(0.67); C406(0.67); C249(0.90); C171(0.91)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C395(0.70); C406(0.70); C171(0.76); C196(0.76)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C395(0.55); C406(0.55); C319(0.83); C13(0.96)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C613(0.81); C13(0.81); C14(0.81); C395(0.83)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C171(0.75); C196(0.75); C249(0.78); C241(0.86)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C613(0.76); C171(0.82); C196(0.82); C241(0.85)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C395(0.69); C406(0.69); C613(0.80); C319(0.94)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C395(0.45); C406(0.45); C171(0.46); C196(0.46)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C395(0.78); C406(0.78); C13(0.85); C14(0.85)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C171(0.55); C196(0.55); C395(0.58); C406(0.58)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C395(0.30); C406(0.30); C171(0.68); C196(0.68)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C395(0.55); C406(0.55); C249(0.75); C241(0.75)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C395(0.46); C406(0.46); C249(0.73); C241(0.73)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C395(0.41); C406(0.41); C249(0.71); C241(0.71)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C395(0.75); C406(0.75); C249(0.79); C241(0.79)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C395(0.69); C406(0.69); C249(0.84); C241(0.84)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C395(0.76); C406(0.76); C249(0.89); C241(0.89)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C395(0.54); C406(0.54); C249(0.76); C241(0.76)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C395(0.73); C406(0.73); C249(0.83); C241(0.83)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C395(0.53); C406(0.53); C249(0.86); C241(0.86)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C395(0.69); C406(0.69); C249(0.76); C241(0.76)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C395(0.53); C406(0.53); C249(0.67); C241(0.67)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C395(0.69); C406(0.69); C249(0.77); C241(0.77)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C249(0.70); C241(0.70); C319(0.92); C226(0.94)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C249(0.88); C241(0.88); C395(0.93); C406(0.93)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C395(0.52); C406(0.52); C249(0.82); C241(0.82)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C489(0.27); C249(0.69); C241(0.69); C319(1.00)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C489(0.52); C249(0.78); C241(0.78); C23(0.81)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C151(0.83); C288(1.00); C23(0.83); C38(0.83)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C171(0.41); C196(0.41); C395(0.63); C406(0.63)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C395(0.35); C406(0.35); C171(0.48); C196(0.48)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C624(1.00)  LDD0078  [12]
 LDCM0088  C45 HEK-293T 20.00  LDD0203  [5]
 LDCM0632  CL-Sc Hep-G2 C319(0.86); C613(0.84); C319(0.76)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C319(0.95); C395(1.08); C406(1.08); C624(1.08)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C319(0.62); C489(0.87); C288(1.11); C273(1.19)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C171(0.48); C196(0.48); C288(0.92); C249(1.01)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C171(0.43); C196(0.43); C395(0.59); C406(0.59)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C171(0.49); C196(0.49); C395(0.67); C406(0.67)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C171(0.85); C196(0.85); C13(0.85); C14(0.85)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C395(0.64); C406(0.64); C489(0.77); C319(0.78)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C489(0.60); C171(0.85); C196(0.85); C319(0.89)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C171(0.65); C196(0.65); C489(0.69); C319(0.81)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C489(0.47); C171(0.62); C196(0.62); C151(0.70)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C489(0.52); C171(0.78); C196(0.78); C319(0.92)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C489(0.54); C319(0.99); C395(1.06); C406(1.06)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C489(0.75); C319(1.00); C395(1.10); C406(1.10)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C489(0.59); C171(1.04); C196(1.04); C395(1.04)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C489(0.65); C395(0.88