General Information of Experiment

Probe Name P13  Probe Info 
Probe concentration 1 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name C45  Competitor Info 
Competitor Concentration 1 mM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04030  Biotinidase (BTD) 20.0
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 20.0
 LDTP02055  Thymidylate synthase (TYMS) 14.3
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 11.8
 LDTP03662  Long-chain-fatty-acid--CoA ligase 1 (ACSL1) 11.5
 LDTP02918  S-adenosylmethionine decarboxylase proenzyme (AMD1) 10.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) 8.1
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 6.9
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 6.5
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 20.0
 LDTP08926  Solute carrier family 15 member 4 (SLC15A4) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.6
Other
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 20.0
 LDTP16078  Heme-binding protein 1 (HEBP1) 13.9
 LDTP13044  Ribosome-binding protein 1 (RRBP1) 10.5
 LDTP12412  Reticulon-4 (RTN4) 6.0

References

1 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.