); C406(0.88); C171(1.07)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C171(0.60); C196(0.60); C319(0.69); C489(0.81)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C489(0.51); C171(0.52); C196(0.52); C319(0.67)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C489(0.50); C171(0.53); C196(0.53); C319(0.68)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C489(0.43); C171(0.59); C196(0.59); C319(0.76)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C171(0.29); C196(0.29); C489(0.43); C319(0.73)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C395(0.71); C406(0.71); C489(0.75); C288(1.14)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C226(0.65); C489(0.93); C395(0.97); C406(0.97)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C226(0.69); C395(0.83); C406(0.83); C489(0.88)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C319(0.72); C489(0.72); C171(1.05); C196(1.05)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C226(0.85); C395(0.98); C406(0.98); C23(0.99)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C489(0.50); C624(0.91); C241(0.99); C249(1.01)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C249(0.83); C489(0.87); C241(0.87); C395(0.95)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C249(0.68); C241(0.69); C489(0.87); C395(0.95)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C249(0.65); C241(0.70); C395(0.86); C406(0.86)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C23(0.93); C38(0.93); C489(0.97); C395(1.10)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C489(0.90); C395(1.04); C406(1.04); C241(1.12)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C395(0.89); C406(0.89); C23(1.03); C38(1.03)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C395(0.71); C406(0.71); C489(0.75); C241(0.86)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C319(0.74); C249(0.92); C241(0.92); C273(1.10)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C319(0.81); C489(1.01); C273(1.13); C624(1.19)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C489(0.68); C319(0.81); C171(1.21); C196(1.21)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C489(0.63); C319(0.90); C288(0.97); C395(1.01)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C489(0.79); C319(0.90); C624(1.08); C613(1.32)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C319(0.77); C249(0.87); C241(0.87); C613(0.99)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C489(0.72); C319(0.73); C624(0.97); C249(1.00)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C319(0.74); C23(0.98); C38(0.98); C13(0.99)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C489(0.43); C319(0.63); C249(1.04); C241(1.04)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C489(0.64); C319(0.83); C395(1.03); C406(1.03)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C489(0.35); C395(0.63); C406(0.63); C319(1.03)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C489(0.49); C319(0.81); C395(0.90); C406(0.90)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C489(0.56); C319(0.61); C395(0.73); C406(0.73)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C288(1.73); C23(1.97); C38(1.97); C249(1.53)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C288(1.28); C23(1.17); C38(1.17); C249(1.01)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C288(1.40); C23(1.22); C38(1.22); C249(1.23)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C288(1.40); C23(1.57); C38(1.57); C249(1.48)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C288(1.47); C23(1.35); C38(1.35); C249(0.97)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C288(1.08); C23(1.31); C38(1.31); C249(1.40)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C288(1.14); C23(1.14); C38(1.14); C249(1.13)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C151(2.91); C288(1.38); C23(1.56); C38(1.56)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C151(1.79); C288(1.33); C23(1.29); C38(1.29)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C151(2.18); C288(4.38); C23(5.39); C38(5.39)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C151(2.00); C288(2.02); C23(3.34); C38(3.34)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C151(1.60); C288(1.38); C23(1.47); C38(1.47)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C151(4.14); C288(2.17); C23(1.67); C38(1.67)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C151(1.84); C288(2.95); C23(1.67); C38(1.67)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C151(1.95); C288(1.64); C23(1.98); C38(1.98)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C288(2.21); C23(2.21); C38(2.21); C249(1.26)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C151(4.22); C288(2.03); C23(2.00); C38(2.00)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C151(4.66); C288(1.58); C23(1.62); C38(1.62)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C151(4.17); C288(2.46); C23(2.60); C38(2.60)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C151(3.39); C288(1.75); C23(1.80); C38(1.80)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C151(2.97); C288(1.67); C23(1.71); C38(1.71)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C151(4.19); C288(2.20); C23(1.87); C38(1.87)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C151(1.67); C288(1.35); C23(1.23); C38(1.23)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C151(3.35); C288(1.21); C23(0.96); C38(0.96)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C151(2.75); C288(1.30); C23(1.11); C38(1.11)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C151(1.95); C288(1.24); C23(1.22); C38(1.22)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C288(0.92); C23(0.94); C38(0.94); C249(1.02)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C151(3.54); C288(1.28); C23(1.02); C38(1.02)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C151(3.12); C288(1.51); C23(1.02); C38(1.02)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C151(1.28); C288(1.43); C23(1.10); C38(1.10)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C151(2.96); C288(1.28); C23(1.16); C38(1.16)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C151(2.11); C288(1.66); C23(2.37); C38(2.37)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C151(0.97); C288(1.20); C23(1.33); C38(1.33)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C151(2.79); C288(1.33); C23(1.09); C38(1.09)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C151(4.84); C288(1.46); C23(1.32); C38(1.32)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C151(1.10); C288(1.08); C23(1.18); C38(1.18)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C151(1.67); C288(1.17); C23(1.08); C38(1.08)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C288(1.28); C23(1.17); C38(1.17); C249(1.44)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C151(2.63); C288(1.36); C23(1.23); C38(1.23)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C151(1.71); C288(1.36); C23(0.94); C38(0.94)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C151(2.09); C288(1.25); C23(1.08); C38(1.08)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C151(5.91); C288(1.72); C23(1.02); C38(1.02)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C151(4.43); C288(1.96); C23(1.31); C38(1.31)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C151(1.26); C288(1.35); C23(0.95); C38(0.95)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C151(4.12); C288(1.95); C23(1.34); C38(1.34)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C151(1.55); C288(1.30); C23(1.11); C38(1.11)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C151(2.94); C288(1.78); C23(1.48); C38(1.48)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C151(3.73); C288(1.80); C23(1.84); C38(1.84)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C288(1.23); C23(1.12); C38(1.12); C249(1.11)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C151(2.25); C288(1.52); C23(1.08); C38(1.08)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C151(6.98); C288(1.30); C23(1.20); C38(1.20)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C151(1.50); C288(1.16); C23(1.05); C38(1.05)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C151(8.04); C288(1.55); C23(2.54); C38(2.54)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C151(6.56); C288(1.46); C23(1.44); C38(1.44)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C151(1.64); C288(0.92); C23(1.15); C38(1.15)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C151(5.87); C288(1.12); C23(3.69); C38(3.69)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C151(2.19); C288(1.28); C23(1.36); C38(1.36)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C151(3.27); C288(1.08); C23(1.54); C38(1.54)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C288(2.15); C23(2.49); C38(2.49); C249(1.43)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C151(2.08); C288(0.99); C23(1.22); C38(1.22)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C151(3.03); C288(1.10); C23(1.24); C38(1.24)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C151(2.88); C288(0.96); C23(1.53); C38(1.53)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C151(8.85); C288(1.28); C23(1.61); C38(1.61)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C151(7.82); C288(1.25); C23(2.04); C38(2.04)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C151(2.91); C288(0.95); C23(1.25); C38(1.25)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C151(3.18); C288(1.07); C23(1.12); C38(1.12)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C151(8.37); C288(1.03); C23(1.35); C38(1.35)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C151(5.27); C288(0.96); C23(1.67); C38(1.67)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C151(5.03); C288(1.01); C23(1.77); C38(1.77)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C288(1.23); C23(1.29); C38(1.29); C249(1.27)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C151(7.66); C288(5.43); C23(3.49); C38(3.49)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C288(1.32); C23(1.01); C38(1.01); C249(0.98)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C288(1.30); C23(1.65); C38(1.65); C249(1.03)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C288(1.06); C23(1.76); C38(1.76); C249(1.03)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C288(0.98); C23(1.35); C38(1.35); C249(1.31)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C288(1.39); C23(1.40); C38(1.40); C249(1.23)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C288(1.16); C23(1.03); C38(1.03); C249(1.04)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C288(1.30); C23(1.06); C38(1.06); C249(1.05)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C288(1.13); C23(1.06); C38(1.06); C249(0.96)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C288(0.98); C23(0.92); C38(0.92); C249(0.97)  LDD0811  [12]
 LDCM0033  Curcusone1d MCF-7 2.04  LDD0188  [8]
 LDCM0634  CY-0357 Hep-G2 C288(0.90)  LDD2228  [14]
 LDCM0027  Dopamine HEK-293T 4.32  LDD0179  [10]
 LDCM0495  E2913 HEK-293T C288(0.91); C613(0.97); C226(1.09); C319(1.09)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C13(3.49); C319(1.74); C613(0.84)  LDD1702  [6]
 LDCM0202  EV-93 T cell C288(5.73)  LDD0514  [20]
 LDCM0625  F8 Ramos C288(1.24); C319(1.05)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C288(1.65)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C288(0.80)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C288(2.22)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C288(3.21)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C288(1.56); C319(0.81)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C288(1.33)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C288(2.88)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C288(0.35)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C288(1.22)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C288(1.88); C319(0.81)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C288(0.83)  LDD2199  [21]
 LDCM0468  Fragment33 HCT 116 C151(2.89); C288(1.47); C23(1.18); C38(1.18)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C288(1.80)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C288(0.74); C319(1.23)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C151(4.48); C288(6.61); C23(2.05); C38(2.05)  LDD0744  [12]
 LDCM0614  Fragment56 Ramos C288(9.08)  LDD2205  [21]
 LDCM0617  Fragment63-S Jurkat _(8.39)  LDD1490  [9]
 LDCM0569  Fragment7 Jurkat _(5.06)  LDD1485  [9]
 LDCM0022  KB02 HCT 116 C288(16.39); C613(3.46); C624(3.22)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C288(18.23); C613(2.53); C624(2.18)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C288(20.00); C613(8.42); C624(3.73)  LDD0082  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C13(1.13)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C13(0.83)  LDD2137  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C288(0.32)  LDD2206  [22]
 LDCM0628  OTUB2-COV-1 HEK-293T C288(0.33)  LDD2207  [22]
 LDCM0099  Phenelzine HEK-293T 20.00  LDD0386  [2]
 LDCM0003  Sulforaphane MDA-MB-231 5.88  LDD0160  [7]
 LDCM0021  THZ1 HCT 116 C288(1.13); C23(1.11); C38(1.11); C624(0.97)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) 5'-AMP-activated protein kinase gamma subunit family P54619
Aspartoacylase (ASPA) AspA/AstE family P45381
Cullin-3 (CUL3) Cullin family Q13618
Interferon-induced helicase C domain-containing protein 1 (IFIH1) Helicase family Q9BYX4
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Diphosphoinositol polyphosphate phosphohydrolase 2 (NUDT4) Nudix hydrolase family Q9NZJ9
Dipeptidyl peptidase 3 (DPP3) Peptidase M49 family Q9NY33
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Sestrin-2 (SESN2) Sestrin family P58004
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1) . Q9NPC3
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycophorin-A (GYPA) Glycophorin A family P02724
Kelch-like protein 2 (KLHL2) . O95198
Kelch-like protein 3 (KLHL3) . Q9UH77
Nuclear pore complex protein Nup50 (NUP50) . Q9UKX7
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) BZIP family Q9Y2D1
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) BZIP family Q14494
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Zinc finger and SCAN domain-containing protein 32 (ZSCAN32) Krueppel C2H2-type zinc-finger protein family Q9NX65
Zinc finger protein 121 (ZNF121) Krueppel C2H2-type zinc-finger protein family P58317
TSC22 domain family protein 4 (TSC22D4) TSC-22/Dip/Bun family Q9Y3Q8
Transcription factor p65 (RELA) . Q04206
Transcriptional-regulating factor 1 (TRERF1) . Q96PN7
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 1 (ICAM1) ICAM family P05362
Other
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
APC membrane recruitment protein 1 (AMER1) Amer family Q5JTC6
Autophagy protein 5 (ATG5) ATG5 family Q9H1Y0
DNA damage-inducible transcript 4 protein (DDIT4) DDIT4 family Q9NX09
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Eukaryotic peptide chain release factor subunit 1 (ETF1) Eukaryotic release factor 1 family P62495
Collagen alpha-1(I) chain (COL1A1) Fibrillar collagen family P02452
Progranulin (GRN) Granulin family P28799
Integrin beta-2 (ITGB2) Integrin beta chain family P05107
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) MAD2 family Q13257
Protein Niban 2 (NIBAN2) Niban family Q96TA1
Plectin (PLEC) Plakin or cytolinker family Q15149
Securin (PTTG1) Securin family O95997
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
U6 snRNA-associated Sm-like protein LSm3 (LSM3) SnRNP Sm proteins family P62310
UPF0561 protein C2orf68 (C2orf68) UPF0561 family Q2NKX9
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Glutamate-rich protein 5 (ERICH5) . Q6P6B1
IQ domain-containing protein C (IQCC) . Q4KMZ1
Kelch-like protein 24 (KLHL24) . Q6TFL4
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
Partner and localizer of BRCA2 (PALB2) . Q86YC2
Protein FAM117B (FAM117B) . Q6P1L5
Sequestosome-1 (SQSTM1) . Q13501
Signal-transducing adaptor protein 2 (STAP2) . Q9UGK3
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TBC1 domain family member 7 (TBC1D7) . Q9P0N9
Telomeric repeat-binding factor 1 (TERF1) . P54274
Whirlin (WHRN) . Q9P202

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dimethyl Fumarate Small molecular drug DB08908
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cxa10 Small molecular drug DF1JO7
Preclinical
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vcb101 Small molecular drug D46EBX
Vcb102 Small molecular drug DG07UD
Patented
Click To Hide/Show 32 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-hydroxybenzamide Derivative 1 Small molecular drug D02YNU
2-hydroxybenzamide Derivative 2 Small molecular drug D0VW9H
Chalcone Derivative 1 Small molecular drug D0U9TR
Chalcone Derivative 2 Small molecular drug D0EO3S
Chalcone Derivative 3 Small molecular drug D0G1LS
Chalcone Derivative 4 Small molecular drug D02SPI
Diterpenoid Derivative 1 Small molecular drug D09FZF
Diterpenoid Derivative 2 Small molecular drug D0Q9QQ
Pmid28454500-compound-10 Small molecular drug D0WN1Y
Pmid28454500-compound-11 Small molecular drug D0RM4V
Pmid28454500-compound-12 Small molecular drug D0AX4Q
Pmid28454500-compound-13 Small molecular drug D0AJ2T
Pmid28454500-compound-3 Small molecular drug D0JH8Z
Pmid28454500-compound-32 Small molecular drug D0L1JQ
Pmid28454500-compound-33 Small molecular drug D0FM3Q
Pmid28454500-compound-34 Small molecular drug D0FH6P
Pmid28454500-compound-35 Small molecular drug D0MX0Q
Pmid28454500-compound-36 Small molecular drug D01PKZ
Pmid28454500-compound-37 Small molecular drug D0SA1N
Pmid28454500-compound-40 Small molecular drug D0MQ3X
Pmid28454500-compound-41 Small molecular drug D0C1PB
Pmid28454500-compound-49 Small molecular drug D0N1VC
Pmid28454500-compound-50 Small molecular drug D0G4EK
Pmid28454500-compound-8 Small molecular drug D01GTU
Pmid28454500-compound-9 Small molecular drug D0N9GH
Pyrazino[2,1-a]Isoquinolin Derivative 1 Small molecular drug D0AZ8T
Pyrazino[2,1-a]Isoquinolin Derivative 2 Small molecular drug D06LEF
Pyrazino[2,1-a]Isoquinolin Derivative 3 Small molecular drug D0VA2G
Pyrazino[2,1-a]Isoquinolin Derivative 4 Small molecular drug D01MZI
Pyridyl Compound 1 Small molecular drug D0KX0J
Trepenoid Derivative 1 Small molecular drug D0XL2V
Vinyl Sulfone Derivative 1 Small molecular drug D04ILM

References

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2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
9 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.